BRPI0613771A2 - derivado de heterociclideno acetamida - Google Patents
derivado de heterociclideno acetamidaInfo
- Publication number
- BRPI0613771A2 BRPI0613771A2 BRPI0613771-7A BRPI0613771A BRPI0613771A2 BR PI0613771 A2 BRPI0613771 A2 BR PI0613771A2 BR PI0613771 A BRPI0613771 A BR PI0613771A BR PI0613771 A2 BRPI0613771 A2 BR PI0613771A2
- Authority
- BR
- Brazil
- Prior art keywords
- group
- compound
- salt
- isomer
- solvate
- Prior art date
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A61P11/06—Antiasthmatics
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- A61P11/08—Bronchodilators
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
DERIVADO DE HETEROCICLIDENO ACETAMIDA. Um composto representado pela fórmula (I') (em que m, n, e p cada um representa O a 2; q representa O ou 1; R¹ representa halogênio, um grupo hidrocarboneto, um grupo heterocíclico, um grupo alcoxi, um grupo alcoxicarbonil, um grupo sulfamoil, um grupo CN, um grupo NO~ 2~, ou outros; R² representa halogênio, amino, um grupo hidrocarboneto, um grupo heterocíclico aromático, ou um grupo oxo; X~ 1~ representa O, -NR³-, ou -S(O)r-; X~ 2~ representa um grupo metileno, O, -NR³-, ou -S(O)r-; Q' representa um grupo heteroaril, um grupo heteroarilalquil, um grupo aril substituído, ou um grupo aralquil; Porção de ciclo representa um anel aril ou um anel heteroaril; e a linha ondulada representa um E-isómero ou um Z-isómero), um sal do composto, ou um solvato do composto ou o sal. Uma composição farmacêutica e um Antagonista de receptor tipo I potencial de receptor transitório (TRPV1) cada um contendo, como um ingrediente ativo, pelo menos um do composto, um sal do composto e um solvato do composto ou o sal.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005213534 | 2005-07-22 | ||
JP2005-213534 | 2005-07-22 | ||
JP2005330890 | 2005-11-15 | ||
JP2005-330890 | 2005-11-15 | ||
JP2006045985 | 2006-02-22 | ||
JP2006-045985 | 2006-02-22 | ||
PCT/IB2006/002016 WO2007010383A1 (ja) | 2005-07-22 | 2006-07-24 | 新規なヘテロシクリデンアセトアミド誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0613771A2 true BRPI0613771A2 (pt) | 2009-05-19 |
BRPI0613771B1 BRPI0613771B1 (pt) | 2021-11-23 |
Family
ID=37668470
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0613771-7A BRPI0613771B1 (pt) | 2005-07-22 | 2006-07-24 | Composto derivado de heterociclideno acetamida, composição farmacêutica e antagonista de receptor de tipo i vaniloide com potencial de receptor transitório (trpv1) |
Country Status (14)
Country | Link |
---|---|
US (2) | US7910751B2 (pt) |
EP (1) | EP1908753B1 (pt) |
JP (2) | JP4754566B2 (pt) |
KR (2) | KR101136183B1 (pt) |
AU (1) | AU2006271297C1 (pt) |
BR (1) | BRPI0613771B1 (pt) |
CA (1) | CA2616079C (pt) |
CR (1) | CR9660A (pt) |
EC (1) | ECSP088129A (pt) |
ES (1) | ES2531621T3 (pt) |
NO (1) | NO341962B1 (pt) |
NZ (1) | NZ565080A (pt) |
PT (1) | PT1908753E (pt) |
WO (1) | WO2007010383A1 (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2616079C (en) | 2005-07-22 | 2012-09-25 | Mochida Pharmaceutical Co., Ltd. | Novel heterocyclidene acetamide derivative |
PE20081692A1 (es) * | 2007-01-24 | 2008-12-18 | Mochida Pharm Co Ltd | Nuevo derivado de heterocicliden acetamida |
US20100016285A1 (en) * | 2007-01-24 | 2010-01-21 | Mochida Pharmaceutical Co., Ltd. | Heterocyclidene-n-(aryl) acetamide derivative |
JP2011201776A (ja) * | 2008-07-23 | 2011-10-13 | Mochida Pharmaceut Co Ltd | ヘテロシクリデン−n−(3,4−ジヒドロ−2(1h)−キナゾリノン−5−イル)アセトアミド誘導体 |
US8765815B2 (en) | 2007-09-20 | 2014-07-01 | Ramot At Tel-Aviv University Ltd. | N-phenyl anthranilic acid derivatives and uses thereof |
AU2009269720A1 (en) * | 2008-06-17 | 2012-01-19 | Glenmark Pharmaceuticals S.A. | Chromane derivatives as TRPV3 modulators |
JP2011201777A (ja) * | 2008-07-23 | 2011-10-13 | Mochida Pharmaceut Co Ltd | 光学活性なヘテロシクリデン−n−アリールアセトアミド誘導体 |
JP2011201778A (ja) * | 2008-07-23 | 2011-10-13 | Mochida Pharmaceut Co Ltd | p−置換アリールアセトアミドを有するヘテロシクリデン誘導体 |
US8802711B2 (en) | 2011-03-25 | 2014-08-12 | Abbvie Inc. | TRPV1 antagonists |
WO2013096223A1 (en) | 2011-12-19 | 2013-06-27 | Abbvie Inc. | Trpv1 antagonists |
US8969325B2 (en) | 2011-12-19 | 2015-03-03 | Abbvie Inc. | TRPV1 antagonists |
US8796328B2 (en) | 2012-06-20 | 2014-08-05 | Abbvie Inc. | TRPV1 antagonists |
US9643947B2 (en) | 2013-08-28 | 2017-05-09 | Northwestern University | 7-membered fused heterocycles and methods of their synthesis |
KR102022154B1 (ko) * | 2016-11-24 | 2019-09-18 | 한양대학교 산학협력단 | MBD2-p66α(GATAD2A)의 상호작용을 억제하는 화합물을 포함하는 암 전이 억제 및 암 질환 예방 및 치료용 조성물 |
CN110149795B (zh) | 2016-12-02 | 2023-10-03 | 西姆莱斯股份公司 | 化妆品混合物 |
JP6230743B1 (ja) * | 2017-05-31 | 2017-11-15 | 持田製薬株式会社 | ヘテロシクリデンアセトアミド誘導体の結晶 |
JP7320113B2 (ja) | 2019-08-23 | 2023-08-02 | 持田製薬株式会社 | ヘテロシクリデンアセトアミド誘導体の製造方法 |
CN112409191A (zh) * | 2019-08-23 | 2021-02-26 | 持田制药株式会社 | 光学活性的氨基醇的制备方法 |
WO2021039023A1 (ja) * | 2019-08-23 | 2021-03-04 | 持田製薬株式会社 | ヘテロシクリデンアセトアミド誘導体の製造方法 |
MX2022002017A (es) * | 2019-08-23 | 2022-03-11 | Mochida Pharm Co Ltd | Metodo para producir derivado de heterociclideno acetamida. |
US20220370404A1 (en) * | 2019-10-04 | 2022-11-24 | Senju Pharmaceutical Co., Ltd. | Pharmaceutical drug containing heterocyclidene acetamide derivative |
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- 2006-07-24 JP JP2007525444A patent/JP4754566B2/ja active Active
- 2006-07-24 KR KR1020087004378A patent/KR101136183B1/ko active IP Right Grant
- 2006-07-24 NZ NZ565080A patent/NZ565080A/en unknown
- 2006-07-24 ES ES06779892.6T patent/ES2531621T3/es active Active
- 2006-07-24 EP EP06779892.6A patent/EP1908753B1/en active Active
- 2006-07-24 AU AU2006271297A patent/AU2006271297C1/en active Active
- 2006-07-24 US US11/988,659 patent/US7910751B2/en active Active
- 2006-07-24 WO PCT/IB2006/002016 patent/WO2007010383A1/ja active Application Filing
- 2006-07-24 KR KR1020117017275A patent/KR20110093948A/ko not_active Application Discontinuation
- 2006-07-24 BR BRPI0613771-7A patent/BRPI0613771B1/pt active IP Right Grant
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US20110112071A1 (en) | 2011-05-12 |
JP5303590B2 (ja) | 2013-10-02 |
KR20110093948A (ko) | 2011-08-18 |
JP4754566B2 (ja) | 2011-08-24 |
JP2011153146A (ja) | 2011-08-11 |
NZ565080A (en) | 2011-03-31 |
AU2006271297C1 (en) | 2012-06-14 |
CR9660A (es) | 2008-05-22 |
CA2616079C (en) | 2012-09-25 |
EP1908753B1 (en) | 2014-12-17 |
US7910751B2 (en) | 2011-03-22 |
NO20080917L (no) | 2008-04-22 |
BRPI0613771B1 (pt) | 2021-11-23 |
JPWO2007010383A1 (ja) | 2009-01-29 |
ECSP088129A (es) | 2008-04-28 |
NO341962B1 (no) | 2018-03-05 |
ES2531621T3 (es) | 2015-03-18 |
EP1908753A4 (en) | 2009-11-11 |
AU2006271297A1 (en) | 2007-01-25 |
KR20080031971A (ko) | 2008-04-11 |
PT1908753E (pt) | 2015-02-06 |
US8383839B2 (en) | 2013-02-26 |
US20080287428A1 (en) | 2008-11-20 |
WO2007010383A1 (ja) | 2007-01-25 |
KR101136183B1 (ko) | 2012-04-17 |
CA2616079A1 (en) | 2007-01-25 |
EP1908753A1 (en) | 2008-04-09 |
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