BRPI0607702A2 - composto, composição farmacêutica, uso do referido composto, e método de preparação de um composto - Google Patents

composto, composição farmacêutica, uso do referido composto, e método de preparação de um composto

Info

Publication number
BRPI0607702A2
BRPI0607702A2 BRPI0607702-1A BRPI0607702A BRPI0607702A2 BR PI0607702 A2 BRPI0607702 A2 BR PI0607702A2 BR PI0607702 A BRPI0607702 A BR PI0607702A BR PI0607702 A2 BRPI0607702 A2 BR PI0607702A2
Authority
BR
Brazil
Prior art keywords
compound
conformational structures
certain
amino
compounds
Prior art date
Application number
BRPI0607702-1A
Other languages
English (en)
Inventor
Daniel Chu
Maria Preobrazhenskaya
Svetlana Printsevskaya
Eugenia Olsufyeva
Original Assignee
Novartis Vaccines & Diagnostic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic
Publication of BRPI0607702A2 publication Critical patent/BRPI0607702A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPOSTO, COMPOSIçãO FARMACêUTICA, USO DO REFERIDO COMPOSTO, E MéTODO DE PREPARAçãO DE UM COMPOSTO. Glicopeptídeos semi-sintéticos possuindo atividade antibacteriana são baseados em modificações de estruturas conformacionais de eremomicina, A82846B, vancomicina, teicoplatina, e A-40.926, em particular, acilação dos grupos açúcar nestas estruturas conformacionais com certos grupos acua; e/ou conVersão de um grupo ácido no anel macrocíclico destas estruturas conformacionais em certas amidas substituidas; ou ter uma combinação de uma modificação por alquilação do substituinte amino no grupo açúcar amino-substituído nestas estruturas conformacionais com certos grupos alquila ou modificação por acilação do substituinte amino no grupo açúcar amino-substituído nestas estruturas conformacionais com certos grupos alquila, e conversão do grupo ácido no anel macrocíclico destas estruturas conformacionais em certas amidas substituidas. Também são proporcionados métodos para a síntese dos compostos, composições farmacêuticas contendo os compostos, e métodos de uso dos compostos para o tratamento e/ou a profilaxia de doenças, especialmente de infecções bacterianas.
BRPI0607702-1A 2005-02-28 2006-02-27 composto, composição farmacêutica, uso do referido composto, e método de preparação de um composto BRPI0607702A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65729705P 2005-02-28 2005-02-28
PCT/US2006/007049 WO2006093947A2 (en) 2005-02-28 2006-02-27 Semi-synthetic glycopeptides with antibiotic activity

Publications (1)

Publication Number Publication Date
BRPI0607702A2 true BRPI0607702A2 (pt) 2009-11-03

Family

ID=36941732

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607702-1A BRPI0607702A2 (pt) 2005-02-28 2006-02-27 composto, composição farmacêutica, uso do referido composto, e método de preparação de um composto

Country Status (10)

Country Link
US (1) US7632918B2 (pt)
EP (1) EP1861115A4 (pt)
JP (2) JP2008531702A (pt)
KR (1) KR20080004455A (pt)
CN (1) CN101222933A (pt)
AU (1) AU2006218665A1 (pt)
BR (1) BRPI0607702A2 (pt)
CA (1) CA2600453A1 (pt)
MX (1) MX2007010478A (pt)
WO (1) WO2006093947A2 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7632918B2 (en) 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
CA2710602A1 (en) * 2007-12-26 2009-07-09 Lead Therapeutics, Inc. Novel semi-synthetic glycopeptides as antibacterial agents
CN101343313B (zh) * 2008-09-03 2011-11-16 南京农业大学 一种葡萄糖二肽类化合物及其制备方法和用途
WO2010048340A2 (en) * 2008-10-24 2010-04-29 Lead Therapeutics, Inc. Novel semi-synthetic glycopeptides as antibacterial agents
GB2465863A (en) * 2008-12-05 2010-06-09 Lead Therapeutics Inc Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections
CN101928330B (zh) * 2009-06-26 2013-10-16 上海来益生物药物研究开发中心有限责任公司 一种新的化合物及其应用
CA2972276A1 (en) 2014-12-25 2016-06-30 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Glycopeptides and uses thereof
MX2017013792A (es) * 2015-09-16 2018-07-06 Xuanzhu Pharma Co Ltd INHIBIDORES DE íŸ-LACTAMASA Y USOS DE LOS MISMOS.
CN107619432B (zh) * 2016-07-15 2023-03-17 上海来益生物药物研究开发中心有限责任公司 糖肽类衍生物及其药学可接受的盐、制备方法和应用
JP7210476B2 (ja) 2017-05-22 2023-01-23 インスメッド インコーポレイテッド リポ‐グリコペプチド可切断性誘導体及びその使用
CN109422800A (zh) * 2017-08-22 2019-03-05 复旦大学 抗革兰氏阳性菌季铵盐糖肽类化合物及其药用用途
CN108774158A (zh) * 2018-06-20 2018-11-09 南京肽业生物科技有限公司 一种Fmoc和疏水性氨基酸的反应
CN110938114B (zh) * 2018-09-21 2023-04-28 中国科学院上海药物研究所 一类万古霉素硫鎓衍生物、其制备方法、药物组合物和用途
US20210388028A1 (en) * 2018-11-21 2021-12-16 Insmed Incorporated Glycopeptide derivative compounds and uses thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3011278B1 (de) 1980-03-24 1981-04-02 Rohde & Schwarz GmbH & Co KG, 8000 München Funkpeiler
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
GB8522574D0 (en) * 1985-09-12 1985-10-16 Lepetit Spa Amides of teicoplanin compounds
GB8701872D0 (en) 1987-01-28 1987-03-04 Lepetit Spa N15-alkyl & n15,n15-dialkyl derivatives
CA1339808C (en) 1988-10-19 1998-04-07 Manuel Debono Glycopeptide antibiotics
US5500410A (en) * 1989-03-29 1996-03-19 Gruppo Lepetit S.P.A. Substituted alkylamide derivatives of teicoplanin
AU703106B2 (en) 1994-01-28 1999-03-18 Eli Lilly And Company Glycopeptide antibiotic derivatives
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
US5488131A (en) * 1994-03-23 1996-01-30 California Institute Of Technology Synthesis of compounds with predetermined chirality
US5919756A (en) * 1996-06-28 1999-07-06 Eli Lilly And Company Amides
HU230190B1 (hu) * 1998-12-23 2015-09-28 Theravance, Inc Glikopeptidszármazékok és ezeket tartalmazó gyógyászati kompozíciók
US6699836B2 (en) 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
AU4054900A (en) 1999-04-02 2000-10-23 Advanced Medicine East, Inc. Desleucyl glycopeptide antibiotics and methods of making same
AU5029700A (en) 1999-05-19 2000-12-05 Merck & Co., Inc. Glycopeptide antibacterial compounds, compositions containing same and methods of using same
JP2003522197A (ja) 2000-02-11 2003-07-22 イーライ リリー アンド カンパニー Ａ８２８４６グリコペプチドアナログの選択的ｎ−アシル化
US20030008812A1 (en) * 2001-02-02 2003-01-09 Christensen Burton G. Glycopeptide derivatives
US7348309B2 (en) * 2001-03-30 2008-03-25 Wisconsin Alumni Research Foundation Glycorandomization and production of novel vancomycin analogs
AU2003260198A1 (en) 2002-08-30 2004-03-19 Chiron Corporation Glycopeptide antibiotic and semisynthetic derivatives thereof and their use as antiviral agents
WO2004044222A2 (en) * 2002-11-12 2004-05-27 Enzon Pharmaceuticals, Inc. Polymeric prodrugs of vancomycin
US7521418B2 (en) * 2003-05-27 2009-04-21 Theravance, Inc. Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
US20070185015A1 (en) 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7368422B2 (en) 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity

Also Published As

Publication number Publication date
US20060276623A1 (en) 2006-12-07
KR20080004455A (ko) 2008-01-09
MX2007010478A (es) 2008-02-07
EP1861115A4 (en) 2011-03-16
JP2008531702A (ja) 2008-08-14
CN101222933A (zh) 2008-07-16
WO2006093947A2 (en) 2006-09-08
WO2006093947A3 (en) 2007-05-31
CA2600453A1 (en) 2006-09-08
AU2006218665A1 (en) 2006-09-08
EP1861115A2 (en) 2007-12-05
US7632918B2 (en) 2009-12-15
JP2009102446A (ja) 2009-05-14

Similar Documents

Publication Publication Date Title
BRPI0607702A2 (pt) composto, composição farmacêutica, uso do referido composto, e método de preparação de um composto
BRPI0607701A2 (pt) composto ou um sal, éster, solvato, estereoisÈmero, tautÈmero ou pró-droga farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de uma quantidade antibacterialmente eficaz de um composto junto com um veìculo farmaceuticamente aceitável, e, método de preparação de um composto
BRPI0607695A2 (pt) composto ou um sal, éster, solvato, estereoisÈmero, tautÈmero ou pró-droga farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos de tratamento de um mamìfero, e para preparar um composto
BRPI0923326A2 (pt) Composto, composição farmacêutica, métodos para inibir girasse de dna bacteriana e/ou topisomerase iv bacteriana, para produzir um efeito antibacteriano em um animal de sangue quente, e para tratar uma infecção bacteriana, uso de um composto, e, processo para preparar um composto.
NO20092476L (no) Antibakterielle polycykliske ureaforbindelser
BRPI0618451A2 (pt) derivados de piridopirazina, seu uso, composição farmacêutica e estojo
IL165715A0 (en) 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof
MY150958A (en) Compounds for the treatment of multi-drug resistant bacterial infections
CL2008001122A1 (es) Compuestos derivados de imidazo[1,2,3-ij]-1,8-naftiridin-4,9-diona; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de infecciones bacterianas.
BR112012021931A2 (pt) composto, composição farmacêutica, método para tratar uma infecção bacteriana, e, uso de composto
UY30030A1 (es) Derivados sustituidos de la 8-piracin-2-il-1,2,4,4a-tetrahidro-2´h, 6h-espiro (1,4-oxacin(4,3-a)quinolin-5,5´-pirimidin)-2´, 4´, 6´ (1´h, 3´h)-tiona, composiciones y aplicaciones
BR0010520A (pt) Novos compostos farmaceuticamente ativos
ES2340502T3 (es) Compuestos de 1,4,8-triazaespiro(4,5)decan-2-ona sustituidos para el tratamiento de la obesidad.
EA200600280A1 (ru) Композиции на основе производных липопептидных антибиотиков и способы их применения
BRPI0417157A (pt) composto, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica
BR112014002958A2 (pt) "3,4-di-hidro-1h-[1,8]naftiridinonas substituídas com piperidinila antibacterianas, composição farmacêutica compreendendo os referidos compostos, processos para preparação destes e uso".
MY148124A (en) Preparation of a crystalline antibiotic substance
WO2004011477A3 (en) 6,11-4-carbon bridged ketolides
CO2021009396A2 (es) Análogos de rifamicina y conjugados de fármaco-anticuerpo de los mismos
PT1057828E (pt) Suspensoes de trovafloxacina para administracao oral
CL2007001542A1 (es) Compuestos derivados de aminotiazoles, composicion farmaceutica; y uso para el tratamiento de infecciones bacterianas.
BR0213154A (pt) Compostos de glicopeptìdeo - cefalosporina de ligação reticulada, composições farmacêuticas de tais compostos, método de fabricação dos mesmos e seus usos
AR066345A1 (es) Glucopeptidos semisinteticos con actividad antibacteriana
BRPI0509667B8 (pt) composto, processo para a preparação de um composto de fórmula (i), medicamento e uso de um composto
TW200736203A (en) New pleuromutilin derivative and its use

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.