BRPI0518647A2 - processo para a produÇço de um composto, e, composto - Google Patents
processo para a produÇço de um composto, e, compostoInfo
- Publication number
- BRPI0518647A2 BRPI0518647A2 BRPI0518647-1A BRPI0518647A BRPI0518647A2 BR PI0518647 A2 BRPI0518647 A2 BR PI0518647A2 BR PI0518647 A BRPI0518647 A BR PI0518647A BR PI0518647 A2 BRPI0518647 A2 BR PI0518647A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- production
- intermediates
- processes
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCESSO PARA A PRODUÇçO DE UM COMPOSTO, E, COMPOSTO. É descrito um processo para a formação de um composto da fórmula (I) ou um sal farmaceuticamente aceitável do mesmo através de uma reação Heck. São também descritos intermediários úteis no processo e processos para a produção dos referidos intermediários.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0428328.9A GB0428328D0 (en) | 2004-12-24 | 2004-12-24 | Chemical process |
PCT/GB2005/004999 WO2006067456A2 (en) | 2004-12-24 | 2005-12-22 | Process for preparing rosuvastatin |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0518647A2 true BRPI0518647A2 (pt) | 2008-12-02 |
Family
ID=34130901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0518647-1A BRPI0518647A2 (pt) | 2004-12-24 | 2005-12-22 | processo para a produÇço de um composto, e, composto |
Country Status (15)
Country | Link |
---|---|
US (1) | US8034932B2 (pt) |
EP (2) | EP2361906A1 (pt) |
JP (1) | JP5127460B2 (pt) |
KR (1) | KR20070092307A (pt) |
CN (1) | CN101084197B (pt) |
AU (1) | AU2005317880B2 (pt) |
BR (1) | BRPI0518647A2 (pt) |
CA (1) | CA2589775A1 (pt) |
GB (1) | GB0428328D0 (pt) |
IL (1) | IL183528A (pt) |
MX (1) | MX2007007777A (pt) |
NO (1) | NO20072872L (pt) |
NZ (1) | NZ555769A (pt) |
WO (1) | WO2006067456A2 (pt) |
ZA (1) | ZA200704535B (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0011120D0 (en) | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
NL1015744C2 (nl) * | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
BR0211072A (pt) | 2001-07-13 | 2004-12-14 | Astrazeneca Uk Ltd | Processo para preparar um composto, composto, e, método para a preparação de um composto |
EP1323717A1 (en) | 2001-12-27 | 2003-07-02 | Dsm N.V. | Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives |
EP1375493A1 (en) | 2002-06-17 | 2004-01-02 | Dsm N.V. | Process for the preparation of an dioxane acetic acid ester |
GB0218781D0 (en) * | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
US7524955B2 (en) | 2002-12-16 | 2009-04-28 | Astrazeneca Uk Limited | Process for the preparation of pyrimidine compounds |
GB0312896D0 (en) * | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
UY28501A1 (es) * | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
WO2005051921A1 (en) | 2003-11-24 | 2005-06-09 | Teva Pharmaceutical Industries Ltd. | Crystalline ammonium salts of rosuvastatin |
US7851624B2 (en) | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
CA2594017C (en) | 2005-02-22 | 2010-04-20 | Teva Pharmaceutical Industries Ltd. | Preparation of rosuvastatin |
GB0514078D0 (en) * | 2005-07-08 | 2005-08-17 | Astrazeneca Uk Ltd | Chemical process |
KR20080060284A (ko) | 2006-09-18 | 2008-07-01 | 테바 파마슈티컬 인더스트리즈 리미티드 | 결정질 로수바스타틴 칼슘 |
TW200831469A (en) * | 2006-12-01 | 2008-08-01 | Astrazeneca Uk Ltd | Chemical process |
EP1978020A1 (en) * | 2007-04-03 | 2008-10-08 | LEK Pharmaceuticals D.D. | Processes for the preparation of statins, particularly rosuvastatin, and intermediates for the preparation thereof |
EP2134696B1 (en) | 2007-04-03 | 2017-05-17 | LEK Pharmaceuticals d.d. | Processes for the preparation of statins, particularly rosuvastatin, and intermediates for the preparation thereof |
US20110295005A1 (en) * | 2007-08-20 | 2011-12-01 | Ratiopharm Gmbh | Process for preparing pyrimidine derivatives |
EP2181089A2 (en) | 2007-08-28 | 2010-05-05 | Ratiopharm GmbH | Process for preparing pentanoic diacid derivatives |
CN102186843A (zh) * | 2008-09-09 | 2011-09-14 | 拜康有限公司 | 用于制备瑞舒伐他汀缩丙酮钙的方法 |
CN105669561B (zh) * | 2014-11-19 | 2018-11-27 | 南京博优康远生物医药科技有限公司 | 一种4-(4-氟苯基)-5-烷氧基羰基-6-异丙基-3,4-二氢嘧啶-2(1h)-酮的制备方法 |
US10246423B2 (en) * | 2015-01-23 | 2019-04-02 | Centrient Pharmaceuticals Netherlands B.V. | Process for preparing statin precursor |
KR20160126700A (ko) | 2015-04-24 | 2016-11-02 | 미래파인켐 주식회사 | 스타틴의 중간체, 이의 제조방법 및 이를 이용한 로수바스타틴의 제조방법 |
JP7220218B2 (ja) | 2018-08-13 | 2023-02-09 | 日本碍子株式会社 | 車室暖房用ヒーターエレメント及びその使用方法、並びに車室暖房用ヒーター |
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US480621A (en) | 1892-08-09 | Oiler for handsaws | ||
US4645858A (en) * | 1982-03-22 | 1987-02-24 | G. D. Searle & Co. | Pentanedioic acid derivatives |
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US4650890A (en) * | 1984-04-03 | 1987-03-17 | Sandoz Corp. | Preparation of olefinic compounds and intermediates thereof |
US4613610A (en) * | 1984-06-22 | 1986-09-23 | Sandoz Pharmaceuticals Corp. | Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives |
US4677211A (en) * | 1984-06-29 | 1987-06-30 | Sandoz Pharmaceuticals Corp. | Preparation of lactones |
US4808621A (en) * | 1986-07-07 | 1989-02-28 | Warner-Lambert Company | Trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl]- or ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
US5102893A (en) * | 1986-07-07 | 1992-04-07 | Warner-Lambert Company | Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl- or ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
US4957971A (en) * | 1986-07-07 | 1990-09-18 | Warner-Lambert Company | Trans-6-(2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl)-or ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
DE3739882A1 (de) * | 1987-11-25 | 1989-06-08 | Bayer Ag | Substituierte hydroxylamine |
DE3741508A1 (de) | 1987-12-08 | 1989-06-22 | Hoechst Ag | Wasserloesliche disazoverbindungen, verfahren zu ihrer herstellung und ihre verwendung als farbstoffe |
DE3741509A1 (de) | 1987-12-08 | 1989-06-22 | Hoechst Ag | Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte |
GB2244705B (en) | 1988-02-18 | 1992-07-15 | Bristol Myers Co | Preparation of antihypercholesterolemic tetrazole compounds and intermediates thereof |
AU3214689A (en) * | 1988-10-06 | 1990-05-01 | Sandoz Ag | Pyrimidinyl-substituted hydroxyacids, lactones and esters and pharmaceutical compositions containing them |
FR2665159B1 (fr) | 1990-07-24 | 1992-11-13 | Rhone Poulenc Sante | Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent. |
JP2648897B2 (ja) | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
WO1993008823A1 (en) | 1991-11-06 | 1993-05-13 | Tanabe Seiyaku Co., Ltd. | Guanidinyl and related cell adhesion modulation compounds |
US5278313A (en) * | 1992-03-27 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors |
ATE158579T1 (de) * | 1992-07-02 | 1997-10-15 | Hoechst Ag | Verfahren zur herstellung von (3r,5s)6-hydroxy- 3,5-0-isopropyliden-3,5-dihydroxy-hexansäure- tert.-butylester |
JP3197971B2 (ja) | 1993-03-01 | 2001-08-13 | 塩野義製薬株式会社 | 5−カルボアルコキシピリミジン誘導体の合成方法 |
CZ151297A3 (cs) | 1994-11-16 | 1998-07-15 | Synaptic Pharmaceutical Corporation | Dihydropyrimidinové sloučeniny a farmaceutické prostředky na jejich bázi |
DE19517186A1 (de) * | 1995-05-11 | 1996-11-14 | Bayer Ag | Verfahren zur Herstellung substituierter 2-Fluor-pyrimidine |
FR2741620B1 (fr) | 1995-11-28 | 1997-12-26 | Oreal | Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline |
US6278001B1 (en) * | 1995-11-28 | 2001-08-21 | L'oréal | Method for preparing (+) compactin and (+) mevinolin analog compounds having a β-hydroxy-δ-lactone grouping |
EP0882026A4 (en) | 1995-12-14 | 1999-04-07 | Merck & Co Inc | PROCESS RELATING TO THE MANUFACTURE OF DIHYDROPYRIMIDINONES |
WO1999003973A1 (en) * | 1997-07-14 | 1999-01-28 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
JP2001512724A (ja) | 1997-08-05 | 2001-08-28 | メルク エンド カムパニー インコーポレーテッド | α1aアドレナリン受容体拮抗薬 |
ATE283849T1 (de) * | 1998-12-10 | 2004-12-15 | Kaneka Corp | Verfahren zur herstellung eines simvastatin precursors |
GB9903472D0 (en) * | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Chemical process |
JP4204132B2 (ja) | 1999-02-19 | 2009-01-07 | 大塚化学ホールディングス株式会社 | 摩擦材 |
EP1193259A4 (en) | 1999-06-23 | 2003-01-29 | Ajinomoto Kk | dihydropyrimidine |
EP1194582A1 (de) * | 1999-07-09 | 2002-04-10 | Forschungszentrum Jülich Gmbh | Verfahren zur reduktion von keto-carbonsäuren und deren estern |
JP4649813B2 (ja) * | 1999-07-13 | 2011-03-16 | ロンザ アーゲー | 2−アミノ−4−(4−フルオロフェニル)−6−アルキルピリミジン−5−カルボキシレートの製造方法 |
GB0003305D0 (en) | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
AU2000254249A1 (en) | 2000-03-28 | 2001-10-08 | Biocon India Limited | Synthesis of (r-(r*,r*))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1- |
GB0011120D0 (en) * | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
GB0011163D0 (en) | 2000-05-10 | 2000-06-28 | Astrazeneca Ab | Chemical compound |
US8374574B1 (en) | 2000-07-06 | 2013-02-12 | Motorola Mobility Llc | Method and apparatus for storing a message for playback during a user-initiated emergency telephone call from a wireless device |
NL1015744C2 (nl) * | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
DE60123458T2 (de) * | 2000-11-10 | 2007-08-02 | F. Hoffmann-La Roche Ag | Pyrimidinderivate und deren verwendung als neuropeptid-y-rezeptorliganden |
MXPA03011195A (es) * | 2001-06-06 | 2004-03-18 | Bristol Myers Squibb Co | Proceso para preparacion de sulfonas de diol quirales e inhibidores de coa-reductasa del dihidroxiacido hmg. |
SE0102299D0 (sv) * | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
CA2448917A1 (en) | 2001-07-06 | 2003-01-16 | Reinhold Ohrlein | Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof |
BR0211072A (pt) * | 2001-07-13 | 2004-12-14 | Astrazeneca Uk Ltd | Processo para preparar um composto, composto, e, método para a preparação de um composto |
US20050032875A1 (en) * | 2001-08-22 | 2005-02-10 | Heinz Wolleb | Process for the preparation of indole derivatives |
EP1323717A1 (en) | 2001-12-27 | 2003-07-02 | Dsm N.V. | Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives |
US6835838B2 (en) | 2002-01-28 | 2004-12-28 | Novartis Ag | Process for the manufacture of organic compounds |
KR100511533B1 (ko) | 2002-04-09 | 2005-08-31 | 임광민 | 키랄 중간체, 그의 제조방법 및 그를 이용한 HMG-CoA환원저해제의 제조방법 |
EP1375493A1 (en) | 2002-06-17 | 2004-01-02 | Dsm N.V. | Process for the preparation of an dioxane acetic acid ester |
GB0218781D0 (en) | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
CN1742000A (zh) * | 2002-12-10 | 2006-03-01 | 兰贝克赛实验室有限公司 | 制备若舒伐他汀的方法 |
US7524955B2 (en) * | 2002-12-16 | 2009-04-28 | Astrazeneca Uk Limited | Process for the preparation of pyrimidine compounds |
WO2004103977A2 (en) | 2003-05-21 | 2004-12-02 | Ciba Specialty Chemicals Holding Inc. | Process for the preparation of pyrimidine derivatives |
GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
UY28501A1 (es) | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
GB0321827D0 (en) | 2003-09-18 | 2003-10-15 | Astrazeneca Uk Ltd | Chemical compounds |
GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
DE10352659B4 (de) | 2003-11-11 | 2007-09-13 | Ratiopharm Gmbh | Verfahren zur Herstellung von Statinen und Tetrahydropyranonderivate zur Verwendung in dem Verfahren |
WO2005054207A1 (en) * | 2003-12-04 | 2005-06-16 | Glenmark Pharmaceuticals Limited | Process for the preparation of pyrimidine derivatives |
CA2645396A1 (en) | 2003-12-24 | 2005-07-14 | Teva Pharmaceutical Industries, Ltd | Process for preparation of statins with high syn to anti ratio |
GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
CA2498978A1 (en) | 2005-02-28 | 2006-08-28 | Apotex Pharmachem Inc. | An improved process for the preparation of atorvastatin and intermediates |
GB0514078D0 (en) * | 2005-07-08 | 2005-08-17 | Astrazeneca Uk Ltd | Chemical process |
TW200831469A (en) * | 2006-12-01 | 2008-08-01 | Astrazeneca Uk Ltd | Chemical process |
-
2004
- 2004-12-24 GB GBGB0428328.9A patent/GB0428328D0/en not_active Ceased
-
2005
- 2005-12-22 EP EP11162467A patent/EP2361906A1/en not_active Withdrawn
- 2005-12-22 NZ NZ555769A patent/NZ555769A/en not_active IP Right Cessation
- 2005-12-22 EP EP05820940A patent/EP1871747A2/en not_active Withdrawn
- 2005-12-22 AU AU2005317880A patent/AU2005317880B2/en not_active Ceased
- 2005-12-22 KR KR1020077017101A patent/KR20070092307A/ko not_active Application Discontinuation
- 2005-12-22 US US11/793,418 patent/US8034932B2/en not_active Expired - Fee Related
- 2005-12-22 CN CN2005800440532A patent/CN101084197B/zh active Active
- 2005-12-22 BR BRPI0518647-1A patent/BRPI0518647A2/pt not_active IP Right Cessation
- 2005-12-22 WO PCT/GB2005/004999 patent/WO2006067456A2/en active Application Filing
- 2005-12-22 CA CA002589775A patent/CA2589775A1/en not_active Abandoned
- 2005-12-22 JP JP2007547647A patent/JP5127460B2/ja not_active Expired - Fee Related
- 2005-12-22 MX MX2007007777A patent/MX2007007777A/es unknown
-
2007
- 2007-05-29 IL IL183528A patent/IL183528A/en not_active IP Right Cessation
- 2007-05-31 ZA ZA200704535A patent/ZA200704535B/xx unknown
- 2007-06-06 NO NO20072872A patent/NO20072872L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1871747A2 (en) | 2008-01-02 |
KR20070092307A (ko) | 2007-09-12 |
MX2007007777A (es) | 2007-08-14 |
NZ555769A (en) | 2010-01-29 |
IL183528A (en) | 2012-02-29 |
IL183528A0 (en) | 2007-09-20 |
NO20072872L (no) | 2007-09-17 |
WO2006067456A2 (en) | 2006-06-29 |
JP2008525407A (ja) | 2008-07-17 |
AU2005317880B2 (en) | 2009-05-28 |
WO2006067456A3 (en) | 2006-09-21 |
CN101084197A (zh) | 2007-12-05 |
ZA200704535B (en) | 2008-11-26 |
GB0428328D0 (en) | 2005-02-02 |
US8034932B2 (en) | 2011-10-11 |
US20080207903A1 (en) | 2008-08-28 |
AU2005317880A1 (en) | 2006-06-29 |
CN101084197B (zh) | 2012-06-13 |
CA2589775A1 (en) | 2006-06-29 |
JP5127460B2 (ja) | 2013-01-23 |
EP2361906A1 (en) | 2011-08-31 |
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