BRPI0518465A2 - composto, mÉtodo para a preparaÇço de composto, composiÇço farmacÊutica, mÉtodo de preparar uma composiÇço, e, uso de um composto - Google Patents

composto, mÉtodo para a preparaÇço de composto, composiÇço farmacÊutica, mÉtodo de preparar uma composiÇço, e, uso de um composto

Info

Publication number
BRPI0518465A2
BRPI0518465A2 BRPI0518465-7A BRPI0518465A BRPI0518465A2 BR PI0518465 A2 BRPI0518465 A2 BR PI0518465A2 BR PI0518465 A BRPI0518465 A BR PI0518465A BR PI0518465 A2 BRPI0518465 A2 BR PI0518465A2
Authority
BR
Brazil
Prior art keywords
compound
alkyl
hydrogen
preparing
tetrahydropyridin
Prior art date
Application number
BRPI0518465-7A
Other languages
English (en)
Inventor
Hes Roelof Van
Pieter Smid
Cornelis G Kruse
Martinus Th M Tulp
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of BRPI0518465A2 publication Critical patent/BRPI0518465A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPOSTO, MÉTODO PARA A PREPARAÇçO DE COMPOSTO, COMPOSIÇçO FARMACÊUTICA, MÉTODO DE PREPARAR UMA COMPOSIÇçO, E, USO DE UM COMPOSTO. A presente invenção diz respeito a um grupo de novos tetraidropiridin-4-il indóis com um modo duplo de ação: inibição da reabsorção de serotonina e afinidade para receptores de dopamina-D2, a métodos para a preparação destes compostos e a novos intermediários úteis para a síntese dos ditos tetraidropiridin-4-il indóis. A invenção também diz respeito ao uso de um composto divulgado neste para a fabricação de uma droga que dá um efeito benéfico. A invenção diz respeito a novos tetraidropiridin-4-il indóis da fórmula (1) e tautômeros, estereoisômeros, pró-drogas, N-óxidos, sais, hidratos e solvatos farmaceuticamente aceitáveis do mesmo, em que: - R~ 1~ é hidrogênio, halogênio, alquila (C~ 1-3~) ou alcóxi (C~ 1-3~), CN ou CF~ 3~, - R~ 2~ é hidrogênio ou alquila (C~ 1-3~), R~ 3~ é hidrogênio ou alquila (C~ 1-3~ ), - Z é hidrogênio ou alquila (C~ 1-3~), alcóxi (C~ 1-3~) ou alquiltio (C~ 1-3~), - A é hidrogênio ou alquila (C~ 1-3~) ou - A e Z juntos formam um anel de 5 ou 6 membros saturado ou (parcialmente) insaturado que pode ser substituído com halogênio, alquila (C~ 1-3~) ou fenila, em que o anel Z representas carbono, enxofre ou nitrogênio.
BRPI0518465-7A 2004-12-07 2005-12-06 composto, mÉtodo para a preparaÇço de composto, composiÇço farmacÊutica, mÉtodo de preparar uma composiÇço, e, uso de um composto BRPI0518465A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04106351 2004-12-07
PCT/EP2005/056501 WO2006061373A2 (en) 2004-12-07 2005-12-06 Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-d2 receptors and serotonin reuptake sites

Publications (1)

Publication Number Publication Date
BRPI0518465A2 true BRPI0518465A2 (pt) 2008-11-18

Family

ID=34930005

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518465-7A BRPI0518465A2 (pt) 2004-12-07 2005-12-06 composto, mÉtodo para a preparaÇço de composto, composiÇço farmacÊutica, mÉtodo de preparar uma composiÇço, e, uso de um composto

Country Status (14)

Country Link
EP (1) EP1828168A2 (pt)
JP (1) JP2008523027A (pt)
KR (1) KR20070091009A (pt)
CN (1) CN101072770A (pt)
AR (1) AR052146A1 (pt)
AU (1) AU2005313387A1 (pt)
BR (1) BRPI0518465A2 (pt)
CA (1) CA2587936A1 (pt)
MX (1) MX2007006757A (pt)
RU (1) RU2007125692A (pt)
SA (1) SA05260388B1 (pt)
TW (1) TW200626575A (pt)
WO (1) WO2006061373A2 (pt)
ZA (1) ZA200704155B (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2249649A4 (en) * 2008-02-05 2012-09-26 Watson Pharma Private Ltd IMPROVED METHOD FOR THE MANUFACTURE OF PALIPERIDONE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8900382D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
WO2000069424A2 (en) * 1999-05-12 2000-11-23 Solvay Pharmaceuticals B.V. Method of treating psychotic disorders
AU2003257407A1 (en) * 2002-08-29 2004-03-19 H. Lundbeck A/S S-(+)-3-{1-(2-(2,3-dihydro-1h-indol-3-yl)ethyl)-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof

Also Published As

Publication number Publication date
ZA200704155B (en) 2008-08-27
TW200626575A (en) 2006-08-01
RU2007125692A (ru) 2009-01-20
MX2007006757A (es) 2007-11-09
AR052146A1 (es) 2007-03-07
CN101072770A (zh) 2007-11-14
EP1828168A2 (en) 2007-09-05
WO2006061373A2 (en) 2006-06-15
CA2587936A1 (en) 2006-06-15
JP2008523027A (ja) 2008-07-03
AU2005313387A1 (en) 2006-06-15
SA05260388B1 (ar) 2009-06-09
WO2006061373A3 (en) 2006-09-21
KR20070091009A (ko) 2007-09-06

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.