BRPI0516243A - precursores de esteróide sexual isolados ou em combinação com um modulador de receptor estrogênio seletivo e/ou com estrogênios e/ou inibidor de fosfodiesterase de cgmp tipo 5 para a prevenção e tratamento de secura vaginal e disfunção sexual em mulheres na pós-menopausa - Google Patents

precursores de esteróide sexual isolados ou em combinação com um modulador de receptor estrogênio seletivo e/ou com estrogênios e/ou inibidor de fosfodiesterase de cgmp tipo 5 para a prevenção e tratamento de secura vaginal e disfunção sexual em mulheres na pós-menopausa

Info

Publication number
BRPI0516243A
BRPI0516243A BRPI0516243-2A BRPI0516243A BRPI0516243A BR PI0516243 A BRPI0516243 A BR PI0516243A BR PI0516243 A BRPI0516243 A BR PI0516243A BR PI0516243 A BRPI0516243 A BR PI0516243A
Authority
BR
Brazil
Prior art keywords
treatment
prevention
estrogen
combination
receptor modulator
Prior art date
Application number
BRPI0516243-2A
Other languages
English (en)
Inventor
Mohamed El-Alfy
Fernand Labrie
Louise Berger
Original Assignee
Endorech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endorech Inc filed Critical Endorech Inc
Publication of BRPI0516243A publication Critical patent/BRPI0516243A/pt
Publication of BRPI0516243B1 publication Critical patent/BRPI0516243B1/pt
Publication of BRPI0516243B8 publication Critical patent/BRPI0516243B8/pt
Publication of BRPI0516243C1 publication Critical patent/BRPI0516243C1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

PRECURSORES DE ESTERóIDE SEXUAL ISOLADOS OU EM COMBINAçãO COM UM MODULADOR DE RECEPTOR ESTROGêNIO SELETIVO E/OU COM ESTROGêNIOS E/OU INIBIDOR DE FOSFODIESTERASE DE CGMP TIPO 5 PARA A PREVENçãO E TRATAMENTO DE SECURA VAGINAL E DISFUNçãO SEXUAL EM MULHERES NA PóS-MENOPAUSA. Novos métodos para o tratamento ou redução da probabilidade de adquirir disfunção vaginal, mais particularmente secura vaginal e dispareunia, levando a disfunção sexual e baixo desejo e performance sexual, em animais de sangue quente suscetíveis incluindo humanos que envolve a administração de um precursor de esteróide sexual. A administração adicional de estrogênio ou modulador de receptor estrogênio seletivo, particularmente aqueles selecionados do grupo que consiste em Raloxifeno, Arzoxifeno, Tamoxifeno, Droloxifeno, toremifeno, Iodoxifeno, GW 5638, TSE-424, ERA-923 e lasofoxifeno, e mais particularmente compostos que têm a estrutura geral são especificamente revelados para o tratamento médico e/ou inibição do desenvolvimento de algumas das doenças acima mencionadas. Composições farmacêuticas para liberação de ingrediente(s) ativo(s) e kit(s) úteis para a invenção também são revelados.
BRPI0516243A 2004-10-20 2005-10-20 uso de um precursor de esteróide sexual selecionado do grupo que consiste em dehidroepiandrosterona, sulfato de dehidroepiandrosterona, androst-5-eno-3b,17b-diol e 4-androsten-3,17-diona, uso do referido precursor em 5 associação com um modulador de receptor de estrogênio seletivo para proteção uterina e da glândula mamária contra câncer, composição farmacêutica e kit BRPI0516243C1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62045204P 2004-10-20 2004-10-20
US60/620,452 2004-10-20
PCT/CA2005/001612 WO2006042409A1 (en) 2004-10-20 2005-10-20 Sex steroid precursors alone or in combination with a selective estrogen receptor modulator and/or with estrogens and/or a type 5 cgmp phosphodiesterase inhibitor for the prevention and treatment of vaginal dryness and sexual dysfunction in postmenopausal women

Publications (4)

Publication Number Publication Date
BRPI0516243A true BRPI0516243A (pt) 2008-08-26
BRPI0516243B1 BRPI0516243B1 (pt) 2020-08-11
BRPI0516243B8 BRPI0516243B8 (pt) 2021-02-23
BRPI0516243C1 BRPI0516243C1 (pt) 2021-05-25

Family

ID=36202646

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0516243A BRPI0516243C1 (pt) 2004-10-20 2005-10-20 uso de um precursor de esteróide sexual selecionado do grupo que consiste em dehidroepiandrosterona, sulfato de dehidroepiandrosterona, androst-5-eno-3b,17b-diol e 4-androsten-3,17-diona, uso do referido precursor em 5 associação com um modulador de receptor de estrogênio seletivo para proteção uterina e da glândula mamária contra câncer, composição farmacêutica e kit

Country Status (27)

Country Link
US (3) US8835413B2 (pt)
EP (1) EP1802312B1 (pt)
JP (3) JP5057983B2 (pt)
KR (1) KR20070067235A (pt)
CN (5) CN102357248A (pt)
AP (1) AP2365A (pt)
AU (1) AU2005297367B2 (pt)
BR (1) BRPI0516243C1 (pt)
CA (2) CA2749235C (pt)
DK (1) DK1802312T3 (pt)
EA (1) EA014878B1 (pt)
ES (1) ES2553101T3 (pt)
GE (1) GEP20105066B (pt)
HK (1) HK1225629A1 (pt)
HR (1) HRP20070169B1 (pt)
HU (1) HUE025651T2 (pt)
IL (3) IL182633A (pt)
MA (1) MA29018B1 (pt)
MX (3) MX2007004830A (pt)
NO (1) NO340123B1 (pt)
NZ (1) NZ554619A (pt)
RS (1) RS20070166A (pt)
SG (2) SG155258A1 (pt)
TN (1) TNSN07147A1 (pt)
UA (1) UA93985C2 (pt)
WO (1) WO2006042409A1 (pt)
ZA (1) ZA200703198B (pt)

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