BRPI0515944A - processo para a preparação de 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carboni l)amino]fenóxi}n-metilpiridina-2-carboxamida - Google Patents

processo para a preparação de 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carboni l)amino]fenóxi}n-metilpiridina-2-carboxamida

Info

Publication number
BRPI0515944A
BRPI0515944A BRPI0515944-0A BRPI0515944A BRPI0515944A BR PI0515944 A BRPI0515944 A BR PI0515944A BR PI0515944 A BRPI0515944 A BR PI0515944A BR PI0515944 A BRPI0515944 A BR PI0515944A
Authority
BR
Brazil
Prior art keywords
amino
chloro
formula
methylpyridine
carboxamide
Prior art date
Application number
BRPI0515944-0A
Other languages
English (en)
Inventor
Michael Loegers
Reinhold Gehring
Oliver Kuhn
Mike Matthaeus
Klaus Mohrs
Matthias Mueller-Gliemann
Juergen Stiehl
Mathias Berwe
Jana Lenz
Werner Heilmann
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35457568&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0515944(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of BRPI0515944A publication Critical patent/BRPI0515944A/pt
Publication of BRPI0515944B1 publication Critical patent/BRPI0515944B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE 4-{4-¢({¢4-CLORO-3-(TRIFLUOROMETIL)FENIL!AMINO!CARBONI L)AMINO!FENóXI!N-METILPIRIDINA-2-CARBOXAMIDA". A presente invenção refere-se a um processo para preparo de 4-{4-¢({¢4-cloro-3-(trifluorometil)fenil!amino}carbonil)amino!fenóxi}-N- metilpiridina-2-carboxamida e seu sal de tosilato. Fórmula I, a qual compreende, em uma primeira etapa, reação do composto da fórmula (V) com isocianato de 4-cloro-3-trifluorometilfenila em um solvente orgânico não-clorado, inerte com relação a isocianatos, através de inicialmente carregamento do composto da fórmula (V) a uma temperatura de 20<198>C a 60<198>C e mistura com isocianato de 4-cloro-3-trifluorometilfenila de um tal modo que a temperatura de reação não exceda 70<198>C para produzir o composto da fórmula (II) e, em uma segunda etapa, mistura do composto da fórmula (II) com ácido p-toluenossulfónico em um solvente polar a uma temperatura de reação de 40<198>C até a temperatura de refluxo do solvente usado.
BRPI0515944-0A 2004-09-29 2005-09-20 Processo para a preparação de 4-{4-[({[4-cloro-3-(trifluorometil)fe-nil]amino}carbonil) amino]fenóxi}nmetilpiridina-2-carboxamida BRPI0515944B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04023131 2004-09-29
EP04023131.8 2004-09-29
PCT/EP2005/010118 WO2006034796A1 (en) 2004-09-29 2005-09-20 Process for the preparation of 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide

Publications (2)

Publication Number Publication Date
BRPI0515944A true BRPI0515944A (pt) 2008-08-12
BRPI0515944B1 BRPI0515944B1 (pt) 2021-11-09

Family

ID=35457568

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515944-0A BRPI0515944B1 (pt) 2004-09-29 2005-09-20 Processo para a preparação de 4-{4-[({[4-cloro-3-(trifluorometil)fe-nil]amino}carbonil) amino]fenóxi}nmetilpiridina-2-carboxamida

Country Status (35)

Country Link
US (1) US8124782B2 (pt)
EP (1) EP1797037B1 (pt)
JP (2) JP2008514657A (pt)
KR (1) KR101263032B1 (pt)
CN (1) CN101052619B (pt)
AR (1) AR053973A1 (pt)
AU (1) AU2005289099B2 (pt)
BR (1) BRPI0515944B1 (pt)
CA (1) CA2581835C (pt)
CU (1) CU23754B7 (pt)
CY (1) CY1116126T1 (pt)
DK (1) DK1797037T3 (pt)
DO (1) DOP2005000183A (pt)
EC (1) ECSP077357A (pt)
ES (1) ES2532377T3 (pt)
GT (1) GT200500269A (pt)
HK (1) HK1113484A1 (pt)
HN (1) HN2005000768A (pt)
HR (1) HRP20150295T1 (pt)
IL (1) IL182046A0 (pt)
MA (1) MA28883B1 (pt)
MY (1) MY149873A (pt)
NO (1) NO339647B1 (pt)
NZ (1) NZ554119A (pt)
PE (5) PE20060825A1 (pt)
PL (1) PL1797037T3 (pt)
PT (1) PT1797037E (pt)
SG (1) SG155997A1 (pt)
SI (1) SI1797037T1 (pt)
SV (1) SV2006002243A (pt)
TW (1) TWI382973B (pt)
UA (1) UA90691C2 (pt)
UY (1) UY29143A1 (pt)
WO (1) WO2006034796A1 (pt)
ZA (1) ZA200702511B (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE556713T1 (de) 1999-01-13 2012-05-15 Bayer Healthcare Llc Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer
SI1478358T1 (sl) 2002-02-11 2013-09-30 Bayer Healthcare Llc Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi
PT1626714E (pt) 2003-05-20 2007-08-24 Bayer Pharmaceuticals Corp Diarilureias para doenças mediadas por pdgfr
EA010485B1 (ru) 2003-07-23 2008-10-30 Байер Фамэсьютиклс Копэрейшн Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты)
CN101052619B (zh) 2004-09-29 2012-02-22 拜耳先灵制药股份公司 制备4-{4-[({[4-氯-3-(三氟甲基)苯基]氨基}羰基)氨基]苯氧基}-n-甲基吡啶-2-甲酰胺的方法
ES2387812T3 (es) 2004-09-29 2012-10-02 Bayer Pharma Aktiengesellschaft Forma termodinámicamente estable del tosilato BAY 43-9006
KR101335932B1 (ko) 2005-03-07 2013-12-04 바이엘 헬스케어 엘엘씨 암의 치료를 위한 오메가-카르복시아릴 치환된 디페닐우레아를 포함하는 제약 조성물
AR062927A1 (es) 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
CA2669158A1 (en) * 2006-11-14 2008-05-22 Bayer Schering Pharma Aktiengesellschaft Polymorph ii of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide
EP2195286A2 (en) * 2007-09-10 2010-06-16 Cipla Limited Process for the preparation of a raf kinase inhibitor and intermediates for use in the process
WO2009054004A2 (en) * 2007-10-22 2009-04-30 Natco Pharma Limited Process for the preparation of sorafenib
EP2231612A1 (en) * 2008-01-17 2010-09-29 Sicor, Inc. Polymorph form iii of sorafenib tosylate, sorafenib tosylate methanol solvate and sorafenib tosylate ethanol solvate, and processes for preparation thereof
US20090253913A1 (en) * 2008-03-06 2009-10-08 Pierluigi Rossetto Process for the preparation of sorafenib and salts thereof
CN103254126A (zh) * 2008-09-19 2013-08-21 苏州泽璟生物制药有限公司 氘代的ω-二苯基脲及衍生物以及包含该化合物的药物组合物
CA2775229C (en) * 2009-09-24 2014-07-29 Ranbaxy Laboratories Limited Process for the preparation of sorafenib tosylate
WO2011036648A1 (en) 2009-09-24 2011-03-31 Ranbaxy Laboratories Limited Polymorphs of sorafenib acid addition salts
EP2499116A1 (en) 2009-11-12 2012-09-19 Ranbaxy Laboratories Limited Sorafenib ethylsulfonate salt, process for preparation and use
WO2011076711A2 (en) 2009-12-23 2011-06-30 Ratiopharm Gmbh Polymorphs of 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide
WO2011092663A2 (en) 2010-01-29 2011-08-04 Ranbaxy Laboratories Limited 4-(4-{3-[4-chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-n2-methylpyridine-2-carboxamide dimethyl sulphoxide solvate
CN102190616B (zh) * 2010-03-18 2015-07-29 苏州泽璟生物制药有限公司 一种氘代的ω-二苯基脲的合成及生产的方法和工艺
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
CN102617458A (zh) * 2010-05-18 2012-08-01 张南 抗癌用化合物的制备方法
CA2805874A1 (en) 2010-07-19 2012-01-26 Bayer Healthcare Llc Drug combinations with fluoro-substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
SG189038A1 (en) 2010-10-01 2013-05-31 Bayer Ip Gmbh Substituted n-(2-arylamino)aryl sulfonamide-containing combinations
WO2012071425A1 (en) 2010-11-22 2012-05-31 Teva Pharmaceutical Industries Ltd. Solid state forms of sorafenib besylate, and processes for preparations thereof
EP2559431A1 (en) 2011-08-17 2013-02-20 Ratiopharm GmbH Pharmaceutical composition comprising 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
CN103664771B (zh) * 2012-09-19 2016-03-30 齐鲁制药有限公司 索拉非尼的晶型a及其制备方法
WO2014118807A1 (en) * 2013-02-04 2014-08-07 Intas Pharmaceuticals Limited A novel process for the preparation of sorafenib tosylate form iii
CN104710354A (zh) * 2013-12-13 2015-06-17 江苏豪森药业股份有限公司 高纯度索拉非尼的制备方法
CN104761492A (zh) * 2014-01-03 2015-07-08 正大天晴药业集团股份有限公司 对甲苯磺酸索拉非尼的晶型及其制备方法
CN104177292A (zh) * 2014-08-08 2014-12-03 亿腾药业（泰州）有限公司 一种工业化生产甲苯磺酸索拉非尼多晶型ⅰ的方法
CN110204483B (zh) * 2014-12-01 2021-06-29 石药集团中奇制药技术（石家庄）有限公司 一种甲苯磺酸索拉非尼新晶型及其制备方法
EP3109236B1 (en) 2015-06-23 2017-08-09 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Scalable process for the preparation of sorafenib tosylate ethanol solvate and sorafenib tosylate form iii
CN105181844A (zh) * 2015-09-11 2015-12-23 江苏嘉逸医药有限公司 一种高效液相色谱法测定甲苯磺酸索拉非尼含量和有关物质的方法
CN105585523A (zh) * 2015-12-29 2016-05-18 上海北卡医药技术有限公司 一种对甲苯磺酸索拉非尼的新晶型及其制备方法和用途
CN107840823B (zh) * 2016-09-20 2021-08-17 意大利合成制造有限公司 用于制备甲苯磺酸索拉非尼乙醇溶剂化物和iii型甲苯磺酸索拉非尼的可变规模的方法
CN107915676A (zh) * 2017-10-26 2018-04-17 魏海霞 索拉非尼的制备方法
CN109796400B (zh) * 2017-11-16 2022-07-29 四川科伦药物研究院有限公司 一种甲苯磺酸索拉菲尼晶型及其制备方法
CN113773249A (zh) * 2020-06-10 2021-12-10 杭州中美华东制药有限公司 索拉非尼游离碱晶型Form X及其制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU86960A1 (fr) * 1987-07-31 1989-03-08 Oreal Procede de preparation de piperidino-6 diamino-2,4 pyrimidine oxyde-3 et composes nouveaux
JPH02934A (ja) * 1988-05-27 1990-01-05 Konica Corp 非線形光学材料
JP2971291B2 (ja) * 1993-06-02 1999-11-02 田辺製薬株式会社 光学活性２−アミノ酪酸の製法
JP3866323B2 (ja) * 1996-03-27 2007-01-10 ポーラ化成工業株式会社 新規ｎ−ベンジルベンズアミド誘導体
JPH09316069A (ja) * 1996-03-28 1997-12-09 Ajinomoto Co Inc 新規キサントン誘導体
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
WO2000042012A1 (en) 1999-01-13 2000-07-20 Bayer Corporation φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS
EE04913B1 (et) * 1999-01-13 2007-10-15 Bayer Corporation Omega-karboksarlasendatud difenlkarbamiidid kui RAF-kinaasi inhibiitorid ja neid sisaldavad farmatseutilised kompositsioonid
GB2367816A (en) * 2000-10-09 2002-04-17 Bayer Ag Urea- and thiourea-containing derivatives of beta-amino acids
ES2275931T5 (es) 2001-12-03 2018-10-23 Bayer Healthcare Llc Compuestos de aril-urea en combinación con otros agentes citostáticos o citotóxicos para tratamiento de cánceres humanos
US20030207872A1 (en) * 2002-01-11 2003-11-06 Bayer Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
DE10203086A1 (de) * 2002-01-28 2003-07-31 Bayer Ag 5-Ring Heterozyklen
SI1478358T1 (sl) * 2002-02-11 2013-09-30 Bayer Healthcare Llc Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi
KR20050087776A (ko) * 2002-08-13 2005-08-31 산도즈 아게 세프디니르 중간체
ES2294317T3 (es) * 2002-10-21 2008-04-01 Kirin Pharma Kabushiki Kaisha Sal de n-(2-cloro-4-((6,7-dimetoxi-4-quinolil)oxi)fenil)-n'-(5-metil-3-isoxazolil)urea de forma cristalina.
PT1626714E (pt) 2003-05-20 2007-08-24 Bayer Pharmaceuticals Corp Diarilureias para doenças mediadas por pdgfr
CN101052619B (zh) 2004-09-29 2012-02-22 拜耳先灵制药股份公司 制备4-{4-[({[4-氯-3-(三氟甲基)苯基]氨基}羰基)氨基]苯氧基}-n-甲基吡啶-2-甲酰胺的方法

Also Published As

Publication number Publication date
IL182046A0 (en) 2007-07-24
HK1113484A1 (en) 2008-10-03
CY1116126T1 (el) 2017-02-08
HN2005000768A (es) 2010-09-17
PE20091587A1 (es) 2009-11-05
MY149873A (en) 2013-10-31
JP2013067625A (ja) 2013-04-18
MA28883B1 (fr) 2007-09-03
JP2008514657A (ja) 2008-05-08
DOP2005000183A (es) 2006-03-31
NO339647B1 (no) 2017-01-16
SI1797037T1 (sl) 2015-06-30
PE20091585A1 (es) 2009-10-31
NO20072173L (no) 2007-06-14
SG155997A1 (en) 2009-10-29
KR20070058676A (ko) 2007-06-08
JP5583190B2 (ja) 2014-09-03
PL1797037T3 (pl) 2015-07-31
WO2006034796A1 (en) 2006-04-06
PE20060825A1 (es) 2006-10-20
AR053973A1 (es) 2007-05-30
CN101052619B (zh) 2012-02-22
PT1797037E (pt) 2015-03-17
ZA200702511B (en) 2008-07-30
CU20070069A7 (es) 2010-11-27
HRP20150295T1 (hr) 2015-05-22
TW200626551A (en) 2006-08-01
ES2532377T3 (es) 2015-03-26
DK1797037T3 (en) 2015-03-30
UY29143A1 (es) 2006-04-28
US20080262236A1 (en) 2008-10-23
EP1797037A1 (en) 2007-06-20
GT200500269A (es) 2006-05-11
ECSP077357A (es) 2007-04-26
CN101052619A (zh) 2007-10-10
KR101263032B1 (ko) 2013-05-09
US8124782B2 (en) 2012-02-28
UA90691C2 (en) 2010-05-25
NZ554119A (en) 2010-07-30
CU23754B7 (es) 2012-01-31
CA2581835A1 (en) 2006-04-06
EP1797037B1 (en) 2014-12-17
TWI382973B (zh) 2013-01-21
BRPI0515944B1 (pt) 2021-11-09
CA2581835C (en) 2012-12-18
SV2006002243A (es) 2006-10-13
AU2005289099A1 (en) 2006-04-06
PE20091586A1 (es) 2009-10-31
AU2005289099B2 (en) 2012-07-19
PE20091584A1 (es) 2009-10-28

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