BRPI0515154A - uso de (halobenzilóxi)benzilamino-propanamidas para a fabricação de medicamentos ativos, compostos e composição farmacêutica - Google Patents
uso de (halobenzilóxi)benzilamino-propanamidas para a fabricação de medicamentos ativos, compostos e composição farmacêuticaInfo
- Publication number
- BRPI0515154A BRPI0515154A BRPI0515154-6A BRPI0515154A BRPI0515154A BR PI0515154 A BRPI0515154 A BR PI0515154A BR PI0515154 A BRPI0515154 A BR PI0515154A BR PI0515154 A BRPI0515154 A BR PI0515154A
- Authority
- BR
- Brazil
- Prior art keywords
- halobenzyloxy
- benzylamino
- manufacture
- disorders
- pharmaceutically acceptable
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
USO DE (HALOBENZILóXI)BENZILAMINO-PROPANAMIDAS PARA A FABRICAçãO DE MEDICAMENTOS ATIVOS, COMPOSTOS E COMPOSIçãO FARMACêUTICA A presente invenção refere-se ao uso de selecionadas (R)-2- ¢(halobenzilóxi)benzilamino!propanamidas e os sais farmaceuticamente aceitáveis das mesmas, para a fabricação de medicamentos, que são seletivamente ativos como moduladores do canal de sódio e/ou cálcio e, portanto, de utilidade na prevenção, alívio e cura de uma ampla faixa de patologias, incluindo, dor, enxaqueca, doenças periféricas, doenças cardiovasculares, processos inflamatórios que afetam todos os sistemas do corpo, distúrbios que afetam a pele e tecidos relacionados, distúrbios do sistema respiratório, distúrbios dos sistemas imune e endocrinológico, distúrbios gastrointestinais, urogenitais, metabólicos e de convulsão, onde os mecanismos acima, conforme descrito, desempenham uma função patológica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04021525 | 2004-09-10 | ||
PCT/EP2005/008200 WO2006027052A2 (en) | 2004-09-10 | 2005-07-28 | (halobenzyloxy) benzylamino-propanamides as sodium and/or calcium channel selective modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0515154A true BRPI0515154A (pt) | 2008-07-08 |
Family
ID=34926488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0515154-6A BRPI0515154A (pt) | 2004-09-10 | 2005-07-28 | uso de (halobenzilóxi)benzilamino-propanamidas para a fabricação de medicamentos ativos, compostos e composição farmacêutica |
Country Status (28)
Country | Link |
---|---|
US (2) | US20080096965A1 (pt) |
EP (1) | EP1809271B9 (pt) |
JP (1) | JP5319920B2 (pt) |
KR (1) | KR101277520B1 (pt) |
CN (1) | CN101018546B (pt) |
AR (1) | AR050638A1 (pt) |
AT (1) | ATE471147T1 (pt) |
AU (1) | AU2005282028B2 (pt) |
BR (1) | BRPI0515154A (pt) |
CA (1) | CA2577408C (pt) |
CY (1) | CY1110770T1 (pt) |
DE (1) | DE602005021907D1 (pt) |
DK (1) | DK1809271T5 (pt) |
ES (1) | ES2347581T3 (pt) |
HK (1) | HK1105359A1 (pt) |
HR (1) | HRP20100400T1 (pt) |
IL (1) | IL181445A (pt) |
ME (1) | ME01801B (pt) |
MX (1) | MX2007002713A (pt) |
NO (1) | NO338713B1 (pt) |
NZ (1) | NZ553970A (pt) |
PL (1) | PL1809271T3 (pt) |
PT (1) | PT1809271E (pt) |
RS (1) | RS51411B (pt) |
RU (1) | RU2391973C2 (pt) |
SI (1) | SI1809271T1 (pt) |
TW (1) | TWI351950B (pt) |
WO (1) | WO2006027052A2 (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1423168T3 (da) * | 2001-09-03 | 2006-05-15 | Newron Pharm Spa | Farmaceutisk præparat omfattende gabapentin eller en analog deraf og et alfa-aminoamid og dets analgetiske anvendelse |
EP1438956A1 (en) * | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
EP1658062B1 (en) * | 2003-08-25 | 2010-02-17 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as anti-inflammatory agents |
EP1809271B9 (en) * | 2004-09-10 | 2010-09-22 | Newron Pharmaceuticals S.p.A. | Use of (r)-(halobenzyloxy) benzylamino-propanamides as sodium and/or calcium channel selective modulators |
CN101309909B (zh) | 2005-12-22 | 2012-11-14 | 纽朗制药有限公司 | 作为钙和/或钠通道调节剂的2-苯基乙基氨基衍生物 |
DK2474521T3 (en) | 2006-06-19 | 2016-10-31 | Newron Pharm Spa | High-purity 2- [4- (3- and 2-fluorobenzyloxy) benzylamino] propanamides for use as pharmaceuticals and pharmaceutical formulations thus |
JP5440496B2 (ja) | 2007-06-15 | 2014-03-12 | ニユーロン・フアーマシユーテイカルズ・エツセ・ピー・アー | 置換2−[2−(フェニル)エチルアミノ]アルカンアミド誘導体ならびにナトリウムおよび/またはカルシウムチャネル調節剤としてのこれらの使用 |
EA030250B1 (ru) * | 2007-12-11 | 2018-07-31 | Ньюрон Фармасьютикалс С.П.А. | Применение 2-[4-(3- или 2-фторбензилокси)бензиламино]пропанамидов с высокой степенью чистоты и содержащие их фармацевтические композиции |
EA019529B1 (ru) * | 2007-12-19 | 2014-04-30 | Ньюрон Фармасьютикалс С.П.А. | Альфа-аминоамидные производные, применяемые в лечении психиатрических расстройств |
WO2009109334A1 (en) * | 2008-03-07 | 2009-09-11 | Newron Pharmaceuticals S.P.A. | (s)-(+)-2-[4-fluorbenzyloxy)benzylamino]propanamide for use in the treatment of mixed or combined pain |
WO2010138794A2 (en) | 2009-05-29 | 2010-12-02 | The University Of North Carolina At Chapel Hill | Regulation of sodium channels by plunc proteins |
AU2011246707B2 (en) | 2010-04-27 | 2014-11-20 | Newron Pharmaceuticals S.P.A. | Process for the production of ralfinamide methanesulfonate salts or their R-enantiomers |
WO2013000651A1 (en) | 2011-06-27 | 2013-01-03 | Newron Pharmaceuticals S.P.A. | Fluorinated arylalkylaminocarboxamide derivatives |
SG11201702769QA (en) | 2014-10-08 | 2017-05-30 | Univ North Carolina | Improved peptide inhibitors of sodium channels |
JP6592702B1 (ja) | 2017-06-20 | 2019-10-23 | ラクオリア創薬株式会社 | Nav1.7およびNav1.8遮断薬としてのアミド誘導体 |
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JP2006515327A (ja) * | 2003-01-30 | 2006-05-25 | ダイノジェン ファーマシューティカルズ, インコーポレイテッド | ナトリウムチャネル調節因子を用いた下部尿路障害を処置するための方法 |
AR044007A1 (es) * | 2003-04-11 | 2005-08-24 | Newron Pharmaceuticals Inc | Metodos para el tratamiento de la enfermedad de parkinson |
EP1658062B1 (en) * | 2003-08-25 | 2010-02-17 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as anti-inflammatory agents |
EP1535908A1 (en) * | 2003-11-24 | 2005-06-01 | Newron Pharmaceuticals S.p.A. | N-acyl-N'-benzyl-alkylendiamino drivatives |
EP1557166A1 (en) * | 2004-01-21 | 2005-07-27 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders |
EP1588704A1 (en) * | 2004-04-22 | 2005-10-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders |
EP1809271B9 (en) * | 2004-09-10 | 2010-09-22 | Newron Pharmaceuticals S.p.A. | Use of (r)-(halobenzyloxy) benzylamino-propanamides as sodium and/or calcium channel selective modulators |
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2005
- 2005-07-28 EP EP05769799A patent/EP1809271B9/en active Active
- 2005-07-28 RS RSP-2010/0331A patent/RS51411B/en unknown
- 2005-07-28 MX MX2007002713A patent/MX2007002713A/es active IP Right Grant
- 2005-07-28 SI SI200531091T patent/SI1809271T1/sl unknown
- 2005-07-28 PL PL05769799T patent/PL1809271T3/pl unknown
- 2005-07-28 DE DE602005021907T patent/DE602005021907D1/de active Active
- 2005-07-28 JP JP2007530600A patent/JP5319920B2/ja active Active
- 2005-07-28 US US11/574,751 patent/US20080096965A1/en not_active Abandoned
- 2005-07-28 PT PT05769799T patent/PT1809271E/pt unknown
- 2005-07-28 AT AT05769799T patent/ATE471147T1/de active
- 2005-07-28 AU AU2005282028A patent/AU2005282028B2/en active Active
- 2005-07-28 NZ NZ553970A patent/NZ553970A/en unknown
- 2005-07-28 RU RU2007113190/15A patent/RU2391973C2/ru active
- 2005-07-28 DK DK05769799.7T patent/DK1809271T5/da active
- 2005-07-28 CN CN2005800303817A patent/CN101018546B/zh active Active
- 2005-07-28 CA CA2577408A patent/CA2577408C/en active Active
- 2005-07-28 KR KR1020077008185A patent/KR101277520B1/ko active IP Right Grant
- 2005-07-28 ME MEP-2010-331A patent/ME01801B/me unknown
- 2005-07-28 BR BRPI0515154-6A patent/BRPI0515154A/pt not_active Application Discontinuation
- 2005-07-28 ES ES05769799T patent/ES2347581T3/es active Active
- 2005-07-28 WO PCT/EP2005/008200 patent/WO2006027052A2/en active Application Filing
- 2005-08-15 TW TW094127695A patent/TWI351950B/zh active
- 2005-09-09 AR ARP050103774A patent/AR050638A1/es not_active Application Discontinuation
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2007
- 2007-02-20 IL IL181445A patent/IL181445A/en active IP Right Grant
- 2007-04-04 NO NO20071792A patent/NO338713B1/no unknown
- 2007-10-04 HK HK07110722.7A patent/HK1105359A1/xx unknown
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2010
- 2010-07-20 HR HR20100400T patent/HRP20100400T1/hr unknown
- 2010-09-07 CY CY20101100816T patent/CY1110770T1/el unknown
- 2010-11-04 US US12/939,726 patent/US20110184068A1/en not_active Abandoned
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
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Free format text: AS CLASSIFICACOES ANTERIORES ERAM: A61K 31/165 , A61K 31/00 , A61K 45/06 , A61P 29/00 , A61P 25/06 , A61P 25/02 , A61P 9/00 , A61P 13/00 , A61P 3/00 , A61P 1/00 , A61P 17/00 , A61P 11/00 , A61P 37/00 , A61P 25/08 , A61P 5/00 Ipc: A61K 45/06 (2006.01), A61P 29/00 (2006.01), A61P 2 |
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Owner name: NEWRON PHARMACEUTICALS S.P.A. (IT) |
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