BRPI0512705A - composto, processo de preparação deste e método para o tratamento e profilaxia de diabetes, obesidade, distúrbios alimentares, dilipidemia, hipertensão e diabetes do tipo ii - Google Patents
composto, processo de preparação deste e método para o tratamento e profilaxia de diabetes, obesidade, distúrbios alimentares, dilipidemia, hipertensão e diabetes do tipo iiInfo
- Publication number
- BRPI0512705A BRPI0512705A BRPI0512705-0A BRPI0512705A BRPI0512705A BR PI0512705 A BRPI0512705 A BR PI0512705A BR PI0512705 A BRPI0512705 A BR PI0512705A BR PI0512705 A BRPI0512705 A BR PI0512705A
- Authority
- BR
- Brazil
- Prior art keywords
- diabetes
- dilipidemia
- obesity
- compound
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
COMPOSTO, PROCESSO DE PREPARAçãO DESTE E MéTODO PARA O TRATAMENTO E PROFILAXIA DE DIABETES, OBESIDADE, DISTúRBIOS ALIMENTARES, DILIPIDEMIA, HIPERTENSãO E DIABETES DO TIPO II Trata-se de compostos de fórmula (I), assim como sais e ésteres farmaceuticamente aceitáveis destes, onde R¬ 1¬ a R¬ 5¬ possuem o significado dado na reivindicação 1 que pode ser utilizado na forma de composições farmacêuticas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04102999 | 2004-06-28 | ||
PCT/EP2005/006649 WO2006000371A2 (en) | 2004-06-28 | 2005-06-20 | Pyrimidine derivatives as 11beta-hsd1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0512705A true BRPI0512705A (pt) | 2008-04-01 |
Family
ID=35478760
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0512705-0A BRPI0512705A (pt) | 2004-06-28 | 2005-06-20 | composto, processo de preparação deste e método para o tratamento e profilaxia de diabetes, obesidade, distúrbios alimentares, dilipidemia, hipertensão e diabetes do tipo ii |
Country Status (23)
Country | Link |
---|---|
US (1) | US7507733B2 (pt) |
EP (1) | EP1763517B1 (pt) |
JP (1) | JP4809339B2 (pt) |
CN (1) | CN1972918B (pt) |
AR (1) | AR049699A1 (pt) |
AT (1) | ATE509011T1 (pt) |
AU (1) | AU2005256442B2 (pt) |
BR (1) | BRPI0512705A (pt) |
CA (1) | CA2571361C (pt) |
DK (1) | DK1763517T3 (pt) |
ES (1) | ES2362884T3 (pt) |
HK (1) | HK1104553A1 (pt) |
IL (1) | IL179914A0 (pt) |
MX (1) | MXPA06014892A (pt) |
MY (1) | MY143568A (pt) |
NO (1) | NO20070445L (pt) |
NZ (1) | NZ551859A (pt) |
PL (1) | PL1763517T3 (pt) |
PT (1) | PT1763517E (pt) |
RU (1) | RU2375351C2 (pt) |
TW (1) | TWI299040B (pt) |
WO (1) | WO2006000371A2 (pt) |
ZA (1) | ZA200610415B (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5140577B2 (ja) * | 2005-03-31 | 2013-02-06 | タケダ カリフォルニア インコーポレイテッド | ヒドロキシステロイドデヒドロゲナーゼ阻害剤 |
EP1981848A2 (en) * | 2006-02-07 | 2008-10-22 | Wyeth | 11-beta hsd1 inhibitors |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
US8318941B2 (en) | 2006-07-06 | 2012-11-27 | Bristol-Myers Squibb Company | Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
TW200827346A (en) | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
TW200836719A (en) | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
US20100022572A1 (en) | 2008-07-18 | 2010-01-28 | Kowa Company, Ltd. | Novel spiro compound and medicine comprising the same |
EP2331095B1 (en) | 2008-08-04 | 2014-10-15 | CHDI Foundation, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
JP5574431B2 (ja) | 2008-08-29 | 2014-08-20 | 興和株式会社 | 1−アダマンチルアゼチジン−2−オン誘導体及びこれを含有する医薬 |
JP5477973B2 (ja) | 2008-10-29 | 2014-04-23 | 興和株式会社 | 1,2−ジアゼチジン−3−オン誘導体及びこれを含有する医薬 |
MX2012008346A (es) | 2010-01-25 | 2012-11-12 | Chdi Foundation Inc | Determinados inhibidores de cinurenina-3-monooxigenasa, composiciones farmceuticas y metodos de uso de los mismos. |
WO2012051139A1 (en) * | 2010-10-15 | 2012-04-19 | Amgen Inc. | New uses for substituted 2-amino-thiazolones in treating alzheimer's disease |
JPWO2012102366A1 (ja) * | 2011-01-28 | 2014-06-30 | 日本たばこ産業株式会社 | 新規ピペラジン化合物の製造方法 |
US9428464B2 (en) | 2011-08-30 | 2016-08-30 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
CA2844128C (en) | 2011-08-30 | 2020-09-01 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
AU2015289492B2 (en) | 2014-07-17 | 2020-02-20 | Chdi Foundation, Inc. | Methods and compositions for treating HIV-related disorders |
WO2017160922A1 (en) | 2016-03-16 | 2017-09-21 | Kalyra Pharmaceuticals, Inc. | Analgesic compounds |
EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1229413A (pt) * | 1967-06-14 | 1971-04-21 | ||
HU206337B (en) * | 1988-12-29 | 1992-10-28 | Mitsui Petrochemical Ind | Process for producing pyrimidine derivatives and pharmaceutical compositions |
JP2744663B2 (ja) * | 1988-12-29 | 1998-04-28 | 三井化学株式会社 | ピリミジン類及びその薬学的に許容される塩類 |
TW287160B (pt) | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
TW394761B (en) | 1993-06-28 | 2000-06-21 | Hoffmann La Roche | Novel Sulfonylamino Pyrimidines |
SE0001899D0 (sv) * | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
EP2399903A1 (en) * | 2002-05-24 | 2011-12-28 | Millennium Pharmaceuticals, Inc. | Ccr9 inhibitors and methods of use thereof |
US7820704B2 (en) * | 2004-04-20 | 2010-10-26 | Transtech Pharma, Inc. | Substituted heteroaryl derivatives, compositions, and methods of use |
-
2005
- 2005-06-20 ES ES05755629T patent/ES2362884T3/es active Active
- 2005-06-20 CN CN2005800209571A patent/CN1972918B/zh not_active Expired - Fee Related
- 2005-06-20 PL PL05755629T patent/PL1763517T3/pl unknown
- 2005-06-20 MX MXPA06014892A patent/MXPA06014892A/es active IP Right Grant
- 2005-06-20 EP EP05755629A patent/EP1763517B1/en active Active
- 2005-06-20 NZ NZ551859A patent/NZ551859A/en not_active IP Right Cessation
- 2005-06-20 AT AT05755629T patent/ATE509011T1/de active
- 2005-06-20 DK DK05755629.2T patent/DK1763517T3/da active
- 2005-06-20 PT PT05755629T patent/PT1763517E/pt unknown
- 2005-06-20 CA CA2571361A patent/CA2571361C/en not_active Expired - Fee Related
- 2005-06-20 BR BRPI0512705-0A patent/BRPI0512705A/pt not_active IP Right Cessation
- 2005-06-20 AU AU2005256442A patent/AU2005256442B2/en not_active Ceased
- 2005-06-20 WO PCT/EP2005/006649 patent/WO2006000371A2/en active Application Filing
- 2005-06-20 JP JP2007518500A patent/JP4809339B2/ja not_active Expired - Fee Related
- 2005-06-20 RU RU2007103303/04A patent/RU2375351C2/ru not_active IP Right Cessation
- 2005-06-24 TW TW094121333A patent/TWI299040B/zh not_active IP Right Cessation
- 2005-06-24 AR ARP050102606A patent/AR049699A1/es unknown
- 2005-06-27 MY MYPI20053011A patent/MY143568A/en unknown
- 2005-06-27 US US11/168,031 patent/US7507733B2/en not_active Expired - Fee Related
-
2006
- 2006-12-07 IL IL179914A patent/IL179914A0/en unknown
- 2006-12-12 ZA ZA200610415A patent/ZA200610415B/en unknown
-
2007
- 2007-01-24 NO NO20070445A patent/NO20070445L/no not_active Application Discontinuation
- 2007-11-26 HK HK07112870.3A patent/HK1104553A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2362884T3 (es) | 2011-07-14 |
CA2571361A1 (en) | 2006-01-05 |
JP2008504321A (ja) | 2008-02-14 |
ZA200610415B (en) | 2008-06-25 |
AU2005256442B2 (en) | 2009-02-12 |
CA2571361C (en) | 2011-07-26 |
US20050288308A1 (en) | 2005-12-29 |
WO2006000371A2 (en) | 2006-01-05 |
AU2005256442A1 (en) | 2006-01-05 |
HK1104553A1 (en) | 2008-01-18 |
IL179914A0 (en) | 2007-05-15 |
AR049699A1 (es) | 2006-08-30 |
RU2375351C2 (ru) | 2009-12-10 |
ATE509011T1 (de) | 2011-05-15 |
WO2006000371A3 (en) | 2006-04-27 |
RU2007103303A (ru) | 2008-08-10 |
US7507733B2 (en) | 2009-03-24 |
CN1972918A (zh) | 2007-05-30 |
MY143568A (en) | 2011-05-31 |
NZ551859A (en) | 2010-05-28 |
MXPA06014892A (es) | 2007-02-28 |
EP1763517A2 (en) | 2007-03-21 |
JP4809339B2 (ja) | 2011-11-09 |
DK1763517T3 (da) | 2011-06-06 |
TWI299040B (en) | 2008-07-21 |
CN1972918B (zh) | 2010-10-13 |
NO20070445L (no) | 2007-01-24 |
EP1763517B1 (en) | 2011-05-11 |
PL1763517T3 (pl) | 2011-10-31 |
TW200616976A (en) | 2006-06-01 |
PT1763517E (pt) | 2011-07-01 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |