BRPI0510526A - formulações lìquidas estabilizadas de interferon - Google Patents
formulações lìquidas estabilizadas de interferonInfo
- Publication number
- BRPI0510526A BRPI0510526A BRPI0510526-9A BRPI0510526A BRPI0510526A BR PI0510526 A BRPI0510526 A BR PI0510526A BR PI0510526 A BRPI0510526 A BR PI0510526A BR PI0510526 A BRPI0510526 A BR PI0510526A
- Authority
- BR
- Brazil
- Prior art keywords
- interferon
- liquid formulations
- stabilized liquid
- stabilized
- ifn
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
FORMULAçõES LìQUIDAS ESTABILIZADAS DE INTERFERON. A presente invenção refere-se a uma composição farmacêutica líquida estabilizada livre de HSA, que compreende um interferon (IFN), sendo que a referida formulação é uma solução que compreende um tampão, um aminoácido e um antioxidante. De preferência o interferon é um IFN-beta recombinante humano.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04076626 | 2004-06-01 | ||
US61637804P | 2004-10-06 | 2004-10-06 | |
PCT/EP2005/052414 WO2005117949A1 (en) | 2004-06-01 | 2005-05-27 | Stabilized interferon liquid formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0510526A true BRPI0510526A (pt) | 2007-10-30 |
Family
ID=34928261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0510526-9A BRPI0510526A (pt) | 2004-06-01 | 2005-05-27 | formulações lìquidas estabilizadas de interferon |
Country Status (15)
Country | Link |
---|---|
US (1) | US7731948B2 (pt) |
EP (1) | EP1750751B1 (pt) |
JP (1) | JP4988562B2 (pt) |
CN (1) | CN1993139B (pt) |
AU (1) | AU2005249233B2 (pt) |
BR (1) | BRPI0510526A (pt) |
CA (1) | CA2567310A1 (pt) |
EA (1) | EA010979B1 (pt) |
ES (1) | ES2418833T3 (pt) |
HK (1) | HK1102563A1 (pt) |
IL (1) | IL179620A (pt) |
MX (1) | MXPA06014078A (pt) |
NO (1) | NO20065860L (pt) |
UA (1) | UA92146C2 (pt) |
WO (1) | WO2005117949A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL1691825T3 (pl) | 2003-12-11 | 2012-02-29 | Ares Trading Sa | Stabilizowane ciekłe formulacje interferonu |
NZ550926A (en) * | 2004-05-17 | 2010-01-29 | Ares Trading Sa | Hydrogel interferon formulations |
EP1800673A3 (en) * | 2005-12-23 | 2007-08-15 | Canadian Blood Services | Nitrophenyls and related compounds and thimerosal for the inhibition of immune related cell or tissue destruction |
TW200806317A (en) * | 2006-03-20 | 2008-02-01 | Wyeth Corp | Methods for reducing protein aggregation |
WO2008066322A1 (en) * | 2006-11-28 | 2008-06-05 | Daewoong Co., Ltd. | A stable hsa-free and antioxidant-free pharmaceutical composition comprising interferon-beta |
CA2692165A1 (en) | 2007-06-25 | 2008-12-31 | Amgen Inc. | Compositions of specific binding agents to hepatocyte growth factor |
EP2234645B1 (en) | 2007-12-20 | 2012-05-02 | Merck Serono S.A. | Peg-interferon-beta formulations |
CN105521491B (zh) * | 2010-03-01 | 2020-03-24 | 西托戴恩有限公司 | 浓缩蛋白制剂及其用途 |
US20120269770A1 (en) * | 2010-11-22 | 2012-10-25 | Mark Brader | Stable Preserved Compositions of Interferon-Beta |
US9198955B2 (en) * | 2011-03-15 | 2015-12-01 | Biogen Inc. | Method for reducing flu-like symptoms associated with intramuscular administration of interferon using a fast titration escalating dosing regimen |
RU2527701C1 (ru) * | 2013-05-24 | 2014-09-10 | Федеральное государственное бюджетное учреждение "Научный центр реконструктивной и восстановительной хирургии" Сибирского отделения Российской академии медицинских наук (ФГБУ "НЦРВХ" СО РАМН) | Способ приготовления средства, обладающего свойством стимуляции регенерации хрящевой, костной, мышечной тканей и способ стимуляции регенерации хрящевой, костной, мышечной тканей с использованием приготовленного средства |
AU2015239104B2 (en) | 2014-04-04 | 2018-12-20 | Ares Trading S.A. | Novel IFN beta protein analogs |
US9744209B2 (en) | 2015-01-30 | 2017-08-29 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9937223B2 (en) | 2015-01-30 | 2018-04-10 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9925233B2 (en) | 2015-01-30 | 2018-03-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9687526B2 (en) | 2015-01-30 | 2017-06-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9750785B2 (en) | 2015-01-30 | 2017-09-05 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9375478B1 (en) | 2015-01-30 | 2016-06-28 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
CN114053397B (zh) * | 2022-01-17 | 2022-12-20 | 北京三元基因药业股份有限公司 | 一种稳定的干扰素多剂量注射液及其制备方法 |
Family Cites Families (37)
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US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
EP0098110B1 (en) | 1982-06-24 | 1989-10-18 | NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD | Long-acting composition |
US4737462A (en) | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
US4588585A (en) | 1982-10-19 | 1986-05-13 | Cetus Corporation | Human recombinant cysteine depleted interferon-β muteins |
US4469228A (en) | 1983-05-31 | 1984-09-04 | Schering Corporation | Interferon kit |
US4636383A (en) | 1984-08-29 | 1987-01-13 | Schering Corporation | Interferon-cyclaradine combination |
US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
US5116943A (en) | 1985-01-18 | 1992-05-26 | Cetus Corporation | Oxidation-resistant muteins of Il-2 and other protein |
US5017691A (en) | 1986-07-03 | 1991-05-21 | Schering Corporation | Mammalian interleukin-4 |
US4879111A (en) | 1986-04-17 | 1989-11-07 | Cetus Corporation | Treatment of infections with lymphokines |
US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
IT1244511B (it) | 1991-04-15 | 1994-07-15 | Isi Ist Sierovaccinogeno Ital | Idrogeli a base di policarbossilati sintetici e proteine per il rilascio controllato di farmaci e procedimento per la loro preparazione. |
KR960009385B1 (en) * | 1993-11-24 | 1996-07-18 | Samsung Bp Chemicals Co Ltd | Apparatus and method for wastewater treatment by activated sludge process type |
IT1272252B (it) | 1994-05-16 | 1997-06-16 | Applied Research Systems | Formulazioni liquide di interferone beta |
TW426523B (en) | 1995-04-06 | 2001-03-21 | Hoffmann La Roche | Interferon solution |
US5858001A (en) | 1995-12-11 | 1999-01-12 | Elan Medical Technologies Limited | Cartridge-based drug delivery device |
DE69705746T2 (de) | 1996-12-20 | 2001-10-31 | Alza Corp | Injizierbare depotgelzubereitung und herstellungsverfahren |
US6013253A (en) | 1997-08-15 | 2000-01-11 | Amgen, Inc. | Treatment of multiple sclerosis using consensus interferon and IL-1 receptor antagonist |
CA2304808C (en) * | 1997-09-23 | 2011-03-22 | Michael Tschope | Liquid interferon-.beta. formulations |
AU761577C (en) * | 1997-12-08 | 2004-02-05 | Genentech Inc. | Human interferon-epsilon: a type I interferon |
SK286654B6 (sk) | 1998-04-28 | 2009-03-05 | Laboratoires Serono Sa | Spôsob postupného pripájania polyetylénglykolových častí a použitie PEG-polypeptidových konjugátov vyrobených týmto spôsobom |
US6143314A (en) | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
JP4944324B2 (ja) | 1999-07-13 | 2012-05-30 | ボルダー バイオテクノロジー, インコーポレイテッド | 免疫グロブリン融合タンパク質 |
US6531122B1 (en) | 1999-08-27 | 2003-03-11 | Maxygen Aps | Interferon-β variants and conjugates |
CA2386228A1 (en) * | 1999-10-04 | 2001-04-12 | Chiron Corporation | Stabilized liquid pharmaceutical compositions comprising tissue factor pathway inhibitor (tfpi) polypeptides |
CN1175901C (zh) * | 1999-12-06 | 2004-11-17 | 天津华立达生物工程有限公司 | 一种稳定的干扰素水溶液 |
US6465425B1 (en) | 2000-02-10 | 2002-10-15 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins |
WO2002003430A2 (en) | 2000-06-29 | 2002-01-10 | California Institute Of Technology | Aerosol process for fabricating discontinuous floating gate microelectronic devices |
KR100396983B1 (ko) | 2000-07-29 | 2003-09-02 | 이강춘 | 고반응성의 가지 달린 고분자 유도체 및 고분자와 단백질또는 펩타이드의 접합체 |
IL156532A0 (en) | 2000-12-27 | 2004-01-04 | Ares Trading Sa | Lipid microparticles, their preparation and pharmaceutical compositions containing them |
US6887462B2 (en) * | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
US20040028733A1 (en) | 2002-02-08 | 2004-02-12 | Alkermes Controlled Therapeutics, Inc. | Polymer-based compositions for sustained release |
US20040037809A1 (en) | 2002-06-28 | 2004-02-26 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of interferon beta |
TWI272948B (en) | 2003-05-01 | 2007-02-11 | Ares Trading Sa | HSA-free stabilized interferon liquid formulations |
AR044302A1 (es) | 2003-05-13 | 2005-09-07 | Ares Trading Sa | Formulaciones con proteinas liquidas estabilizadas en recipientes farmaceuticos |
NZ550926A (en) | 2004-05-17 | 2010-01-29 | Ares Trading Sa | Hydrogel interferon formulations |
-
2005
- 2005-05-27 CN CN2005800257255A patent/CN1993139B/zh active Active
- 2005-05-27 CA CA002567310A patent/CA2567310A1/en not_active Withdrawn
- 2005-05-27 US US11/597,987 patent/US7731948B2/en active Active
- 2005-05-27 MX MXPA06014078A patent/MXPA06014078A/es active IP Right Grant
- 2005-05-27 BR BRPI0510526-9A patent/BRPI0510526A/pt not_active IP Right Cessation
- 2005-05-27 ES ES05752765T patent/ES2418833T3/es active Active
- 2005-05-27 AU AU2005249233A patent/AU2005249233B2/en active Active
- 2005-05-27 EP EP05752765.7A patent/EP1750751B1/en active Active
- 2005-05-27 EA EA200602257A patent/EA010979B1/ru not_active IP Right Cessation
- 2005-05-27 JP JP2007513938A patent/JP4988562B2/ja active Active
- 2005-05-27 WO PCT/EP2005/052414 patent/WO2005117949A1/en active Application Filing
- 2005-05-27 UA UAA200612406A patent/UA92146C2/ru unknown
-
2006
- 2006-11-27 IL IL179620A patent/IL179620A/en not_active IP Right Cessation
- 2006-12-19 NO NO20065860A patent/NO20065860L/no not_active Application Discontinuation
-
2007
- 2007-10-09 HK HK07110897.6A patent/HK1102563A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
WO2005117949A1 (en) | 2005-12-15 |
JP2008500996A (ja) | 2008-01-17 |
US20070292391A1 (en) | 2007-12-20 |
HK1102563A1 (en) | 2007-11-30 |
ES2418833T3 (es) | 2013-08-16 |
NO20065860L (no) | 2006-12-19 |
EA200602257A1 (ru) | 2007-04-27 |
IL179620A (en) | 2013-04-30 |
MXPA06014078A (es) | 2007-02-15 |
EP1750751B1 (en) | 2013-04-10 |
UA92146C2 (ru) | 2010-10-11 |
AU2005249233B2 (en) | 2010-10-07 |
CN1993139A (zh) | 2007-07-04 |
EP1750751A1 (en) | 2007-02-14 |
JP4988562B2 (ja) | 2012-08-01 |
CA2567310A1 (en) | 2005-12-15 |
US7731948B2 (en) | 2010-06-08 |
AU2005249233A1 (en) | 2005-12-15 |
EA010979B1 (ru) | 2008-12-30 |
IL179620A0 (en) | 2007-05-15 |
CN1993139B (zh) | 2011-02-16 |
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Legal Events
Date | Code | Title | Description |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2257 DE 08/04/2014. |