BRPI0509824A - compostos heterocìclicos [3.2.0] e métodos de uso dos mesmos - Google Patents
compostos heterocìclicos [3.2.0] e métodos de uso dos mesmosInfo
- Publication number
- BRPI0509824A BRPI0509824A BRPI0509824-6A BRPI0509824A BRPI0509824A BR PI0509824 A BRPI0509824 A BR PI0509824A BR PI0509824 A BRPI0509824 A BR PI0509824A BR PI0509824 A BRPI0509824 A BR PI0509824A
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- compounds
- cancer
- heterocyclic compounds
- inflammatory
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000001093 anti-cancer Effects 0.000 abstract 3
- 230000000845 anti-microbial effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Abstract
COMPOSTOS HETEROCìCLICOS ¢3.2.0! E MéTODOS DE USO DOS MESMOS São descritos compostos das Fórmulas I-VI e seus derivados tendo propriedades anti-câncer, anti-inflamatórias, e anti-microbianas e composições incluindo um ou mais compostos e seus derivados ou análogos tendo propriedades anti-câncer, anti-inflamatórias e anti-microbianas. São também descritas composições farmacêuticas compreendendo tais compostos e métodos para tratamento de câncer, condições inflamatórias, e infecções microbianas com os ditos compostos ou composições farmacêuticas.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56733604P | 2004-04-30 | 2004-04-30 | |
US58083804P | 2004-06-18 | 2004-06-18 | |
US59119004P | 2004-07-26 | 2004-07-26 | |
US62746204P | 2004-11-12 | 2004-11-12 | |
US64413205P | 2005-01-13 | 2005-01-13 | |
US65938505P | 2005-03-04 | 2005-03-04 | |
PCT/US2005/014846 WO2006028525A2 (en) | 2004-04-30 | 2005-04-29 | [3.2.0] heterocyclic compounds and methods of using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0509824A true BRPI0509824A (pt) | 2007-10-09 |
Family
ID=36036772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0509824-6A BRPI0509824A (pt) | 2004-04-30 | 2005-04-29 | compostos heterocìclicos [3.2.0] e métodos de uso dos mesmos |
Country Status (10)
Country | Link |
---|---|
US (2) | US7276530B2 (pt) |
EP (3) | EP2266988A1 (pt) |
JP (1) | JP2007535559A (pt) |
AU (1) | AU2005283141B2 (pt) |
BR (1) | BRPI0509824A (pt) |
CA (1) | CA2565235A1 (pt) |
IL (1) | IL178899A0 (pt) |
MX (1) | MXPA06012421A (pt) |
NZ (1) | NZ550910A (pt) |
WO (1) | WO2006028525A2 (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
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JP4395549B2 (ja) * | 2000-11-16 | 2010-01-13 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | 薬物及び発酵生成物の発見のための海洋放線菌分類群 |
US7179834B2 (en) * | 2002-06-24 | 2007-02-20 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
NZ544858A (en) * | 2003-06-20 | 2009-07-31 | Univ California | Salinosporamides and methods for use thereof |
MXPA05013982A (es) | 2003-06-20 | 2006-05-25 | Nereus Pharmaceuticals Inc | Metodos para utilizar compuestos {3.2.0} heterociclicos y sus analogos. |
AU2005283141B2 (en) * | 2004-04-30 | 2012-05-10 | Nereus Pharmaceuticals, Inc. | (3.2.0) heterocyclic compounds and methods of using the same |
US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
KR20070086895A (ko) * | 2004-12-03 | 2007-08-27 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 〔3.2.0〕헤테로사이클릭 화합물 및 그의 유도체의사용방법 |
WO2006060676A1 (en) | 2004-12-03 | 2006-06-08 | Dana Farber Cancer Institute | Compositions and methods for treating neoplastic diseases |
WO2006118973A2 (en) * | 2005-04-29 | 2006-11-09 | Nereus Pharmaceuticals, Inc. | Methods of using heterobyclic compounds for treatment of rectal cancer |
US7572606B1 (en) * | 2005-09-09 | 2009-08-11 | Nereus Pharmaceuticals, Inc. | Biosyntheses of salinosporamide A and its analogs and related methods of making salinosporamide A and its analogs |
NZ572026A (en) * | 2006-04-06 | 2011-12-22 | Nereus Pharmaceuticals Inc | Total synthesis of salinosporamide a and analogs thereof |
US8986971B2 (en) | 2006-09-22 | 2015-03-24 | Triphase Research And Development I Corp. | Salt formulations for the fermentation of marine microorganisms |
WO2008095195A2 (en) * | 2007-02-02 | 2008-08-07 | Nereus Pharmaceuticals, Inc. | Lyophilized formulations of salinosporamide a |
WO2008124699A1 (en) * | 2007-04-06 | 2008-10-16 | Nereus Pharmaceuticals, Inc. | A method of using proteasome inhibitors in combination with histone deacetylase inhibitors to treat cancer |
US20080280968A1 (en) * | 2007-05-04 | 2008-11-13 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof for treating infectious diseases |
US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
US8003802B2 (en) | 2008-03-07 | 2011-08-23 | Nereus Pharmaceuticals, Inc. | Total synthesis of Salinosporamide A and analogs thereof |
WO2009140287A1 (en) * | 2008-05-12 | 2009-11-19 | Nereus Pharmaceuticals, Inc. | Salinosporamide derivatives as proteasome inhibitors |
EP2297347B1 (en) | 2008-05-14 | 2017-03-08 | Millennium Pharmaceuticals, Inc. | Methods and kits for monitoring the effects of immunomodulators on adaptive immunity |
US20120093791A1 (en) * | 2009-06-15 | 2012-04-19 | Cormier Yvon | Stimulation of innate immunity with an antigen from bacterial origin |
CN103443103B (zh) * | 2010-07-20 | 2016-06-22 | 韩国生命工学研究院 | 新型Fusarisetin化合物及其用途 |
EP3463458B1 (en) | 2016-06-01 | 2024-04-10 | Celgene Tri A Holdings Ltd. | Combined use of marizomib and bevacizumab for the treatment of central nervous system (cns) cancers |
WO2018033631A1 (en) * | 2016-08-19 | 2018-02-22 | Celgene International Ii Sàrl | Morphic forms of marizomib and uses thereof |
CN112521398B (zh) * | 2020-07-30 | 2022-03-15 | 上海交通大学医学院附属仁济医院 | 一种海绵共附生菌来源开环重排甾体化合物及其制备方法与应用 |
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US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
AU2005283141B2 (en) | 2004-04-30 | 2012-05-10 | Nereus Pharmaceuticals, Inc. | (3.2.0) heterocyclic compounds and methods of using the same |
US20060264495A1 (en) | 2004-04-30 | 2006-11-23 | Michael Palladino | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
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-
2005
- 2005-04-29 AU AU2005283141A patent/AU2005283141B2/en not_active Ceased
- 2005-04-29 JP JP2007511021A patent/JP2007535559A/ja active Pending
- 2005-04-29 NZ NZ550910A patent/NZ550910A/en not_active IP Right Cessation
- 2005-04-29 CA CA002565235A patent/CA2565235A1/en not_active Abandoned
- 2005-04-29 WO PCT/US2005/014846 patent/WO2006028525A2/en active Application Filing
- 2005-04-29 EP EP10179249A patent/EP2266988A1/en not_active Withdrawn
- 2005-04-29 MX MXPA06012421A patent/MXPA06012421A/es active IP Right Grant
- 2005-04-29 EP EP05818192A patent/EP1812443A2/en not_active Withdrawn
- 2005-04-29 EP EP08168314A patent/EP2025679A3/en not_active Withdrawn
- 2005-04-29 BR BRPI0509824-6A patent/BRPI0509824A/pt not_active IP Right Cessation
- 2005-04-29 US US11/118,260 patent/US7276530B2/en active Active
-
2006
- 2006-10-26 IL IL178899A patent/IL178899A0/en unknown
-
2007
- 2007-10-01 US US11/865,704 patent/US7544814B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2266988A1 (en) | 2010-12-29 |
AU2005283141B2 (en) | 2012-05-10 |
AU2005283141A1 (en) | 2006-03-16 |
US20050288352A1 (en) | 2005-12-29 |
US7544814B2 (en) | 2009-06-09 |
EP2025679A3 (en) | 2009-07-08 |
JP2007535559A (ja) | 2007-12-06 |
CA2565235A1 (en) | 2006-03-16 |
EP2025679A2 (en) | 2009-02-18 |
EP1812443A2 (en) | 2007-08-01 |
IL178899A0 (en) | 2007-05-15 |
WO2006028525A3 (en) | 2007-05-18 |
US20080070969A1 (en) | 2008-03-20 |
WO2006028525A2 (en) | 2006-03-16 |
MXPA06012421A (es) | 2007-01-31 |
NZ550910A (en) | 2011-06-30 |
US7276530B2 (en) | 2007-10-02 |
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