BRPI0509582A - compostos de tiazol-amina e respectivas composições farmacêuticas - Google Patents
compostos de tiazol-amina e respectivas composições farmacêuticasInfo
- Publication number
- BRPI0509582A BRPI0509582A BRPI0509582-4A BRPI0509582A BRPI0509582A BR PI0509582 A BRPI0509582 A BR PI0509582A BR PI0509582 A BRPI0509582 A BR PI0509582A BR PI0509582 A BRPI0509582 A BR PI0509582A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical compositions
- thiazol
- amine compounds
- compounds
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Abstract
COMPOSTOS DE TIAZOL-AMINA E RESPECTIVAS COMPOSIçõES FARMACêUTICAS. A presente invenção refere-se aos compostos da Fórmula <124> em que R¬ 1¬, R¬ 3¬, R¬ 4¬, R¬ 5¬, R¬ 6¬ e R¬ 7¬ são como definidos. Compostos da Fórmula <124> têm atividade de inibição da produção de peptídeo A<225>. A invenção também refere-se às composições farmacêuticas e métodos de tratamento de distúrbios e doenças, por exemplo, distúrbios neurodegenerativos e/ou neurológicos, por exemplo, Doença de Alzheimer, em um mamífero compreendendo compostos da Fórmula <124>.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55890204P | 2004-04-01 | 2004-04-01 | |
PCT/IB2005/000825 WO2005095367A1 (en) | 2004-04-01 | 2005-03-23 | Thiazole-amine compounds for the treatment of neurodegenerative disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0509582A true BRPI0509582A (pt) | 2007-10-09 |
Family
ID=34962046
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0509582-4A BRPI0509582A (pt) | 2004-04-01 | 2005-03-23 | compostos de tiazol-amina e respectivas composições farmacêuticas |
Country Status (6)
Country | Link |
---|---|
US (2) | US7384968B2 (pt) |
EP (1) | EP1735292A1 (pt) |
JP (1) | JP2007530662A (pt) |
BR (1) | BRPI0509582A (pt) |
CA (1) | CA2562123A1 (pt) |
WO (1) | WO2005095367A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1934091B (zh) | 2004-03-23 | 2012-02-08 | 辉瑞产品公司 | 治疗神经变性障碍的咪唑化合物 |
BRPI0616141A2 (pt) * | 2005-09-22 | 2011-06-07 | Pfizer Prod Inc | compostos imidazol para o tratamento de distúrbios neurológicos |
FR2913886B1 (fr) | 2007-03-22 | 2012-03-02 | Guerbet Sa | Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer |
EP2042172A1 (en) * | 2007-09-26 | 2009-04-01 | Inserm | Use of tocopherol derivatives as inhibitors of the notch signalling pathway |
US9241999B2 (en) | 2009-06-15 | 2016-01-26 | Board Of Regents Of The University Of Texas System | Method of producing physiological and therapeutic levels of nitric oxide through an oral delivery system |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1168432B (de) | 1961-10-25 | 1964-04-23 | Hoechst Ag | Verfahren zur Herstellung von N-substituierten 2-Nitro-1-aminoarylverbindungen |
JPS5516147B2 (pt) | 1971-12-24 | 1980-04-30 | ||
US4217355A (en) | 1978-04-24 | 1980-08-12 | Pfizer Inc. | Amide therapeutic agents |
GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
RU2312860C2 (ru) * | 1999-04-15 | 2007-12-20 | Бристол-Маерс Сквибб Компани | Циклические ингибиторы протеинтирозинкиназ |
WO2002067918A1 (fr) * | 2001-02-27 | 2002-09-06 | Banyu Pharmaceutical Co., Ltd. | Nouveau derive de diallylmethylamine |
JP2003064064A (ja) * | 2001-08-29 | 2003-03-05 | Tokuyama Corp | アミドチアゾール誘導体エステル化合物の製造方法 |
FR2842523A1 (fr) | 2002-07-17 | 2004-01-23 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
EP1551815A1 (en) | 2002-10-09 | 2005-07-13 | Pfizer Products Inc. | Thiazole compounds for the treatment of neurodegenerative disorders |
EP1664006A2 (en) | 2003-09-06 | 2006-06-07 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
-
2005
- 2005-03-11 US US11/078,880 patent/US7384968B2/en not_active Expired - Fee Related
- 2005-03-23 JP JP2007505661A patent/JP2007530662A/ja not_active Withdrawn
- 2005-03-23 EP EP05718308A patent/EP1735292A1/en not_active Withdrawn
- 2005-03-23 BR BRPI0509582-4A patent/BRPI0509582A/pt not_active IP Right Cessation
- 2005-03-23 WO PCT/IB2005/000825 patent/WO2005095367A1/en active Application Filing
- 2005-03-23 CA CA002562123A patent/CA2562123A1/en not_active Abandoned
-
2008
- 2008-05-01 US US12/113,609 patent/US20080207712A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20080207712A1 (en) | 2008-08-28 |
WO2005095367A1 (en) | 2005-10-13 |
EP1735292A1 (en) | 2006-12-27 |
US20060084689A1 (en) | 2006-04-20 |
CA2562123A1 (en) | 2005-10-13 |
JP2007530662A (ja) | 2007-11-01 |
US7384968B2 (en) | 2008-06-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2137 DE 20/12/2011. |