BRPI0509377A - compostos de ácido alfa arila ou heteroaril metil beta piperidino propanóico como antagonistas do receptor orl1 - Google Patents

compostos de ácido alfa arila ou heteroaril metil beta piperidino propanóico como antagonistas do receptor orl1

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Publication number
BRPI0509377A
BRPI0509377A BRPI0509377-5A BRPI0509377A BRPI0509377A BR PI0509377 A BRPI0509377 A BR PI0509377A BR PI0509377 A BRPI0509377 A BR PI0509377A BR PI0509377 A BRPI0509377 A BR PI0509377A
Authority
BR
Brazil
Prior art keywords
propanoic acid
receptor antagonists
acid compounds
methyl beta
compounds
Prior art date
Application number
BRPI0509377-5A
Other languages
English (en)
Inventor
Yoshinobu Hashizume
Masako Hirota
Sachiko Mihara
Hiroshi Nakamura
Hiroki Koike
Yukari Matsumoto
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BRPI0509377A publication Critical patent/BRPI0509377A/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/20—Hypnotics; Sedatives
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

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  • Obesity (AREA)
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Abstract

"COMPOSTOS DE áCIDO ALFA ARIL OU HETEROARIL METIL BETA PIPERIDINO PROPANóICO COMO ANTAGONISTAS DO RECEPTOR ORL1". A presente invenção refere-se aos compostos de fórmula (1): ou um éster farmaceuticamente aceitável deste composto, ou um sal farmaceuticamente aceitável dos mesmos, ande R1 e R2 independentemente representam um átomo de hidrogênio ou outros; R3 representa um grupo arila tendo de 6 a 10 átomos na anel ou outros; X representa um átomo de oxigênio ou outros; Y representa um átomo de oxigênio ou similares; e n representa o inteiro 0, 1 ou 2. Estes compostos possuem atividade antagonística do receptor ORL-1; e portanto são úteis para tratar doenças ou condições tais como dor, várias doenças do CNS etc.
BRPI0509377-5A 2004-03-29 2005-03-16 compostos de ácido alfa arila ou heteroaril metil beta piperidino propanóico como antagonistas do receptor orl1 BRPI0509377A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55759804P 2004-03-29 2004-03-29
PCT/IB2005/000679 WO2005092895A2 (en) 2004-03-29 2005-03-16 Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as orl1-receptor antagonists

Publications (1)

Publication Number Publication Date
BRPI0509377A true BRPI0509377A (pt) 2007-09-11

Family

ID=34961283

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0509307-4A BRPI0509307A (pt) 2004-03-29 2005-03-16 compostos de alfa aril ou heteroaril metil beta piperidino propanamida como antagonistas do receptor orl1
BRPI0509377-5A BRPI0509377A (pt) 2004-03-29 2005-03-16 compostos de ácido alfa arila ou heteroaril metil beta piperidino propanóico como antagonistas do receptor orl1

Family Applications Before (1)

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BRPI0509307-4A BRPI0509307A (pt) 2004-03-29 2005-03-16 compostos de alfa aril ou heteroaril metil beta piperidino propanamida como antagonistas do receptor orl1

Country Status (13)

Country Link
US (2) US7354925B2 (pt)
EP (2) EP1732928A2 (pt)
JP (2) JP2007530656A (pt)
AR (1) AR048340A1 (pt)
BR (2) BRPI0509307A (pt)
CA (2) CA2563164A1 (pt)
DO (1) DOP2005000046A (pt)
MX (1) MXPA06011265A (pt)
NL (1) NL1028624C2 (pt)
PA (1) PA8627801A1 (pt)
TW (1) TW200533641A (pt)
UY (1) UY28823A1 (pt)
WO (2) WO2005092895A2 (pt)

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JP6126134B2 (ja) * 2012-02-03 2017-05-10 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 線維筋痛症および慢性疲労症候群の治療のための、（１ｒ，４ｒ）−６’−フルオロ−（Ｎ−メチル−またはＮ，Ｎ−ジメチル−）−４−フェニル−４’，９’−ジヒドロ−３’Ｈ−スピロ［シクロヘキサン−１，１’−ピラノ［３，４，ｂ］インドール］−４−アミン
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CA2561488A1 (en) 2005-10-06
AR048340A1 (es) 2006-04-19
WO2005092858A2 (en) 2005-10-06
WO2005092895A3 (en) 2006-03-02
JP2007530653A (ja) 2007-11-01
PA8627801A1 (es) 2006-05-16
NL1028624C2 (nl) 2006-02-21
JP2007530656A (ja) 2007-11-01
TW200533641A (en) 2005-10-16
US20070197500A1 (en) 2007-08-23
EP1732893A2 (en) 2006-12-20
BRPI0509307A (pt) 2007-09-04
CA2563164A1 (en) 2005-10-06
MXPA06011265A (es) 2006-12-15
DOP2005000046A (es) 2005-11-30
EP1732928A2 (en) 2006-12-20
US7354925B2 (en) 2008-04-08
US20050277659A1 (en) 2005-12-15
NL1028624A1 (nl) 2005-10-03
WO2005092858A3 (en) 2006-03-02
US7279486B2 (en) 2007-10-09

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