BRPI0507790A - substituted pyrazoline compound, process for its manufacture, medicines and their uses - Google Patents

substituted pyrazoline compound, process for its manufacture, medicines and their uses

Info

Publication number
BRPI0507790A
BRPI0507790A BRPI0507790-7A BRPI0507790A BRPI0507790A BR PI0507790 A BRPI0507790 A BR PI0507790A BR PI0507790 A BRPI0507790 A BR PI0507790A BR PI0507790 A BRPI0507790 A BR PI0507790A
Authority
BR
Brazil
Prior art keywords
medicines
manufacture
substituted pyrazoline
pyrazoline compound
compounds
Prior art date
Application number
BRPI0507790-7A
Other languages
Portuguese (pt)
Inventor
Rosa Cuberes Altisen
Bonifacio Gutierrez Silva
Jordi Frigola Constansa
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04021974A external-priority patent/EP1637522A1/en
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of BRPI0507790A publication Critical patent/BRPI0507790A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • C07B2200/09—Geometrical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)

Abstract

COMPOSTOS DE PIRAZOLINA SUBSTITUìDA, PROCESSO PARA A SUA MANUFATURA, MEDICAMENTOS E SEUS USOS. A presente invenção relaciona-se a compostos de pirazolina substituída, métodos para sua preparação, medicamentos que compreendem esses compostos assim como seu uso para a preparação de um medicamento para o tratamento de humanos e de animais.REPLACED PIRAZOLINE COMPOUNDS, PROCESS FOR MANUFACTURING, MEDICINAL PRODUCTS AND THEIR USES. The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising such compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

BRPI0507790-7A 2004-02-17 2005-02-14 substituted pyrazoline compound, process for its manufacture, medicines and their uses BRPI0507790A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ES200400378 2004-02-17
US80453404A 2004-03-19 2004-03-19
EP04021974A EP1637522A1 (en) 2004-09-16 2004-09-16 Substituted pyrazoline compounds for reducing triglycerides in blood
PCT/EP2005/001465 WO2005077909A1 (en) 2004-02-17 2005-02-14 Substituted pyrazoline compounds for reducing triglycerides in blood

Publications (1)

Publication Number Publication Date
BRPI0507790A true BRPI0507790A (en) 2007-07-17

Family

ID=34864786

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507790-7A BRPI0507790A (en) 2004-02-17 2005-02-14 substituted pyrazoline compound, process for its manufacture, medicines and their uses

Country Status (10)

Country Link
EP (1) EP1718619A1 (en)
JP (1) JP2007522252A (en)
KR (1) KR20060135815A (en)
AU (1) AU2005212817A1 (en)
BR (1) BRPI0507790A (en)
CA (1) CA2556568A1 (en)
IL (1) IL177454A0 (en)
NO (1) NO20064186L (en)
RU (1) RU2006133260A (en)
WO (1) WO2005077909A1 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005044785A1 (en) 2003-10-30 2005-05-19 Merck & Co., Inc. Aralkyl amines as cannabinoid receptor modulators
TW200533657A (en) * 2004-02-17 2005-10-16 Esteve Labor Dr Substituted pyrazoline compounds, their preparation and use as medicaments
EP1745781A1 (en) * 2005-07-15 2007-01-24 Laboratorios Del Dr. Esteve, S.A. Combination of pyrazoline type cannabinoid receptor antagonist and statin
EP1743637A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazole compounds and combinations thereof for the treatment of the metabolic syndrome
ES2336883B1 (en) * 2005-07-15 2011-03-22 Laboratorios Del Dr. Esteve, S.A. SUBSTITUTED PIRAZOLINE COMPOUNDS, WITH A DEFAULT STEREOCHEMISTRY, FOR THE REDUCTION OF TRIGLICERIDS IN BLOOD.
ES2330993B1 (en) * 2005-07-15 2010-07-06 Laboratorios Del Dr. Esteve, S.A. COMBINATION OF ANTAGONIST RECEIVER OF CANNABINOIDS OF TYPE PIRAZOLINA AND STATIN.
EP1749527A1 (en) * 2005-07-15 2007-02-07 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of the lipid parameters of the metabolic syndrome
EP1743639A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of coagulation related diseases
WO2007009701A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazole compounds and combinations thereof for the treatment of the metabolic syndrome
EP1746090A1 (en) * 2005-07-15 2007-01-24 Laboratorios del Dr. Esteve S.A. Sustituted pyrazoline compounds, having predetermined stereochemistry, for reducing triglycerides in blood
WO2007009704A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of food disorders, including obesity or metabolic syndrome in patients with developed diabetes
ES2334967B1 (en) * 2005-07-15 2010-10-21 Laboratorios Del Dr. Esteve, S.A. SUBSTITUTED PIRAZOLINE COMPOUNDS, WITH A DEFAULT STEREOCHEMISTRY, FOR REDUCTION OF TRIGLICERIDS IN BLOOD.
WO2007009683A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr.Esteve, S.A. Pharmaceutical formulations of substituted pyrazoline compounds
EP1749526A1 (en) * 2005-07-15 2007-02-07 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of food disorders, including obesity or metabolic syndrome in patients with developed diabetes
WO2007009700A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of the lipid parameters of the metabolic syndrome
EP1743889A1 (en) * 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Sustituted pyrazoline compounds, having predetermined stereochemistry, for reducing triglycerides in blood
WO2007009707A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of coagulation related diseases
EP1944296A1 (en) * 2007-01-15 2008-07-16 Laboratorios del Dr. Esteve S.A. Amorphous phase of a substituted pyrazoline, its preparation and use as medicaments
EP1944295A1 (en) * 2007-01-15 2008-07-16 Laboratorios del Dr. Esteve S.A. Non-racemic mixtures of (R)-N-piperidinyl-5-(4-chlorophenyl)1-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide and (S)-N-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide
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