BRPI0417672A - processos para produzir composições de vìrus estáveis em armazenamento, composições de vìrus e imunogênicas - Google Patents
processos para produzir composições de vìrus estáveis em armazenamento, composições de vìrus e imunogênicasInfo
- Publication number
- BRPI0417672A BRPI0417672A BRPI0417672-3A BRPI0417672A BRPI0417672A BR PI0417672 A BRPI0417672 A BR PI0417672A BR PI0417672 A BRPI0417672 A BR PI0417672A BR PI0417672 A BRPI0417672 A BR PI0417672A
- Authority
- BR
- Brazil
- Prior art keywords
- virus
- compositions
- storage stable
- processes
- producing storage
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
- C12N2760/18634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
- C12N2760/18651—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
"PROCESSOS PARA PRODUZIR COMPOSIçõES DE VìRUS ESTáVEIS EM ARMAZENAMENTO, COMPOSIçõES DE VìRUS E IMUNOGêNICAS". A invenção refere-se a métodos para produzir composições de vírus estáveis em armazenamento. Em determinadas concretizações, a invenção refere-se a uma ou mais formulações e etapas de processo que resultam em composições de vírus estáveis em armazenamento, em que a composição é estável em armazenamento como uma composição sólida liofilizada ou uma composição líquida congelada.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53032503P | 2003-12-17 | 2003-12-17 | |
PCT/US2004/041803 WO2005058356A2 (en) | 2003-12-17 | 2004-12-10 | Methods for porducing storage stable viruses and immunogenic compositions thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0417672A true BRPI0417672A (pt) | 2007-03-20 |
Family
ID=34700123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0417672-3A BRPI0417672A (pt) | 2003-12-17 | 2004-12-10 | processos para produzir composições de vìrus estáveis em armazenamento, composições de vìrus e imunogênicas |
Country Status (13)
Country | Link |
---|---|
US (1) | US8603796B2 (pt) |
EP (1) | EP1701738B1 (pt) |
JP (1) | JP4691509B2 (pt) |
CN (1) | CN1893973B (pt) |
AR (1) | AR046900A1 (pt) |
AU (1) | AU2004299057B2 (pt) |
BR (1) | BRPI0417672A (pt) |
CA (1) | CA2549197C (pt) |
DK (1) | DK1701738T3 (pt) |
ES (1) | ES2536322T3 (pt) |
IL (1) | IL176109A0 (pt) |
MX (1) | MXPA06006947A (pt) |
WO (1) | WO2005058356A2 (pt) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2458125C2 (ru) * | 2004-11-05 | 2012-08-10 | Веллстат Байолоджикс Корпорейшн | Способ стабилизации вируса ньюкаслской болезни для хранения в водном растворе и способ сохранения его стабильности |
US8124397B2 (en) * | 2005-08-08 | 2012-02-28 | Oregon Health & Science University | Inactivating pathogens with oxidizing agents for vaccine production |
PT1954308E (pt) * | 2005-09-16 | 2011-11-03 | Merial Ltd | Estabilizadores para vacinas liofilizadas |
AU2007251122B2 (en) * | 2006-05-12 | 2013-01-10 | Bharat Biotech International Limited | A composition useful as a vaccine |
GB0614460D0 (en) * | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
DE102007023198A1 (de) * | 2007-05-18 | 2008-11-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Magazin für zylindrische Gefässe |
BR112012000588A2 (pt) * | 2009-07-13 | 2020-08-11 | Bharat Biotech International Limited | composição, composição líquida, composição liofilizada e método para produzir um rotavirus atenuado |
KR102136036B1 (ko) | 2010-04-15 | 2020-07-20 | 신 니뽄 바이오메디칼 라보라토리즈, 엘티디. | 비강내 전달을 위한 방법 및 조성물 |
KR101863920B1 (ko) * | 2010-08-13 | 2018-06-01 | 어드밴스드 바이오뉴트리션 코프. | 생물학적 물질용 저장 안정화 건조 조성물 |
KR102023207B1 (ko) * | 2010-12-02 | 2019-11-25 | 온콜리틱스 바이오테크 인코포레이티드 | 동결건조 바이러스 제형 |
AU2011336413B2 (en) | 2010-12-02 | 2015-01-22 | Oncolytics Biotech Inc. | Liquid viral formulations |
US8771402B2 (en) * | 2011-06-14 | 2014-07-08 | Ut-Battelle, Llc | Membrane based apparatus for measurement of volatile particles |
JP6041361B2 (ja) | 2011-08-12 | 2016-12-07 | メリアル インコーポレイテッド | 生物学的製品、特にはワクチンの真空保存 |
WO2013040196A2 (en) | 2011-09-14 | 2013-03-21 | Immunovative Therapies, Ltd. | Automated device for biologic drug distribution |
EP2822540B1 (en) * | 2012-03-05 | 2020-04-08 | De Staat der Nederlanden, Vert. Door de Minister van VWS | Methods and compositions for stabilizing dried biological materials |
CN102813933A (zh) * | 2012-08-30 | 2012-12-12 | 青岛康地恩药业股份有限公司 | 鸡传染性法氏囊病卵黄抗体冻干保护剂 |
TWI610861B (zh) * | 2012-09-13 | 2018-01-11 | 梵提夫免疫療法公司 | 用於生物藥品分配的自動化裝置 |
TWI690322B (zh) * | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
CN111729077A (zh) * | 2013-03-14 | 2020-10-02 | 武田疫苗股份有限公司 | 减毒活甲病毒制剂的组合物和方法 |
BR112020008482A8 (pt) * | 2017-11-01 | 2023-01-31 | Merck Sharp & Dohme | Composto leuco |
CN110938603B (zh) * | 2019-12-20 | 2022-11-22 | 阿吉安(福州)基因医学检验实验室有限公司 | 一种通用型病毒样本保存缓冲液及其制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4084330A (en) * | 1976-07-02 | 1978-04-18 | Fts Systems, Inc. | Flask for freeze drying with adjustable seal |
US4273762A (en) * | 1979-12-03 | 1981-06-16 | Merck & Co., Inc. | Lyophilization process for live viral compositions |
IL105456A (en) * | 1992-04-21 | 1996-12-05 | American Home Prod | Vaccines of attenuated respiratory syncytial virus |
TW275632B (pt) * | 1992-04-21 | 1996-05-11 | American Cyanamid Co | |
US5489266A (en) * | 1994-01-25 | 1996-02-06 | Becton, Dickinson And Company | Syringe assembly and method for lyophilizing and reconstituting injectable medication |
JPH10503993A (ja) * | 1994-08-19 | 1998-04-14 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | 凍結乾燥用のベント式バイアルと凍結乾燥された生産品の汚染を最少限にする方法 |
US6077514A (en) * | 1996-04-04 | 2000-06-20 | The Regents Of The University Of Michigan | Attenuated respiratory syncytial virus |
JP4413999B2 (ja) * | 1996-07-15 | 2010-02-10 | アメリカ合衆国 | クローニングされたヌクレオチド配列からの弱毒化呼吸シンシチウムウィルスワクチンの製造 |
US6290967B1 (en) * | 1996-12-20 | 2001-09-18 | Merck & Co., Inc. | Stabilizers for lyophilized vaccines |
US6410023B1 (en) * | 1997-05-23 | 2002-06-25 | United States Of America | Recombinant parainfluenza virus vaccines attenuated by deletion or ablation of a non-essential gene |
AU2001278337A1 (en) | 2000-07-31 | 2002-02-13 | Aventis Pasteur Limited | Respiratory syncytial virus vaccine |
GB0024089D0 (en) * | 2000-10-02 | 2000-11-15 | Smithkline Beecham Biolog | Novel compounds |
US20040042972A1 (en) | 2002-04-11 | 2004-03-04 | Medimmune Vaccines, Inc. | Spray freeze dry of compositions for intranasal administration |
KR20050062542A (ko) | 2002-08-26 | 2005-06-23 | 화이자 프로덕츠 인코포레이티드 | 소의 호흡기 및 생식기계 감염에 대한 백신 |
-
2004
- 2004-12-10 DK DK04814040.4T patent/DK1701738T3/en active
- 2004-12-10 BR BRPI0417672-3A patent/BRPI0417672A/pt not_active Application Discontinuation
- 2004-12-10 US US10/582,461 patent/US8603796B2/en not_active Expired - Fee Related
- 2004-12-10 MX MXPA06006947A patent/MXPA06006947A/es active IP Right Grant
- 2004-12-10 CA CA2549197A patent/CA2549197C/en not_active Expired - Fee Related
- 2004-12-10 ES ES04814040.4T patent/ES2536322T3/es active Active
- 2004-12-10 WO PCT/US2004/041803 patent/WO2005058356A2/en active Application Filing
- 2004-12-10 EP EP04814040.4A patent/EP1701738B1/en active Active
- 2004-12-10 AU AU2004299057A patent/AU2004299057B2/en not_active Ceased
- 2004-12-10 JP JP2006545794A patent/JP4691509B2/ja not_active Expired - Fee Related
- 2004-12-10 CN CN2004800377252A patent/CN1893973B/zh not_active Expired - Fee Related
- 2004-12-16 AR ARP040104693A patent/AR046900A1/es unknown
-
2006
- 2006-06-04 IL IL176109A patent/IL176109A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2549197A1 (en) | 2005-06-30 |
ES2536322T3 (es) | 2015-05-22 |
WO2005058356A2 (en) | 2005-06-30 |
WO2005058356A3 (en) | 2005-11-17 |
AU2004299057B2 (en) | 2010-06-24 |
IL176109A0 (en) | 2006-10-05 |
JP4691509B2 (ja) | 2011-06-01 |
DK1701738T3 (en) | 2015-03-30 |
AU2004299057A1 (en) | 2005-06-30 |
CN1893973B (zh) | 2010-12-08 |
EP1701738B1 (en) | 2015-03-11 |
AR046900A1 (es) | 2005-12-28 |
MXPA06006947A (es) | 2007-01-26 |
US8603796B2 (en) | 2013-12-10 |
US20080206281A1 (en) | 2008-08-28 |
CA2549197C (en) | 2015-04-14 |
EP1701738A2 (en) | 2006-09-20 |
CN1893973A (zh) | 2007-01-10 |
JP2007514450A (ja) | 2007-06-07 |
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Legal Events
Date | Code | Title | Description |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |