BRPI0414816A - queleritrina, análogos dessa e seu uso no tratamento de distúrbio bipolar e outros distúrbios cognitivos - Google Patents
queleritrina, análogos dessa e seu uso no tratamento de distúrbio bipolar e outros distúrbios cognitivosInfo
- Publication number
- BRPI0414816A BRPI0414816A BRPI0414816-9A BRPI0414816A BRPI0414816A BR PI0414816 A BRPI0414816 A BR PI0414816A BR PI0414816 A BRPI0414816 A BR PI0414816A BR PI0414816 A BRPI0414816 A BR PI0414816A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- chelerythrin
- treatment
- bipolar disorder
- cognitive disorders
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"QUELERITRINA, ANáLOGOS DESSA E SEU USO NO TRATAMENTO DE DISTúRBIO BIPOLAR E OUTROS DISTúRBIOS COGNITIVOS". A presente invenção se relaciona ao uso de queleritrina e análogos de queleritrina em composições farmacêuticas para o tratamento de distúrbio cognitivos corticais pré-frontais, que incluem distúrbio bipolar, entre outros. Composições farmacêuticas de acordo com a presente invenção compreendem uma quantidade eficaz de de um composto ou um estereoisómero, sal, solvato ou polimorfo farmaceuticamente aceitável desse de acordo com a estrutura: fórmula (I) ou fórmula (II) na qual: R¬ 1¬ e R¬ 2¬ são independentemente selecionados de H, C~ 1~-C~ 3~ alquil, F, Cl, Br, I, OH, O (C~ 1~-C~ 6~ alquil) , O-C (=O) - (C~ 1~-C~ 6~) alquil ou C(=O)-O- (C~ 1~-C~ 6~) alquil; R¬ 3¬ é H ou um grupo C~ 1~-C~ 6~ alquil; R¬ 4¬, R¬ 5¬, R¬ 6¬, R¬ 7¬ e R¬ 8¬ são independentemente selecionados de H, C~ 1~-C~ 6~ alquil, F, Cl, Br, I, OH, -(CH~ 2~)~ n~O(C~ 1~-C~ 6~ alquil), -(CH~ 2~)~ n~O-C(=O)-(C~ 1~-C~ 6~) alquil ou -(CH~ 2~)~ n~C(=O)-O-(C~ 1~-C~ 6~) alquil; R¬ 9¬ e R¬ 10¬ são independentemente H, C~ 1~-C~ 6~ alquil ou juntos formam um grupo -(CH~ 2~)~ m~- para produzir um anel de 5-7 membros; n é de 0 a 5; m é de 1 a 3; e A- é um ânion farmaceuticamente aceitável de um sal farmacêutico, que forma um sal com o grupo de amina quaternizada, opcionalmente em combinação com um transportador, aditivo ou excipiente farmaceuticamente aceitável.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/672,626 US20050070565A1 (en) | 2003-09-26 | 2003-09-26 | Chelerythrine, analogs thereof and their use in the treatment of bipolar disorder and other cognitive disorders |
PCT/US2004/031567 WO2005030143A2 (en) | 2003-09-26 | 2004-09-27 | Chelerythrine, analogs thereof and their use in the treatment of bipolar disorder and other cognitive disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0414816A true BRPI0414816A (pt) | 2006-11-14 |
Family
ID=34376422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0414816-9A BRPI0414816A (pt) | 2003-09-26 | 2004-09-27 | queleritrina, análogos dessa e seu uso no tratamento de distúrbio bipolar e outros distúrbios cognitivos |
Country Status (11)
Country | Link |
---|---|
US (2) | US20050070565A1 (pt) |
EP (1) | EP1662875A4 (pt) |
JP (1) | JP2007506784A (pt) |
CN (1) | CN1859846A (pt) |
AU (1) | AU2004275852A1 (pt) |
BR (1) | BRPI0414816A (pt) |
CA (1) | CA2540151A1 (pt) |
IL (1) | IL174303A0 (pt) |
MX (1) | MXPA06003423A (pt) |
NO (1) | NO20061357L (pt) |
WO (1) | WO2005030143A2 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7928070B2 (en) | 2000-04-20 | 2011-04-19 | The Research Foundation Of State University Of Ny | Memory enhancing protein |
US20080145351A1 (en) * | 2000-04-20 | 2008-06-19 | The Research Foundation Of State University Of New York | Memory influencing protein |
WO2007089774A2 (en) * | 2006-01-31 | 2007-08-09 | Yale University | Compositions and methods for treating cognitive disorders |
US8362028B2 (en) * | 2006-07-31 | 2013-01-29 | Yale University | Pseudobase benzo[c]phenanthridines with improved efficacy, stability and safety |
WO2008048194A1 (en) * | 2006-10-20 | 2008-04-24 | Yesilogluj Aysegul Yildiz | Use of the protein kinase c inhibitor tamoxifen for the treatment of bipolar disorder |
CN101209043B (zh) * | 2006-12-27 | 2011-08-10 | 长沙世唯科技有限公司 | 血根碱或白屈菜红碱在血吸虫病防治上的应用 |
WO2008118403A2 (en) * | 2007-03-22 | 2008-10-02 | Yale University | Method of using a pkc inhibitor to reverse prefrontal cortical declines |
WO2011022292A2 (en) * | 2009-08-19 | 2011-02-24 | Lunera Research, Inc. | Method of treating bipolar disorder or depression using an antiestrogen |
US20170189391A1 (en) * | 2015-12-31 | 2017-07-06 | Macau University of Science ang Technology | Protein kinase C inhibitor for treating triple-negative breast cancer |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683133A (en) * | 1985-08-20 | 1987-07-28 | Vipont Laboratories, Inc. | Method for treating periodontal disease |
US5747502A (en) * | 1989-12-13 | 1998-05-05 | Nippon Kayaku Kabushiki Kaisha | Process for preparing benzo c!phenanthridinium derivatives, novel compounds prepared by said process, and antitumor agents |
JP2784104B2 (ja) * | 1991-08-06 | 1998-08-06 | 三菱電機株式会社 | タイミングシミュレーションシステム |
US5922571A (en) * | 1997-03-06 | 1999-07-13 | Incyte Pharmaceuticals, Inc. | Polynucleotides encoding a protein kinase C homolog |
US6717030B2 (en) * | 1998-07-06 | 2004-04-06 | The Regents Of The University Of California | Protein kinase C epsilon as modulator of anxiety, alcohol consumption and self-administration of drugs of abuse |
AUPQ801700A0 (en) * | 2000-06-07 | 2000-06-29 | Peplin Research Pty Ltd | Enzyme and viral activation |
US6664266B2 (en) * | 2002-03-14 | 2003-12-16 | Children's Medical Center Corporation | Axon regeneration with PKC inhibitiors |
-
2003
- 2003-09-26 US US10/672,626 patent/US20050070565A1/en not_active Abandoned
-
2004
- 2004-09-27 BR BRPI0414816-9A patent/BRPI0414816A/pt not_active IP Right Cessation
- 2004-09-27 WO PCT/US2004/031567 patent/WO2005030143A2/en active Application Filing
- 2004-09-27 MX MXPA06003423A patent/MXPA06003423A/es unknown
- 2004-09-27 CN CNA2004800280172A patent/CN1859846A/zh active Pending
- 2004-09-27 EP EP04785084A patent/EP1662875A4/en not_active Withdrawn
- 2004-09-27 JP JP2006528278A patent/JP2007506784A/ja not_active Withdrawn
- 2004-09-27 AU AU2004275852A patent/AU2004275852A1/en not_active Abandoned
- 2004-09-27 CA CA002540151A patent/CA2540151A1/en not_active Abandoned
-
2006
- 2006-03-13 IL IL174303A patent/IL174303A0/en unknown
- 2006-03-24 NO NO20061357A patent/NO20061357L/no not_active Application Discontinuation
-
2009
- 2009-08-25 US US12/546,737 patent/US20100222376A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NO20061357L (no) | 2006-06-16 |
CA2540151A1 (en) | 2005-04-07 |
WO2005030143A3 (en) | 2005-09-15 |
IL174303A0 (en) | 2006-08-01 |
WO2005030143A2 (en) | 2005-04-07 |
CN1859846A (zh) | 2006-11-08 |
US20100222376A1 (en) | 2010-09-02 |
EP1662875A4 (en) | 2009-04-15 |
US20050070565A1 (en) | 2005-03-31 |
MXPA06003423A (es) | 2006-06-27 |
JP2007506784A (ja) | 2007-03-22 |
AU2004275852A1 (en) | 2005-04-07 |
EP1662875A2 (en) | 2006-06-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0518068A (pt) | composto ou um éster ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, inibidor seletivo de aurora a, agente anti-tumor, e, preparação combinada | |
BRPI0612926B8 (pt) | compostos fluorados de 4-(2-amino-1-hidroxietila)fenol como agonistas de receptores b2 adrenérgicos, composição farmacêutica, combinação e uso de um composto | |
AP2001002307A0 (en) | B3 adrenergic receptor agonists and uses thereof. | |
UY28374A1 (es) | Agentes terapéuticos | |
BRPI0518615A2 (pt) | derivados de malonamida | |
WO2008012635A3 (en) | Amine derivatives useful as anticancer agents | |
BR0213612A (pt) | Composto, composição farmacêutica, uso do composto e método para tratamento de doença ou condição | |
BRPI0507495A (pt) | composto, composição farmacêutica, uso do composto método para o tratamento de distúrbios mediados por mglur5, e, método para inibir a ativação de receptores de mglur5 | |
BR0112475A (pt) | N-óxidos como pró-drogas antagonistas de receptor de nk1 de derivados 4-fenil-piridina | |
UY28752A1 (es) | Agentes terapeuticos | |
BR0317435A (pt) | Derivados de pirimidina para o tratamento do crescimento celular anormal | |
AR023363A1 (es) | Compuestos derivados de 3,3-biarilpiperidina y 2,2-biarilmorfolina, composicion y uso de los mismos | |
SE0104334D0 (sv) | Therapeutic agents | |
IL189156A (en) | A bite-containing (theo-hydrazide-rich) preparation, a flake cation and a thickening additive, a method for making this lipophilate and the leophilizate | |
BRPI0507499A (pt) | composto ou um sal farmaceuticamente aceitável ou hidrato dos mesmos, composição farmacêutica, uso do composto, e, métodos para tratar distúrbios mediados por mglur 5 e para inibir a ativação de receptores de mglur 5 | |
BRPI0509512A (pt) | método de tratar esquizofrenia e/ou anormalidades glicorregulatórias | |
ATE457988T1 (de) | A2a-adenosin-rezeptor-antagonisten | |
BR0213760A (pt) | Composto, composição farmacêutica, uso do composto e método para tratamento de doença ou condição | |
BRPI0414816A (pt) | queleritrina, análogos dessa e seu uso no tratamento de distúrbio bipolar e outros distúrbios cognitivos | |
BRPI0518043A (pt) | tetraidroisoquinolinas substituìdas por 4-fenila e uso destas para bloquear a recaptação de norepinefrina, dopamina e serotonina | |
ECSP034628A (es) | Formas de sal de amida de acido 3-(4-bromo-2,6-difluorobenciloxi)-5-[3-(4-oirrolidin-1-ilbutil) ureido] isotiazol-4-carboxilico y metodo de produccion | |
BRPI0408353A (pt) | composto, composição farmacêutica, métodos para o tratamento de neoplasias suscetìveis e para o tratamento de infecções virais, e, uso de um composto | |
BRPI0500590A (pt) | Processo para a sìntese de compostos de 1,3,4,5-tetraidro-2h-3-benzazepin-2-ona, e aplicação na sìntese de ivabradina e sais de adição desta com um ácido farmaceuticamente aceitável | |
BR0112337A (pt) | Derivados de fosfolipìdeos de ácido valpróico e suas misturas | |
BR9814055A (pt) | Composto, composição farmacêutica, processo para o tratamento de uma doença alérgica, uso do composto, e, processos para preparar e para produzir um composto |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |