BRPI0414527A - tratamento de tumores estromáticos gastrointestinais com imatinib e midostaurina - Google Patents
tratamento de tumores estromáticos gastrointestinais com imatinib e midostaurinaInfo
- Publication number
- BRPI0414527A BRPI0414527A BRPI0414527-5A BRPI0414527A BRPI0414527A BR PI0414527 A BRPI0414527 A BR PI0414527A BR PI0414527 A BRPI0414527 A BR PI0414527A BR PI0414527 A BRPI0414527 A BR PI0414527A
- Authority
- BR
- Brazil
- Prior art keywords
- imatinib
- midostaurin
- treatment
- gastrointestinal stromal
- stromal tumors
- Prior art date
Links
- 239000005517 L01XE01 - Imatinib Substances 0.000 title abstract 4
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 title abstract 4
- 229960002411 imatinib Drugs 0.000 title abstract 4
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 title abstract 3
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 title abstract 3
- BMGQWWVMWDBQGC-IIFHNQTCSA-N midostaurin Chemical compound CN([C@H]1[C@H]([C@]2(C)O[C@@H](N3C4=CC=CC=C4C4=C5C(=O)NCC5=C5C6=CC=CC=C6N2C5=C43)C1)OC)C(=O)C1=CC=CC=C1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 0.000 title abstract 3
- 229950010895 midostaurin Drugs 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
"TRATAMENTO DE TUMORES ESTROMáTICOS GASTROINTESTINAIS COM IMATINIB E MIDOSTAURINA". A presente invenção refere-se ao uso de uma combinação que compreende (a) imatinib ou um sal farmaceuticamente aceitável do mesmo e midostaurina ou um sal farmaceuticamente aceitável do mesmo para a preparação de um medicamento para o tratamento de tumores estromáticos gastrointestinais, como por exemplo tumores estromáticos gastrointestinais resistentes ao imatinib.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50424503P | 2003-09-19 | 2003-09-19 | |
PCT/EP2004/010467 WO2005027971A1 (en) | 2003-09-19 | 2004-09-17 | Treatment of gastrointestinal stromal tumors with imatinib and midostaurin |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0414527A true BRPI0414527A (pt) | 2006-11-07 |
Family
ID=34375467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0414527-5A BRPI0414527A (pt) | 2003-09-19 | 2004-09-17 | tratamento de tumores estromáticos gastrointestinais com imatinib e midostaurina |
Country Status (11)
Country | Link |
---|---|
US (1) | US20080096864A1 (pt) |
EP (1) | EP1667719B1 (pt) |
JP (1) | JP2007505859A (pt) |
CN (1) | CN100467064C (pt) |
AT (1) | ATE489109T1 (pt) |
AU (1) | AU2004273605B2 (pt) |
BR (1) | BRPI0414527A (pt) |
CA (1) | CA2538523A1 (pt) |
DE (1) | DE602004030265D1 (pt) |
MX (1) | MXPA06003056A (pt) |
WO (1) | WO2005027971A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2324917T3 (es) * | 2003-11-18 | 2009-08-19 | Novartis Ag | Inhibidores de la forma mutante de kit. |
RU2410098C2 (ru) * | 2004-08-31 | 2011-01-27 | Новартис Аг | Применение мидостаурина для лечения желудочно-кишечных стромальных опухолей |
US20080176879A1 (en) * | 2005-05-02 | 2008-07-24 | Leila Alland | Pyrimidylaminobenzamide Derivatives For Sytemic Mastocytosis |
AU2006271652B2 (en) * | 2005-07-20 | 2010-04-29 | Peter Valent | Compositions for treatment of systemic mastocytosis |
US7973032B2 (en) | 2005-11-14 | 2011-07-05 | University Of Zurich | Staurosporine derivatives for use in alveolar rhabdomyosarcoma |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CO4940418A1 (es) * | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
ITMI992711A1 (it) * | 1999-12-27 | 2001-06-27 | Novartis Ag | Composti organici |
CA2424470C (en) * | 2000-10-27 | 2009-06-09 | Novartis Ag | Treatment of gastrointestinal stromal tumors |
CA2477558A1 (en) * | 2002-02-28 | 2003-09-04 | Novartis Ag | N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine coated stents |
ES2303585T3 (es) * | 2002-04-10 | 2008-08-16 | Virginia Commonwealth University | Combinacion de glivec(sti571) con un inhibidor de quinasa dependiente de ciclina, especialmente flavopiridol en el tratamiento de cancer. |
-
2004
- 2004-09-17 CA CA002538523A patent/CA2538523A1/en not_active Abandoned
- 2004-09-17 BR BRPI0414527-5A patent/BRPI0414527A/pt not_active IP Right Cessation
- 2004-09-17 MX MXPA06003056A patent/MXPA06003056A/es not_active Application Discontinuation
- 2004-09-17 AT AT04765359T patent/ATE489109T1/de not_active IP Right Cessation
- 2004-09-17 US US10/572,259 patent/US20080096864A1/en not_active Abandoned
- 2004-09-17 DE DE602004030265T patent/DE602004030265D1/de active Active
- 2004-09-17 JP JP2006526596A patent/JP2007505859A/ja active Pending
- 2004-09-17 EP EP04765359A patent/EP1667719B1/en not_active Not-in-force
- 2004-09-17 WO PCT/EP2004/010467 patent/WO2005027971A1/en active Application Filing
- 2004-09-17 AU AU2004273605A patent/AU2004273605B2/en not_active Ceased
- 2004-09-17 CN CNB2004800270630A patent/CN100467064C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE602004030265D1 (de) | 2011-01-05 |
EP1667719B1 (en) | 2010-11-24 |
AU2004273605A1 (en) | 2005-03-31 |
ATE489109T1 (de) | 2010-12-15 |
CN1852738A (zh) | 2006-10-25 |
CA2538523A1 (en) | 2005-03-31 |
EP1667719A1 (en) | 2006-06-14 |
WO2005027971A1 (en) | 2005-03-31 |
MXPA06003056A (es) | 2006-05-31 |
JP2007505859A (ja) | 2007-03-15 |
CN100467064C (zh) | 2009-03-11 |
US20080096864A1 (en) | 2008-04-24 |
AU2004273605B2 (en) | 2008-07-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2009000349A1 (es) | Compuestos derivados de 4,5-dihidro-oxazol-2-ilamina; procedimiento de preparacion; composicion farmaceutica; y su uso para el tratamiento de la enfermedad de alzheimer. | |
BRPI0720551A2 (pt) | composto ou um sal farmaceuticamente aceitável do mesmo, e, uso do mesmo, método para o tratamento de câncer, processos para a preparação de uma composição farmacêutica e de um composto ou de um sal farmaceuticamente aceitável do mesmo | |
BRPI0007487B8 (pt) | difenil-uréias substituídas com w-carbóxi-arilas como inibidores de raf cinase | |
IS2517B (is) | Notkun á setnum 2-amínótetralínum í fyrirbyggjandi meðferð á Parkinsons-veiki | |
BRPI0410418A (pt) | fenil quinolinas e seu uso como moduladores do receptor de estrogênio | |
CL2008003593A1 (es) | Compuestos derivados de isoxazolo-piridazina; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de trastornos cognitivos como el alzheimer | |
BR0312573A (pt) | Derivados de fenil-[4-(3-fenil-1h-pirazol-4-il)-pirimidin-2-il]-amina | |
BRPI0418099A (pt) | compostos, composição farmacêutica, e uso de um composto | |
CL2007001427A1 (es) | Sal de maleato de 5-amino-3-(2',3'-di-o-acetil-beta-d-ribofuranosil)-3h-tiazolo[4,5-d]pirimidin-2-ona; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de una infeccion po | |
TN2009000180A1 (en) | NOVEL 1,4-BENZOTHIEPIN-l,1-DIOXIDE DERIVATIVES WHICH ARE SUBSTITUTED WITH BENZYL GROUPS, METHOD FOR PRODUCING DRUGS CONTAINING SAID COMPOUNDS AND USE THEREOF | |
ECSP067043A (es) | Derivados de pirrolotriazina útiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogénesis | |
CL2008001932A1 (es) | Compuestos derivados de 6-cicloamino-3-(piridin-4-il)imidazo[1,2-b]piridazina, inhibidores de cq1epsilon y/o ck1delta; procedimiento de preparacion; composicion farmaceutica que los comprende; y uso en el tratamiento de desordenes del sueno, trastorno del ritmo circadiano, cancer y enfermedad de alzheimer. | |
ECSP088283A (es) | Compuestos de piridina 5- (fenilisoxazoliletoxi) -triazol- 3-ilo substituidos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor | |
CL2007001205A1 (es) | Compuestos derivados de n-fenil-3-tio-4-fenil-azetedin-2-ona; procedimiento de preparacion; composicion farmaceutica; combinacion; uso en el tratamiento de una condicion hiperlipidemica, ateroesclerosis, alzheimer y tumores asociados a colesterol | |
CU23260B7 (es) | PREPARADO FARMACéUTICO DE MOXIFLOXACINA | |
CL2008001820A1 (es) | Compuestos derivados de aril-isoxasol-imidazol; procedimiento de preparacion; composicion farmaceutica que los contiene; y uso en la preparacion de medicamentos utiles en el tratamiento de trastornos cognitivos y enfermedades relacionadas con alzheimer. | |
GT200600106A (es) | Agentes endoparasiticidas | |
BR0113590A (pt) | 7-oxo-piridopirimidinas | |
BR0213684A (pt) | Uso de antagonistas do receptor de endotelina para o tratamento de doenças tumorìgenas | |
UA106200C2 (uk) | Заміщені похідні оксіндолу та їхнє застосування для лікування захворювань, залежних від вазопресину | |
GB0606015D0 (en) | therapeutic agents | |
CL2008001719A1 (es) | Compuestos derivados de [1,10]-fenantrolina; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento de enfermedades neurodegenerativas o hematologicas. | |
GT200800066A (es) | Derivados de 9-cloro-15-deoxiprostaglandina, procedimiento para su preparacion y su uso como medicamento. | |
BRPI0414527A (pt) | tratamento de tumores estromáticos gastrointestinais com imatinib e midostaurina | |
CL2007003281A1 (es) | Compuesto 1-(4-metilfenil)dihidro-1h-pirrolo[1,2-a]imidazol-2,5-(3h,6h)-diona; composicion farmaceutica; y uso para el tratamiento terapeutico o preventivo de la neurotoxicidad periferica inducida por quimioterapeuticos. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2167 DE 17/07/2012. |