BRPI0413574A - aplicação de polipeptìdeos da famìlia cupredoxina na terapia do cáncer - Google Patents
aplicação de polipeptìdeos da famìlia cupredoxina na terapia do cáncerInfo
- Publication number
- BRPI0413574A BRPI0413574A BRPI0413574-1A BRPI0413574A BRPI0413574A BR PI0413574 A BRPI0413574 A BR PI0413574A BR PI0413574 A BRPI0413574 A BR PI0413574A BR PI0413574 A BRPI0413574 A BR PI0413574A
- Authority
- BR
- Brazil
- Prior art keywords
- application
- cancer therapy
- cytotoxic factors
- family polypeptides
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/80—Cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/415—Cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Botany (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
"APLICAçãO DE POLIPEPTìDEOS DA FAMìLIA CUPREDOXINA NA TERAPIA DO CáNCER". São revelados fatores citotóxicos tendo aplicação na modulação da morte celular, e sua aplicação em métodos para tratar condições relacionadas com necroses ou apoptose. A invenção também refere-se a métodos para identificar agentes ativos úteis para tratar condições relacionadas com morte celular ou crescimento descontrolado. Os inventores presentes descobriram que diferentes microorganismos produzem diferentes fatores citotóxicos tendo atividade anticancerígena. Os fatores citotóxicos essencialmente puros podem ser usados em um método para tratar uma doença infecciosa ou um câncer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41455003P | 2003-08-15 | 2003-08-15 | |
US10/720,603 US7491394B2 (en) | 2001-02-15 | 2003-11-24 | Cytotoxic factors for modulating cell death |
PCT/US2004/025982 WO2005018662A1 (en) | 2003-08-15 | 2004-08-10 | Use of polypeptides of the cupredoxin family in cancer therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0413574A true BRPI0413574A (pt) | 2006-10-17 |
Family
ID=34221130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0413574-1A BRPI0413574A (pt) | 2003-08-15 | 2004-08-10 | aplicação de polipeptìdeos da famìlia cupredoxina na terapia do cáncer |
Country Status (19)
Country | Link |
---|---|
US (4) | US7491394B2 (pt) |
EP (2) | EP2263682A1 (pt) |
JP (1) | JP2007502818A (pt) |
KR (1) | KR20060098358A (pt) |
AP (1) | AP2006003537A0 (pt) |
AT (1) | ATE470672T1 (pt) |
AU (1) | AU2004266632A1 (pt) |
BR (1) | BRPI0413574A (pt) |
CA (1) | CA2535581A1 (pt) |
DE (1) | DE602004027637D1 (pt) |
EA (1) | EA009897B1 (pt) |
EC (1) | ECSP066422A (pt) |
GE (1) | GEP20105022B (pt) |
IL (1) | IL173576A0 (pt) |
NO (1) | NO20061168L (pt) |
NZ (1) | NZ545355A (pt) |
OA (1) | OA13308A (pt) |
TN (1) | TNSN06059A1 (pt) |
WO (1) | WO2005018662A1 (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9096663B2 (en) * | 2001-02-15 | 2015-08-04 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating conditions related to ephrin signaling with cupredoxins and mutants thereof |
US7381701B2 (en) | 2001-02-15 | 2008-06-03 | The Borad Of Trustees Of The University Of Illinois | Compositions and methods for treating conditions related to ephrin signaling with cupredoxins |
US7491394B2 (en) | 2001-02-15 | 2009-02-17 | The Board Of Trustees Of The University Of Illinois | Cytotoxic factors for modulating cell death |
US7618939B2 (en) * | 2001-02-15 | 2009-11-17 | The Board Of Trustees Of The University Of Illinois | Compositions and methods to prevent cancer with cupredoxins |
US7556810B2 (en) | 2005-07-19 | 2009-07-07 | The Board Of Trustees Of The University Of Ilinois | Compositions and methods to control angiogenesis with cupredoxins |
US7338766B2 (en) | 2001-02-15 | 2008-03-04 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating malaria with cupredoxin and cytochrome |
US7807183B2 (en) * | 2005-07-19 | 2010-10-05 | The Board Of Trustees Of The University Of Illinois | Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof |
US9434770B2 (en) * | 2004-10-07 | 2016-09-06 | Tapas K Das Gupta | Modified cupredoxin derived peptides |
JP2008515428A (ja) | 2004-10-07 | 2008-05-15 | チャクラバルティ、アナンダ | キュプレドキシンに由来する輸送因子及びそれを使用する方法 |
US10675326B2 (en) | 2004-10-07 | 2020-06-09 | The Board Of Trustees Of The University Of Illinois | Compositions comprising cupredoxins for treating cancer |
US9968685B2 (en) | 2004-10-07 | 2018-05-15 | Brad N. Taylor | Methods to treat cancer with cupredoxins |
JP2008545398A (ja) * | 2005-05-20 | 2008-12-18 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ | キュプレドキシンおよびシトクロムcを用いてhiv感染を治療するための組成物および方法 |
CA2607739A1 (en) * | 2005-05-20 | 2006-11-30 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating malaria with cupredoxin and cytochrome |
BRPI0612424A2 (pt) * | 2005-05-20 | 2009-01-27 | Univ Illinois | composiÇÕes e mÉtodos para tratar condiÇÕes relacionadas com a sinalizaÇço da efrina com cupredoxinas |
BRPI0615555A2 (pt) * | 2005-07-19 | 2009-07-14 | Univ Illinois | composições e métodos para o controle de angiogênese com cupredoxinas |
US10266868B2 (en) | 2006-05-19 | 2019-04-23 | The Board Of Trustees Of The University Of Illinois | Compositions for treating HIV infection with cupredoxin and cytochrome C |
RU2009113562A (ru) | 2006-09-11 | 2010-10-20 | Дзе Борд Оф Трастиз Оф Дзе Юниверсити Оф Иллинойс (Us) | Модификации пептидов, происходящих из купредоксина, и способы их применения |
RU2009113812A (ru) * | 2006-09-14 | 2010-10-20 | Дзе Борд Оф Трастиз Оф Дзе Юниверсити Оф Иллинойс (Us) | Композиции и способы для профилактики рака с помощью купредоксинов |
RU2009125599A (ru) | 2006-12-04 | 2011-01-20 | Дзе Борд Оф Трастиз Оф Дзе Юниверсити Оф Иллинойс (Us) | Композиции и способы лечения рака cpg-богатой днк и купредоксинами |
EP2117573A4 (en) * | 2007-01-11 | 2011-02-16 | Univ Illinois | COMPOSITIONS AND METHODS FOR TREATING EPHRIN SIGNALING WITH CUPREDOXINES AND MUTANTS THEREOF |
RU2009133473A (ru) * | 2007-02-08 | 2011-03-20 | Дзе Борд Оф Трастиз Оф Дзе Юниверсити Оф Иллинойс (Us) | Композиции и способы для предотвращения рака с помощью купредоксинов |
JP5658157B2 (ja) * | 2008-09-18 | 2015-01-21 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 置換ピロリジン−2−カルボキサミド |
DK2971039T3 (da) | 2013-03-14 | 2020-04-06 | Immusoft Corp | Fremgangsmåder til in vitro-differentiering af hukommelses-b-celler og transduktion med vsv-g-pseudotypeomdannede virusvektorer |
PL3234107T3 (pl) | 2014-12-19 | 2023-01-16 | Immusoft Corporation | Limfocyty b do dostarczania in vivo środków terapeutycznych |
US11136613B2 (en) | 2015-04-30 | 2021-10-05 | Board Of Regents, The University Of Texas System | Antibacterial polypeptide libraries and methods for screening the same |
CN111705026B (zh) * | 2020-06-02 | 2021-11-26 | 华中农业大学 | 一种牛支原体Mbov_0280基因突变株及其应用 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4585644A (en) | 1984-06-04 | 1986-04-29 | Phillips Petroleum Company | Changing oil tubes in a carbon black reactor |
US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
US6024983A (en) | 1986-10-24 | 2000-02-15 | Southern Research Institute | Composition for delivering bioactive agents for immune response and its preparation |
US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
US5827934A (en) | 1988-03-08 | 1998-10-27 | The University Of Wyoming | Cytotoxic diphtheria toxin fragments |
ATE240401T1 (de) | 1989-03-21 | 2003-05-15 | Vical Inc | Expression von exogenen polynukleotidsequenzen in wirbeltieren |
US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
US5407683A (en) * | 1990-06-01 | 1995-04-18 | Research Corporation Technologies, Inc. | Pharmaceutical solutions and emulsions containing taxol |
ES2242954T3 (es) | 1992-03-11 | 2005-11-16 | Powderject Vaccines, Inc. | Vacuna genetica para el virus de la inmunodeficiencia. |
WO1993024640A2 (en) | 1992-06-04 | 1993-12-09 | The Regents Of The University Of California | Methods and compositions for in vivo gene therapy |
CA2153391C (en) | 1993-01-11 | 2000-08-15 | Kenneth Rock | Inducing cytotoxic t lymphocyte responses |
US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
US5789389A (en) | 1995-03-17 | 1998-08-04 | Board Of Trustees Of University Of Illinois | BCL2 derived genetic elements associated with sensitivity to chemotherapeutic drugs |
US5972899A (en) | 1996-01-25 | 1999-10-26 | New York University | Apoptosis induced by Shigella IpaB |
US6551795B1 (en) * | 1998-02-18 | 2003-04-22 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics |
US7338766B2 (en) | 2001-02-15 | 2008-03-04 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating malaria with cupredoxin and cytochrome |
JP4881536B2 (ja) | 2001-02-15 | 2012-02-22 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ | 細胞死を調節する細胞障害性因子 |
US7301010B2 (en) | 2001-02-15 | 2007-11-27 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating HIV infection with cupredoxin and cytochrome c |
US7491394B2 (en) | 2001-02-15 | 2009-02-17 | The Board Of Trustees Of The University Of Illinois | Cytotoxic factors for modulating cell death |
UA88272C2 (ru) | 2003-08-15 | 2009-10-12 | Борд Оф Трастиз Оф Зе Юниверсити Оф Иллинойс | Применение полипептидов семейства купредоксина в лечении рака |
JP2008515428A (ja) | 2004-10-07 | 2008-05-15 | チャクラバルティ、アナンダ | キュプレドキシンに由来する輸送因子及びそれを使用する方法 |
US7807183B2 (en) | 2005-07-19 | 2010-10-05 | The Board Of Trustees Of The University Of Illinois | Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof |
CA2607739A1 (en) | 2005-05-20 | 2006-11-30 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating malaria with cupredoxin and cytochrome |
JP2008545398A (ja) | 2005-05-20 | 2008-12-18 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ | キュプレドキシンおよびシトクロムcを用いてhiv感染を治療するための組成物および方法 |
-
2003
- 2003-11-24 US US10/720,603 patent/US7491394B2/en not_active Expired - Lifetime
-
2004
- 2004-08-10 NZ NZ545355A patent/NZ545355A/en unknown
- 2004-08-10 JP JP2006523922A patent/JP2007502818A/ja active Pending
- 2004-08-10 GE GEAP20049294A patent/GEP20105022B/en unknown
- 2004-08-10 KR KR1020067002935A patent/KR20060098358A/ko active IP Right Grant
- 2004-08-10 AP AP2006003537A patent/AP2006003537A0/xx unknown
- 2004-08-10 OA OA1200600056A patent/OA13308A/en unknown
- 2004-08-10 EP EP10156218A patent/EP2263682A1/en not_active Withdrawn
- 2004-08-10 BR BRPI0413574-1A patent/BRPI0413574A/pt not_active IP Right Cessation
- 2004-08-10 AT AT04780764T patent/ATE470672T1/de not_active IP Right Cessation
- 2004-08-10 EA EA200600424A patent/EA009897B1/ru not_active IP Right Cessation
- 2004-08-10 DE DE602004027637T patent/DE602004027637D1/de active Active
- 2004-08-10 AU AU2004266632A patent/AU2004266632A1/en not_active Abandoned
- 2004-08-10 WO PCT/US2004/025982 patent/WO2005018662A1/en active Application Filing
- 2004-08-10 EP EP04780764A patent/EP1653990B1/en active Active
- 2004-08-10 CA CA002535581A patent/CA2535581A1/en not_active Abandoned
-
2006
- 2006-02-07 IL IL173576A patent/IL173576A0/en unknown
- 2006-02-15 TN TNP2006000059A patent/TNSN06059A1/en unknown
- 2006-03-13 NO NO20061168A patent/NO20061168L/no not_active Application Discontinuation
- 2006-03-15 EC EC2006006422A patent/ECSP066422A/es unknown
- 2006-08-23 US US11/508,173 patent/US7888468B2/en not_active Expired - Fee Related
- 2006-08-25 US US11/509,682 patent/US20080182782A1/en not_active Abandoned
-
2013
- 2013-11-08 US US14/075,994 patent/US10421801B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE470672T1 (de) | 2010-06-15 |
EA009897B1 (ru) | 2008-04-28 |
US20080182782A1 (en) | 2008-07-31 |
TNSN06059A1 (en) | 2007-10-03 |
OA13308A (en) | 2007-04-13 |
US10421801B2 (en) | 2019-09-24 |
US7491394B2 (en) | 2009-02-17 |
US7888468B2 (en) | 2011-02-15 |
US20060040269A1 (en) | 2006-02-23 |
IL173576A0 (en) | 2006-07-05 |
US20060292136A1 (en) | 2006-12-28 |
GEP20105022B (en) | 2010-06-25 |
KR20060098358A (ko) | 2006-09-18 |
EP1653990B1 (en) | 2010-06-09 |
US20140179617A1 (en) | 2014-06-26 |
EA200600424A1 (ru) | 2006-08-25 |
AU2004266632A1 (en) | 2005-03-03 |
CA2535581A1 (en) | 2005-03-03 |
ECSP066422A (es) | 2006-11-24 |
DE602004027637D1 (de) | 2010-07-22 |
JP2007502818A (ja) | 2007-02-15 |
NO20061168L (no) | 2006-05-15 |
AP2006003537A0 (en) | 2006-04-30 |
EP1653990A1 (en) | 2006-05-10 |
EP2263682A1 (en) | 2010-12-22 |
NZ545355A (en) | 2009-10-30 |
WO2005018662A1 (en) | 2005-03-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2266 DE 10/06/2014. |