BRPI0412236A - compostos, processo para a sua manufatura, composições farmacêuticas que compreendem os mesmos, método para o tratamento e/ou prevenção de enfermidades que são moduladas por agonistas ppar(delta) e/ou ppar(alfa), e utilização desses compostos - Google Patents
compostos, processo para a sua manufatura, composições farmacêuticas que compreendem os mesmos, método para o tratamento e/ou prevenção de enfermidades que são moduladas por agonistas ppar(delta) e/ou ppar(alfa), e utilização desses compostosInfo
- Publication number
- BRPI0412236A BRPI0412236A BRPI0412236-4A BRPI0412236A BRPI0412236A BR PI0412236 A BRPI0412236 A BR PI0412236A BR PI0412236 A BRPI0412236 A BR PI0412236A BR PI0412236 A BRPI0412236 A BR PI0412236A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- ppar
- modulated
- diseases
- prevention
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
"COMPOSTOS, PROCESSO PARA A SUA MANUFATURA, COMPOSIçõES FARMACêUTICAS QUE COMPREENDEM OS MESMOS, MéTODO PARA O TRATAMENTO E/OU PREVENçãO DE ENFERMIDADES QUE SãO MODULADAS POR AGONISTAS PPAR<sym> E/OU PPAR<244>, E UTILIZAçãO DESSES COMPOSTOS". Refere-se a presente invenção a compostos da fórmula em que um de R¬ 6¬ R¬ 7¬ ou R¬ 8¬ é e X, Y, R¬ 1¬ a R¬ 13¬ e n são tais como definidos na descrição, e todos os seus enantiómeros e sais e/ou ésteres farmaceuticamente aceitáveis. A invenção refere-se ainda a composições farmacêuticas que contêm esses compostos, a um processo para a sua preparação e ao seu uso para o tratamento e/ou prevenção de enfermidades que são moduladas por agonistas PPAR<sym> e/ou PPAR<244>.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03014476 | 2003-07-02 | ||
EP04100157 | 2004-01-20 | ||
PCT/EP2004/006924 WO2005005423A1 (en) | 2003-07-02 | 2004-06-25 | Indolyl derivatives substituted with a thiazole ring and their use as ppar modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0412236A true BRPI0412236A (pt) | 2006-09-12 |
Family
ID=33553804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0412236-4A BRPI0412236A (pt) | 2003-07-02 | 2004-06-25 | compostos, processo para a sua manufatura, composições farmacêuticas que compreendem os mesmos, método para o tratamento e/ou prevenção de enfermidades que são moduladas por agonistas ppar(delta) e/ou ppar(alfa), e utilização desses compostos |
Country Status (14)
Country | Link |
---|---|
US (1) | US7235572B2 (pt) |
EP (1) | EP1644368B1 (pt) |
JP (1) | JP4627298B2 (pt) |
KR (1) | KR100796093B1 (pt) |
CN (1) | CN1816550B (pt) |
AT (1) | ATE406369T1 (pt) |
AU (1) | AU2004255580B2 (pt) |
BR (1) | BRPI0412236A (pt) |
CA (1) | CA2530452C (pt) |
DE (1) | DE602004016162D1 (pt) |
ES (1) | ES2313022T3 (pt) |
MX (1) | MXPA06000235A (pt) |
RU (1) | RU2344135C2 (pt) |
WO (1) | WO2005005423A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050203151A1 (en) * | 2003-12-19 | 2005-09-15 | Kalypsys, Inc. | Novel compounds, compositions and uses thereof for treatment of metabolic disorders and related conditions |
KR100989093B1 (ko) | 2008-01-18 | 2010-10-25 | 한화제약주식회사 | 생강나무 가지의 추출물을 포함하는 심혈관계 질환의 예방 및 치료용 조성물 |
US9227969B2 (en) | 2013-08-14 | 2016-01-05 | Novartis Ag | Compounds and compositions as inhibitors of MEK |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1280753C (en) | 1985-07-02 | 1991-02-26 | Philip Michael Carabateas | Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans |
GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
US6531609B2 (en) | 2000-04-14 | 2003-03-11 | Hoffmann-La Roche Inc. | Process for the preparation of thiazolidinedione derivatives |
GB0024362D0 (en) | 2000-10-05 | 2000-11-22 | Glaxo Group Ltd | Medicaments |
CN1505613A (zh) * | 2000-10-10 | 2004-06-16 | ʷ��˿�������ȳ�ķ����˾ | 取代的吲哚、含这类吲哚的药物组合物及它们作为PPAR-γ结合剂的用途 |
GB0031107D0 (en) | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
EP1405848B1 (en) * | 2001-06-18 | 2008-05-07 | Ono Pharmaceutical Co., Ltd. | Tetrahydroquinoline derivative compound and drug containing the compound as active ingredient |
CA2458621A1 (en) * | 2001-08-29 | 2003-03-06 | Warner-Lambert Company Llc | Oral antidiabetic agents |
US6867224B2 (en) * | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
AU2003300131A1 (en) * | 2003-01-06 | 2004-11-04 | Eli Lilly And Company | Indole derivatives as ppar modulators |
RU2367659C2 (ru) * | 2003-11-05 | 2009-09-20 | Ф.Хоффманн-Ля Рош Аг | Гетероарильные производные в качестве активаторов рецепторов, активируемых пролифераторами пероксисом (ppar) |
-
2004
- 2004-06-25 KR KR1020057025397A patent/KR100796093B1/ko not_active IP Right Cessation
- 2004-06-25 RU RU2006102866/04A patent/RU2344135C2/ru not_active IP Right Cessation
- 2004-06-25 AT AT04740332T patent/ATE406369T1/de active
- 2004-06-25 CN CN2004800188566A patent/CN1816550B/zh not_active Expired - Fee Related
- 2004-06-25 ES ES04740332T patent/ES2313022T3/es active Active
- 2004-06-25 JP JP2006518042A patent/JP4627298B2/ja not_active Expired - Fee Related
- 2004-06-25 BR BRPI0412236-4A patent/BRPI0412236A/pt not_active IP Right Cessation
- 2004-06-25 AU AU2004255580A patent/AU2004255580B2/en not_active Ceased
- 2004-06-25 CA CA2530452A patent/CA2530452C/en not_active Expired - Fee Related
- 2004-06-25 DE DE602004016162T patent/DE602004016162D1/de active Active
- 2004-06-25 WO PCT/EP2004/006924 patent/WO2005005423A1/en active IP Right Grant
- 2004-06-25 EP EP04740332A patent/EP1644368B1/en not_active Not-in-force
- 2004-06-25 MX MXPA06000235A patent/MXPA06000235A/es active IP Right Grant
- 2004-06-28 US US10/878,473 patent/US7235572B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1816550A (zh) | 2006-08-09 |
US20050004187A1 (en) | 2005-01-06 |
KR20060027830A (ko) | 2006-03-28 |
JP4627298B2 (ja) | 2011-02-09 |
ES2313022T3 (es) | 2009-03-01 |
RU2006102866A (ru) | 2007-08-20 |
EP1644368A1 (en) | 2006-04-12 |
DE602004016162D1 (de) | 2008-10-09 |
KR100796093B1 (ko) | 2008-01-21 |
CN1816550B (zh) | 2010-04-28 |
EP1644368B1 (en) | 2008-08-27 |
ATE406369T1 (de) | 2008-09-15 |
CA2530452A1 (en) | 2005-01-20 |
RU2344135C2 (ru) | 2009-01-20 |
AU2004255580B2 (en) | 2009-10-08 |
MXPA06000235A (es) | 2006-04-11 |
US7235572B2 (en) | 2007-06-26 |
JP2009501693A (ja) | 2009-01-22 |
AU2004255580A1 (en) | 2005-01-20 |
WO2005005423A1 (en) | 2005-01-20 |
CA2530452C (en) | 2011-07-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014. |