BRPI0409592A - compostos imidazopiridina tendo atividade agonìstica do receptor 5-ht4 e atividade antagonìstica do receptor 5-ht3 - Google Patents
compostos imidazopiridina tendo atividade agonìstica do receptor 5-ht4 e atividade antagonìstica do receptor 5-ht3Info
- Publication number
- BRPI0409592A BRPI0409592A BRPI0409592-8A BRPI0409592A BRPI0409592A BR PI0409592 A BRPI0409592 A BR PI0409592A BR PI0409592 A BRPI0409592 A BR PI0409592A BR PI0409592 A BRPI0409592 A BR PI0409592A
- Authority
- BR
- Brazil
- Prior art keywords
- receptor
- activity
- compounds
- antagonistic activity
- agonistic activity
- Prior art date
Links
- 230000001270 agonistic effect Effects 0.000 title abstract 3
- 230000003042 antagnostic effect Effects 0.000 title abstract 3
- 108091005477 5-HT3 receptors Proteins 0.000 title 1
- 102000035037 5-HT3 receptors Human genes 0.000 title 1
- 108091005482 5-HT4 receptors Proteins 0.000 title 1
- 125000004857 imidazopyridinyl group Chemical class N1C(=NC2=C1C=CC=N2)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000006549 dyspepsia Diseases 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000005232 imidazopyridines Chemical class 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
"COMPOSTOS IMIDAZOPIRIDINA TENDO ATIVIDADE AGONìSTICA DO RECEPTOR 5-HT~ 4~ E ATIVIDADE ANTAGONìSTICA DO RECEPTOR 5-HT~ 3~". A presente invenção refere-se a um composto com a fórmula (I): em que R¬ 1¬ representa um átomo de hidrogênio ou um átomo de halogênio; R¬ 2¬ representa um grupo metila ou um grupo etila; ou seus sais farmaceuticamente aceitáveis. Estes compostos têm atividade agonística do receptor 5-HT~ 4~ e atividade antagonística do receptor 5-HT~ 3~, e por conseguinte são úteis para o tratamento de doença de refluxo gastroesofágico, dispepsia sem úlcera, dispepsia funcional, síndrome do intestino irritável, diabetes ou semelhantes em mamíferos, especialmente humanos. A presente invenção também se relaciona com uma composição farmacêutica, um método de tratamento e utilização, compreendendo os compostos acima.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46426303P | 2003-04-21 | 2003-04-21 | |
| PCT/IB2004/001269 WO2004094418A1 (en) | 2003-04-21 | 2004-04-13 | Imidazopyridine compounds having 5-ht4 receptor agonistic activity and 5-ht3 receptor antagonistic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0409592A true BRPI0409592A (pt) | 2006-05-02 |
Family
ID=33310862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0409592-8A BRPI0409592A (pt) | 2003-04-21 | 2004-04-13 | compostos imidazopiridina tendo atividade agonìstica do receptor 5-ht4 e atividade antagonìstica do receptor 5-ht3 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040266814A1 (pt) |
| EP (1) | EP1620435A1 (pt) |
| BR (1) | BRPI0409592A (pt) |
| CA (1) | CA2523077A1 (pt) |
| MX (1) | MXPA05011270A (pt) |
| WO (1) | WO2004094418A1 (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| US20090170899A1 (en) * | 2004-09-14 | 2009-07-02 | Guy Debonnel | Stimulators of 5-HT4 receptors and uses thereof |
| US7396933B2 (en) * | 2004-11-05 | 2008-07-08 | Theravance, Inc. | Quinolinone-carboxamide compounds |
| EP1807422B1 (en) * | 2004-11-05 | 2009-09-02 | Theravance, Inc. | 5-ht4 receptor agonist compounds |
| ATE469897T1 (de) * | 2004-12-22 | 2010-06-15 | Theravance Inc | Indazolcarbonsäureamidverbindungen |
| BRPI0608392A2 (pt) * | 2005-03-02 | 2009-12-29 | Theravance Inc | compostos de quinolinona como agonistas do receptor 5-ht4 |
| US8642772B2 (en) | 2008-10-14 | 2014-02-04 | Sk Biopharmaceuticals Co., Ltd. | Piperidine compounds, pharmaceutical composition comprising the same and its use |
| US8232315B2 (en) | 2009-06-26 | 2012-07-31 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating drug addiction and improving addiction-related behavior |
| JP5836280B2 (ja) | 2009-11-06 | 2015-12-24 | エスケー バイオファーマスティカルズ カンパニー リミテッド | 注意欠陥／多動性障害（ａｄｈｄ）の治療方法 |
| JP5901528B2 (ja) | 2009-11-06 | 2016-04-13 | エスケー バイオファーマスティカルズ カンパニー リミテッド | 線維筋痛症候群の治療方法 |
| US9610274B2 (en) | 2010-06-30 | 2017-04-04 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating bipolar disorder |
| US8623913B2 (en) | 2010-06-30 | 2014-01-07 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating restless legs syndrome |
| CA2932428C (en) | 2013-12-16 | 2017-10-24 | Suven Life Sciences Limited | Indazole compounds as 5-ht4 receptor agonists |
| AU2015342883B2 (en) | 2014-11-06 | 2020-07-02 | Bial - R&D Investments, S.A. | Substituted pyrrolo(1,2-a)pyrimidines and their use in the treatment of medical disorders |
| US20170333435A1 (en) | 2014-11-06 | 2017-11-23 | Lysosomal Therapeutics Inc. | Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
| AU2015342887B2 (en) | 2014-11-06 | 2020-09-10 | Bial - R&D Investments, S.A. | Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders |
| WO2017176961A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| JP7034935B2 (ja) | 2016-04-06 | 2022-03-14 | リソソーマル・セラピューティクス・インコーポレイテッド | ピロロ［１，２－ａ］ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用 |
| MX2018012211A (es) | 2016-04-06 | 2019-03-28 | Lysosomal Therapeutics Inc | Compuestos de pirazol[1,5-a]pirimidinil carboxamida y su uso en el tratamiento de trastornos médicos. |
| CN109311902B (zh) | 2016-05-05 | 2022-07-15 | Bial研发投资股份有限公司 | 取代的咪唑并[1,2-b]哒嗪、咪唑并[1,5-b]哒嗪、相关化合物及其用途 |
| EP3452455A4 (en) | 2016-05-05 | 2019-11-13 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMDAZO [1,2-] PYRIDINES, SUBSTITUTED IMIDAZO [1,2-] PYRAZINES, RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF ILLNESSES |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9221468D0 (en) * | 1992-10-13 | 1992-11-25 | Smithkline Beecham Plc | Pharmaceuticals |
| US6069152A (en) * | 1997-10-07 | 2000-05-30 | Eli Lilly And Company | 5-HT4 agonists and antagonists |
| IT1303123B1 (it) * | 1998-10-13 | 2000-10-30 | Rotta Research Lab | Derivati basici di benz(e)isoindol-1-oni e pirrolo(3,4-c)chinolin-1-oni ad attivita' 5ht3 antagonista, loro preparazione ed |
| ATE307812T1 (de) * | 2001-10-22 | 2005-11-15 | Pfizer | Imidazopyridinverbindungen als 5-ht4- rezeptormodulatoren |
| US6624162B2 (en) * | 2001-10-22 | 2003-09-23 | Pfizer Inc. | Imidazopyridine compounds as 5-HT4 receptor modulators |
| DOP2003000703A (es) * | 2002-09-20 | 2004-03-31 | Pfizer | Compuestos de imidazopiradina como agonistas del receptor 5-ht4 |
| CA2499494A1 (en) * | 2002-09-20 | 2004-04-01 | Pfizer Inc. | N-substituted piperidinyl-imidazopyridine compounds as 5-ht4 receptor modulators |
-
2004
- 2004-04-13 WO PCT/IB2004/001269 patent/WO2004094418A1/en not_active Application Discontinuation
- 2004-04-13 BR BRPI0409592-8A patent/BRPI0409592A/pt not_active Application Discontinuation
- 2004-04-13 EP EP04727067A patent/EP1620435A1/en not_active Withdrawn
- 2004-04-13 MX MXPA05011270A patent/MXPA05011270A/es unknown
- 2004-04-13 CA CA002523077A patent/CA2523077A1/en not_active Abandoned
- 2004-04-20 US US10/827,701 patent/US20040266814A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1620435A1 (en) | 2006-02-01 |
| WO2004094418A8 (en) | 2005-09-29 |
| US20040266814A1 (en) | 2004-12-30 |
| WO2004094418A1 (en) | 2004-11-04 |
| CA2523077A1 (en) | 2004-11-04 |
| MXPA05011270A (es) | 2006-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |