BRPI0408996A - saia de inibidores tricìclicos de poli(adpp-ribose) polimerases - Google Patents

saia de inibidores tricìclicos de poli(adpp-ribose) polimerases

Info

Publication number
BRPI0408996A
BRPI0408996A BRPI0408996-0A BRPI0408996A BRPI0408996A BR PI0408996 A BRPI0408996 A BR PI0408996A BR PI0408996 A BRPI0408996 A BR PI0408996A BR PI0408996 A BRPI0408996 A BR PI0408996A
Authority
BR
Brazil
Prior art keywords
poly
tricyclic
adpp
ribose
skirt
Prior art date
Application number
BRPI0408996-0A
Other languages
English (en)
Inventor
Stacie Sara Canan-Koch
Jan-Jon Chu
Jia Liu
Jean Joo Matthews
Original Assignee
Pfizer
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, Cancer Rec Tech Ltd filed Critical Pfizer
Publication of BRPI0408996A publication Critical patent/BRPI0408996A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

"SAIS DE INIBIDORES TRICìCLICOS DE POLI(ADPRIBOSE) POLIMERASES". A presente invenção refere-se aos sais farmaceuticamente aceitáveis de compostos de fórmula (I) que são inibidores da poli(ADP-ribosil)transferase (PARP), e que são úteis como terapêutica no tratamento de cânceres e melhoria dos efeitos de acidente vascular cerebral, traumatismo craniano e doença neurodegenerativa. Como terapêutica do câncer, os compostos da invenção podem ser utilizados, por exemplo, em combinação com agentes citotóxicos e/ou radiação.
BRPI0408996-0A 2003-03-31 2004-03-19 saia de inibidores tricìclicos de poli(adpp-ribose) polimerases BRPI0408996A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45943303P 2003-03-31 2003-03-31
PCT/IB2004/000915 WO2004087713A1 (en) 2003-03-31 2004-03-19 Salts of tricyclic inhibitors of poly(adp-ribose) polymerases

Publications (1)

Publication Number Publication Date
BRPI0408996A true BRPI0408996A (pt) 2006-03-28

Family

ID=33131884

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408996-0A BRPI0408996A (pt) 2003-03-31 2004-03-19 saia de inibidores tricìclicos de poli(adpp-ribose) polimerases

Country Status (12)

Country Link
US (1) US20040248879A1 (pt)
EP (1) EP1611137A1 (pt)
JP (1) JP2006522088A (pt)
AR (1) AR043950A1 (pt)
BR (1) BRPI0408996A (pt)
CA (1) CA2520997A1 (pt)
MX (1) MXPA05010563A (pt)
NL (1) NL1025842C2 (pt)
PA (1) PA8598801A1 (pt)
TW (1) TW200424206A (pt)
UY (1) UY28245A1 (pt)
WO (1) WO2004087713A1 (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7531530B2 (en) 2003-07-25 2009-05-12 Cancer Research Technology Limited Therapeutic compounds
CA2580833C (en) 2004-09-22 2010-12-21 Pfizer, Inc. Method of preparing poly(adp-ribose) polymerases inhibitors
CN101133061B (zh) * 2004-09-22 2011-09-07 辉瑞有限公司 8-氟-2-{4-[（甲基氨基）甲基]苯基}-1,3,4,5-四氢-6H-氮杂卓并[5,4,3-cd]吲哚-6-酮的磷酸盐的多晶型物和非晶物
KR20070046183A (ko) * 2004-09-22 2007-05-02 화이자 인코포레이티드 폴리(에이디피-리보오스) 폴리머라제 저해제를 포함하는치료 배합물
ATE551345T1 (de) 2004-09-22 2012-04-15 Pfizer Polymorphe formen des phosphatsalzes von 8-fluor- 2-ä4-ä(methylamino)methylüphenylü-1,3,4,5- tetrahydro-6h-azepinoä5,4,3-cdüindol-6-on
BRPI0613783A2 (pt) 2005-07-18 2011-02-01 Bipar Sciences Inc tratamento de cáncer
SI2338487T1 (sl) * 2006-01-17 2014-01-31 Abbott Laboratories Kombinacijska terapija z inhibitorji PARP
AU2007292387A1 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Treatment of cancer
AU2007292306A1 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof
AU2008321128A1 (en) 2007-11-12 2009-05-22 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
GB0804755D0 (en) 2008-03-14 2008-04-16 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2011058367A2 (en) 2009-11-13 2011-05-19 Astrazeneca Ab Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor
EP3150610B1 (en) * 2010-02-12 2019-07-31 Pfizer Inc Salts and polymorphs of 8-fluoro-2-{4-[(methylamino}methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one
WO2014045101A1 (en) 2012-09-21 2014-03-27 Cellzome Gmbh Tetrazolo quinoxaline derivatives as tankyrase inhibitors
HUE052930T2 (hu) * 2013-04-09 2021-05-28 Univ Illinois DNQ vagy DNQ-87 alkalmazása PARP1-inhibitorral kombinációban rák kezelésére
WO2016028689A1 (en) 2014-08-22 2016-02-25 Clovis Oncology, Inc. High dosage strength tablets of rucaparib
CN104592232A (zh) * 2015-03-02 2015-05-06 中国药科大学 8,9-二氢-2,4,7,9a-四氮杂苯并薁-6(7H)-酮类衍生物
DK3594343T3 (da) 2015-07-23 2021-06-28 Inst Curie Anvendelse af en kombination af dbait-molekyle og parp-inhibitorer til behandling af kræft
GB201519573D0 (en) 2015-11-05 2015-12-23 King S College London Combination
WO2018022851A1 (en) 2016-07-28 2018-02-01 Mitobridge, Inc. Methods of treating acute kidney injury
EP3534957A1 (en) 2016-11-02 2019-09-11 Immunogen, Inc. Combination treatment with antibody-drug conjugates and parp inhibitors
WO2018122168A1 (en) 2016-12-29 2018-07-05 Bayer Pharma Aktiengesellschaft Combinations of bub1 kinase and parp inhibitors
WO2018140377A1 (en) * 2017-01-24 2018-08-02 Assia Chemical Industries Ltd. Solid state forms of rucaparib and of rucaparib salts
WO2018162439A1 (en) 2017-03-08 2018-09-13 Onxeo New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
US20200129476A1 (en) 2017-04-28 2020-04-30 Akribes Biomedical Gmbh PARP Inhibitor in Combination with a Glucocorticoid and/or Ascorbic Acid and/or a Protein Growth Factor for the Treatment of Impaired Wound Healing
EP3704124A1 (en) * 2017-11-03 2020-09-09 Sandoz AG Crystalline salt of a tricyclic poly(adp-ribose) polymerase inhibitor
PE20211305A1 (es) 2018-01-05 2021-07-20 Cybrexa 1 Inc Compuestos, composiciones y metodos para tratar enfermedades que involucren tejidos con enfermedades acidas o hipoxicas
WO2019175132A1 (en) 2018-03-13 2019-09-19 Onxeo A dbait molecule against acquired resistance in the treatment of cancer
KR20220051332A (ko) 2019-07-10 2022-04-26 싸이브렉사 3, 인크. 치료제로서의 미세소관 표적화제의 펩티드 접합체
CN114341162A (zh) 2019-07-10 2022-04-12 赛博克萨2公司 作为治疗剂的细胞毒素的肽缀合物
WO2021018298A1 (zh) * 2019-08-01 2021-02-04 南京明德新药研发有限公司 作为parp抑制剂吲哚并七元酰肟化合物
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
EP4100125A1 (en) 2020-02-03 2022-12-14 Sandoz AG Polymorph of rucaparib mesylate
CN115485271A (zh) 2020-04-28 2022-12-16 理森制药股份公司 用作聚(adp-核糖)聚合酶（parp）抑制剂的新型化合物
WO2022015557A1 (en) 2020-07-14 2022-01-20 Assia Chemical Industries Ltd Solid state forms of rucaparib salts
WO2022090938A1 (en) 2020-10-31 2022-05-05 Rhizen Pharmaceuticals Ag Phthalazinone derivatives useful as parp inhibitors
CN117321044A (zh) 2021-04-08 2023-12-29 理森制药股份公司 聚(adp-核糖)聚合酶抑制剂
WO2023137060A1 (en) 2022-01-11 2023-07-20 Assia Chemical Industries Ltd. Solid state forms of rucaparib tosylate

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883590A (en) * 1971-06-01 1975-05-13 Universal Oil Prod Co Preparation of n-alkylarylcarboxamides
DE2322434A1 (de) * 1973-05-04 1974-11-21 Bayer Ag 2-trifluormethylimino-1,3-dithioloeckige klammer auf 4,5-b eckige klammer zu -chinoxaline, verfahren zu ihrer herstellung, sowie ihre verwendung als insektizide, akarizide und fungizide
US4033960A (en) * 1973-07-31 1977-07-05 Bayer Aktiengesellschaft 2-Mercaptoquinoxaline-di-N-oxide products and a method for their preparation
US3950343A (en) * 1973-11-06 1976-04-13 Ayerst, Mckenna And Harrison Ltd. Pyrroloisoquinoline derivatives
US3978066A (en) * 1973-11-06 1976-08-31 Ayerst, Mckenna And Harrison Ltd. Certain 4,6-dihydropyrrolotriazoline-quinoline derivatives
US3900477A (en) * 1973-11-06 1975-08-19 Ayerst Mckenna & Harrison 5-amino-and 5-hydrazinodihydropyrroloisoquinoline derivatives
US5215738A (en) * 1985-05-03 1993-06-01 Sri International Benzamide and nicotinamide radiosensitizers
US4910193A (en) * 1985-12-16 1990-03-20 Sandoz Ltd. Treatment of gastrointestinal disorders
GB9117987D0 (en) * 1991-08-20 1991-10-09 Ici Plc Heterocyclic compounds
US5342946A (en) * 1992-12-02 1994-08-30 Guilford Pharmaceuticals Inc. Phosphonoalkylquinolin-2-ones as novel antagonists of non-NMDA ionotropic excitatory amino acid receptors
US5572143A (en) * 1993-10-19 1996-11-05 Mac Tools, Inc. Circuit testing device
US5587384A (en) * 1994-02-04 1996-12-24 The Johns Hopkins University Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
JPH08111047A (ja) * 1994-10-12 1996-04-30 Hitachi Ltd 磁気記録再生装置
US5589483A (en) * 1994-12-21 1996-12-31 Geron Corporation Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence
US5756548A (en) * 1995-04-03 1998-05-26 Centaur Pharmaceuticals, Inc. Acetamidobenzamide compounds for neurodegenerative disorders
US5659082A (en) * 1995-04-03 1997-08-19 Centaur Pharmaceuticals, Inc. Nitro- and aminobenzamide compounds for neurodegenerative disorders
SK287338B6 (sk) * 1999-01-11 2010-07-07 Agouron Pharmaceuticals, Inc. Tricyklická zlúčenina, jej použitie a farmaceutická kompozícia s jej obsahom
MXPA02011218A (es) * 2000-05-15 2004-08-19 Celgene Corp Composiciones y metodos para el tratamiento de cancer.
US7531530B2 (en) * 2003-07-25 2009-05-12 Cancer Research Technology Limited Therapeutic compounds
ATE551345T1 (de) * 2004-09-22 2012-04-15 Pfizer Polymorphe formen des phosphatsalzes von 8-fluor- 2-ä4-ä(methylamino)methylüphenylü-1,3,4,5- tetrahydro-6h-azepinoä5,4,3-cdüindol-6-on

Also Published As

Publication number Publication date
WO2004087713A1 (en) 2004-10-14
JP2006522088A (ja) 2006-09-28
CA2520997A1 (en) 2004-10-14
US20040248879A1 (en) 2004-12-09
NL1025842A1 (nl) 2004-10-01
PA8598801A1 (es) 2004-11-26
AR043950A1 (es) 2005-08-17
UY28245A1 (es) 2004-11-08
NL1025842C2 (nl) 2005-11-15
EP1611137A1 (en) 2006-01-04
TW200424206A (en) 2004-11-16
WO2004087713A8 (en) 2005-01-20
MXPA05010563A (es) 2005-11-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.