BRPI0407215A - Derivados de azepinas tricìclicas, processo de preparação dos mesmos e as composições farmacêuticas que contêm os mesmos - Google Patents

Derivados de azepinas tricìclicas, processo de preparação dos mesmos e as composições farmacêuticas que contêm os mesmos

Info

Publication number
BRPI0407215A
BRPI0407215A BR0407215-4A BRPI0407215A BRPI0407215A BR PI0407215 A BRPI0407215 A BR PI0407215A BR PI0407215 A BRPI0407215 A BR PI0407215A BR PI0407215 A BRPI0407215 A BR PI0407215A
Authority
BR
Brazil
Prior art keywords
group
pharmaceutical compositions
compositions containing
preparing
tricyclic
Prior art date
Application number
BR0407215-4A
Other languages
English (en)
Inventor
Sebastien Gallet
Pascal Berthelot
Nicolas Lebegue
Nathalie Flouquet
Pascal Carato
John Hickman
Alain Pierre
Bruno Pfeiffer
Pierre Renard
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI0407215A publication Critical patent/BRPI0407215A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"DERIVADOS DE AZEPINAS TRICìCLICAS, PROCESSO DE PREPARAçãO DOS MESMOS E AS COMPOSIçõES FARMACêUTICAS QUE CONTêM OS MESMOS". A presente invenção refere-se a compostos de fórmula (I) na qual (a) representa um grupamento benzo ou pirido, eventualmente fundido ou na posição (2-3, 3-4 ou 4-5) e eventualmente substituído, (W) representa um grupamento (X-Y ou Y-X) com (X) representando um grupamento (b) e Y representando um átomo de oxigênio ou um grupamento (N-R~ 3~), n representa zero ou um número inteiro tal que 1 <243> n <243> 6 (G, R~ 1~, R~ 2~ e R~ 3~) são tais como definidos no relatório descritivo, enanciómeros, diaestereoisómeros dos mesmos, assim como sais de adição dos mesmos a um ácido ou a uma base farmaceuticamente aceitável. Medicamentos.
BR0407215-4A 2003-02-03 2004-02-03 Derivados de azepinas tricìclicas, processo de preparação dos mesmos e as composições farmacêuticas que contêm os mesmos BRPI0407215A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0301181A FR2850654A1 (fr) 2003-02-03 2003-02-03 Nouveaux derives d'azepines tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2004/000234 WO2004069843A1 (fr) 2003-02-03 2004-02-03 Derives d'azepines tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
BRPI0407215A true BRPI0407215A (pt) 2006-01-24

Family

ID=32696289

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0407215-4A BRPI0407215A (pt) 2003-02-03 2004-02-03 Derivados de azepinas tricìclicas, processo de preparação dos mesmos e as composições farmacêuticas que contêm os mesmos

Country Status (18)

Country Link
US (1) US20060079677A1 (pt)
EP (1) EP1590355A1 (pt)
JP (1) JP2006515350A (pt)
KR (1) KR20050096970A (pt)
CN (1) CN1745087A (pt)
AR (1) AR043691A1 (pt)
AU (1) AU2004208890A1 (pt)
BR (1) BRPI0407215A (pt)
CA (1) CA2513059A1 (pt)
EA (1) EA200501232A1 (pt)
FR (1) FR2850654A1 (pt)
MA (1) MA27576A1 (pt)
MX (1) MXPA05007977A (pt)
MY (1) MY138865A (pt)
NO (1) NO20054092L (pt)
PL (1) PL376621A1 (pt)
WO (1) WO2004069843A1 (pt)
ZA (1) ZA200505430B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008059513A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Compounds suitable as modulators of hdl
ES2604668T3 (es) 2009-02-05 2017-03-08 Immunogen, Inc. Nuevos derivados de benzodiacepina
SG10202007640VA (en) 2011-02-15 2020-09-29 Immunogen Inc Cytotoxic benzodiazepine derivatives
WO2014031566A1 (en) 2012-08-22 2014-02-27 Immunogen, Inc. Cytotoxic benzodiazepine derivatives
WO2016036804A1 (en) 2014-09-03 2016-03-10 Immunogen, Inc. Cytotoxic benzodiazepine derivatives
CR20170111A (es) 2014-09-03 2017-05-23 Immunogen Inc Derivados de benzodiazepina citotóxicos
US20180346488A1 (en) 2017-04-20 2018-12-06 Immunogen, Inc. Cytotoxic benzodiazepine derivatives and conjugates thereof
JP2021508714A (ja) 2017-12-28 2021-03-11 イミュノジェン・インコーポレーテッド ベンゾジアゼピン誘導体
TW202102506A (zh) 2019-03-29 2021-01-16 美商伊繆諾金公司 苯二氮平衍生物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1204680B (de) * 1963-05-31 1965-11-11 Thomae Gmbh Dr K Verfahren zur Herstellung von in 5-Stellung substituierten 6-Oxo-5, 6-dihydro-11H-pyrido [2, 3-b][1, 4]benzodiazepinen
DE1238479B (de) * 1964-01-28 1967-04-13 Thomae Gmbh Dr K Verfahren zur Herstellung von 5, 6-Dihydro-5-oxo-11H-pyrido-[2, 3-b] [1, 5]-benzodiazepinen
DE1251767B (de) * 1964-02-28 1968-04-18 Dr Karl Thomae Gesellschaft mit beschrankter Haftung Biberach/Riß Verfahren zur Herstellung von neuen m 6 Stellung substituierten 5 6 Dihydro-5oxo HH pyrido[2,3-b] [l,5]benzodiazepinen
FR6006M (pt) * 1965-01-05 1968-05-06
DE2424811C3 (de) * 1974-05-22 1981-08-20 Dr. Karl Thomae Gmbh, 7950 Biberach Pyrido-benzodiazepinone, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US3966736A (en) * 1975-04-07 1976-06-29 The Upjohn Company 2,9-Dihydro-3H-pyrido[3,2-c]-s-triazolo[4,3-a][1,5]-benzodiazepin-3-ones
DE2644121A1 (de) * 1976-09-30 1978-04-06 Thomae Gmbh Dr K Neue pyridobenzodiazepinone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
IT1130973B (it) * 1980-03-17 1986-06-18 Microsules Argentina Sa De S C Processo per la preparazione di derivati di 5,11-di-idro-6h-pirido(2,3-b) (1,4)-benzodiazepin-6-one,derivati finali ed intermedi di sintesi in tal modo ottenuti
DE3643666A1 (de) * 1986-12-20 1988-06-30 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
IT8721978A0 (it) * 1987-09-21 1987-09-21 Angeli Inst Spa Nuovi derivati ammidinici triciclici.
DE3818299A1 (de) * 1988-05-30 1989-12-07 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE69031845T2 (de) * 1989-04-20 1998-05-07 Boehringer Ingelheim Pharma 6,11-Dihydro-5H-pyrido(2,3-b)(1,5)benzodiazepin-5-one und Thione und ihre Verwendung für die Vorbeugung oder Behandlung von AIDS
ES2058656T3 (es) * 1989-04-20 1994-11-01 Boehringer Ingelheim Pharma 5,11-dihidro-6h-dipirido(3,2-b:2',3'-e)(1,4)diazepin-6-onas y su uso en la prevencion o tratamiento del sida.
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
BE1004596A4 (fr) * 1990-09-26 1992-12-22 Therabel Res S A N V Derives de methylpiperazinoazepine, leur preparation et leur utilisation.
US5087625A (en) * 1990-10-19 1992-02-11 Boehringer Ingelheim Pharmaceuticals, Inc. Pyridodiazepines and their use in the prevention or treatment of HIV infection
AU5883794A (en) * 1993-01-20 1994-08-15 A. Menarini Industrie Farmaceutiche Riunite S.R.L. Diazepin derivatives and antiviral compositions
US6090803A (en) * 1998-07-24 2000-07-18 American Home Products Corporation Tricyclic vasopressin agonists

Also Published As

Publication number Publication date
JP2006515350A (ja) 2006-05-25
CN1745087A (zh) 2006-03-08
WO2004069843A1 (fr) 2004-08-19
PL376621A1 (pl) 2006-01-09
AR043691A1 (es) 2005-08-10
CA2513059A1 (fr) 2004-08-19
MY138865A (en) 2009-08-28
KR20050096970A (ko) 2005-10-06
FR2850654A1 (fr) 2004-08-06
MXPA05007977A (es) 2005-09-20
MA27576A1 (fr) 2005-10-03
EA200501232A1 (ru) 2006-02-24
EP1590355A1 (fr) 2005-11-02
AU2004208890A1 (en) 2004-08-19
ZA200505430B (en) 2006-09-27
US20060079677A1 (en) 2006-04-13
NO20054092L (no) 2005-09-02

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Legal Events

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B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.