BRPI0011834B8 - bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them - Google Patents
bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing themInfo
- Publication number
- BRPI0011834B8 BRPI0011834B8 BRPI0011834A BR0011834A BRPI0011834B8 BR PI0011834 B8 BRPI0011834 B8 BR PI0011834B8 BR PI0011834 A BRPI0011834 A BR PI0011834A BR 0011834 A BR0011834 A BR 0011834A BR PI0011834 B8 BRPI0011834 B8 BR PI0011834B8
- Authority
- BR
- Brazil
- Prior art keywords
- bicyclic heterocycles
- preparing
- compounds
- processes
- pharmaceutical compositions
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
patente de invenção: "heterociclos bicíclicos, composições farmacêuticas contendo estes compostos, seu uso e processos para prepara-los". a presente invenção relaciona-se aos heterociclos bicíclicos de fórmula geral em que r~ a~ a r~ c~, a até e e x são definidos como na reivindicação 1, aos tautômeros, aos estereoisômeros e aos sais dos mesmos, particularmente os seus sais fisiologicamente aceitáveis com ácidos ou bases inorgânicas ou orgânicas, os quais têm propriedades farmacológicas valiosas, em particular um efeito inibitório sobre a transdução de sinal mediada por tirosina cinases, ao seu uso no tratamento de doenças, especialmente as doenças tumorais e as doenças dos pulmões e vias aéreas, e à preparação dos mesmos."Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them". The present invention relates to bicyclic heterocycles of general formula wherein R 1 to R 8 are defined as in claim 1, to tautomers, stereoisomers and salts thereof, particularly their physiologically acceptable salts. with inorganic or organic acids or bases which have valuable pharmacological properties, in particular an inhibitory effect on tyrosine kinases mediated signal transduction, their use in the treatment of diseases, especially tumoral diseases and lung and airway diseases , and their preparation.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19928281.1 | 1999-06-21 | ||
| DE1999128281 DE19928281A1 (en) | 1999-06-21 | 1999-06-21 | Arylamino and aralkylamino substituted quinoline and quinazoline derivatives, useful for the treatment of e.g. tumors, pulmonary, respiratory and gastrointestinal disorders and psoriasis |
| US10023085.7 | 2000-05-11 | ||
| DE2000123085 DE10023085A1 (en) | 2000-05-11 | 2000-05-11 | Arylamino and aralkylamino substituted quinoline and quinazoline derivatives, useful for the treatment of e.g. tumors, pulmonary, respiratory and gastrointestinal disorders and psoriasis |
| PCT/EP2000/005547 WO2000078735A1 (en) | 1999-06-21 | 2000-06-16 | Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BR0011834A BR0011834A (en) | 2002-03-12 |
| BR0011834B1 BR0011834B1 (en) | 2014-08-12 |
| BRPI0011834B8 true BRPI0011834B8 (en) | 2015-12-22 |
| BRPI0011834C1 BRPI0011834C1 (en) | 2021-05-25 |
Family
ID=26005635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0011834A BRPI0011834C1 (en) | 1999-06-21 | 2000-06-16 | bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes to prepare them |
Country Status (7)
| Country | Link |
|---|---|
| AR (1) | AR024418A1 (en) |
| BR (1) | BRPI0011834C1 (en) |
| CO (1) | CO5180636A1 (en) |
| MY (1) | MY140484A (en) |
| PL (1) | PL212659B1 (en) |
| TW (1) | TWI230156B (en) |
| UY (1) | UY32855A (en) |
-
2000
- 2000-06-16 BR BRPI0011834A patent/BRPI0011834C1/en not_active IP Right Cessation
- 2000-06-16 PL PL352357A patent/PL212659B1/en unknown
- 2000-06-20 TW TW89112051A patent/TWI230156B/en not_active IP Right Cessation
- 2000-06-20 CO CO00045906A patent/CO5180636A1/en active IP Right Grant
- 2000-06-21 MY MYPI20002798 patent/MY140484A/en unknown
- 2000-06-21 AR ARP000103072 patent/AR024418A1/en active Pending
-
2010
- 2010-08-26 UY UY0001032855A patent/UY32855A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL212659B1 (en) | 2012-11-30 |
| AR024418A1 (en) | 2002-10-02 |
| BRPI0011834C1 (en) | 2021-05-25 |
| BR0011834A (en) | 2002-03-12 |
| CO5180636A1 (en) | 2002-07-30 |
| TWI230156B (en) | 2005-04-01 |
| UY32855A (en) | 2012-03-30 |
| PL352357A1 (en) | 2003-08-11 |
| BR0011834B1 (en) | 2014-08-12 |
| MY140484A (en) | 2009-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 13 E 25 DA LPI. |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/08/2014, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: REFERENTE A RPI 2275 DE 12/08/2014, QUANTO AO NUMERO DA PRIORIDADE. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/06/2000 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 16/06/2020 |