BRMU8602999U - medicamento "rosuvastatina + metformina" em forma combinada para doenças cardiovasculares - Google Patents

medicamento "rosuvastatina + metformina" em forma combinada para doenças cardiovasculares

Info

Publication number
BRMU8602999U
BRMU8602999U BRMU8602999-1U BRMU8602999U BRMU8602999U BR MU8602999 U BRMU8602999 U BR MU8602999U BR MU8602999 U BRMU8602999 U BR MU8602999U BR MU8602999 U BRMU8602999 U BR MU8602999U
Authority
BR
Brazil
Prior art keywords
insulin
rosuvastatin
cardiovascular diseases
metformine
hypertension
Prior art date
Application number
BRMU8602999-1U
Other languages
English (en)
Inventor
Walter Junior Santos
Original Assignee
Walter Junior Santos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Walter Junior Santos filed Critical Walter Junior Santos
Priority to BRMU8602999-1U priority Critical patent/BRMU8602999U/pt
Priority to PCT/BR2007/000349 priority patent/WO2008058358A2/en
Publication of BRMU8602999U publication Critical patent/BRMU8602999U/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Abstract

O MEDICAMENTO "ROSUVASTATINA + METFORMINA EM FORMA COMBINADA PARA DOENçAS CARDIOVASCULARES, resuma-se a combinação de dois medicamentos utilizados contra as doenças cardiovasculares são a principal causa de morte em nosso país. Há nítida correlação entre o ganho ponderal e o excesso de peso com risco de doenças cardiovasculares. O excesso de peso predispõe a estas doenças devido anormalidades no metabolismo dos lípides, glicose e pressão arterial. A resistência à insulina / hiperinsulinemia parece ser um fator de risco independente de outros fatores de risco associados, como a obesidade, hiperlipidemia e hipertensão, tanto em homens como em mulheres. A insulina e os fatores de crescimento semelhantes à insulina estimulam a atividade das células musculares lisas e estão envolvidas na aterogênese e mesmo na reestenose que se segue ao repara coronário pela angioplastia. Outros efeitos da insulina estão relacionados aos mecanismos que contribuem para o desenvolvimento tanto da hipertensão como da dislipidemia. O MEDICAMENTO "ROSUVASTATINA + METFORMINA" EM FORMA COMBINADA PARA DOENCAS CARDIOVASCULARES, diminuindo a resistência insulínica, a pressão arterial, o ganho ponderal e melhorando o perfil lipídico destes paciente, reduziriam muito a probabilidade de eventos cardiovasculares e conseqüentemente o óbito dessa natureza em nossa população.
BRMU8602999-1U 2006-11-16 2006-11-16 medicamento "rosuvastatina + metformina" em forma combinada para doenças cardiovasculares BRMU8602999U (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BRMU8602999-1U BRMU8602999U (pt) 2006-11-16 2006-11-16 medicamento "rosuvastatina + metformina" em forma combinada para doenças cardiovasculares
PCT/BR2007/000349 WO2008058358A2 (en) 2006-11-16 2007-11-14 Descriptive report of the patent of invention of the medicament 'rosuvastatin + metformin' in combined form for cardiovascular diseases.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRMU8602999-1U BRMU8602999U (pt) 2006-11-16 2006-11-16 medicamento "rosuvastatina + metformina" em forma combinada para doenças cardiovasculares

Publications (1)

Publication Number Publication Date
BRMU8602999U true BRMU8602999U (pt) 2008-07-08

Family

ID=39402026

Family Applications (1)

Application Number Title Priority Date Filing Date
BRMU8602999-1U BRMU8602999U (pt) 2006-11-16 2006-11-16 medicamento "rosuvastatina + metformina" em forma combinada para doenças cardiovasculares

Country Status (2)

Country Link
BR (1) BRMU8602999U (pt)
WO (1) WO2008058358A2 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11759441B2 (en) 2011-01-07 2023-09-19 Anji Pharmaceuticals Inc. Biguanide compositions and methods of treating metabolic disorders
US9211263B2 (en) 2012-01-06 2015-12-15 Elcelyx Therapeutics, Inc. Compositions and methods of treating metabolic disorders
US8796338B2 (en) 2011-01-07 2014-08-05 Elcelyx Therapeutics, Inc Biguanide compositions and methods of treating metabolic disorders
KR20140035331A (ko) 2011-01-07 2014-03-21 엘셀릭스 테라퓨틱스 인코포레이티드 화학감각 수용체 리간드-기반 요법
US9480663B2 (en) 2011-01-07 2016-11-01 Elcelyx Therapeutics, Inc. Biguanide compositions and methods of treating metabolic disorders
US9572784B2 (en) 2011-01-07 2017-02-21 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
KR20190120430A (ko) 2012-01-06 2019-10-23 엘셀릭스 테라퓨틱스 인코포레이티드 바이구아나이드 조성물 및 대사 장애를 치료하는 방법
JP6175074B2 (ja) 2012-01-06 2017-08-02 エルセリクス セラピューティクス インコーポレイテッド 代謝障害を治療するための組成物および方法
JP2015522080A (ja) * 2012-07-11 2015-08-03 エルセリクス セラピューティクス インコーポレイテッド スタチン、ビグアナイド、およびさらなる薬剤を含む心血管代謝性リスクを減少させるための組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030171407A1 (en) * 2002-03-07 2003-09-11 Upsher-Smith Laboratories, Inc. Composition for reducing blood glucose and cholesterol

Also Published As

Publication number Publication date
WO2008058358A3 (en) 2009-04-16
WO2008058358A2 (en) 2008-05-22

Similar Documents

Publication Publication Date Title
BRMU8602999U (pt) medicamento "rosuvastatina + metformina" em forma combinada para doenças cardiovasculares
Young et al. Milrinone: a preliminary review of its pharmacological properties and therapeutic use
Toklu et al. Resveratrol improves cardiovascular function and reduces oxidative organ damage in the renal, cardiovascular and cerebral tissues of two-kidney, one-clip hypertensive rats
da Luz et al. Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats
Baltaci et al. Resveratrol and exercise
Sekar et al. Antidiabetic effect of mangiferin in combination with oral hypoglycemic agents metformin and gliclazide
Koyasu et al. Impact of acarbose on carotid intima-media thickness in patients with newly diagnosed impaired glucose tolerance or mild type 2 diabetes mellitus: a one-year, prospective, randomized, open-label, parallel-group study in Japanese adults with established coronary artery disease
Hennekens et al. Aspirin in the treatment and prevention of cardiovascular disease: past and current perspectives and future directions
CN102958362A (zh) 含有白藜芦醇的组合物和应用方法
Smirin et al. Sarcopoterium spinosum extract as an antidiabetic agent: in vitro and in vivo study
Bampi et al. Depression-like behavior, hyperglycemia, oxidative stress, and neuroinflammation presented in diabetic mice are reversed by the administration of 1-methyl-3-(phenylselanyl)-1H-indole
PT1680112E (pt) N-(5-adamantano-1-il-metoxi-pentil)desoxinojirimicina ou um seu sal aceite na indústria farmacêutica para ser usado no tratamento da resistência à insulina
CY1116303T1 (el) Παραγωγο ακυλβενζολιου
US20160346340A1 (en) Compositions including milk thistle and methods for the treatment of various disorders using the same
BRMU8602970U (pt) medicamento "telmisartam + metformina" em forma combinada para doenças cardiovasculares
BRMU8602979U (pt) medicamento "atorvastatina + metformina" em forma combinada para doenças cardiovasculares
BRMU8602991U (pt) medicamento "candesartana + metformina" em forma combinada para doenças cardiovasculares
BRMU8602968U (pt) medicamento "ramipril + metformina" em forma combinada para doenças cardiovasculares
BRMU8403417U (pt) medicamento sinvastatina + metformina em forma combinada para doenças cardiovasculares
Nettelblad et al. Psoralens used for cosmetic sun tanning: an unusual cause of extensive burn injury
BRMU8403463U (pt) medicamento combinado amlodipino + metformina em forma combinada para doenças cardiovasculares
BRMU8403462U (pt) medicamento valsartan + metformina em forma combinada para doenças cardiovasculares
Hiyama et al. Effects of metformin on burn-induced hepatic endoplasmic reticulum stress in male rats
Graham et al. Limitations of drug concentrations used in cell culture studies for understanding clinical responses of NSAIDs
BRMU8403482U (pt) "enalapril+metformina" em forma combinada para doenças cardiovasculares

Legal Events

Date Code Title Description
B03A Publication of an application: publication of a patent application or of a certificate of addition of invention
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE AS 4A E 5A ANUIDADES.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2156 DE 02/05/2012.