BR9916848A - Processo para produzir intermediários de ácido ascórbico - Google Patents

Processo para produzir intermediários de ácido ascórbico

Info

Publication number
BR9916848A
BR9916848A BR9916848-0A BR9916848A BR9916848A BR 9916848 A BR9916848 A BR 9916848A BR 9916848 A BR9916848 A BR 9916848A BR 9916848 A BR9916848 A BR 9916848A
Authority
BR
Brazil
Prior art keywords
ascorbic acid
acid intermediates
producing ascorbic
methods
producing
Prior art date
Application number
BR9916848-0A
Other languages
English (en)
Inventor
Matthew G Boston
Barbara A Swanson
Original Assignee
Genencor Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genencor Int filed Critical Genencor Int
Publication of BR9916848A publication Critical patent/BR9916848A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

"PROCESSO PARA PRODUZIR INTERMEDIáRIOS DE áCIDO ASCóRBICO". A presente invenção refere-se a processos não-fermentativos para a produção de intermediários de ASA, KDG, DKG e KLG e processos para a regeneração de co-fator. A invenção provê células hospedeiras geneticamente engenheiradas compreendendo ácido nucléico heterólogo codificando enzimas utilizáveis no processo.
BR9916848-0A 1998-12-22 1999-12-22 Processo para produzir intermediários de ácido ascórbico BR9916848A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/218,700 US6599722B2 (en) 1998-12-22 1998-12-22 Method for producing ascorbic acid intermediates
PCT/US1999/030918 WO2000037667A1 (en) 1998-12-22 1999-12-22 Method for producing ascorbic acid intermediates

Publications (1)

Publication Number Publication Date
BR9916848A true BR9916848A (pt) 2002-11-05

Family

ID=22816130

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916848-0A BR9916848A (pt) 1998-12-22 1999-12-22 Processo para produzir intermediários de ácido ascórbico

Country Status (15)

Country Link
US (4) US6599722B2 (pt)
EP (1) EP1141368B1 (pt)
JP (1) JP2003517278A (pt)
KR (1) KR100750363B1 (pt)
CN (1) CN1247790C (pt)
AT (1) ATE326542T1 (pt)
AU (1) AU2485500A (pt)
BR (1) BR9916848A (pt)
CA (2) CA2371534C (pt)
CZ (1) CZ298605B6 (pt)
DE (1) DE69931394T2 (pt)
DK (1) DK1141368T3 (pt)
MX (1) MXPA01006337A (pt)
PL (1) PL351711A1 (pt)
WO (1) WO2000037667A1 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10024314A1 (de) * 2000-05-17 2001-11-22 Basf Ag Verfahren, umfassend die indirekte elektrochemische Regeneration von NAD(P)H
CA2443145C (en) * 2001-04-04 2013-01-22 Genencor International, Inc. Uncoupled productive and catabolic host cell pathways
ATE409235T1 (de) * 2001-04-04 2008-10-15 Genencor Int Verfahren zur herstellung von ascorbinsäurezwischenprodukten in wirtszellen
ES2331118T3 (es) 2002-02-22 2009-12-22 Genencor International, Inc. Agente de dorado.
FI20020592A (fi) * 2002-03-27 2003-09-28 Danisco Sweeteners Oy Menetelmä sokereiden, sokerialkoholien, hiilihydraattien ja niiden seosten erottamiseksi niitä sisältävistä liuoksista
DK2295559T3 (en) * 2002-08-16 2015-12-14 Danisco Us Inc Hitherto UNKNOWN HYPROCREA JECORINA CBH1 CELLULASE VARIETY WITH INCREASED THERMAL STABILITY COMPREHENSIVE SUBSTITUTION OR DELETION AT POSITION T255
JP2007525186A (ja) * 2003-05-22 2007-09-06 ジェネンコー・インターナショナル・インク 非機能化された内因性グルコン酸トランスポーターを有する代謝を修飾したバクテリア系統
JPWO2005001066A1 (ja) * 2003-06-18 2006-11-02 住友ベークライト株式会社 新規分解菌及びそれを用いた有機化合物の分解処理方法
CN1829800B (zh) * 2003-07-30 2010-06-09 金克克国际有限公司 具有增加的2-酮基-d-葡萄糖酸累积的代谢工程细菌株
ES2554467T3 (es) 2004-12-30 2015-12-21 Danisco Us Inc. Variantes de celulasas CBH2 de Hypocrea jecorina
WO2006084664A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Novel gene rcs 09
JP4966189B2 (ja) * 2005-02-25 2012-07-04 株式会社カネカ 光学活性２級アルコールの製造方法
CN101341250B (zh) 2005-09-09 2013-03-20 帝斯曼知识产权资产管理有限公司 使用具有被打断的葡糖脱氢酶基因(gms 01)的微生物来生产生物质的工艺
CN101688226B (zh) 2007-07-06 2014-07-30 巴斯夫欧洲公司 由玉米生产葡萄糖水溶液的方法
US8236542B2 (en) 2008-06-06 2012-08-07 Danisco Us Inc. Compositions and methods comprising cellulase variants with reduced affinity to non-cellulosic materials
US8409839B2 (en) 2008-12-10 2013-04-02 Direvo Industrial Biotechnology Gmbh Polypeptides having cellobiohydrolase II activity
US8679816B2 (en) 2009-06-03 2014-03-25 Danisco Us Inc. Cellulase variants with improved expression, activity and stability, and use thereof
KR20150093190A (ko) 2012-12-12 2015-08-17 다니스코 유에스 인크. 셀로바이오하이드롤라제의 변이체
EP3192866A1 (en) 2016-01-15 2017-07-19 CIC nanoGUNE - Asociación Centro de Investigación Cooperativa en Nanociencias Endocellulases and uses thereof
EP3502126A1 (en) 2017-12-19 2019-06-26 CIC nanoGUNE - Asociación Centro de Investigación Cooperativa en Nanociencias Ancestral cellulases and uses thereof
CN112154206A (zh) * 2018-05-17 2020-12-29 Bp北美公司 丝状真菌中2-酮基-3-脱氧-d-葡萄糖酸的产生
CN109055292B (zh) * 2018-08-20 2020-08-04 上海凌凯医药科技有限公司 一种生产l-木糖的重组变形假单胞菌及其应用
CN112430560B (zh) * 2019-08-26 2024-01-05 中国科学院分子植物科学卓越创新中心 一种2-酮基-l-古龙酸生产菌株及其构建方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3790444A (en) 1971-03-09 1974-02-05 Daiichi Seiyaku Co Process for preparing diketogluconic acid
JPS6041596B2 (ja) 1980-08-14 1985-09-18 塩野義製薬株式会社 ２，５−ジケト−ｄ−グルコン酸の製造方法
JPS58162298A (ja) 1982-03-05 1983-09-26 Shionogi & Co Ltd ２−ケト−ｌ−グロン酸の製造方法
US4758514A (en) * 1983-06-28 1988-07-19 Genentech, Inc. Ascorbic acid intermediates and process enzymes
US5004690A (en) 1983-06-28 1991-04-02 Genetech, Inc. Ascorbic acid intermediates and process enzymes
US4757012A (en) 1983-06-28 1988-07-12 Genentech, Inc. Ascorbic acid intermediates and process enzymes
DE3326546A1 (de) 1983-07-22 1985-02-07 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München Verfahren zur kontinuierlichen enzymatischen herstellung von gluconsaeure oder ihren derivaten und sorbit und/oder mannit
US5008193A (en) 1984-06-14 1991-04-16 Genentech, Inc. Ascorbic acid intermediates and process enzymes
GB8519536D0 (en) 1985-08-02 1985-09-11 Biogen Nv Vitamin c precursor
US5032514A (en) 1988-08-08 1991-07-16 Genentech, Inc. Metabolic pathway engineering to increase production of ascorbic acid intermediates
GB8826429D0 (en) 1988-11-11 1988-12-14 Univ Leeds Ind Service Ltd Enzyme stabilisation systems
US5376544A (en) 1992-09-08 1994-12-27 Rutgers The State University Of New Jersey Enzymes for the production of 2-keto-L-gulonic acid
US5795761A (en) * 1996-01-11 1998-08-18 Rutgers, The State University Of New Jersey Mutants of 2,5-diketo-D-gluconic acid (2,5-DKG) reductase A

Also Published As

Publication number Publication date
CN1331749A (zh) 2002-01-16
DE69931394T2 (de) 2007-05-03
AU2485500A (en) 2000-07-12
US6599722B2 (en) 2003-07-29
PL351711A1 (en) 2003-06-02
CA2371534C (en) 2012-07-17
CZ298605B6 (cs) 2007-11-21
WO2000037667A1 (en) 2000-06-29
MXPA01006337A (es) 2002-04-24
KR20010093149A (ko) 2001-10-27
JP2003517278A (ja) 2003-05-27
EP1141368B1 (en) 2006-05-17
DK1141368T3 (da) 2006-09-18
US20040180413A1 (en) 2004-09-16
KR100750363B1 (ko) 2007-08-17
CA2776920A1 (en) 2000-06-29
DE69931394D1 (de) 2006-06-22
US20020177198A1 (en) 2002-11-28
CN1247790C (zh) 2006-03-29
CA2371534A1 (en) 2000-06-29
US20020177197A1 (en) 2002-11-28
US20050227337A1 (en) 2005-10-13
ATE326542T1 (de) 2006-06-15
EP1141368A1 (en) 2001-10-10
CZ20012285A3 (cs) 2001-10-17

Similar Documents

Publication Publication Date Title
BR9916848A (pt) Processo para produzir intermediários de ácido ascórbico
BR0012712B1 (pt) métodos de produção de l-aminoácidos aumentando-se o nadph celular.
BR9814404A (pt) " clonagem de expressão em fungos filamentosos "
DK0956338T3 (da) Værtsceller og fremgangsmåder til produktion af proteiner
AU5102899A (en) Process and materials for production of glucosamine
BR9908119A (pt) Processo de preparação fermentativa para citostáticos e formas de cristal dos mesmos
AU3246300A (en) Polypeptides having galactose oxidase activity and nucleic acids encoding same
DE60040967D1 (de) Chromatographisches verfahren zur reinigung von albumin
AU2001242299A1 (en) Fungal transcriptional activator useful in methods for producing polypeptides
FI950628A0 (fi) Modifioidut sienisolut ja menetelmä rekombinanttituotteiden tuottamiseksi
SI1428878T1 (sl) Postopek za proizvodnjo in čiščenje eritropoietina
WO2002046429A3 (en) Polypeptides having glucoamylase activity and nucleic acids encoding same
EP0976829A3 (en) Protein-deamidating enzyme, gene encoding the same, production process therefor, and use thereof
AU2002338340A1 (en) Uncoupled productive and catabolic host cell pathways
DK1117798T3 (da) Fungal transskriptionel aktivator egnet ved fremgangsmåder til produktion af polypeptider
DE60038886D1 (de) Neue enzyme, welche glycerin entwässern
AU4940096A (en) Host cell expressing reduced levels of a metalloprotease and methods using the host cell in protein production
BR0014519A (pt) Sequências de sinais para a preparação de leu-herudin através da secreção por e. coli no meio de cultura
DE60104807D1 (de) Verfahren mit hoher Produktionskapazität von Prenylalkohol durch Mikroorganismen
WO2004090094A3 (de) L-carnitin dehydrogenasen, deren derivate und ein verfahren zur herstellung von substituierten (s)-alkanolen
WO2000028043A3 (en) Polypeptides having lactonohydrolase activity and nucleic acids encoding same
WO2005012498A3 (en) Production of porphyrins
EP0979876A3 (en) Method for producing fermentative product and stress-resistant microorganism
WO2004027043A3 (en) Method for production of a multimeric protein by cell fusion
AU7645400A (en) Polypeptides having glucanotransferase activity and nucleic acids encoding same

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5O, 6O E 7O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.