BR9916314A - Tricyclic farnesyl transferase protein inhibitors - Google Patents

Tricyclic farnesyl transferase protein inhibitors

Info

Publication number
BR9916314A
BR9916314A BR9916314-4A BR9916314A BR9916314A BR 9916314 A BR9916314 A BR 9916314A BR 9916314 A BR9916314 A BR 9916314A BR 9916314 A BR9916314 A BR 9916314A
Authority
BR
Brazil
Prior art keywords
group
farnesyl transferase
compounds
protein inhibitors
transferase protein
Prior art date
Application number
BR9916314-4A
Other languages
Portuguese (pt)
Inventor
Arthur G Taveras
Ronald J Doll
Alan B Cooper
Johan A Ferreira
Timothy Guzi
Alan K Mallams
Dinanath F Rane
Viyyoor M Girijavallabhan
Adriano Afonso
Cynthia J Aki
Jianping Chao
Carmen Alvarez
Joseph M Kelly
Tarik Lalwani
Jagdish A Desai
James J-S Wang
Jay Weinstein
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of BR9916314A publication Critical patent/BR9916314A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Electroluminescent Light Sources (AREA)

Abstract

Patente de Invenção: <B>"INIBIDORES TRICìCLICOS DA PROTEìNA FARNESIL TRANSFERASE"<D>. Estão descritos compostos de fórmula (1.0) onde R^ 13^ representa um anel imidazol; R^ 14^ representa um grupo carbamato, uréia, amida ou sulfonamida; R^ 8^ representa H quando a cadeia alquila entre o grupo amida e o grupo imidazol R^ 13^ é substituída, ou R^ 8^ representa um substituinte tal como arilalquila, heteroarilalquila ou cicloalquila; e os outros substituintes são como definidos neste relatório. Também estão descritos compostos onde R^ 8^ é H, e a cadeia alquila entre o grupo amida e o grupo imidazol R^ 13^ é não-substituída. Também está descrito um método de tratamento de câncer e um método de inibição da proteína farnesil transferase usando os compostos descritos.Invention Patent: <B> "TRICYCLIC INHIBITORS OF PROTEIN FARNESIL TRANSFERASE" <D>. Compounds of formula (1.0) are described where R3 13 represents an imidazole ring; R ^ 14 ^ represents a carbamate, urea, amide or sulfonamide group; R ^ 8 ^ represents H when the alkyl chain between the amide group and the imidazole group R ^ 13 ^ is substituted, or R ^ 8 ^ represents a substituent such as arylalkyl, heteroarylalkyl or cycloalkyl; and the other substituents are as defined in this report. Also described are compounds where R ^8 8 is H, and the alkyl chain between the amide group and the imidazole group R ^13 ^ is unsubstituted. Also described is a method of treating cancer and a method of inhibiting the farnesyl transferase protein using the described compounds.

BR9916314-4A 1998-12-18 1999-12-16 Tricyclic farnesyl transferase protein inhibitors BR9916314A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21639898A 1998-12-18 1998-12-18
PCT/US1999/027939 WO2000037459A1 (en) 1998-12-18 1999-12-16 Tricyclic farnesyl protein transferase inhibitors

Publications (1)

Publication Number Publication Date
BR9916314A true BR9916314A (en) 2001-10-02

Family

ID=22806914

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916314-4A BR9916314A (en) 1998-12-18 1999-12-16 Tricyclic farnesyl transferase protein inhibitors

Country Status (20)

Country Link
EP (1) EP1140902A1 (en)
JP (1) JP2002533336A (en)
KR (1) KR20010081116A (en)
CN (1) CN1326850C (en)
AR (1) AR021718A1 (en)
AU (1) AU776558B2 (en)
BR (1) BR9916314A (en)
CA (1) CA2354779A1 (en)
CO (1) CO5160350A1 (en)
CZ (1) CZ20011950A3 (en)
HU (1) HUP0202152A2 (en)
IL (1) IL143408A0 (en)
NO (1) NO20012961L (en)
NZ (1) NZ511878A (en)
PE (1) PE20001342A1 (en)
PL (1) PL348293A1 (en)
SK (1) SK7592001A3 (en)
TR (1) TR200101755T2 (en)
WO (1) WO2000037459A1 (en)
ZA (1) ZA200104233B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU776558B2 (en) 1998-12-18 2004-09-16 Schering Corporation Tricyclic farnesyl protein transferase inhibitors
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
US6645966B2 (en) 2001-01-22 2003-11-11 Schering Corporation Treatment of malaria with farnesyl protein transferase inhibitors
WO2002080895A2 (en) * 2001-04-06 2002-10-17 Schering Corporation Treatment of malaria with farsenyl protein transferase inhibitors
CA2590979A1 (en) * 2004-12-13 2006-06-22 Schering Corporation Novel farnesyl protein transferase inhibitors and their use to treat cancer
CN101128202A (en) 2004-12-14 2008-02-20 先灵公司 Farnesyl protein transferase inhibitors and methods for treating proliferative diseases
WO2007084498A1 (en) * 2006-01-19 2007-07-26 Schering Corporation Piperazine derivatives as farnesyl protein transferase inhibitors
US9988365B2 (en) 2014-03-19 2018-06-05 Vps-3, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation
KR102441242B1 (en) * 2014-03-19 2022-09-07 브이피에스-3, 엘엘씨 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Pharmaceutical compositions for inhibition of g-protein function and for treatment of proliferative diseases containing tricyclic compounds some such compounds and process for preparing part of them
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases and pharmaceutical compositions comprising them
US5801175A (en) * 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
PE92098A1 (en) * 1996-07-31 1998-12-31 Schering Corp TRICYCLIC N-CYANOIMINES USEFUL AS PROTEIN TRANSFERASE INHIBITORS FARNESILO
EP0989983B1 (en) * 1997-06-17 2004-08-11 Schering Corporation Benzpyrido cycloheptane compounds useful for inhibition of farnesyl protein transferase
AU776558B2 (en) 1998-12-18 2004-09-16 Schering Corporation Tricyclic farnesyl protein transferase inhibitors

Also Published As

Publication number Publication date
CO5160350A1 (en) 2002-05-30
NO20012961L (en) 2001-08-16
CZ20011950A3 (en) 2001-12-12
CN1334811A (en) 2002-02-06
TR200101755T2 (en) 2001-09-21
IL143408A0 (en) 2002-04-21
CA2354779A1 (en) 2000-06-29
HUP0202152A2 (en) 2002-10-28
NZ511878A (en) 2003-10-31
NO20012961D0 (en) 2001-06-15
ZA200104233B (en) 2002-08-22
SK7592001A3 (en) 2002-03-05
WO2000037459A1 (en) 2000-06-29
AU776558B2 (en) 2004-09-16
AR021718A1 (en) 2002-07-31
PE20001342A1 (en) 2000-12-09
CN1326850C (en) 2007-07-18
EP1140902A1 (en) 2001-10-10
JP2002533336A (en) 2002-10-08
PL348293A1 (en) 2002-05-20
AU2030700A (en) 2000-07-12
KR20010081116A (en) 2001-08-27

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5O, 6O E 7O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.