BR9915643A - Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation - Google Patents
Benzylmaltotriosides as inhibitors of smooth muscle cell proliferationInfo
- Publication number
- BR9915643A BR9915643A BR9915643-1A BR9915643A BR9915643A BR 9915643 A BR9915643 A BR 9915643A BR 9915643 A BR9915643 A BR 9915643A BR 9915643 A BR9915643 A BR 9915643A
- Authority
- BR
- Brazil
- Prior art keywords
- carbon atoms
- inhibitors
- hydrogen
- smooth muscle
- cell proliferation
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/08—Polyoxyalkylene derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Patente de Invenção: <B>"BENZILMALTOTRIOSìDEOS COMO INIBIDORES DE PROLIFERAçãO DE CéLULAS DO MúSCULO LISO"<D>. Esta invenção proporciona inibidores de proliferação de células de músculo liso de fórmula <B>(I)<D> que apresentam a estrutura onde X é <B>(A)<D> onde R^ 1^ ,R^ 2^, R^ 3^,R^ 4^, R^ 5^, R^ 6^, R^ 7^, R^ 8^, R^ 9^ e R^ 10^ são cada um, independentemente, hidrogênio, acila de 2-7 átomos de carbono, perfluoracila de 2-10 átomos de carbono, alquila de 1-6 átomos de carbono, perfluoralquila de 1-6 átomos de carbono, benzoíla, benzila ou -SO~ 3~M; M é hidrogênio, lítio, sódio, potássio ou amónio; R^ 11^ é hidrogênio, alquila de 1-6 átomos de carbono, perfluoralquila de 1-6 átomos de carbono, halogênio, nitrila, nitro ou alcóxi de 1-6 átomos de carbono; R^ 12^ é hidrogênio, nitro, amino, acilamino de 2-7 átomos de carbono, perfluoracilamino de 2-7 átomos de carbono, alquilamino de 1-6 átomos de carbono, perfluoralquilamino de 1-6 átomos de carbono, dialquilamino onde cada cadeia alquila é independentemente de 1-6 átomos de carbono, perfluordialquilamino onde cada cadeia alquila é independentemente de 1-6 átomos de carbono, alquilsulfonilamino de 1-6 átomos de carbono, perfluoralquilsulfonilamino de 1-6 átomos de carbono, arilsulfonilamino de 6-10 átomos de carbono ou arilsulfonilamino substituído com halo de 6-10 átomos de carbono; ou um sal farmaceuticamente aceitável dos inibidores.Invention Patent: <B> "BENZYLMALTOTHYRIES AS PROBLE INHIBITORS OF SMOOTH MUSCLE CELLS" <D>. This invention provides smooth muscle cell proliferation inhibitors of formula <B> (I) <D> which have the structure where X is <B> (A) <D> where R ^ 1 ^, R ^ 2 ^, R ^ 3 ^, R ^ 4 ^, R ^ 5 ^, R ^ 6 ^, R ^ 7 ^, R ^ 8 ^, R ^ 9 ^ and R ^ 10 ^ are each, independently, hydrogen, 2- acyl 7 carbon atoms, perfluoracil of 2-10 carbon atoms, alkyl of 1-6 carbon atoms, perfluoralkyl of 1-6 carbon atoms, benzoyl, benzyl or -SO ~ 3 ~ M; M is hydrogen, lithium, sodium, potassium or ammonium; R ^ 11 ^ is hydrogen, alkyl of 1-6 carbon atoms, perfluoralkyl of 1-6 carbon atoms, halogen, nitrile, nitro or alkoxy of 1-6 carbon atoms; R ^ 12 ^ is hydrogen, nitro, amino, acylamino of 2-7 carbon atoms, perfluoracilamino of 2-7 carbon atoms, alkylamino of 1-6 carbon atoms, perfluoralkylamino of 1-6 carbon atoms, dialkylamino where each alkyl chain is independently of 1-6 carbon atoms, perfluordialalkylamino where each alkyl chain is independently of 1-6 carbon atoms, alkylsulfonylamino of 1-6 carbon atoms, perfluoralkylsulfonylamino of 1-6 carbon atoms, arylsulfonylamino of 6-10 carbon atoms or arylsulfonylamino substituted with a halo of 6-10 carbon atoms; or a pharmaceutically acceptable salt of the inhibitors.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19880598A | 1998-11-24 | 1998-11-24 | |
| PCT/US1999/027775 WO2000031095A2 (en) | 1998-11-24 | 1999-11-23 | Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9915643A true BR9915643A (en) | 2001-08-07 |
Family
ID=22734935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9915643-1A BR9915643A (en) | 1998-11-24 | 1999-11-23 | Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1133506A2 (en) |
| JP (1) | JP2002530420A (en) |
| CN (1) | CN1333778A (en) |
| AU (1) | AU1919800A (en) |
| BR (1) | BR9915643A (en) |
| CA (1) | CA2350759A1 (en) |
| WO (1) | WO2000031095A2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040248945A1 (en) | 1999-04-23 | 2004-12-09 | Smithkline Beecham P.L.C. | Thiazolidinedione derivative and its use as antidiabetic |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL115745A (en) * | 1994-11-07 | 2000-11-21 | American Home Prod | Acylated benzylglycosides and pharmaceutical compositions containing them |
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1999
- 1999-11-23 AU AU19198/00A patent/AU1919800A/en not_active Abandoned
- 1999-11-23 CA CA002350759A patent/CA2350759A1/en not_active Abandoned
- 1999-11-23 BR BR9915643-1A patent/BR9915643A/en not_active Application Discontinuation
- 1999-11-23 EP EP99962844A patent/EP1133506A2/en not_active Withdrawn
- 1999-11-23 WO PCT/US1999/027775 patent/WO2000031095A2/en not_active Application Discontinuation
- 1999-11-23 JP JP2000583923A patent/JP2002530420A/en active Pending
- 1999-11-23 CN CN99815706A patent/CN1333778A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU1919800A (en) | 2000-06-13 |
| CA2350759A1 (en) | 2000-06-02 |
| JP2002530420A (en) | 2002-09-17 |
| WO2000031095A2 (en) | 2000-06-02 |
| WO2000031095A3 (en) | 2001-01-04 |
| EP1133506A2 (en) | 2001-09-19 |
| CN1333778A (en) | 2002-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |