BR9912501A - Tratamento de distúrbios hiperproliferativos - Google Patents

Tratamento de distúrbios hiperproliferativos

Info

Publication number
BR9912501A
BR9912501A BR9912501-3A BR9912501A BR9912501A BR 9912501 A BR9912501 A BR 9912501A BR 9912501 A BR9912501 A BR 9912501A BR 9912501 A BR9912501 A BR 9912501A
Authority
BR
Brazil
Prior art keywords
inhibitor
ceramide
treatment
preferred
inhibitors
Prior art date
Application number
BR9912501-3A
Other languages
English (en)
Inventor
Barry James Maurer
C Patrick Reynolds
Myles Cabot
Original Assignee
Los Angeles Childrens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Los Angeles Childrens Hospital filed Critical Los Angeles Childrens Hospital
Publication of BR9912501A publication Critical patent/BR9912501A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/15—Suppositories

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Patente de Invenção: <B>"TRATAMENTO DE DISTúRBIOS HIPERPROLIFERATIVOS"<D>. Método para tratamento de um distúrbio hiperproliferativo em um indivíduo necessitando deste tratamento, compreendendo a administração ao referido indivíduo, em combinação, de uma quantidade eficiente de um tratamento com: (a) um retinóide gerador de ceramida, como a fenretinida, ou um sal farmaceuticamente aceitável da mesma; e (b) pelo menos um (e, em certas modalidades, pelo menos dois) inibidor de degradação da ceramida, como os compostos selecionados do grupo que consiste em (i) inibidores de síntese de glicosilceramida, (ii) inibidores de síntese de esfingosina-1-fosfato, e (iii) inibidores de quinase da proteína C. Um inibidor de síntese de glicosilceramida preferido é o 1-fenil-2-palmitoilamino-3-morfolino-1-propanol. Um inibidor de síntese de esfingosina-1-fosfato preferido é D-eritro-N, N-dimetilesfingosina. Um inibidor de quinase de proteína C preferido é L-treo-dihidroesfingosina.
BR9912501-3A 1998-06-29 1999-06-28 Tratamento de distúrbios hiperproliferativos BR9912501A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9113898P 1998-06-29 1998-06-29
PCT/US1999/014591 WO2000000207A1 (en) 1998-06-29 1999-06-28 Treatment of hyperproliferative disorders

Publications (1)

Publication Number Publication Date
BR9912501A true BR9912501A (pt) 2001-05-02

Family

ID=22226266

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9912501-3A BR9912501A (pt) 1998-06-29 1999-06-28 Tratamento de distúrbios hiperproliferativos

Country Status (12)

Country Link
US (1) US6352844B1 (pt)
EP (1) EP1091745B1 (pt)
JP (1) JP4965764B2 (pt)
CN (1) CN100358529C (pt)
AT (1) ATE409486T1 (pt)
AU (1) AU4724599A (pt)
BR (1) BR9912501A (pt)
CA (1) CA2335941C (pt)
DE (1) DE69939651D1 (pt)
DK (1) DK1091745T3 (pt)
ES (1) ES2316188T3 (pt)
WO (1) WO2000000207A1 (pt)

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US6098631A (en) * 1998-01-21 2000-08-08 The Regents Of The University Of Michigan Compositions and methods for treating autoimmune disease
US6368831B1 (en) * 1998-06-29 2002-04-09 Childrens Hospital Los Angeles Treatment of hyperproliferative disorders
GB0006539D0 (en) * 2000-03-17 2000-05-10 Oxford Glycosciences Uk Ltd Therapies
AUPQ744700A0 (en) * 2000-05-11 2000-06-01 Medvet Science Pty. Ltd. A method of treatment and agents useful for same
EP1195604A1 (en) * 2000-09-29 2002-04-10 Warner-Lambert Company Methods and compositions for screening modulators of lipid kinases
JP4384409B2 (ja) 2000-12-05 2009-12-16 チルドレンズ・ホスピタル・ロス・アンジエルス バイオアベイラビリティが増加したフェンレチニドの医薬組成物、およびその使用方法
EP1363643A2 (en) * 2000-12-22 2003-11-26 Medlyte, Inc. Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor
US20040097587A1 (en) * 2002-03-27 2004-05-20 Arbiser Jack L Compositions and methods of treatment of ulcerating diseases, burns, and related conditions
US20030226181P1 (en) * 2002-05-31 2003-12-04 Mason Harleigh C. Apple tree named 'Rosy Glow'
JP3405981B1 (ja) * 2002-06-26 2003-05-12 日本財経株式会社 酢酸セルロースの製造方法
CA2499523C (en) * 2002-09-20 2011-04-19 Medisyn Technologies, Inc. Therapeutic agents and corresponding treatments
US7785621B2 (en) * 2003-01-31 2010-08-31 Childrens Hospital Los Angeles Oral compositions of fenretinide having increased bioavailability and methods of using the same
EP1594488B1 (en) * 2003-02-21 2006-06-28 Childrens Hospital of Los Angeles Research Institute Stabilized pharmaceutical compositions of safingol and methods of using the same
US20050101674A1 (en) * 2003-11-12 2005-05-12 Maurer Barry J. PPMP as a ceramide catabolism inhibitor for cancer treatment
US20070258970A1 (en) * 2003-12-09 2007-11-08 Robert Blumenthal Methods for Inhibiting Hiv and Other Viral Infections by Modulating Ceramide Metabolism
CA2558429C (en) 2004-03-02 2011-02-01 Mcgill University Compositions and methods for preventing or treating an inflammatory response
US7794713B2 (en) * 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
WO2005123055A2 (en) * 2004-06-14 2005-12-29 Musc Foundation For Research Development Methods for treating inflammatory disorders
CN101022803B (zh) * 2004-07-09 2011-11-23 药物合成技术公司 治疗化合物和治疗
CA2581061C (en) * 2004-10-28 2014-09-02 Lpath Therapeutics, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US20060257493A1 (en) * 2005-04-28 2006-11-16 Amiji Mansoor M Nanoparticulate delivery systems for treating multi-drug resistance
US20090074720A1 (en) * 2005-10-28 2009-03-19 Sabbadini Roger A Methods for decreasing immune response and treating immune conditions
US20080213274A1 (en) * 2005-10-28 2008-09-04 Sabbadini Roger A Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye
NZ572601A (en) 2006-03-29 2012-03-30 Univ Wayne State Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery
US7862812B2 (en) * 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
US9217749B2 (en) * 2006-05-31 2015-12-22 Lpath, Inc. Immune-derived moieties reactive against lysophosphatidic acid
US8796429B2 (en) * 2006-05-31 2014-08-05 Lpath, Inc. Bioactive lipid derivatives, and methods of making and using same
US9274130B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
US9274129B2 (en) * 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
AU2007313822A1 (en) * 2006-10-27 2008-05-08 Lpath, Inc. Compositions and methods for treating ocular diseases and conditions
CA2667574A1 (en) 2006-10-27 2008-06-12 Roger A. Sabbadini Compositions and methods for binding sphingosine-1-phosphate
WO2009045345A1 (en) * 2007-09-28 2009-04-09 Childrens Hospital Los Angeles Research Institute Metabolic degradation inhibitors for anti-hyperproliferative agents
US8361465B2 (en) * 2007-10-26 2013-01-29 Lpath, Inc. Use of anti-sphingosine-1-phosphate antibodies in combination with chemotherapeutic agents
GB0803352D0 (en) 2008-02-22 2008-04-02 Ntnu Technology Transfer As Oligopeptidic compounds and uses thereof
US20090253733A1 (en) * 2008-04-02 2009-10-08 Biointeractions, Ltd. Rapamycin carbonate esters
US8088822B2 (en) * 2008-07-08 2012-01-03 Ji Zhang Use of fenretinide or bioactive derivatives thereof and pharmaceutical compositions comprising the same
CN101623277B (zh) * 2008-07-08 2014-07-16 上海交通大学医学院附属瑞金医院 芬维a胺及其活性衍生物的新用途及其药物组合物
US8871202B2 (en) 2008-10-24 2014-10-28 Lpath, Inc. Prevention and treatment of pain using antibodies to sphingosine-1-phosphate
CN102892748A (zh) * 2009-11-12 2013-01-23 德克萨斯理工大学 用于治疗过度增生性疾病的组合物和方法
WO2011140296A1 (en) * 2010-05-05 2011-11-10 Infinity Pharmaceuticals Triazoles as inhibitors of fatty acid synthase
WO2012068169A2 (en) * 2010-11-15 2012-05-24 Texas Tech University Substance for increasing the production of a specific acyl-chain dihydroceramide(s) for improving the effectiveness of cancer treatments

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Also Published As

Publication number Publication date
JP4965764B2 (ja) 2012-07-04
EP1091745A4 (en) 2003-08-27
JP2002519329A (ja) 2002-07-02
ES2316188T3 (es) 2009-04-01
ATE409486T1 (de) 2008-10-15
US6352844B1 (en) 2002-03-05
EP1091745B1 (en) 2008-10-01
AU4724599A (en) 2000-01-17
CN1308538A (zh) 2001-08-15
EP1091745A1 (en) 2001-04-18
WO2000000207A9 (en) 2000-05-18
DK1091745T3 (da) 2008-12-15
CA2335941C (en) 2011-03-22
WO2000000207A1 (en) 2000-01-06
DE69939651D1 (de) 2008-11-13
CN100358529C (zh) 2008-01-02
CA2335941A1 (en) 2000-01-06

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1919 DE 16/10/2007.