BR9909129A - Conjugados de proteases - Google Patents

Conjugados de proteases

Info

Publication number
BR9909129A
BR9909129A BR9909129-1A BR9909129A BR9909129A BR 9909129 A BR9909129 A BR 9909129A BR 9909129 A BR9909129 A BR 9909129A BR 9909129 A BR9909129 A BR 9909129A
Authority
BR
Brazil
Prior art keywords
amino acid
protease
acid sequence
conjugates
group
Prior art date
Application number
BR9909129-1A
Other languages
English (en)
Inventor
David John Weisberger
Donn Nelton Rubingh
Paul Elliott Correa
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of BR9909129A publication Critical patent/BR9909129A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66Enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A61Q11/02Preparations for deodorising, bleaching or disinfecting dentures
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/02Preparations for cleaning the hair
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005Other compounding ingredients characterised by their effect
    • C11D3/0078Compositions for cleaning contact lenses, spectacles or lenses
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/38Products with no well-defined composition, e.g. natural products
    • C11D3/386Preparations containing enzymes, e.g. protease or amylase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Birds (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"CONJUGADOS DE PROTEASES". A presente invenção refere-se a conjugados das proteases subtilisinas, compreendendo um agrupamento protease e um ou mais grupos de adição, em que o grupamento protease tem uma seq³ência de amonoácidos modificada de uma seq³ência de aminoácidos parental, sendo que a seq³ência de aminoácidos parental compreende uma primeira região de epítopo, uma segunda região de epítopo, e uma terceira região de epítopo, em que a seq³ência de aminoácidos modificada compreende uma substituição com um aminoácido substituinte em uma ou mais posições das regiões de epítopos, e onde cada grupamento de adição está ligado de modo covalente a um dos grupamentos substituintes. A presente invenção refere-se ainda a composições de limpeza e de higiene pessoal, que compreendem esses conjugados de proteases.
BR9909129-1A 1998-03-26 1999-03-25 Conjugados de proteases BR9909129A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4817498A 1998-03-26 1998-03-26
US09/088,912 US6495136B1 (en) 1998-03-26 1998-06-02 Proteases having modified amino acid sequences conjugated to addition moieties
PCT/IB1999/000511 WO1999048918A1 (en) 1998-03-26 1999-03-25 Protease conjugates

Publications (1)

Publication Number Publication Date
BR9909129A true BR9909129A (pt) 2000-12-19

Family

ID=26725868

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909129-1A BR9909129A (pt) 1998-03-26 1999-03-25 Conjugados de proteases

Country Status (9)

Country Link
US (1) US6495136B1 (pt)
EP (1) EP1068228A1 (pt)
JP (1) JP3642735B2 (pt)
KR (1) KR20010034685A (pt)
CN (1) CN1163507C (pt)
AU (1) AU2742399A (pt)
BR (1) BR9909129A (pt)
CA (1) CA2324506A1 (pt)
WO (1) WO1999048918A1 (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8798198A (en) * 1997-08-29 1999-03-22 Novo Nordisk A/S Protease variants and compositions
US6495136B1 (en) 1998-03-26 2002-12-17 The Procter & Gamble Company Proteases having modified amino acid sequences conjugated to addition moieties
WO1999049056A1 (en) 1998-03-26 1999-09-30 The Procter & Gamble Company Serine protease variants having amino acid substitutions
US6908757B1 (en) 1998-03-26 2005-06-21 The Procter & Gamble Company Serine protease variants having amino acid deletions and substitutions
US6936249B1 (en) * 1998-04-15 2005-08-30 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6835550B1 (en) * 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US6838269B1 (en) * 1998-04-15 2005-01-04 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
MXPA02000842A (es) 1999-07-22 2002-07-30 Procter & Gamble Conjugados de proteasa que tienen sitios de corte protegidos estericamente.
CZ2002212A3 (cs) 1999-07-22 2002-07-17 The Procter & Gamble Company Varianty subtilisinové proteasy mající aminokyselinové substituce v definovaných epitopových oblastech
CN1373802A (zh) 1999-07-22 2002-10-09 宝洁公司 在特定表位区域具有氨基酸缺失和取代的枯草杆菌蛋白酶变体
US6946128B1 (en) 1999-07-22 2005-09-20 The Procter & Gamble Company Protease conjugates having sterically protected epitope regions
CZ2002211A3 (cs) * 1999-07-22 2002-05-15 The Procter & Gamble Company Proteázové konjugáty se stericky chráněnými oblastmi epitopu
US20030170846A1 (en) * 2000-04-24 2003-09-11 Weisgerber David John Enzyme variants having one or more D-amino acid substitutions
US20030206896A1 (en) * 2000-09-13 2003-11-06 O'prey Conor James Cosmetic method
ATE414711T1 (de) * 2001-06-28 2008-12-15 Mountain View Pharmaceuticals Polymerstabilisierte proteinasen
MXPA04005382A (es) * 2001-11-07 2005-02-24 Mannkind Corp Vectores de expresion que codifican epitopes de antigenos asociados al objetivo y metodos para su diseno.
AU2002340415A1 (en) * 2001-11-13 2003-05-26 The Procter And Gamble Company Compositions containing enzymes stabilized with certain osmo-protectants and methods for using such compositions in personal care
DK1530637T3 (da) * 2002-02-26 2010-05-31 Genencor Int Carlsberg-subtilisin-proteiner med nedsat immunogenitet
KR101025143B1 (ko) 2002-12-31 2011-04-01 넥타르 테라퓨틱스 가수분해상으로 안정한 말레이미드-종결 중합체
US7432331B2 (en) 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
AU2004204136B2 (en) 2003-01-06 2008-10-09 Nektar Therapeutics Thiol-selective water-soluble polmer derivatives
US20050118058A1 (en) * 2003-12-01 2005-06-02 Erning Xia Gentle preservative compositions for self-preserving solutions
US20050118129A1 (en) * 2003-12-01 2005-06-02 Erning Xia Gentle and enhanced preservative systems
DE602005007928D1 (de) * 2004-11-08 2008-08-14 Unilever Nv Flüssiges waschmittel
CN101275363B (zh) * 2008-05-08 2010-09-08 江南大学 一种用复配酶制剂对棉织物进行同浴煮练和漂白的方法
EP2216392B1 (en) * 2009-02-02 2013-11-13 The Procter and Gamble Company Liquid hand dishwashing detergent composition
EP2213714B1 (en) * 2009-02-02 2014-06-11 The Procter and Gamble Company Liquid hand dishwashing detergent composition
EP2216390B1 (en) * 2009-02-02 2013-11-27 The Procter and Gamble Company Hand dishwashing method
CA2751171A1 (en) * 2009-02-02 2010-08-05 The Procter & Gamble Company Liquid hand dishwashing detergent composition
EP2213715A1 (en) * 2009-02-02 2010-08-04 The Procter & Gamble Company Liquid hand dishwashing detergent composition
PL2213713T3 (pl) * 2009-02-02 2014-07-31 Procter & Gamble Płynna kompozycja środka czyszczącego do ręcznego mycia naczyń
EP2216391A1 (en) * 2009-02-02 2010-08-11 The Procter & Gamble Company Liquid hand dishwashing detergent composition
WO2011094357A2 (en) * 2010-01-26 2011-08-04 The Regents Of The University Of Colorado Conjugates utilizing platform technology for stimulating immune response
JP5819684B2 (ja) * 2010-11-24 2015-11-24 花王株式会社 硬質表面用液体洗浄剤組成物
JP5819685B2 (ja) * 2010-11-24 2015-11-24 花王株式会社 硬質表面用液体洗浄剤組成物
EP3672408B1 (en) * 2017-08-25 2021-10-13 Unilever Global IP Limited An antimicrobial composition
KR20220130101A (ko) 2019-11-27 2022-09-26 로레알 모발 트리트먼트 조성물, 키트, 및 사용 방법

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE795238A (fr) 1972-02-09 1973-08-09 Schering Ag Derives d'insuline reticules de maniere intramoleculaire, leur procede de preparation et leur utilisation
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
DE2631656C2 (de) 1976-07-14 1983-02-10 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung eines Hydroxysuccinimidoester-Derivats zur Bindung von biologisch aktiven Proteinen aneinander und/oder an flüssige oder feste Trägerstoffe
EP0006638B1 (en) 1978-07-04 1984-04-18 Novo Nordisk A/S Microbial protease preparation suitable for admixture to washing compositions and process for preparing it
US4556554A (en) 1981-06-01 1985-12-03 Germaine Monteil Cosmetiques Corp. Immobilized enzymes
US4760025A (en) 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US4732863A (en) 1984-12-31 1988-03-22 University Of New Mexico PEG-modified antibody with reduced affinity for cell surface Fc receptors
US4844897A (en) 1985-09-13 1989-07-04 Hiroshi Maeda Anti-tumor protease preparations
WO1987004461A1 (en) 1986-01-15 1987-07-30 Amgen THERMALLY STABLE AND pH STABLE SUBTILISIN ANALOGS AND METHOD FOR PRODUCTION THEREOF
US4980288A (en) 1986-02-12 1990-12-25 Genex Corporation Subtilisin with increased thermal stability
SG30639G (en) 1986-04-30 1995-09-01 Genencor Int Non-human carbonyl hydrolase mutants DNA sequences and vectors encoding same and hosts transformed with said vectors
US4853871A (en) 1987-04-06 1989-08-01 Genex Corporation Computer-based method for designing stablized proteins
US4914031A (en) 1987-04-10 1990-04-03 Amgen, Inc. Subtilisin analogs
US5543302A (en) 1988-05-27 1996-08-06 Solvay Enzymes, Inc. Proteases of altered stability to autolytic degradation
JPH02219571A (ja) 1989-02-20 1990-09-03 Kanebo Ltd 修飾プロテアーゼ及びその製造法
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5324844A (en) 1989-04-19 1994-06-28 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
BR9006827A (pt) 1989-06-26 1991-08-06 Unilever Nv Composicoes detergentes enzimaticas
US5658871A (en) 1989-07-07 1997-08-19 Lever Brothers Company, Division Of Conopco, Inc. Microbial lipase muteins and detergent compositions comprising same
DK97190D0 (da) 1990-04-19 1990-04-19 Novo Nordisk As Oxidationsstabile detergentenzymer
US5230891A (en) 1990-08-20 1993-07-27 Kanebo Limited Modified protease, method of producing the same and cosmetic products containing the modified protease
US5133968A (en) 1990-08-20 1992-07-28 Kanebo, Ltd. Modified protease, method of producing the same and cosmetic products containing the modified protease
BR9107206A (pt) 1990-12-05 1993-11-03 Novo Nordisk As Processo para produzir uma variante de proteina que evoca uma resposta imunogenica diminuida em animais,produtos obtidos,composicao e uso
ES2090481T3 (es) 1991-05-01 1996-10-16 Unilever Nv Composiciones detergentes que contienen enzimas estabilizadas.
US5414135A (en) 1991-12-30 1995-05-09 Sterling Winthrop Inc. Vinyl sulfone coupling of polyoxyalkylenes to proteins
IT1260468B (it) 1992-01-29 1996-04-09 Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole
GB9207288D0 (en) 1992-04-02 1992-05-13 Unilever Plc Cosmetic composition
GB9207280D0 (en) 1992-04-02 1992-05-13 Unilever Plc Skin care method and composition
WO1994004193A1 (en) 1992-08-21 1994-03-03 Enzon, Inc. Novel attachment of polyalkylene oxides to bio-effecting substances
CA2101361A1 (en) 1992-08-27 1994-02-28 Robert A. Snow Low diol polyalkylene oxide biologically active proteinaceous substances
US5567601A (en) 1993-06-01 1996-10-22 University Of Maryland Subtilisin mutants lacking a primary calcium binding site
US6436690B1 (en) 1993-09-15 2002-08-20 The Procter & Gamble Company BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted
MA23346A1 (fr) 1993-10-14 1995-04-01 Genencor Int Variantes de la subtilisine
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
ZA952220B (en) 1994-05-02 1995-12-14 Procter & Gamble Bpn' variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted
US5629384A (en) 1994-05-17 1997-05-13 Consiglio Nazionale Delle Ricerche Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
AU3924095A (en) 1994-11-24 1996-06-17 Novo Nordisk A/S A process for producing polypeptides with reduced allergenicity
CA2206852A1 (en) 1994-12-07 1996-06-13 Novo Nordisk A/S Polypeptide with reduced allergenicity
EP0816381B1 (en) 1995-03-10 2004-01-14 NAKAMURA, Toshikazu Polyethylene glycol modified hepatocyte growth factor (hgf)
WO1996040792A1 (en) 1995-06-07 1996-12-19 Novo Nordisk A/S Modification of polypeptides
AU5893696A (en) 1995-06-07 1996-12-30 Novo Nordisk A/S Modification of polypeptides
DE19530816A1 (de) 1995-08-23 1997-02-27 Cognis Bio Umwelt Verwendung von mutierter Subtilisin-Protease in kosmetischen Produkten
WO1997024421A2 (en) 1995-12-29 1997-07-10 The Procter & Gamble Company Detergent compositions comprising immobilized enzymes
WO1997024427A1 (en) 1995-12-29 1997-07-10 The Procter & Gamble Company Detergent compositions comprising immobilized enzymes
WO1997030148A1 (en) 1996-02-15 1997-08-21 Novo Nordisk A/S Conjugation of polypeptides
US6946280B1 (en) 1996-03-29 2005-09-20 Genencor International, Inc. Enzyme multimer and process of producing same
DK0942962T3 (da) 1996-11-26 2007-05-07 Genencor Int Kemisk modificerede enzymer
CN1253585A (zh) 1997-01-10 2000-05-17 诺沃挪第克公司 一种用于皮肤护理的被修饰酶
AU740207B2 (en) 1997-02-06 2001-11-01 Novozymes A/S Polypeptide-polymer conjugates having added and/or removed attachment groups
WO1999000489A1 (en) 1997-06-25 1999-01-07 Novo Nordisk A/S A modified polypeptide
US6284246B1 (en) * 1997-07-30 2001-09-04 The Procter & Gamble Co. Modified polypeptides with high activity and reduced allergenicity
DK1047445T3 (da) 1998-01-23 2013-11-11 Univ Toronto Modificerede enzymer og anvendelse heraf til peptidsyntese
US6495136B1 (en) 1998-03-26 2002-12-17 The Procter & Gamble Company Proteases having modified amino acid sequences conjugated to addition moieties
WO1999049056A1 (en) 1998-03-26 1999-09-30 The Procter & Gamble Company Serine protease variants having amino acid substitutions
EP1129180B1 (en) 1998-11-10 2009-06-10 The Governing Council Of The University Of Toronto Chemically modified mutant serine hydrolases
JP2002533087A (ja) 1998-12-21 2002-10-08 ジェネンカー インターナショナル,インコーポレイティド 複数荷電変種を有する化学修飾酵素

Also Published As

Publication number Publication date
AU2742399A (en) 1999-10-18
JP3642735B2 (ja) 2005-04-27
CN1163507C (zh) 2004-08-25
WO1999048918A1 (en) 1999-09-30
CN1301270A (zh) 2001-06-27
KR20010034685A (ko) 2001-04-25
CA2324506A1 (en) 1999-09-30
US6495136B1 (en) 2002-12-17
EP1068228A1 (en) 2001-01-17
JP2002507626A (ja) 2002-03-12

Similar Documents

Publication Publication Date Title
BR9909129A (pt) Conjugados de proteases
KR970020098A (ko) 항스트레스 조성물
BR0108713A (pt) Expressão hìbrida de proteìnas de neisseria
ATE490311T1 (de) Mutanten der alpha-amylase
ES2125477T3 (es) Composicion detergente lavavajillas concentrada, liquida o gelificada, que contiene xileno-sulfonato de calcio.
ATE219657T1 (de) Nasale lösungen
BR9909130A (pt) Variantes de protease de serina tendo substituições de amino-ácido
ES2178036T3 (es) Derivados de ciclosporina, su preparacion y las composiciones farmaceuticas que le contienen.
BR9407502A (pt) Variantes subtilisina bpn com adsorção diminuída e hidrólise aumentada
BR0011030A (pt) Composições de cicloporina substancialmente livre de óleo
BR9913617A (pt) Composições de reologia modificada e seus processos
BR0012660A (pt) Variante de protease tipo subtilisina; composição de limpeza; e composição de cuidado pessoal
TR200002078T2 (tr) Sentetik polisakkaridler, hazırlanmaları için proses ve bunları içeren farmasötik kompozisyonlar.
PT830130E (pt) Enzima de conversao de tnf-alfa
KR970032795A (ko) 요산 및 요산 분해 효소의 유효 함량을 함유하는 화장용 및 피부 관리용 조성물
BR0012693A (pt) Variante, de protease tipo subtilisina; composição de limpeza; e composição de cuidado pessoal
TR199800934T2 (xx) Enzimatik deterjan bile�imleri.
BR0012694A (pt) Conjugado de protease, composição de limpeza e composição de tratamento pessoal
EA200000242A1 (ru) Применение фанхинона для лечения болезни альцгеймера
PT1107793E (pt) Conjugados de dextrano-leptina, composicoes farmaceuticas e processos relacionados
DK0865271T3 (da) Stabiliserede solbeskyttelsespræparater
CA2047802A1 (en) Pharmaceutical compositions
EP1064296A4 (en) THERMOSTABLE DNA POLYMERASE FROM THERMOANAEROBACTER THERMOHYDROSULFURICUS
BR9814188A (pt) "agonistas de 5-ht1f"
BR9912519A (pt) Variantes estabilizadas de inibidor de subtilisina de streptomyces

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTA A 6O, 7O E 8O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.