BR9908797A - Aperfeiçoamento na sìntese enzimática de aminas quirais e método de preparação de (s)-1- metoxi-2-aminopropano - Google Patents

Aperfeiçoamento na sìntese enzimática de aminas quirais e método de preparação de (s)-1- metoxi-2-aminopropano

Info

Publication number
BR9908797A
BR9908797A BR9908797-9A BR9908797A BR9908797A BR 9908797 A BR9908797 A BR 9908797A BR 9908797 A BR9908797 A BR 9908797A BR 9908797 A BR9908797 A BR 9908797A
Authority
BR
Brazil
Prior art keywords
aminopropane
methoxy
improvement
enzymatic synthesis
preparing
Prior art date
Application number
BR9908797-9A
Other languages
English (en)
Inventor
Wei Wu
Mohit B Bhatia
Craig M Lewis
Wei Lang
Alice Wang
George W Matcham
Original Assignee
Celgro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgro filed Critical Celgro
Publication of BR9908797A publication Critical patent/BR9908797A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

<B>"APERFEIçOAMENTO NA SìNTESE ENZIMáTICA DE AMINAS QUIRAIS"<D>. O 2-aminopropano é usado como o doador amino na síntese estereoseletiva de uma amina quiral a partir de uma cetona com uma transaminase. Numa forma típica de realização, o (S)-1-metoxi-2-aminopropano é preparado pondo-se metoxiacetona em contato com uma transaminase na presença de 2-aminopropano como um doador amino até que uma quantidade substancial de metoxiacetona seja convertida em (S)-1-metoxi-2-aminopropano e o 2-aminopropano seja convertido em acetona. Numa segunda forma de realização, a L-alanina é preparada pondo-se ácido pirúvico em contato com uma transaminase na presença de 2-aminopropano como um doador amino.
BR9908797-9A 1998-03-11 1999-03-10 Aperfeiçoamento na sìntese enzimática de aminas quirais e método de preparação de (s)-1- metoxi-2-aminopropano BR9908797A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7752098P 1998-03-11 1998-03-11
PCT/US1999/005150 WO1999046398A1 (en) 1998-03-11 1999-03-10 Improvements in the enzymatic synthesis of chiral amines

Publications (1)

Publication Number Publication Date
BR9908797A true BR9908797A (pt) 2000-12-12

Family

ID=22138554

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9908797-9A BR9908797A (pt) 1998-03-11 1999-03-10 Aperfeiçoamento na sìntese enzimática de aminas quirais e método de preparação de (s)-1- metoxi-2-aminopropano

Country Status (24)

Country Link
EP (1) EP1075534B8 (pt)
JP (1) JP2002505884A (pt)
KR (1) KR20010034561A (pt)
CN (1) CN1154746C (pt)
AT (1) ATE295424T1 (pt)
AU (1) AU753904B2 (pt)
BR (1) BR9908797A (pt)
CA (1) CA2322605A1 (pt)
CZ (1) CZ295882B6 (pt)
DE (1) DE69925267T2 (pt)
ES (1) ES2243051T3 (pt)
FI (1) FI20001805A (pt)
HK (1) HK1035000A1 (pt)
HU (1) HUP0101056A3 (pt)
MX (1) MXPA00008573A (pt)
NO (1) NO319671B1 (pt)
NZ (1) NZ506405A (pt)
PL (1) PL342882A1 (pt)
PT (1) PT1075534E (pt)
RU (1) RU2213142C2 (pt)
SK (1) SK284352B6 (pt)
TR (1) TR200002604T2 (pt)
UA (1) UA64784C2 (pt)
WO (1) WO1999046398A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60013939T2 (de) 1999-03-19 2005-10-06 Sumitomo Chemical Co. Ltd. Stereoselektive Transaminase, deren kodierende Gen und deren Verwendungen
JP2001190298A (ja) * 2000-01-13 2001-07-17 Kanegafuchi Chem Ind Co Ltd 光学活性ｎ−メチルアミノ酸の製造方法
EP1818411A1 (en) * 2006-02-13 2007-08-15 Lonza AG Process for the preparation of optically active chiral amines
DE102007042600A1 (de) 2007-09-07 2009-03-12 Evonik Degussa Gmbh Verfahren zur Herstellung von enantiomerenangereichten Aminen
CN102341494B (zh) 2009-01-08 2014-10-15 科德克希思公司 转氨酶多肽
JP5707344B2 (ja) 2009-02-26 2015-04-30 コデクシス， インコーポレイテッド トランスアミナーゼ生体触媒
SG177329A1 (en) 2009-06-22 2012-02-28 Codexis Inc Transaminase reactions
MX2012002561A (es) * 2009-09-02 2012-04-10 Lonza Ag Un proceso para la identificacion y preparacion de una omega-transaminasa (r)-especifica.
US8852900B2 (en) 2010-06-17 2014-10-07 Codexis, Inc. Biocatalysts and methods for the synthesis of (S)-3-(1-aminoethyl)-phenol
US8932836B2 (en) 2010-08-16 2015-01-13 Codexis, Inc. Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
WO2013024453A1 (en) * 2011-08-16 2013-02-21 Embio Limited Enzymatic synthesis of optically active chiral amines
CN104630170A (zh) * 2013-11-08 2015-05-20 中国科学院天津工业生物技术研究所 一种来源于里氏木霉的新(r)-转氨酶及其应用
CN114134126B (zh) * 2021-10-28 2023-12-05 浙江大学杭州国际科创中心 转氨酶及其突变体在制备(s)-1-甲氧基-2-丙胺中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300437A (en) * 1989-06-22 1994-04-05 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
EP0857790B1 (en) * 1995-10-23 2005-08-17 Kaneka Corporation Process for producing optically active amino compounds

Also Published As

Publication number Publication date
KR20010034561A (ko) 2001-04-25
SK284352B6 (sk) 2005-02-04
UA64784C2 (en) 2004-03-15
EP1075534A4 (en) 2003-07-09
ES2243051T3 (es) 2005-11-16
HUP0101056A2 (hu) 2001-07-30
WO1999046398A1 (en) 1999-09-16
DE69925267T2 (de) 2006-01-26
NZ506405A (en) 2003-08-29
TR200002604T2 (tr) 2000-11-21
CZ20003177A3 (cs) 2000-12-13
EP1075534B8 (en) 2005-07-06
ATE295424T1 (de) 2005-05-15
EP1075534B1 (en) 2005-05-11
NO20004036D0 (no) 2000-08-11
SK13382000A3 (sk) 2001-05-10
HUP0101056A3 (en) 2006-03-28
NO319671B1 (no) 2005-09-05
CN1154746C (zh) 2004-06-23
EP1075534A1 (en) 2001-02-14
NO20004036L (no) 2000-10-27
HK1035000A1 (en) 2001-11-09
FI20001805A (fi) 2000-08-15
CZ295882B6 (cs) 2005-11-16
RU2213142C2 (ru) 2003-09-27
AU2993899A (en) 1999-09-27
JP2002505884A (ja) 2002-02-26
PT1075534E (pt) 2005-09-30
MXPA00008573A (es) 2003-07-14
CN1292828A (zh) 2001-04-25
PL342882A1 (en) 2001-07-16
DE69925267D1 (de) 2005-06-16
AU753904B2 (en) 2002-10-31
CA2322605A1 (en) 1999-09-16

Similar Documents

Publication Publication Date Title
BR9908797A (pt) Aperfeiçoamento na sìntese enzimática de aminas quirais e método de preparação de (s)-1- metoxi-2-aminopropano
ATE456648T1 (de) Verfahren zur herstellung von l-aminosäure
ES2084618T3 (es) Enriquecimiento enantiomerico y sintesis estereoselectiva de aminas quirales.
DE60231708D1 (de) Somatische pluripotente Zellen
BR9811971A (pt) Processo para a preparação de glufosinato e de produtos intermediários para ele
NZ515673A (en) Compositions and methods for labeling of nucleic acid molecules
DK0870051T3 (da) Fremstilling af ammoniumacrylat
BRPI9814894A (pt) processo para a preparação de ácidos 8-metóxi-quinolonocarboxílicos.
BR0000897A (pt) Processo para a produção fermentativa de l-aminoácidos usando-se bactéria corineforme
BR9914731A (pt) Processo para a obtenção de gama-decalactona
RU2000125535A (ru) Усовершенствования ферментативного синтеза хиральных аминов
BR9912016A (pt) Processo de hidrólise do 2-hidróxi 4-metiltiobutironitrilo com ácido sulfúrico
FI880151A0 (fi) -glutamyylitranspeptidaasin käyttö glutaryyli-7-amino- tai -ketoadipinyylikefalosporaanihapon entsymaattiseen hydrolysointiin
DK461985A (da) Fremgangsmaade til enzymatisk hydrolyse af d-alfa-aminosyreamider
BR0012572A (pt) Processo para produção de l-aminoácidos de seus derivados racêmicos de n-acetil-d, l por dissociação de racemato enzimática por meio de enzimas isoladas, recombinantes
PT1082291E (pt) Processo quimico para a sintese estereosselectiva de r-(-)-carnitina
ES2085487T3 (es) Un procedimiento para la preparacion de acidos 2-alcanoicos enantiomericos.
BR9814161A (pt) Método de sìntese de pirrolamidas
BR9808554A (pt) Esterase do ácido fenólico e o uso da mesma
BR9911378A (pt) Processo para fabricar um pó antiperspirante.
BR9811342A (pt) Processo para inibir a corrosão de metais em contato com uma solução aquosa de alcanolamina, solução aquosa para remoção de gás ácido, e, composição para inibir a corrosão de metais em contato com uma solução aquosa de alcanolamina
ATE91711T1 (de) Verfahren zur enzymatischen hydrolyse von alpha- aminoadipinyl-monoaminoverbindungen.
BR0016710A (pt) Pó de bisfenol fluidizado
BR0004366A (pt) Processo para melhorar a adesão entre um revestimento e uma membrana de borracha de epdm
BR9811603A (pt) Processo para preparar 3-isocromanona

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 1986 DE 27/01/2009.

B15G Petition not considered as such [chapter 15.7 patent gazette]

Free format text: NAO CONHECIDA PETICAO 018100003519 DE 03/02/2010 EM VIRTUDE DO DISPOSTO NO ARTIGO 219, INCISO II, DA LPI.