BR9908428A - Sais de nitrato, composições, uso de sal e composição, e, processo para preparação de sais de nitrato - Google Patents
Sais de nitrato, composições, uso de sal e composição, e, processo para preparação de sais de nitratoInfo
- Publication number
- BR9908428A BR9908428A BR9908428-7A BR9908428A BR9908428A BR 9908428 A BR9908428 A BR 9908428A BR 9908428 A BR9908428 A BR 9908428A BR 9908428 A BR9908428 A BR 9908428A
- Authority
- BR
- Brazil
- Prior art keywords
- nitrate salts
- compositions
- salt
- preparing
- composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 150000002823 nitrates Chemical class 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- -1 NITRATE SALTS Chemical class 0.000 abstract 1
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N nitrate group Chemical group [N+](=O)([O-])[O-] NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"SAIS DE NITRATO, COMPOSIçõES, USO DE SAL E COMPOSIçãO, E, PROCESSO PARA PREPARAçãO DE SAIS DE NITRATO" Composições de sal de nitrato com medicamentos contra úlcera tendo fórmula (A) e (B): onde para os compostos de classe (A): R = H, OCH~ 3~, OCHF~ 2~; R~ 1~ = CH~ 3~, OCH~ 3~; R~ 2~ = H, CH~ 3~; R~ 3~ = CH~ 3~, CH~ 2~-CF~ 3~, (CH~ 2~)~ 3~-OCH~ 3~; em que para compostos da classe B: R^ I^~ 3~, R^ I^~ 4~ iguais ou diferentes um do outro, são respectivamente valência livre, hidrogênio, (1), CH~ 2~-N(CH~ 3~)~ 2~-, Y = S, N-R^ I^~ 6~, C R^ I^~ 7~ R^ I^~ 8~; X = O, S, N- R^ I^~ 1~; R^ I^~ 2~= H, CH~ 3~; n = 0, 1; Z = N-CN, N- SO~ 2~NH~ 2~, CH-NO~ 2~ ou fórmula (VII~ A~): R^ I^~ 5~ = H, -NH - CH~ 3~, NH~ 2~; R^ I^~ 6~, R^ I^~ 7~, R^ I^~ 8~, R^ I^~ 1~ iguais ou diferentes um do outro, são hidrogênio, valência livre. A invenção também compreende os processos para preparação dos sais acima.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98MI000442A IT1299198B1 (it) | 1998-03-05 | 1998-03-05 | Sali nitrati di farmaci antiulcera |
| PCT/EP1999/001226 WO1999045004A1 (en) | 1998-03-05 | 1999-02-25 | Nitrate salt of anti-ulcer medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9908428A true BR9908428A (pt) | 2000-10-31 |
Family
ID=11379185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9908428-7A BR9908428A (pt) | 1998-03-05 | 1999-02-25 | Sais de nitrato, composições, uso de sal e composição, e, processo para preparação de sais de nitrato |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6503929B1 (pt) |
| EP (1) | EP1068196B1 (pt) |
| JP (1) | JP2002505328A (pt) |
| KR (1) | KR20010041522A (pt) |
| CN (1) | CN1249053C (pt) |
| AT (1) | ATE273297T1 (pt) |
| AU (1) | AU752919B2 (pt) |
| BR (1) | BR9908428A (pt) |
| CA (1) | CA2322493A1 (pt) |
| DE (1) | DE69919341T2 (pt) |
| DK (1) | DK1068196T3 (pt) |
| ES (1) | ES2226357T3 (pt) |
| HU (1) | HUP0100853A3 (pt) |
| IL (1) | IL137721A0 (pt) |
| IT (1) | IT1299198B1 (pt) |
| PT (1) | PT1068196E (pt) |
| RU (1) | RU2228331C2 (pt) |
| SI (1) | SI1068196T1 (pt) |
| WO (1) | WO1999045004A1 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| AU772188B2 (en) | 1998-11-17 | 2004-04-08 | Nitromed, Inc. | Nitrosated and nitrosylated H2 receptor antagonist compounds, compositions and methods of use |
| US6852739B1 (en) | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
| EP1246621A4 (en) | 1999-12-23 | 2004-11-24 | Nitromed Inc | NITROSED AND NITROSYLATED CYCLOOXYGENASE-2 INHIBITORS, COMPOSITIONS AND METHODS FOR THEIR USE |
| IT1317735B1 (it) * | 2000-01-26 | 2003-07-15 | Nicox Sa | Sali di agenti antimicrobici. |
| SE0002476D0 (sv) | 2000-06-30 | 2000-06-30 | Astrazeneca Ab | New compounds |
| JP4092203B2 (ja) | 2000-12-21 | 2008-05-28 | ニトロメッド，インク． | 新規のシクロオキシゲナーゼ２選択的阻害剤としての置換アリール化合物、組成物、および使用方法 |
| US7129161B2 (en) * | 2001-07-19 | 2006-10-31 | Trikon Holdings Limited | Depositing a tantalum film |
| EP1539134A4 (en) | 2002-06-11 | 2007-04-11 | Nitromed Inc | SELECTIVE INHIBITORS OF CYCLOOXIGENASE-2 NITROSIS AND / OR NITROSYLES, COMPOSITIONS AND METHODS OF USE |
| CA2491127A1 (en) | 2002-07-03 | 2004-01-15 | Nitromed, Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| CA2493156A1 (en) | 2002-07-29 | 2004-02-05 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| JP4634144B2 (ja) * | 2002-08-01 | 2011-02-16 | ニコックス エスエー | ニトロソ化プロトンポンプ阻害剤、組成物および使用方法 |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1397436A (en) * | 1972-09-05 | 1975-06-11 | Smith Kline French Lab | Heterocyclic n-cyanoguinidines |
| SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| US4375547A (en) | 1980-10-02 | 1983-03-01 | Eli Lilly And Company | N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine |
| EP0224612A1 (de) * | 1985-12-05 | 1987-06-10 | HEUMANN PHARMA GMBH & CO | Verfahren zur Herstellung von N-Cyano-N'-methyl-N"[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidin |
| EP0285681B1 (de) * | 1987-04-06 | 1993-03-10 | HEUMANN PHARMA GMBH & CO | Verfahren zur Herstellung von Nitroethenderivaten |
-
1998
- 1998-03-05 IT IT98MI000442A patent/IT1299198B1/it active IP Right Grant
-
1999
- 1999-02-25 DE DE69919341T patent/DE69919341T2/de not_active Expired - Fee Related
- 1999-02-25 HU HU0100853A patent/HUP0100853A3/hu unknown
- 1999-02-25 DK DK99911708T patent/DK1068196T3/da active
- 1999-02-25 CN CNB998035343A patent/CN1249053C/zh not_active Expired - Fee Related
- 1999-02-25 US US09/622,068 patent/US6503929B1/en not_active Expired - Fee Related
- 1999-02-25 JP JP2000534547A patent/JP2002505328A/ja not_active Withdrawn
- 1999-02-25 WO PCT/EP1999/001226 patent/WO1999045004A1/en active IP Right Grant
- 1999-02-25 KR KR1020007009693A patent/KR20010041522A/ko active IP Right Grant
- 1999-02-25 CA CA002322493A patent/CA2322493A1/en not_active Abandoned
- 1999-02-25 ES ES99911708T patent/ES2226357T3/es not_active Expired - Lifetime
- 1999-02-25 IL IL13772199A patent/IL137721A0/xx unknown
- 1999-02-25 PT PT99911708T patent/PT1068196E/pt unknown
- 1999-02-25 AT AT99911708T patent/ATE273297T1/de not_active IP Right Cessation
- 1999-02-25 RU RU2000122968/04A patent/RU2228331C2/ru not_active IP Right Cessation
- 1999-02-25 AU AU30303/99A patent/AU752919B2/en not_active Ceased
- 1999-02-25 BR BR9908428-7A patent/BR9908428A/pt not_active Application Discontinuation
- 1999-02-25 EP EP99911708A patent/EP1068196B1/en not_active Expired - Lifetime
- 1999-02-25 SI SI9930655T patent/SI1068196T1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE273297T1 (de) | 2004-08-15 |
| JP2002505328A (ja) | 2002-02-19 |
| RU2228331C2 (ru) | 2004-05-10 |
| KR20010041522A (ko) | 2001-05-25 |
| HUP0100853A3 (en) | 2003-01-28 |
| IL137721A0 (en) | 2001-10-31 |
| EP1068196B1 (en) | 2004-08-11 |
| ITMI980442A1 (it) | 1999-09-05 |
| SI1068196T1 (en) | 2004-12-31 |
| US6503929B1 (en) | 2003-01-07 |
| CN1249053C (zh) | 2006-04-05 |
| CN1291982A (zh) | 2001-04-18 |
| AU752919B2 (en) | 2002-10-03 |
| EP1068196A1 (en) | 2001-01-17 |
| DE69919341D1 (de) | 2004-09-16 |
| ES2226357T3 (es) | 2005-03-16 |
| CA2322493A1 (en) | 1999-09-10 |
| HUP0100853A2 (hu) | 2001-10-28 |
| DK1068196T3 (da) | 2004-11-29 |
| WO1999045004A1 (en) | 1999-09-10 |
| AU3030399A (en) | 1999-09-20 |
| PT1068196E (pt) | 2004-10-29 |
| DE69919341T2 (de) | 2005-09-08 |
| IT1299198B1 (it) | 2000-02-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25G | Requested change of headquarter approved |
Owner name: NICOX S.A. (FR) Free format text: ANOTADAS AS ALTERACOES DE SEDE CONFORME SOLICITADO NA PETICAO NO 020050046572/RJ DE 06/06/2005. |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI |