BR9902019A - Moléculas de polinucleotìdios que codificam proteìnas de neospora. - Google Patents
Moléculas de polinucleotìdios que codificam proteìnas de neospora.Info
- Publication number
- BR9902019A BR9902019A BR9902019-0A BR9902019A BR9902019A BR 9902019 A BR9902019 A BR 9902019A BR 9902019 A BR9902019 A BR 9902019A BR 9902019 A BR9902019 A BR 9902019A
- Authority
- BR
- Brazil
- Prior art keywords
- polynucleotide molecules
- neospora
- present
- proteins
- encode
- Prior art date
Links
- 108091033319 polynucleotide Proteins 0.000 title abstract 5
- 239000002157 polynucleotide Substances 0.000 title abstract 5
- 102000040430 polynucleotide Human genes 0.000 title abstract 5
- 241001147660 Neospora Species 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 101150010973 GRA1 gene Proteins 0.000 abstract 2
- 102100024017 Glycerol-3-phosphate acyltransferase 3 Human genes 0.000 abstract 2
- 101000904259 Homo sapiens Glycerol-3-phosphate acyltransferase 3 Proteins 0.000 abstract 2
- 241001147662 Neospora caninum Species 0.000 abstract 2
- 101100056797 Canis lupus familiaris SAG gene Proteins 0.000 abstract 1
- 101150073248 GRA2 gene Proteins 0.000 abstract 1
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 abstract 1
- 101000692878 Homo sapiens Regulator of MON1-CCZ1 complex Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 102100026436 Regulator of MON1-CCZ1 complex Human genes 0.000 abstract 1
- 101100532512 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) SAG1 gene Proteins 0.000 abstract 1
- 230000002457 bidirectional effect Effects 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
patente de Invenção: <B>"MOLéCULAS DE POLINUCLEOTìDIOS QUE CODIFICAM PROTEìNAS DE NEOSPORA"<D>. A presente invenção provê moléculas polinucleotídicas isoladas compreendendo seq³ências de nucleotídeos que codificam proteínas GRA1, GRA2, SAG1, MIC1, e MAG1 de Neospora caninum, bem como vetores recombinantes, células hospedeiras transformadas e proteínas expressas de forma recombinante. A presente invenção provê ainda uma molécula polinucleotídica que compreende a seq³ência de nucleotídeos do promotor bidirecional GRA1/MAG1 de N. caninum. A presente invenção provê ainda construções genéticas baseadas nas moléculas polinucleotídicas da presente invenção que são úteis na preparação de células de estirpes modificadas de Neospora para utilização em vacinas contra a neosporose.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7938998P | 1998-03-26 | 1998-03-26 | |
US11228298P | 1998-12-15 | 1998-12-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9902019A true BR9902019A (pt) | 2000-05-02 |
Family
ID=26761953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9902019-0A BR9902019A (pt) | 1998-03-26 | 1999-03-26 | Moléculas de polinucleotìdios que codificam proteìnas de neospora. |
Country Status (9)
Country | Link |
---|---|
US (2) | US6600027B1 (pt) |
EP (1) | EP0953641A3 (pt) |
JP (5) | JPH11332583A (pt) |
CN (1) | CN1232087A (pt) |
AR (1) | AR015252A1 (pt) |
AU (1) | AU759103B2 (pt) |
BR (1) | BR9902019A (pt) |
CA (1) | CA2264260A1 (pt) |
NZ (1) | NZ334839A (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0953641A3 (en) * | 1998-03-26 | 2002-03-13 | Pfizer Products Inc. | Polynucleotide molecules encoding neospora proteins |
ES2263317B2 (es) * | 2003-12-04 | 2007-10-01 | Universidad Complutense De Madrid | Uso del gen ncsag4 para el diagnostico y prevencion de la neosporosis, y como marcador para el analisis de la patogenia. |
EP1742659B1 (en) * | 2004-04-05 | 2013-03-13 | Pah Usa 15 Llc | Microfluidized oil-in-water emulsions and vaccine compositions |
ES2319242B1 (es) | 2005-12-23 | 2009-12-01 | Laboratorios Hipra, S.A. | Aislado avirulento de neospora canimum y sus usos. |
ES2326770B1 (es) | 2007-07-13 | 2010-07-26 | Universidad Complutense De Madrid | Uso de un nuevo aislado de neospora caninum para el desarrollo de pruebas de diagnostico y para la fabricacion de productos para el tratamiento y prevencion de la infenccion causada por neospora. |
WO2009156960A2 (en) * | 2008-06-27 | 2009-12-30 | Pfizer Inc. | Novel adjuvant compositions |
CN101831495B (zh) * | 2010-04-30 | 2013-06-19 | 新疆出入境检验检疫局检验检疫技术中心 | 一种牛新孢子虫病的检测方法及应用 |
CN104411338A (zh) * | 2012-04-02 | 2015-03-11 | 现代治疗公司 | 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸 |
FR2994193B1 (fr) | 2012-08-02 | 2016-05-20 | Vitamfero | Souches mutantes de neospora et leurs utilisations |
CN102838984B (zh) * | 2012-09-12 | 2014-06-04 | 浙江理工大学 | 一种胰凝乳蛋白酶保护金纳米团簇荧光材料的制备方法 |
CN107325166A (zh) * | 2017-05-15 | 2017-11-07 | 华中农业大学 | 柔嫩艾美耳球虫表面抗原基因sag6所编码的重组蛋白及其应用 |
CN110407944B (zh) * | 2018-04-29 | 2023-04-21 | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | 隐孢子虫多表位基因片段cpmcef及其融合蛋白和应用 |
CN110183527B (zh) * | 2019-05-21 | 2021-03-12 | 中国农业大学 | 一种新孢子虫NcMIC26抗原及其应用 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3940598A1 (de) * | 1989-12-08 | 1991-06-13 | Behringwerke Ag | Toxoplasma gondii-antigene, ihre herstellung und ihre verwendung |
FR2625099B1 (fr) * | 1987-12-24 | 1991-06-14 | Transgene Sa | Proteines et leur procede de preparation, sequences d'adn, anticorps et leur application, poxvirus, cellules transformees ou infectees et compositions pharmaceutiques utiles dans la prevention de la toxoplasmose |
US5665542A (en) * | 1989-11-03 | 1997-09-09 | Research Institute Of Palo Alto Medical Foundation | Toxoplasma gondii P28 gene and methods for its use |
FR2692282B1 (fr) * | 1992-06-15 | 1995-07-13 | Pasteur Institut | Clonage du gene codant pour la proteine gp28.5 de t. gondii; fragments peptidiques issus de ladite proteine et leurs applications. |
US5643718A (en) | 1993-11-04 | 1997-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Transfection and genetic manipulations in obligate intracellular parasites |
US5976553A (en) | 1993-11-04 | 1999-11-02 | The Board Of Trustees Of The Leland Stanford Junior University | Transfection and genetic manipulations in obligate intracellular parasites |
FR2714074B1 (fr) * | 1993-12-20 | 1996-03-01 | Pasteur Institut | Promoteurs des gènes GRA1, GRA2, GRA5 et GRA6 de toxoplasma gondii et vecteurs d'expression comprenant lesdits promoteurs. |
US5707617A (en) | 1994-03-21 | 1998-01-13 | The Regents Of The University Of California | Bovine neospora isolates |
US5889166A (en) | 1996-05-10 | 1999-03-30 | The Regents Of The University Of California | Recombinant neospora antigens and their uses |
WO1997017082A1 (en) | 1995-11-09 | 1997-05-15 | Trustees Of Dartmouth College | A vaccine against toxoplasma gondii |
US6476192B1 (en) * | 1996-04-15 | 2002-11-05 | Nicola C. Lally | Recombinant antigens useful for the serodiagnosis of neosporosis |
AUPO188396A0 (en) * | 1996-08-26 | 1996-09-19 | Insearch Limited | Detection of protozoan parasites |
DK0841392T3 (da) * | 1996-11-12 | 2004-11-22 | Pfizer | Svækket levende Neospora vaccine |
AUPO690397A0 (en) | 1997-05-20 | 1997-06-12 | Insearch Limited | Large subunit ribosomal dna of neospora species |
BR9803232A (pt) * | 1997-08-26 | 2000-01-11 | Pfizer Prod Inc | Vaicna de neospora. |
NZ504035A (en) | 1997-10-20 | 2002-04-26 | Bayer Ag | Neospora vaccines comprising Neospora caninum antigens |
US6071737A (en) | 1998-03-16 | 2000-06-06 | The Regents Of The University Of California | Equine Neospora isolate and its uses |
EP0953641A3 (en) * | 1998-03-26 | 2002-03-13 | Pfizer Products Inc. | Polynucleotide molecules encoding neospora proteins |
AUPP371798A0 (en) | 1998-05-26 | 1998-06-18 | Insearch Limited | Parasite antigens |
US20040131633A1 (en) * | 1999-04-21 | 2004-07-08 | University Of Technology, Sydney | Parasite antigens |
-
1999
- 1999-03-09 EP EP99301746A patent/EP0953641A3/en not_active Withdrawn
- 1999-03-24 AR ARP990101308A patent/AR015252A1/es unknown
- 1999-03-24 CA CA002264260A patent/CA2264260A1/en not_active Abandoned
- 1999-03-25 NZ NZ334839A patent/NZ334839A/xx unknown
- 1999-03-25 JP JP11081833A patent/JPH11332583A/ja active Pending
- 1999-03-25 US US09/276,438 patent/US6600027B1/en not_active Expired - Fee Related
- 1999-03-26 AU AU22437/99A patent/AU759103B2/en not_active Ceased
- 1999-03-26 CN CN99104381A patent/CN1232087A/zh active Pending
- 1999-03-26 BR BR9902019-0A patent/BR9902019A/pt not_active IP Right Cessation
-
2003
- 2003-04-21 US US10/419,341 patent/US20030180785A1/en not_active Abandoned
-
2005
- 2005-04-05 JP JP2005109190A patent/JP2005211081A/ja active Pending
- 2005-04-05 JP JP2005109167A patent/JP2005245456A/ja active Pending
- 2005-04-05 JP JP2005109198A patent/JP2005211082A/ja active Pending
- 2005-04-05 JP JP2005109203A patent/JP2005253467A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2005245456A (ja) | 2005-09-15 |
AR015252A1 (es) | 2001-04-18 |
EP0953641A2 (en) | 1999-11-03 |
JP2005211082A (ja) | 2005-08-11 |
US20030180785A1 (en) | 2003-09-25 |
CN1232087A (zh) | 1999-10-20 |
AU2243799A (en) | 1999-10-07 |
JP2005253467A (ja) | 2005-09-22 |
AU759103B2 (en) | 2003-04-03 |
JP2005211081A (ja) | 2005-08-11 |
EP0953641A3 (en) | 2002-03-13 |
NZ334839A (en) | 2000-08-25 |
JPH11332583A (ja) | 1999-12-07 |
CA2264260A1 (en) | 1999-09-26 |
US6600027B1 (en) | 2003-07-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A E 10A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 1994 DE 24/03/2009 |