BR9815166A - "método de inibição da replicação de vìrus, composto, método de inibição da replicação de citomegalovìrus, composto antiviral, utilização de um composto, composição farmacêutica, composição farmacêutica inibidora da replicação de vìrus e de citomegalovìrus e composição farmacêutica antiviral" - Google Patents

"método de inibição da replicação de vìrus, composto, método de inibição da replicação de citomegalovìrus, composto antiviral, utilização de um composto, composição farmacêutica, composição farmacêutica inibidora da replicação de vìrus e de citomegalovìrus e composição farmacêutica antiviral"

Info

Publication number
BR9815166A
BR9815166A BR9815166-5A BR9815166A BR9815166A BR 9815166 A BR9815166 A BR 9815166A BR 9815166 A BR9815166 A BR 9815166A BR 9815166 A BR9815166 A BR 9815166A
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
compound
replication
inhibiting
antiviral
Prior art date
Application number
BR9815166-5A
Other languages
English (en)
Inventor
Jean Bedard
Robert Rando
Jean-Francois Lavallee
Guy Falardeau
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Publication of BR9815166A publication Critical patent/BR9815166A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

<B>"MéTODO DE INIBIçãO DA REPLICAçãO DE VìRUS, COMPOSTO, MéTODO DE INIBIçãO DA REPLICAçãO DE CITOMEGALOVìRUS, COMPOSTO ANTIVIRAL, UTILIZAçãO DE UM COMPOSTO, COMPOSIçãO FARMACêUTICA, COMPOSIçãO FARMACêUTICA INIBIDORA DA REPLICAçãO DE VìRUS E DE CITOMEGALOVìRUS E COMPOSIçãO FARMACêUTICA ANTIVIRAL" A presente invenção refere-se a Compostos heterocíclicos que possuem atividade antiviral. Especificamente, Compostos da fórmula (I) em que B, W, X, Y, Q, R~ 1~, R~ 2~, R~ 3~, R~ 4~ e n são conforme definido no presente, são úteis na terapia e profilaxia de infecções virais em mamíferos.
BR9815166-5A 1997-12-11 1998-12-11 "método de inibição da replicação de vìrus, composto, método de inibição da replicação de citomegalovìrus, composto antiviral, utilização de um composto, composição farmacêutica, composição farmacêutica inibidora da replicação de vìrus e de citomegalovìrus e composição farmacêutica antiviral" BR9815166A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6933197P 1997-12-11 1997-12-11
PCT/CA1998/001166 WO1999029318A1 (en) 1997-12-11 1998-12-11 Antiviral compounds

Publications (1)

Publication Number Publication Date
BR9815166A true BR9815166A (pt) 2000-10-10

Family

ID=22088259

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9815166-5A BR9815166A (pt) 1997-12-11 1998-12-11 "método de inibição da replicação de vìrus, composto, método de inibição da replicação de citomegalovìrus, composto antiviral, utilização de um composto, composição farmacêutica, composição farmacêutica inibidora da replicação de vìrus e de citomegalovìrus e composição farmacêutica antiviral"

Country Status (10)

Country Link
US (2) US6255318B1 (pt)
EP (1) EP1037633B1 (pt)
JP (1) JP2001525365A (pt)
CN (1) CN1283995A (pt)
AT (1) ATE249219T1 (pt)
AU (1) AU740745B2 (pt)
BR (1) BR9815166A (pt)
CA (1) CA2314408A1 (pt)
DE (1) DE69818094T2 (pt)
WO (1) WO1999029318A1 (pt)

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ES2259079T3 (es) 2001-01-19 2006-09-16 Smithkline Beecham Corporation Inhibidores de la actividad cinasa del receptor tie2 para tratar enfermedades angiogenicas.
WO2003077850A2 (en) * 2002-03-15 2003-09-25 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
KR100457857B1 (ko) * 2002-05-23 2004-11-18 (주) 비엔씨바이오팜 2-[2-(3-인돌릴)에틸아미노]피리딘 유도체, 그 제조방법및 이를 포함하는 항바이러스용 약학적 조성물
DE10235967B4 (de) * 2002-08-06 2005-09-08 Bayer Healthcare Ag Methode zum Identifizieren von Substanzen mit antimikrobieller Wirkung
EP1388535A1 (en) * 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylated arylcycloalkylamines and their use as pharmaceuticals
US7329664B2 (en) * 2003-07-16 2008-02-12 Neurogen Corporation Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues
JP4795022B2 (ja) * 2003-09-30 2011-10-19 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環化合物を含有する新規な抗真菌剤
CN1560035A (zh) * 2004-03-12 2005-01-05 沈阳药科大学 5－羟基吲哚－3－羧酸脂类衍生物
BRPI0514126A (pt) * 2004-08-03 2008-05-27 Serenex Inc derivados de naftiridina 2,8-dissubstituìdos
WO2007060028A1 (en) * 2004-12-31 2007-05-31 Gpc Biotech Ag Napthyridine compounds as rock inhibitors
WO2007019098A2 (en) * 2005-08-04 2007-02-15 Smithkline Beecham Corporation Hiv integrase inhibitors
TWI385169B (zh) * 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
WO2008035726A1 (fr) 2006-09-21 2008-03-27 Eisai R & D Management Co., Ltd. Dérivé de pyridine substitué par un cycle hétéroaryle, et agent antifongique le comprenant
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
CN102702185A (zh) 2007-04-27 2012-10-03 卫材R&D管理有限公司 杂环取代吡啶衍生物的盐的结晶
TW200841879A (en) 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
JP2010527367A (ja) * 2007-05-15 2010-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウロテンシンｉｉ受容体アンタゴニスト
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
US8236768B2 (en) * 2008-10-03 2012-08-07 3B Pharmaceuticals, Inc. Topical antiviral formulations
US8188119B2 (en) * 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
CN102414180A (zh) * 2009-03-02 2012-04-11 西特里斯药业公司 作为沉默调节蛋白调节剂的8-取代的喹啉及相关的类似物
JP2012176900A (ja) * 2009-06-24 2012-09-13 Eisai R & D Management Co Ltd （（ホスホノオキシ）メチル）ピリジニウム環を有するピリジン誘導体およびそれらを含有する抗真菌剤
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
EP3045452A1 (en) 2010-04-22 2016-07-20 Vertex Pharmaceuticals Inc. Process of producing cycloalkylcarboxamido-indole compounds
AU2012209373A1 (en) 2011-01-24 2013-04-11 Glaxosmithkline Llc Isoquinoline compounds and methods for treating HIV
WO2014079787A1 (en) * 2012-11-20 2014-05-30 F. Hoffmann-La Roche Ag Substituted 1,6-naphthyridines
DE102013107000A1 (de) 2013-07-03 2015-01-08 Kiekert Ag Kraftfahrzeugtürverschluss
SG11201607670XA (en) 2014-04-15 2016-10-28 Vertex Pharma Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases
US10567850B2 (en) 2016-08-26 2020-02-18 International Business Machines Corporation Hierarchical video concept tagging and indexing system for learning content orchestration
CN113039187A (zh) * 2018-11-02 2021-06-25 艾库里斯有限及两合公司 抗乙型肝炎病毒HBV的脲6,7-二氢-4H-噻唑并[5,4-c]吡啶活性剂
CN114206860A (zh) * 2019-06-07 2022-03-18 礼蓝动物保健有限公司 用于治疗体内寄生虫的双环衍生物

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Also Published As

Publication number Publication date
EP1037633B1 (en) 2003-09-10
AU740745B2 (en) 2001-11-15
US6534520B2 (en) 2003-03-18
EP1037633A1 (en) 2000-09-27
AU1657999A (en) 1999-06-28
DE69818094D1 (de) 2003-10-16
US6255318B1 (en) 2001-07-03
US20010031765A1 (en) 2001-10-18
JP2001525365A (ja) 2001-12-11
DE69818094T2 (de) 2004-07-08
WO1999029318A1 (en) 1999-06-17
ATE249219T1 (de) 2003-09-15
CA2314408A1 (en) 1999-06-17
CN1283995A (zh) 2001-02-14

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]