BR9814255A - Partìculas de transfecção - Google Patents
Partìculas de transfecçãoInfo
- Publication number
- BR9814255A BR9814255A BR9814255-0A BR9814255A BR9814255A BR 9814255 A BR9814255 A BR 9814255A BR 9814255 A BR9814255 A BR 9814255A BR 9814255 A BR9814255 A BR 9814255A
- Authority
- BR
- Brazil
- Prior art keywords
- molecules
- nucleic acid
- particles
- transfection
- release
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 6
- 238000001890 transfection Methods 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 6
- 150000007523 nucleic acids Chemical class 0.000 abstract 6
- 102000039446 nucleic acids Human genes 0.000 abstract 6
- 239000012682 cationic precursor Substances 0.000 abstract 2
- 230000008685 targeting Effects 0.000 abstract 2
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000000536 complexating effect Effects 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nanotechnology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Patente de Invenção:<B>"PARTìCULAS DE TRANSFECçãO"<D>. Partículas de transfecção para liberação de ácido nucleico em células eucarióticas superiores in vitro e in vivo compreendem uma ou mais moléculas de ácido nucleico condensadas por moléculas catiónicas orgânicas. As partículas discretas e estáveis são obtidas por compleição das moléculas de ácido nucleico com idênticas ou diferentes moléculas precursoras catiónicas orgânicas sem reticulação das moléculas de ácido nucleico, e covalentemente ligando as moléculas precursoras entre si no ácido nucleico padrão. Para o alvejamento celular específico, as partículas podem transportar moléculas de alvejamento, por exemplo açúcares. As moléculas precursoras catiónicas preferidas são os detergentes lipofílicos que são ligados para formar lipídeos. As partículas contêm preferivelmente apens uma molécula de ácido nucleico que torna-as úteis para a terapia de gene e para a liberação de grandes moléculas de DNA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97121308A EP0945138A1 (en) | 1997-12-04 | 1997-12-04 | Transfection particles |
PCT/EP1998/007695 WO1999029349A1 (en) | 1997-12-04 | 1998-11-28 | Transfection particles |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9814255A true BR9814255A (pt) | 2000-10-10 |
Family
ID=8227738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9814255-0A BR9814255A (pt) | 1997-12-04 | 1998-11-28 | Partìculas de transfecção |
Country Status (18)
Country | Link |
---|---|
EP (2) | EP0945138A1 (pt) |
JP (1) | JP2001525378A (pt) |
KR (1) | KR20010032775A (pt) |
CN (1) | CN1290178A (pt) |
AR (1) | AR014054A1 (pt) |
AU (1) | AU1757799A (pt) |
BR (1) | BR9814255A (pt) |
CA (1) | CA2312890A1 (pt) |
EE (1) | EE200000797A (pt) |
HU (1) | HUP0004322A3 (pt) |
IL (1) | IL136418A0 (pt) |
NO (1) | NO20002793L (pt) |
PL (1) | PL345849A1 (pt) |
SK (1) | SK8222000A3 (pt) |
TR (1) | TR200001597T2 (pt) |
UY (1) | UY25286A1 (pt) |
WO (1) | WO1999029349A1 (pt) |
ZA (1) | ZA9811011B (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE306556T1 (de) | 1998-01-30 | 2005-10-15 | Aventis Pharma Sa | Für reduzierende bedingungen empfindliche transfektions-verbindungen, pharmazeutische zusammensezungen die diese enthalten und deren verwendung. |
US6770740B1 (en) | 1999-07-13 | 2004-08-03 | The Regents Of The University Of Michigan | Crosslinked DNA condensate compositions and gene delivery methods |
KR20170054429A (ko) | 2014-09-03 | 2017-05-17 | 제네세규스 인코포레이티드 | 치료용 나노입자 및 관련 조성물, 방법, 및 시스템 |
CN106496555B (zh) * | 2016-11-23 | 2019-02-01 | 南开大学 | 一种金属配位聚阳离子基因载体及其制备方法和应用 |
US9963428B1 (en) * | 2017-03-20 | 2018-05-08 | Mark Quang Nguyen | Bucillamine prodrugs, pharmaceutical compositions thereof, and methods of use |
JP2022543444A (ja) * | 2019-08-05 | 2022-10-12 | ポリプラス トランスフェクション | カチオン性ポリマーにグラフトしたトリアゾール化合物を含む核酸分子を細胞にトランスフェクトするための組成物及びその用途 |
CN114983942B (zh) * | 2022-05-18 | 2023-09-05 | 中国科学院理化技术研究所 | 治疗幽门螺杆菌感染的多功能微泡、制备及其应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4873187A (en) * | 1986-03-13 | 1989-10-10 | Digene Diagnostics, Incorporated | Bifunctional DNA-protein conjugating agent |
NZ244306A (en) * | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
AU4414497A (en) * | 1996-09-13 | 1998-04-02 | University Technology Corporation | Biocompatible cationic detergents and uses therefor |
-
1997
- 1997-12-04 EP EP97121308A patent/EP0945138A1/en not_active Withdrawn
-
1998
- 1998-11-28 CN CN98813498A patent/CN1290178A/zh active Pending
- 1998-11-28 PL PL98345849A patent/PL345849A1/xx unknown
- 1998-11-28 EP EP98962400A patent/EP1037668A1/en not_active Withdrawn
- 1998-11-28 BR BR9814255-0A patent/BR9814255A/pt not_active IP Right Cessation
- 1998-11-28 CA CA002312890A patent/CA2312890A1/en not_active Abandoned
- 1998-11-28 WO PCT/EP1998/007695 patent/WO1999029349A1/en not_active Application Discontinuation
- 1998-11-28 JP JP2000524018A patent/JP2001525378A/ja active Pending
- 1998-11-28 AU AU17577/99A patent/AU1757799A/en not_active Abandoned
- 1998-11-28 KR KR1020007006071A patent/KR20010032775A/ko not_active Application Discontinuation
- 1998-11-28 HU HU0004322A patent/HUP0004322A3/hu unknown
- 1998-11-28 TR TR2000/01597T patent/TR200001597T2/xx unknown
- 1998-11-28 IL IL13641898A patent/IL136418A0/xx unknown
- 1998-11-28 EE EEP200000797A patent/EE200000797A/xx unknown
- 1998-11-28 SK SK822-2000A patent/SK8222000A3/sk unknown
- 1998-12-02 ZA ZA9811011A patent/ZA9811011B/xx unknown
- 1998-12-04 AR ARP980106157A patent/AR014054A1/es not_active Application Discontinuation
- 1998-12-04 UY UY25286A patent/UY25286A1/es not_active Application Discontinuation
-
2000
- 2000-05-31 NO NO20002793A patent/NO20002793L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2001525378A (ja) | 2001-12-11 |
EP1037668A1 (en) | 2000-09-27 |
IL136418A0 (en) | 2001-06-14 |
CA2312890A1 (en) | 1999-06-17 |
EP0945138A1 (en) | 1999-09-29 |
SK8222000A3 (en) | 2000-12-11 |
NO20002793D0 (no) | 2000-05-31 |
TR200001597T2 (tr) | 2002-03-21 |
HUP0004322A2 (hu) | 2001-02-28 |
CN1290178A (zh) | 2001-04-04 |
WO1999029349A1 (en) | 1999-06-17 |
AU1757799A (en) | 1999-06-28 |
ZA9811011B (en) | 1999-06-04 |
EE200000797A (et) | 2002-06-17 |
NO20002793L (no) | 2000-08-01 |
KR20010032775A (ko) | 2001-04-25 |
HUP0004322A3 (en) | 2003-04-28 |
PL345849A1 (en) | 2002-01-14 |
AR014054A1 (es) | 2001-01-31 |
UY25286A1 (es) | 2001-01-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Gierlich et al. | Click chemistry as a reliable method for the high-density postsynthetic functionalization of alkyne-modified DNA | |
Berndl et al. | Comparison of a nucleosidic vs non-nucleosidic postsynthetic “click” modification of DNA with base-labile fluorescent probes | |
Hurley et al. | Covalent Binding of Antitumor Antibiotics in the Minor Groove of DNA. Mechanism of Action of CC-1065 and the Pyrrolo (1, 4) benzodiazepines | |
Schoch et al. | Post-synthetic modification of DNA by inverse-electron-demand Diels− Alder reaction | |
BR9801878A (pt) | Iniciadores de amplificação de ácido nucleìco modificado | |
ATE237312T1 (de) | In liposomen verkapselte nukleinsäurekomplexe | |
PT93441A (pt) | Processo para a preparacao de novos conjuntos proteina-policatiao e de composicoes farmaceuticas que os contem | |
CY1109744T1 (el) | Συζυγη και μεθοδοι για την παραγωγη τους, και η χρηση τους για την μεταφορα μοριων δια μεσου βιολογικων μεμβρανων | |
AU2003234196A1 (en) | Functionalized nanoparticles and methods of use | |
EP1808180A3 (en) | Modified GP 100 and uses thereof | |
BR9803982A (pt) | Polietilenoiminas de baixo peso molecular, toleráveis biologicamente. | |
Fomich et al. | Azide phosphoramidite in direct synthesis of azide-modified oligonucleotides | |
San Juan et al. | Cationized pullulan 3D matrices as new materials for gene transfer | |
AU8023898A (en) | Combined product associating a nucleic acid with a substance breaking up the extracellular matrix for gene therapy | |
Meng et al. | Two base pair duplexes suffice to build a novel material | |
AU2434195A (en) | Thymidine kinase mutants | |
BR9809506A (pt) | Composto, composição, utilização de um composto, e, processos para preparação de um composto e para transferência de ácidos nucleicos para o interior das células | |
BR9814255A (pt) | Partìculas de transfecção | |
Seelig et al. | Ternary Conjugates of Guanosine Monophosphate as Initiator Nucleotides for the Enzymatic Synthesis of 5 ‘-Modified RNAs | |
BR9811675A (pt) | Genes isolados para proteìna da membrana de célula dentrìtica | |
Ahn et al. | Protein‐Encoding Free‐Standing RNA Hydrogel for Sub‐Compartmentalized Translation | |
Noronha et al. | N4C− Ethyl− N4C cross-linked DNA: Synthesis and characterization of duplexes with interstrand cross-links of different orientations | |
Grant et al. | Sequence-specific alkylation and cleavage of DNA mediated by purine motif triple helix formation | |
DE60037978D1 (de) | Interferon ähnliche moleküle, und deren verwendungen | |
BR0016212A (pt) | Proteìna especìfica do cromossoma sexual e sequência de ácido nucleico isolada e purificada, método para identificar moléculas especìficas de cromossomas sexuais associadas com membranas celulares de esperma animal, anticorpo contra um epìtopo de uma molécula especìfica de cromossomas sexuais, métodos de triagem para uma molécula especifica de cromossomas sexuais, e para separar esperma determinante de macho e fêmea de sêmen nativo kit para executar um método, contraceptivo, proteìna especìfica do cromossoma sexual isolada e purificada, e , molécula |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A,7A E 8A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1912 DE 28/08/2007. |
|
B15K | Others concerning applications: alteration of classification |
Ipc: B82Y 5/00 (2011.01), A61K 47/54 (2017.0 |