BR9812866A - Polimorfo antifúngico cristalino - Google Patents

Polimorfo antifúngico cristalino

Info

Publication number
BR9812866A
BR9812866A BR9812866-3A BR9812866A BR9812866A BR 9812866 A BR9812866 A BR 9812866A BR 9812866 A BR9812866 A BR 9812866A BR 9812866 A BR9812866 A BR 9812866A
Authority
BR
Brazil
Prior art keywords
polymorph
crystalline
antifungal
phenyl
crystalline antifungal
Prior art date
Application number
BR9812866-3A
Other languages
English (en)
Inventor
David R Andrews
William Leong
Anantha R Sudhakar
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of BR9812866A publication Critical patent/BR9812866A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Patente de Invenção: <B>"POLIMORFO ANTIFúNGICO CRISTALINO"<D>. São descritas a forma I do polimorfo cristalino de (-)-4-[4-[4-[4-[[(2R-cis)-5-(2,4-difluorfenil)tetrahidro-5-(1H-1,2,4-triazol- 1-ilmetil)furan-3-il]-metóxi]fenil]-1-piperazinil]fenil]-2,4-dihidro-2-[(S)-1- etil-2(S)-hidroxipropil]-3H-1,2,4-triazol-3-ona, representada pela fórmula (I) composições farmacêuticas contendo tal polimorfo e métodos de uso de tal polimorfo para tratar infecções fúngicas em mamíferos.
BR9812866-3A 1997-10-07 1998-10-05 Polimorfo antifúngico cristalino BR9812866A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94618397A 1997-10-07 1997-10-07
PCT/US1998/020476 WO1999018097A1 (en) 1997-10-07 1998-10-05 Crystalline antifungal polymorph

Publications (1)

Publication Number Publication Date
BR9812866A true BR9812866A (pt) 2000-08-08

Family

ID=25484068

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9812866-3A BR9812866A (pt) 1997-10-07 1998-10-05 Polimorfo antifúngico cristalino

Country Status (31)

Country Link
EP (1) EP1021439B1 (pt)
JP (4) JP2001519346A (pt)
KR (1) KR100626109B1 (pt)
CN (1) CN1125067C (pt)
AR (1) AR015947A1 (pt)
AT (1) ATE263163T1 (pt)
AU (1) AU759982B2 (pt)
BR (1) BR9812866A (pt)
CA (1) CA2305803C (pt)
CO (1) CO4970829A1 (pt)
CZ (1) CZ299835B6 (pt)
DE (1) DE69822859T2 (pt)
DK (1) DK1021439T3 (pt)
ES (1) ES2217594T3 (pt)
HK (1) HK1029588A1 (pt)
HU (1) HU225233B1 (pt)
ID (1) ID29290A (pt)
IL (1) IL135331A (pt)
IN (1) IN1998CH02232A (pt)
MX (1) MX225999B (pt)
MY (1) MY130126A (pt)
NO (1) NO318827B1 (pt)
NZ (1) NZ503662A (pt)
PE (1) PE120499A1 (pt)
PH (1) PH11998002606B1 (pt)
PL (1) PL189317B1 (pt)
PT (1) PT1021439E (pt)
SK (1) SK285190B6 (pt)
TW (1) TW589310B (pt)
WO (1) WO1999018097A1 (pt)
ZA (1) ZA989063B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2130540A1 (en) * 2008-06-02 2009-12-09 Sandoz AG Pharmaceutical compositions containing a crystalline form of posaconazole
EP2141159A1 (en) * 2008-07-03 2010-01-06 Sandoz AG A Crystalline form of posaconazole
EP2451805A1 (en) 2009-07-09 2012-05-16 Sandoz AG A crystalline form of posaconazole
EP2571868B1 (en) 2010-05-19 2016-05-04 Sandoz AG Preparation of posaconazole intermediates
MX342850B (es) * 2010-05-19 2016-10-14 Sandoz Ag Proceso para la preparacion de triazolonas quirales.
AU2011254656B2 (en) 2010-05-19 2015-04-16 Sandoz Ag Process for the preparation of chiral hydrazides
BR112012029228A2 (pt) 2010-05-19 2021-08-03 Sandoz Ag processo para a preparação de um sal de cloreto de hidrogênio, sal de cloreto de hidrogênio, sal de cloreto de hidrogênio cristalino, uso de um sal e uso do processo
CN103635465A (zh) 2011-06-16 2014-03-12 桑多斯股份公司 制备手性化合物的方法
US9102664B2 (en) 2011-09-19 2015-08-11 Msn Laboratories Private Limited Process for the preparation of triazole antifungal drug, its intermediates and polymorphs thereof
WO2015011224A1 (en) 2013-07-25 2015-01-29 Sandoz Ag Improved process for the preparation of crystalline form iv of posaconazole
ITMI20132115A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132118A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132114A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132117A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
HUE051693T2 (hu) 2014-10-21 2021-03-29 Ariad Pharma Inc 5-Klór-N4-[2-(dimetilfoszforil)-fenil]-N2-{2-metoxi-4-[4-(4-metilpiperazin-1-il)-piperidin-1-il] -pirimidin-2,4-diamin kristályos formái
CN104387374A (zh) * 2014-10-21 2015-03-04 江苏恒盛药业有限公司 泊沙康唑晶型i的制备工艺
CN104370894A (zh) * 2014-10-21 2015-02-25 江苏恒盛药业有限公司 无定型泊沙康唑的制备工艺
ES2759801T3 (es) 2015-08-08 2020-05-12 Tiefenbacher Alfred E Gmbh & Co Kg Formulación gastro-resistente que contiene posaconazol
US10836745B2 (en) 2015-12-24 2020-11-17 Takeda Pharmaceutical Company Limited Cocrystal, production method thereof, and medicament containing cocrystal
EP3925601A1 (en) 2016-02-26 2021-12-22 Alfred E. Tiefenbacher (GmbH & Co. KG) Gastro-resistant formulation containing posaconazole and a polymeric precipitation inhibitor
CN105949278B (zh) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 一种取代的四氢呋喃水溶性衍生物及其应用
WO2017032908A1 (en) 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
TR201620462A2 (tr) 2016-12-31 2018-07-23 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ
TR201722493A2 (tr) 2017-12-28 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Posakonazol i̇çeren kati farmasöti̇k kompozi̇syon
WO2022034232A1 (en) 2020-08-13 2022-02-17 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Gastro-resistant high-strength formulation containing posaconazole
WO2023012378A1 (en) 2021-11-25 2023-02-09 Alfred E. Tiefenbacher (Gmbh Und Co. Kg) Granules containing posaconazole
EP4091604B1 (en) 2021-11-25 2024-04-03 Alfred E. Tiefenbacher (GmbH & Co. KG) Granules containing posaconazole

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
CZ294823B6 (cs) * 1993-12-21 2005-03-16 Schering Corporation Fungicidní tetrahydrofurany
SI0741737T1 (en) * 1994-01-24 2000-02-29 Janssen Pharmaceutica N.V. Watersoluble azole antifungals
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
AR002751A1 (es) * 1995-06-02 1998-04-29 Schering Corp Antifungicos de tetrahidrofurano, composiciones farmaceuticas que los contienen y el uso de los compuestos para preparar composiciones farmaceuticas utiles para el tratamiento de infecciones fungicas

Also Published As

Publication number Publication date
ES2217594T3 (es) 2004-11-01
HU225233B1 (en) 2006-08-28
CZ299835B6 (cs) 2008-12-10
MY130126A (en) 2007-06-29
ZA989063B (en) 1999-04-06
NO20001779L (no) 2000-06-06
AU759982B2 (en) 2003-05-01
CN1281449A (zh) 2001-01-24
PL189317B1 (pl) 2005-07-29
EP1021439B1 (en) 2004-03-31
IL135331A0 (en) 2001-05-20
HK1029588A1 (en) 2001-04-06
CZ20001264A3 (cs) 2000-08-16
SK285190B6 (sk) 2006-08-03
MX225999B (es) 2005-02-02
PE120499A1 (es) 1999-12-04
AR015947A1 (es) 2001-05-30
JP2001519346A (ja) 2001-10-23
PT1021439E (pt) 2004-07-30
JP2012153729A (ja) 2012-08-16
DE69822859D1 (de) 2004-05-06
PH11998002606B1 (en) 2006-08-10
HUP0004899A2 (hu) 2002-02-28
NO318827B1 (no) 2005-05-09
CA2305803A1 (en) 1999-04-15
CA2305803C (en) 2009-12-22
SK5122000A3 (en) 2000-09-12
NO20001779D0 (no) 2000-04-06
KR20010030959A (ko) 2001-04-16
KR100626109B1 (ko) 2006-09-20
TW589310B (en) 2004-06-01
CN1125067C (zh) 2003-10-22
ID29290A (id) 2001-08-16
IN1998CH02232A (pt) 2005-03-04
WO1999018097A1 (en) 1999-04-15
PL339659A1 (en) 2001-01-02
JP2012153730A (ja) 2012-08-16
EP1021439A1 (en) 2000-07-26
DE69822859T2 (de) 2005-01-27
JP2008106075A (ja) 2008-05-08
IL135331A (en) 2005-08-31
AU9780398A (en) 1999-04-27
DK1021439T3 (da) 2004-05-10
CO4970829A1 (es) 2000-11-07
MXPA00003404A (es) 2000-11-01
HUP0004899A3 (en) 2002-03-28
ATE263163T1 (de) 2004-04-15
NZ503662A (en) 2002-10-25

Similar Documents

Publication Publication Date Title
BR9812866A (pt) Polimorfo antifúngico cristalino
NO986087L (no) Oralt preparat omfattende en antifungal triazolforbindelse
ES8505364A1 (es) Un procedimiento para la preparacion 1-imidazoles y 1h-1, 2, 4-triazoles
BR9606547A (pt) Novos derivados de pirimidona com atividade fungicida
AU2777089A (en) Substituted pyrrole, pyrazole and triazole angiotensin 11 antagonists
BR9809100B1 (pt) composições fungicidas, processo para sua preparação, aplicação das mesmas e processo para combater fungos.
KR900003157A (ko) 트리아졸 항진균제
EA200401135A1 (ru) Фунгицидные смеси на базе протиоконазола с инсектицидом
ATE245148T1 (de) 5-aryl-1h-1,2,4 triazolverbindungen als cyclooxygenase -2 inhibitoren und dieseenthaltende pharmazeutische zusammensetzungen
NZ315184A (en) Use of fluconazole for inhibiting the growth of cancers and viral infections
AU644531B2 (en) Fungicidal composition
ES2223893T3 (es) Combinaciones de productos activos fungicidas.
NZ332699A (en) Antifungal composition with enhanced bioavailability
WO2001066551A8 (en) Azole compounds as therapeutic agents for fungal infections
RO94053B (ro) Compozitie fungicida sinergetica
PT918758E (pt) Processo para a preparacao de 4-ciano-1,2,3-triazoles 1-substituidos
DE60205239D1 (de) Azol- oder triazol-derivate, verfahren zu deren herstellung und ihre verwendung als antifungale arzneimittel
BR0210701A (pt) Derivados de halofenila intermediária e seu uso em um processo para a preparação de derivados de azol
WO2001079196A3 (en) 1-(h-1,2,4-triazol-1-yl)butan-2-ol derivatives
HUP9802763A2 (hu) Fitomikrobicid készítmények és alkalmazásuk
PH25797A (en) 1-(1-aryl-2-hydroxyethyl)-imidazoles, salts thereof, medicaments containing these compounds
EP0178682A3 (en) 1,3-bis(1h-1,2,4-triazol-1-yl)-2-fluoro-2-(2,4-difluorophenyl)propane, antifungal composition containing it, and process for preparation of the compound and the composition
ECSP982686A (es) Poliformo antifungico cristalino
TH51146A (th) คริสตัลไลน์ แอนตีฟังกัล โพลีมอร์ฟ
ECSP972133A (es) Composiciones antihongos con biodisponibilidad mejorada

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AO ESTABECIDO NOS ART. 8O, 13 E 24 DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]
B25E Requested change of name of applicant rejected

Owner name: SCHERING CORPORATION (US)

B25H Request for change of headquarter rejected

Owner name: SCHERING CORPORATION (US)