BR9812139A - Vacina - Google Patents
VacinaInfo
- Publication number
- BR9812139A BR9812139A BR9812139-1A BR9812139A BR9812139A BR 9812139 A BR9812139 A BR 9812139A BR 9812139 A BR9812139 A BR 9812139A BR 9812139 A BR9812139 A BR 9812139A
- Authority
- BR
- Brazil
- Prior art keywords
- hpv
- vaccine
- provides
- prophylaxis
- linked
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 241000701806 Human papillomavirus Species 0.000 abstract 4
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Patente de Invenção:<B>"VACINA"<D>. A patente de invenção proporciona proteínas de fusão do vírus do papiloma humano (HPV), ligadas a um parceiro de fusão imunológica que proporciona epítopos T auxiliares ao antígeno de HPV. São providas formulações de vacina que são úteis no tratamento ou profilaxia de lesões induzidas por HPV.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9717953.5A GB9717953D0 (en) | 1997-08-22 | 1997-08-22 | Vaccine |
PCT/EP1998/005285 WO1999010375A2 (en) | 1997-08-22 | 1998-08-17 | Vaccine against hpv |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9812139A true BR9812139A (pt) | 2000-07-18 |
Family
ID=10817971
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9812139-1A BR9812139A (pt) | 1997-08-22 | 1998-08-17 | Vacina |
Country Status (23)
Country | Link |
---|---|
US (2) | US6342224B1 (pt) |
EP (1) | EP1007551B1 (pt) |
JP (1) | JP2001513986A (pt) |
KR (1) | KR20010023193A (pt) |
CN (1) | CN1276833A (pt) |
AT (1) | ATE267211T1 (pt) |
AU (1) | AU732946B2 (pt) |
BR (1) | BR9812139A (pt) |
CA (1) | CA2301920C (pt) |
CO (1) | CO4810234A1 (pt) |
DE (1) | DE69824013T2 (pt) |
ES (1) | ES2221198T3 (pt) |
GB (1) | GB9717953D0 (pt) |
HU (1) | HUP0004327A3 (pt) |
IL (1) | IL134392A0 (pt) |
MA (1) | MA24638A1 (pt) |
NO (1) | NO20000850L (pt) |
NZ (1) | NZ502632A (pt) |
PL (1) | PL339009A1 (pt) |
TR (1) | TR200000480T2 (pt) |
UY (1) | UY25146A1 (pt) |
WO (1) | WO1999010375A2 (pt) |
ZA (1) | ZA987591B (pt) |
Families Citing this family (90)
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---|---|---|---|---|
GB9706957D0 (en) | 1997-04-05 | 1997-05-21 | Smithkline Beecham Plc | Formulation |
JP4303418B2 (ja) * | 1997-10-24 | 2009-07-29 | ライフ テクノロジーズ コーポレーション | 組換え部位を有する核酸を使用する組換えクローニング |
GB9820525D0 (en) * | 1998-09-21 | 1998-11-11 | Allergy Therapeutics Ltd | Formulation |
SI1117421T1 (en) * | 1998-10-05 | 2004-12-31 | Pharamexa A/S | Methods for therapeutic vaccination |
EA003634B1 (ru) | 1998-10-05 | 2003-08-28 | Фармэкса А/С | Новые способы терапевтической вакцинации |
DE69935606T9 (de) * | 1998-10-16 | 2021-03-11 | Glaxosmithkline Biologicals S.A. | Adjuvanzsysteme und impfstoffe |
TR200103266T2 (tr) * | 1999-05-13 | 2002-01-21 | American Cyanamid Company | Yardımcı kombinasyon formülasyonları |
GB9921146D0 (en) * | 1999-09-07 | 1999-11-10 | Smithkline Beecham Biolog | Novel composition |
GB0000891D0 (en) | 2000-01-14 | 2000-03-08 | Allergy Therapeutics Ltd | Formulation |
US7015033B1 (en) | 2000-05-25 | 2006-03-21 | Aventis Pasteur Limited | Co-expression of recombination proteins |
CA2412084A1 (en) * | 2000-06-26 | 2002-01-03 | Glaxosmithkline Biologicals S.A. | Triple fusion proteins comprising ubiquitin fused between thioredoxin and a polypeptide of interest |
US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
ES2284559T3 (es) * | 2001-03-23 | 2007-11-16 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Genes y proteinas e6 y e7 modificados del vph utiles como vacuna. |
AU2002340662B2 (en) * | 2001-11-07 | 2008-07-03 | Tekmira Pharmaceuticals Corporation | Mucosal adjuvants comprising an oligonucleotide and a cationic lipid |
US6861410B1 (en) | 2002-03-21 | 2005-03-01 | Chiron Corporation | Immunological adjuvant compositions |
FR2839072A1 (fr) * | 2002-04-24 | 2003-10-31 | Neovacs | Produit d'expression d'un adn codant une proteine e7 mutee de hpv-16, composition immunogene contenant ledit produit d'expression et son procede de preparation |
FR2839080B1 (fr) * | 2003-04-03 | 2007-09-28 | Neovacs | Procede de preparation d'un produit d'expression d'un adn codant une proteine e7 mutee de hpv-16, par des cellules de la levure pichia pastoris |
US20040009944A1 (en) * | 2002-05-10 | 2004-01-15 | Inex Pharmaceuticals Corporation | Methylated immunostimulatory oligonucleotides and methods of using the same |
US20040013649A1 (en) * | 2002-05-10 | 2004-01-22 | Inex Pharmaceuticals Corporation | Cancer vaccines and methods of using the same |
WO2004009768A2 (en) * | 2002-07-18 | 2004-01-29 | Invitrogen Corporation | Viral vectors containing recombination sites |
KR101239242B1 (ko) | 2002-08-02 | 2013-03-11 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 항원 조합물을 포함하는 나이세리아 백신 조성물 |
WO2004019974A2 (en) * | 2002-08-30 | 2004-03-11 | Glaxo Group Limited | Immunogenic composition comprising an il-13 element and t cell epitopes, and its therapeutic use |
KR101145190B1 (ko) * | 2002-10-03 | 2012-05-14 | 와이어쓰 홀딩스 코포레이션 | 사람 파필로마바이러스 폴리펩타이드 및 면역원성 조성물 |
ES2649048T3 (es) | 2002-11-01 | 2018-01-09 | Glaxosmithkline Biologicals S.A. | Procedimiento de secado |
CN100443116C (zh) * | 2002-11-07 | 2008-12-17 | 新纳几美国公司 | 治疗或预防肺炎球菌感染的组合物及其用途 |
CN100506999C (zh) * | 2003-03-24 | 2009-07-01 | 麦克公司 | Hpv31l1在酵母中的优化表达 |
CZ297389B6 (cs) * | 2003-07-03 | 2006-11-15 | Ústav Molekulární Biologie Rostlin Av Cr | Fúzní protein pro vakcinaci proti lidskému papillomaviru a zpusob jeho produkce |
WO2005032584A2 (en) | 2003-10-02 | 2005-04-14 | Glaxosmithkline Biologicals S.A. | Pertussis antigens and use thereof in vaccination |
EP1697534B1 (en) * | 2003-12-01 | 2010-06-02 | Life Technologies Corporation | Nucleic acid molecules containing recombination sites and methods of using the same |
US20070014810A1 (en) * | 2003-12-31 | 2007-01-18 | Denise Baker | Inducing cellular immune responses to human papillomavirus using peptide and nucleic acid compositions |
CN1950483A (zh) * | 2004-04-28 | 2007-04-18 | 上游重油有限公司 | 固定床加氢处理法和***,以及用来升级已有固定床***的方法 |
US10941353B2 (en) * | 2004-04-28 | 2021-03-09 | Hydrocarbon Technology & Innovation, Llc | Methods and mixing systems for introducing catalyst precursor into heavy oil feedstock |
EP2811006A1 (en) * | 2004-04-28 | 2014-12-10 | Headwaters Heavy Oil, LLC | Ebullated bed hydroprocessing methods and systems and methods of upgrading an existing ebullated bed system |
GB0427131D0 (en) * | 2004-12-10 | 2005-01-12 | Glaxosmithkline Biolog Sa | Novel combination |
GB0505996D0 (en) | 2005-03-23 | 2005-04-27 | Glaxosmithkline Biolog Sa | Fermentation process |
KR101408113B1 (ko) | 2005-06-27 | 2014-06-16 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 제조 방법 |
US7732166B2 (en) * | 2005-11-15 | 2010-06-08 | Oncohealth Corporation | Detection method for human pappilomavirus (HPV) and its application in cervical cancer |
TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
CN105063064A (zh) | 2006-07-28 | 2015-11-18 | 宾夕法尼亚大学托管会 | 改进的疫苗及其使用方法 |
TW200821026A (en) * | 2006-09-08 | 2008-05-16 | Wyeth Corp | Arginine wash in protein purification using affinity chromatography |
EP2468300B1 (en) | 2006-09-26 | 2017-12-20 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
CN101522218B (zh) | 2006-10-12 | 2012-09-26 | 葛兰素史密丝克莱恩生物有限公司 | 包含水包油乳液佐剂的疫苗 |
EP2086582B1 (en) | 2006-10-12 | 2012-11-14 | GlaxoSmithKline Biologicals s.a. | Vaccine comprising an oil in water emulsion adjuvant |
US20100003704A1 (en) | 2008-06-13 | 2010-01-07 | Shuling Cheng | IN SITU detection of early stages and late stages HPV infection |
US8968995B2 (en) | 2008-11-12 | 2015-03-03 | Oncohealth Corp. | Detection, screening, and diagnosis of HPV-associated cancers |
WO2010129821A1 (en) | 2009-05-07 | 2010-11-11 | Oncohealth Corporation | Identification of high grade or ≥cin2 for early stages and late stages detection, screening, and diagnosis of human papillomavirus (hpv) and hpv-associated cancers |
AU2008207025B2 (en) * | 2007-01-15 | 2012-08-23 | Glaxosmithkline Biologicals Sa | Vaccine |
US8034232B2 (en) * | 2007-10-31 | 2011-10-11 | Headwaters Technology Innovation, Llc | Methods for increasing catalyst concentration in heavy oil and/or coal resid hydrocracker |
TWI376385B (en) | 2007-12-07 | 2012-11-11 | Nat Health Research Institutes | Production of lipidated proteins in e. coli |
US8466259B2 (en) | 2007-12-07 | 2013-06-18 | National Health Research Institutes | Adjuvants |
US8142645B2 (en) * | 2008-01-03 | 2012-03-27 | Headwaters Technology Innovation, Llc | Process for increasing the mono-aromatic content of polynuclear-aromatic-containing feedstocks |
EP2865389A1 (en) | 2008-12-09 | 2015-04-29 | Pfizer Vaccines LLC | IgE CH3 peptide vaccine |
CA2653478A1 (en) | 2009-01-23 | 2010-07-23 | Gregg Martin | Automated wash system for industrial vehicles |
US8287880B2 (en) | 2009-06-02 | 2012-10-16 | National Health Research Institutes | Lipidated vaccine against dengue virus infection |
CN102481312B (zh) | 2009-06-05 | 2015-07-15 | 传染性疾病研究院 | 合成的吡喃葡萄糖脂佐剂 |
TWI409275B (zh) * | 2009-06-22 | 2013-09-21 | Nat Health Research Institutes | 脂質化腫瘤相關抗原及其免疫治療的組成物及方法 |
KR20130127547A (ko) | 2009-07-30 | 2013-11-22 | 화이자 백신스 엘엘씨 | 항원성 타우 펩타이드 및 이의 용도 |
AR074485A1 (es) * | 2009-12-04 | 2011-01-19 | Consejo Nac Invest Cient Tec | Vacuna contra lesiones neoplasicas o cancerosas causadas por el virus del papiloma humano (vph), procedimientos, usos y metodos |
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CN102869377A (zh) | 2010-03-10 | 2013-01-09 | 葛兰素史密丝克莱恩生物有限公司 | 免疫原性组合物 |
EP2942061A3 (en) | 2010-06-07 | 2016-01-13 | Pfizer Vaccines LLC | Ige ch3 peptide vaccine |
CN103180343B (zh) * | 2010-08-13 | 2016-01-20 | 株式会社吉耐森 | 用于预防或治疗***的、包含人***瘤病毒变形体及免疫增强剂的组合物 |
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TWI507413B (zh) | 2010-11-15 | 2015-11-11 | Nat Health Research Institutes | 脂質化多抗原表位疫苗 |
EA027236B1 (ru) | 2011-04-08 | 2017-07-31 | Иммьюн Дизайн Корп. | Иммуногенные композиции и способы применения таких композиций для индукции гуморального и клеточного иммунного ответа |
US9790440B2 (en) | 2011-09-23 | 2017-10-17 | Headwaters Technology Innovation Group, Inc. | Methods for increasing catalyst concentration in heavy oil and/or coal resid hydrocracker |
ES2646590T3 (es) * | 2012-01-24 | 2017-12-14 | Sanford Health | Polinucleótidos para el tratamiento de tumores positivos para polipéptidos víricos oncogénicos |
ES2729967T3 (es) | 2012-02-07 | 2019-11-07 | Infectious Disease Res Inst | Formulaciones de adyuvante mejoradas que comprenden agonistas de TLR4 y métodos para usar las mismas |
EP3388835B1 (en) | 2012-05-16 | 2020-04-01 | Immune Design Corp. | Vaccines for hsv-2 |
US9644157B2 (en) | 2012-07-30 | 2017-05-09 | Headwaters Heavy Oil, Llc | Methods and systems for upgrading heavy oil using catalytic hydrocracking and thermal coking |
EA034056B1 (ru) | 2013-03-12 | 2019-12-23 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Усовершенствованные вакцины против вируса папилломы человека и способы их применения |
CN105209047B (zh) | 2013-04-18 | 2020-08-18 | 免疫设计股份有限公司 | 用于癌症治疗的gla单一疗法 |
US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
US11801223B2 (en) | 2013-12-31 | 2023-10-31 | Access To Advanced Health Institute | Single vial vaccine formulations |
CN103772508B (zh) * | 2014-01-15 | 2017-05-10 | 深圳泰来生物医药有限公司 | 免疫增强的人***瘤病毒感染及相关疾病的治疗性疫苗 |
CN107073070A (zh) | 2014-08-15 | 2017-08-18 | 格纳西尼有限公司 | 治疗***的方法 |
CN107075491B (zh) * | 2014-10-28 | 2021-07-06 | 谷万达公司 | 用于稳定反式剪接的内含肽修饰的蛋白酶的方法和组合物 |
WO2016090540A1 (zh) * | 2014-12-08 | 2016-06-16 | 刘日廷 | 人***瘤病毒(hpv)18型致癌性e6和e7蛋白的抗原表位最小基序肽 |
JP5973007B2 (ja) * | 2015-01-30 | 2016-08-17 | ジェネクサイン・インコーポレーテッド | ヒトパピローマウイルス変形体及び免疫増強剤を含む子宮頸癌の予防または治療用組成物 |
US11414607B2 (en) | 2015-09-22 | 2022-08-16 | Hydrocarbon Technology & Innovation, Llc | Upgraded ebullated bed reactor with increased production rate of converted products |
US11414608B2 (en) | 2015-09-22 | 2022-08-16 | Hydrocarbon Technology & Innovation, Llc | Upgraded ebullated bed reactor used with opportunity feedstocks |
TWI670280B (zh) * | 2016-02-23 | 2019-09-01 | 財團法人國家衛生研究院 | 人類乳突病毒之脂質抗原及用於人類乳突病毒相關疾病之免疫治療組合物 |
JP7195147B2 (ja) | 2016-05-16 | 2022-12-23 | アクセス ツー アドバンスト ヘルス インスティチュート | Peg化リポソームおよび使用方法 |
US11421164B2 (en) | 2016-06-08 | 2022-08-23 | Hydrocarbon Technology & Innovation, Llc | Dual catalyst system for ebullated bed upgrading to produce improved quality vacuum residue product |
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WO2018232257A1 (en) | 2017-06-15 | 2018-12-20 | Infectious Disease Research Institute | Nanostructured lipid carriers and stable emulsions and uses thereof |
CA3057131C (en) | 2018-10-17 | 2024-04-23 | Hydrocarbon Technology And Innovation, Llc | Upgraded ebullated bed reactor with no recycle buildup of asphaltenes in vacuum bottoms |
PE20231054A1 (es) | 2020-04-24 | 2023-07-11 | Genexine Inc | Metodo para tratamiento del cancer cervicouterino |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2586428B1 (fr) | 1985-08-26 | 1988-11-25 | Pasteur Institut | Polypeptides et anticorps, caracteristiques du papillomavirus et leurs applications au diagnostic in vitro, a la prevention et/ou la lutte contre des infections a papillomavirus |
DE3907721A1 (de) | 1989-03-10 | 1990-09-20 | Behringwerke Ag | Immunogene regionen auf dem e7-protein des humanen papillomvierus typ 16 |
DE4015044A1 (de) | 1990-05-10 | 1991-11-14 | Behringwerke Ag | Seroreaktive epitope auf proteinen des menschlichen papillomavirus (hpv) 18 |
WO1992005248A1 (en) | 1990-09-26 | 1992-04-02 | Bristol-Myers Squibb Company | Human papilloma viral protein expression for use in vaccine compositions |
IL105554A (en) * | 1992-05-05 | 1999-08-17 | Univ Leiden | Peptides of human papillomavirus for use in preparations elicit a human T cell response |
US5869445A (en) * | 1993-03-17 | 1999-02-09 | University Of Washington | Methods for eliciting or enhancing reactivity to HER-2/neu protein |
DE4441197C1 (de) * | 1994-11-18 | 1996-03-28 | Deutsches Krebsforsch | Expressionsplasmide für Hefe |
AUPN015794A0 (en) * | 1994-12-20 | 1995-01-19 | Csl Limited | Variants of human papilloma virus antigens |
JP3958360B2 (ja) * | 1995-02-24 | 2007-08-15 | キャンタブ ファーマシューティカルズ リサーチ リミティド | 免疫治療剤として役立つポリペプチド及びポリペプチド調製の方法 |
US5843752A (en) | 1995-05-12 | 1998-12-01 | Schering Corporation | Soluble active hepatitis C virus protease |
US6224870B1 (en) * | 1997-01-24 | 2001-05-01 | Genitrix, Ltd. | Vaccine compositions and methods of modulating immune responses |
US5958750A (en) * | 1996-07-03 | 1999-09-28 | Inctye Pharmaceuticals, Inc. | Human hyaluronidase |
-
1997
- 1997-08-22 GB GBGB9717953.5A patent/GB9717953D0/en active Pending
-
1998
- 1998-08-17 PL PL98339009A patent/PL339009A1/xx not_active Application Discontinuation
- 1998-08-17 BR BR9812139-1A patent/BR9812139A/pt not_active IP Right Cessation
- 1998-08-17 CA CA2301920A patent/CA2301920C/en not_active Expired - Fee Related
- 1998-08-17 EP EP98945269A patent/EP1007551B1/en not_active Expired - Lifetime
- 1998-08-17 HU HU0004327A patent/HUP0004327A3/hu unknown
- 1998-08-17 WO PCT/EP1998/005285 patent/WO1999010375A2/en active IP Right Grant
- 1998-08-17 CN CN98810251A patent/CN1276833A/zh active Pending
- 1998-08-17 AU AU92639/98A patent/AU732946B2/en not_active Ceased
- 1998-08-17 ES ES98945269T patent/ES2221198T3/es not_active Expired - Lifetime
- 1998-08-17 DE DE69824013T patent/DE69824013T2/de not_active Expired - Lifetime
- 1998-08-17 NZ NZ502632A patent/NZ502632A/en unknown
- 1998-08-17 JP JP2000507701A patent/JP2001513986A/ja active Pending
- 1998-08-17 IL IL13439298A patent/IL134392A0/xx unknown
- 1998-08-17 AT AT98945269T patent/ATE267211T1/de not_active IP Right Cessation
- 1998-08-17 US US09/485,885 patent/US6342224B1/en not_active Expired - Lifetime
- 1998-08-17 TR TR2000/00480T patent/TR200000480T2/xx unknown
- 1998-08-17 KR KR1020007001821A patent/KR20010023193A/ko not_active Application Discontinuation
- 1998-08-19 UY UY25146A patent/UY25146A1/es not_active Application Discontinuation
- 1998-08-20 CO CO98047511A patent/CO4810234A1/es unknown
- 1998-08-21 MA MA25223A patent/MA24638A1/fr unknown
- 1998-08-21 ZA ZA9807591A patent/ZA987591B/xx unknown
-
2000
- 2000-02-21 NO NO20000850A patent/NO20000850L/no not_active Application Discontinuation
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2001
- 2001-11-01 US US10/000,903 patent/US20020182221A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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ATE267211T1 (de) | 2004-06-15 |
WO1999010375A2 (en) | 1999-03-04 |
US6342224B1 (en) | 2002-01-29 |
IL134392A0 (en) | 2001-04-30 |
NO20000850D0 (no) | 2000-02-21 |
MA24638A1 (fr) | 1999-04-01 |
NO20000850L (no) | 2000-04-14 |
CA2301920A1 (en) | 1999-03-04 |
CA2301920C (en) | 2011-01-04 |
GB9717953D0 (en) | 1997-10-29 |
DE69824013D1 (de) | 2004-06-24 |
TR200000480T2 (tr) | 2000-07-21 |
NZ502632A (en) | 2002-03-28 |
DE69824013T2 (de) | 2005-06-02 |
AU732946B2 (en) | 2001-05-03 |
HUP0004327A3 (en) | 2003-08-28 |
CO4810234A1 (es) | 1999-06-30 |
CN1276833A (zh) | 2000-12-13 |
PL339009A1 (en) | 2000-12-04 |
UY25146A1 (es) | 2000-12-29 |
US20020182221A1 (en) | 2002-12-05 |
ES2221198T3 (es) | 2004-12-16 |
ZA987591B (en) | 2000-02-21 |
KR20010023193A (ko) | 2001-03-26 |
EP1007551B1 (en) | 2004-05-19 |
JP2001513986A (ja) | 2001-09-11 |
EP1007551A2 (en) | 2000-06-14 |
WO1999010375A3 (en) | 1999-06-10 |
HUP0004327A1 (en) | 2001-03-28 |
AU9263998A (en) | 1999-03-16 |
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