BR9811599A - Compostos de dipetìdeo que inibem adesão de leucócito mediada por vla-4 - Google Patents
Compostos de dipetìdeo que inibem adesão de leucócito mediada por vla-4Info
- Publication number
- BR9811599A BR9811599A BR9811599-5A BR9811599A BR9811599A BR 9811599 A BR9811599 A BR 9811599A BR 9811599 A BR9811599 A BR 9811599A BR 9811599 A BR9811599 A BR 9811599A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- leukocyte adhesion
- vla
- inhibit
- dipetid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Patente de Invenção: <B>"COMPOSTOS DE DIPEPTìDEO QUE INIBEM ADESãO DE LEUCóCITO MEDIADA POR VLA-4"<D>. São descritos compostos que ligam VLA-4. Alguns destes compostos também inibem adesão de leucócito e, especificamente, adesão de leucócito por VLA-4. Tais compostos são úteis no tratamento de doenças inflamatórias em mamíferos, por exemplo seres humanos, tais como, asma, doença de Alzheimer, arteriosclerose, demência aidética, diabetes, doença do intestino irritável, artrite reumatóide, transplante de tecido, metástase de tumor e isquemia do miocárdio. Os compostos também podem ser administrados para tratamento de doenças cerebrais inflamatórias, tais como, esclerose múltipla.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90441597A | 1997-07-31 | 1997-07-31 | |
PCT/US1998/015314 WO1999006435A1 (en) | 1997-07-31 | 1998-07-30 | Dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9811599A true BR9811599A (pt) | 2000-09-19 |
Family
ID=25419114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9811599-5A BR9811599A (pt) | 1997-07-31 | 1998-07-30 | Compostos de dipetìdeo que inibem adesão de leucócito mediada por vla-4 |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0994895A1 (pt) |
JP (1) | JP2001512137A (pt) |
KR (1) | KR20010022412A (pt) |
CN (1) | CN1265673A (pt) |
AR (1) | AR016387A1 (pt) |
AU (1) | AU8661298A (pt) |
BR (1) | BR9811599A (pt) |
CA (1) | CA2291475A1 (pt) |
HU (1) | HUP0002682A3 (pt) |
IL (1) | IL133642A0 (pt) |
NO (1) | NO20000412L (pt) |
PL (1) | PL338554A1 (pt) |
WO (1) | WO1999006435A1 (pt) |
ZA (1) | ZA986834B (pt) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6903075B1 (en) | 1997-05-29 | 2005-06-07 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
WO1998053818A1 (en) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Sulfonamides as cell adhesion inhibitors |
US6221888B1 (en) | 1997-05-29 | 2001-04-24 | Merck & Co., Inc. | Sulfonamides as cell adhesion inhibitors |
EP0984981B1 (en) * | 1997-05-30 | 2003-12-17 | Celltech Therapeutics Limited | Anti-inflammatory tyrosine derivatives |
ES2206953T3 (es) | 1997-06-23 | 2004-05-16 | Tanabe Seiyaku Co., Ltd. | Inhibidores de la adherencia celular mediada por alfa 4-beta 1. |
US6455550B1 (en) | 1997-08-22 | 2002-09-24 | Hoffmann-La Roche Inc. | N-alkanoylphenylalanine derivatives |
MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
ATE273273T1 (de) | 1998-02-26 | 2004-08-15 | Celltech Therapeutics Ltd | Phenylalaninderivate als inhibitoren von alpha4 integrinen |
US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
GB9811969D0 (en) * | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
GB9812088D0 (en) * | 1998-06-05 | 1998-08-05 | Celltech Therapeutics Ltd | Chemical compounds |
US6685617B1 (en) | 1998-06-23 | 2004-02-03 | Pharmacia & Upjohn Company | Inhibitors of α4β1 mediated cell adhesion |
GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
US6333340B1 (en) * | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
US6339101B1 (en) * | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
GB9821222D0 (en) | 1998-09-30 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
PL349461A1 (en) * | 1999-02-18 | 2002-07-29 | Hoffmann La Roche | Thioamide derivatives |
US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
GEP20053477B (en) * | 1999-08-13 | 2005-03-25 | Biogen Inc | Cell Adhesion Inhibitors and Pharmaceutical Compositions Containing Them |
DE60035204T2 (de) * | 1999-09-24 | 2008-02-21 | Genentech, Inc., South San Francisco | Tyrosinderivate |
US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
JP2003519697A (ja) | 1999-12-28 | 2003-06-24 | ファイザー・プロダクツ・インク | 炎症性疾患、自己免疫疾患および呼吸器疾患の処置に有用な非ペプチド系のvla−4依存性細胞結合阻害薬 |
EP1332132B1 (en) | 2000-04-17 | 2007-10-10 | UCB Pharma, S.A. | Enamine derivatives as cell adhesion molecules |
US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
AU2001267753A1 (en) | 2000-07-07 | 2002-01-21 | Celltech R And D Limited | Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists |
AU2001278986A1 (en) | 2000-07-21 | 2002-02-05 | Elan Pharmaceuticals, Inc. | 3-amino-2-(4-aminocarbonyloxy)phenyl-propionic acid derivatives as alpha-4- integrin inhibitors |
AU2001275724A1 (en) | 2000-08-02 | 2002-02-13 | Celltech R&D Limited | 3-substituted isoquinolin-1-yl derivatives |
MY129000A (en) | 2000-08-31 | 2007-03-30 | Tanabe Seiyaku Co | INHIBITORS OF a4 MEDIATED CELL ADHESION |
JP2004526733A (ja) * | 2001-03-20 | 2004-09-02 | メルク エンド カムパニー インコーポレーテッド | 強力な細胞接着阻害剤としての置換n−アリールスルホニル−プロリン誘導体 |
MY140707A (en) | 2002-02-28 | 2010-01-15 | Mitsubishi Tanabe Pharma Corp | Process for preparing a phenylalanine derivative and intermediates thereof |
JP2007531735A (ja) * | 2004-04-01 | 2007-11-08 | エラン ファーマシューティカルズ,インコーポレイテッド | ステロイド節約剤および該節約剤を使用する方法 |
EP2510941A3 (en) | 2007-02-20 | 2013-01-23 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
BRPI0911652A2 (pt) | 2008-04-11 | 2015-08-04 | Merrimack Pharmaceuticals Inc | Ligantes de albumina sérica humana e seus conjugados |
EP2774919A1 (en) * | 2013-03-06 | 2014-09-10 | Pharmeste S.R.L. In Liquidazione | Novel sulfonamide TRPA1 receptor antagonists |
US9834520B2 (en) | 2013-03-14 | 2017-12-05 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
US10472376B2 (en) | 2013-07-03 | 2019-11-12 | Takeda Pharmaceutical Company Limited | Amide compound |
JP6427491B2 (ja) * | 2013-07-03 | 2018-11-21 | 武田薬品工業株式会社 | 複素環化合物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU693143B2 (en) * | 1993-12-06 | 1998-06-25 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
-
1998
- 1998-07-30 ZA ZA9806834A patent/ZA986834B/xx unknown
- 1998-07-30 HU HU0002682A patent/HUP0002682A3/hu unknown
- 1998-07-30 AU AU86612/98A patent/AU8661298A/en not_active Abandoned
- 1998-07-30 JP JP2000505190A patent/JP2001512137A/ja not_active Withdrawn
- 1998-07-30 IL IL13364298A patent/IL133642A0/xx unknown
- 1998-07-30 AR ARP980103776A patent/AR016387A1/es unknown
- 1998-07-30 WO PCT/US1998/015314 patent/WO1999006435A1/en not_active Application Discontinuation
- 1998-07-30 PL PL98338554A patent/PL338554A1/xx unknown
- 1998-07-30 CA CA002291475A patent/CA2291475A1/en not_active Abandoned
- 1998-07-30 KR KR1020007000992A patent/KR20010022412A/ko not_active Application Discontinuation
- 1998-07-30 BR BR9811599-5A patent/BR9811599A/pt not_active Application Discontinuation
- 1998-07-30 CN CN98807762A patent/CN1265673A/zh active Pending
- 1998-07-30 EP EP98937991A patent/EP0994895A1/en not_active Withdrawn
-
2000
- 2000-01-27 NO NO20000412A patent/NO20000412L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AR016387A1 (es) | 2001-07-04 |
JP2001512137A (ja) | 2001-08-21 |
WO1999006435A1 (en) | 1999-02-11 |
KR20010022412A (ko) | 2001-03-15 |
HUP0002682A1 (hu) | 2001-07-30 |
NO20000412L (no) | 2000-03-24 |
PL338554A1 (en) | 2000-11-06 |
CN1265673A (zh) | 2000-09-06 |
CA2291475A1 (en) | 1999-02-11 |
IL133642A0 (en) | 2001-04-30 |
AU8661298A (en) | 1999-02-22 |
HUP0002682A3 (en) | 2001-12-28 |
EP0994895A1 (en) | 2000-04-26 |
NO20000412D0 (no) | 2000-01-27 |
ZA986834B (en) | 2000-05-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |