PL338554A1 - Dipeptidic compounds inhibiting adhesion of leucocytes occurring through the mediation of vla-4 - Google Patents
Dipeptidic compounds inhibiting adhesion of leucocytes occurring through the mediation of vla-4Info
- Publication number
- PL338554A1 PL338554A1 PL98338554A PL33855498A PL338554A1 PL 338554 A1 PL338554 A1 PL 338554A1 PL 98338554 A PL98338554 A PL 98338554A PL 33855498 A PL33855498 A PL 33855498A PL 338554 A1 PL338554 A1 PL 338554A1
- Authority
- PL
- Poland
- Prior art keywords
- dipeptidic
- leucocytes
- vla
- mediation
- occurring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90441597A | 1997-07-31 | 1997-07-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL338554A1 true PL338554A1 (en) | 2000-11-06 |
Family
ID=25419114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL98338554A PL338554A1 (en) | 1997-07-31 | 1998-07-30 | Dipeptidic compounds inhibiting adhesion of leucocytes occurring through the mediation of vla-4 |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0994895A1 (en) |
JP (1) | JP2001512137A (en) |
KR (1) | KR20010022412A (en) |
CN (1) | CN1265673A (en) |
AR (1) | AR016387A1 (en) |
AU (1) | AU8661298A (en) |
BR (1) | BR9811599A (en) |
CA (1) | CA2291475A1 (en) |
HU (1) | HUP0002682A3 (en) |
IL (1) | IL133642A0 (en) |
NO (1) | NO20000412L (en) |
PL (1) | PL338554A1 (en) |
WO (1) | WO1999006435A1 (en) |
ZA (1) | ZA986834B (en) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6221888B1 (en) | 1997-05-29 | 2001-04-24 | Merck & Co., Inc. | Sulfonamides as cell adhesion inhibitors |
US6903075B1 (en) | 1997-05-29 | 2005-06-07 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
JP2002501537A (en) * | 1997-05-29 | 2002-01-15 | メルク エンド カンパニー インコーポレーテッド | Sulfonamides as cell adhesion inhibitors |
JP2002501518A (en) * | 1997-05-30 | 2002-01-15 | セルテック セラピューティックス リミテッド | Anti-inflammatory tyrosine derivative |
JP2001517246A (en) | 1997-06-23 | 2001-10-02 | 田辺製薬株式会社 | α ▲ Lower 4 ▼ β ▲ Lower 1 ▼ Inhibitor of cell adhesion |
US6455550B1 (en) * | 1997-08-22 | 2002-09-24 | Hoffmann-La Roche Inc. | N-alkanoylphenylalanine derivatives |
MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
ES2226413T3 (en) | 1998-02-26 | 2005-03-16 | Celltech Therapeutics Limited | PHENYLALANINE DERIVATIVES AS INTEGRIN ALFA-4 INHIBITORS. |
US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
GB9811969D0 (en) * | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
GB9812088D0 (en) * | 1998-06-05 | 1998-08-05 | Celltech Therapeutics Ltd | Chemical compounds |
US6685617B1 (en) | 1998-06-23 | 2004-02-03 | Pharmacia & Upjohn Company | Inhibitors of α4β1 mediated cell adhesion |
GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
US6333340B1 (en) * | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
US6339101B1 (en) * | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
GB9821222D0 (en) | 1998-09-30 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
CA2362831C (en) * | 1999-02-18 | 2008-10-07 | F. Hoffmann-La Roche Ag | Thioamide derivatives |
US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
CZ2002518A3 (en) * | 1999-08-13 | 2002-05-15 | Biogen, Inc. | Cellular adhesion inhibitors and pharmaceutical preparations in which they are comprised |
DE60035204T2 (en) * | 1999-09-24 | 2008-02-21 | Genentech, Inc., South San Francisco | tyrosine |
US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
NZ518886A (en) | 1999-12-28 | 2004-02-27 | Pfizer Prod Inc | Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases |
ATE375330T1 (en) | 2000-04-17 | 2007-10-15 | Ucb Pharma Sa | ENAMINE DERIVATIVES AS CELL ADHESION MOLECULES |
US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
US6740654B2 (en) | 2000-07-07 | 2004-05-25 | Celltech R & D Limited | Squaric acid derivatives |
US6689781B2 (en) | 2000-07-21 | 2004-02-10 | Elan Pharmaceuticals, Inc. | Phenylalanine derivatives as alpha 4 integrin inhibitors |
CA2417059A1 (en) | 2000-08-02 | 2002-02-07 | Celltech R&D Limited | 3-substituted isoquinolin-1-yl derivatives |
MY129000A (en) | 2000-08-31 | 2007-03-30 | Tanabe Seiyaku Co | INHIBITORS OF a4 MEDIATED CELL ADHESION |
JP2004526733A (en) * | 2001-03-20 | 2004-09-02 | メルク エンド カムパニー インコーポレーテッド | Substituted N-arylsulfonyl-proline derivatives as potent cell adhesion inhibitors |
MY140707A (en) | 2002-02-28 | 2010-01-15 | Mitsubishi Tanabe Pharma Corp | Process for preparing a phenylalanine derivative and intermediates thereof |
JP2007531735A (en) * | 2004-04-01 | 2007-11-08 | エラン ファーマシューティカルズ,インコーポレイテッド | Steroid saving agents and methods of using the saving agents |
CA2714335A1 (en) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
CN102057054B (en) | 2008-04-11 | 2015-06-10 | 梅里麦克制药股份有限公司 | Human serum albumin linkers and conjugates thereof |
EP2774919A1 (en) * | 2013-03-06 | 2014-09-10 | Pharmeste S.R.L. In Liquidazione | Novel sulfonamide TRPA1 receptor antagonists |
JP6280912B2 (en) | 2013-03-14 | 2018-02-14 | 武田薬品工業株式会社 | Heterocyclic compounds |
WO2015002230A1 (en) | 2013-07-03 | 2015-01-08 | 武田薬品工業株式会社 | Amide compound |
WO2015002231A1 (en) * | 2013-07-03 | 2015-01-08 | 武田薬品工業株式会社 | Heterocyclic compound |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU693143B2 (en) * | 1993-12-06 | 1998-06-25 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
-
1998
- 1998-07-30 KR KR1020007000992A patent/KR20010022412A/en not_active Application Discontinuation
- 1998-07-30 PL PL98338554A patent/PL338554A1/en unknown
- 1998-07-30 CA CA002291475A patent/CA2291475A1/en not_active Abandoned
- 1998-07-30 ZA ZA9806834A patent/ZA986834B/en unknown
- 1998-07-30 IL IL13364298A patent/IL133642A0/en unknown
- 1998-07-30 JP JP2000505190A patent/JP2001512137A/en not_active Withdrawn
- 1998-07-30 WO PCT/US1998/015314 patent/WO1999006435A1/en not_active Application Discontinuation
- 1998-07-30 AU AU86612/98A patent/AU8661298A/en not_active Abandoned
- 1998-07-30 AR ARP980103776A patent/AR016387A1/en unknown
- 1998-07-30 EP EP98937991A patent/EP0994895A1/en not_active Withdrawn
- 1998-07-30 CN CN98807762A patent/CN1265673A/en active Pending
- 1998-07-30 HU HU0002682A patent/HUP0002682A3/en unknown
- 1998-07-30 BR BR9811599-5A patent/BR9811599A/en not_active Application Discontinuation
-
2000
- 2000-01-27 NO NO20000412A patent/NO20000412L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0994895A1 (en) | 2000-04-26 |
CN1265673A (en) | 2000-09-06 |
KR20010022412A (en) | 2001-03-15 |
AR016387A1 (en) | 2001-07-04 |
ZA986834B (en) | 2000-05-02 |
AU8661298A (en) | 1999-02-22 |
NO20000412L (en) | 2000-03-24 |
HUP0002682A3 (en) | 2001-12-28 |
NO20000412D0 (en) | 2000-01-27 |
IL133642A0 (en) | 2001-04-30 |
WO1999006435A1 (en) | 1999-02-11 |
HUP0002682A1 (en) | 2001-07-30 |
JP2001512137A (en) | 2001-08-21 |
BR9811599A (en) | 2000-09-19 |
CA2291475A1 (en) | 1999-02-11 |
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