BR9809628A - Processos para preparação de um composto e para a preparação de um aminoálcool. - Google Patents
Processos para preparação de um composto e para a preparação de um aminoálcool.Info
- Publication number
- BR9809628A BR9809628A BR9809628-1A BR9809628A BR9809628A BR 9809628 A BR9809628 A BR 9809628A BR 9809628 A BR9809628 A BR 9809628A BR 9809628 A BR9809628 A BR 9809628A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- processes
- compound
- amino alcohol
- trifluoromethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"PROCESSOS PARA PREPARAçãO DE UM COMPOSTO E PARA A PREPARAçãO DE UM AMINOáLCOOL". Um processo eficiente para a preparação de intermediário chave na síntese de (-)-6-cloro-4-ciclopropiletinil-4-trifluorometil-1,4-diidro-2H-3,1-benzoxa zin-2-ona, um inibidor de transcriptase reversa, é alcançado usando uma reação de adição quiral a 4-cloro-2-trifluorometilcetoanilina com um complexo organozinco, para fornecer o desejado álcool. Este processo atual tem larga aplicabilidade na adição quiral a uma cetona proquiral.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4671397P | 1997-05-16 | 1997-05-16 | |
GB9711599A GB9711599D0 (en) | 1997-06-05 | 1997-06-05 | Efficient enatioselective addition reation using an organozinc reagent |
US5788497P | 1997-09-03 | 1997-09-03 | |
GB9727129A GB9727129D0 (en) | 1997-12-22 | 1997-12-22 | Efficient enantioselective addition reaction using an organozinc reagent |
US8352598P | 1998-04-29 | 1998-04-29 | |
PCT/US1998/008888 WO1998051676A1 (en) | 1997-05-16 | 1998-05-12 | Efficient enantioselective addition reaction using an organozinc reagent |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9809628A true BR9809628A (pt) | 2000-07-04 |
Family
ID=27547294
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9809628-1A BR9809628A (pt) | 1997-05-16 | 1998-05-12 | Processos para preparação de um composto e para a preparação de um aminoálcool. |
Country Status (26)
Country | Link |
---|---|
US (1) | US6015926A (pt) |
EP (1) | EP0981520B1 (pt) |
JP (1) | JP3273615B2 (pt) |
KR (1) | KR100566683B1 (pt) |
CN (1) | CN1106389C (pt) |
AR (1) | AR011731A1 (pt) |
AT (1) | ATE270666T1 (pt) |
AU (1) | AU739250B2 (pt) |
BR (1) | BR9809628A (pt) |
CA (1) | CA2289206C (pt) |
CZ (1) | CZ297968B6 (pt) |
DE (1) | DE69824958T2 (pt) |
DK (1) | DK0981520T3 (pt) |
EA (1) | EA002192B1 (pt) |
ES (1) | ES2224396T3 (pt) |
HR (1) | HRP980266B1 (pt) |
HU (1) | HU226881B1 (pt) |
NZ (1) | NZ500526A (pt) |
PL (1) | PL193448B1 (pt) |
PT (1) | PT981520E (pt) |
RS (1) | RS49860B (pt) |
SI (1) | SI0981520T1 (pt) |
SK (1) | SK285446B6 (pt) |
TW (1) | TWI221833B (pt) |
UA (1) | UA59396C2 (pt) |
WO (1) | WO1998051676A1 (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6201158B1 (en) * | 1998-06-22 | 2001-03-13 | Merck & Co., Inc. | Process for making intermediate aldehydes |
CA2563063C (en) | 2004-04-27 | 2014-06-03 | Wyeth | Purification of progesterone receptor modulators |
US20090163601A1 (en) * | 2007-12-21 | 2009-06-25 | The Regents Of The University Of California | (r)-2-methyl-(2,5-dimethylphenyl)propanol and (s)-(2-methyl-2,5-dimethylphenyl)propanol |
US9073817B2 (en) | 2008-01-31 | 2015-07-07 | Laurus Labs Private Limited | Efficient process to induce enantioselectivity in procarbonyl compounds |
ZA200806473B (en) * | 2008-01-31 | 2009-04-29 | Aptuit Laurus Pvt Ltd | An efficient process to induce enantioselectivity in procarbonyl compounds |
WO2009133538A1 (en) | 2008-05-01 | 2009-11-05 | Ranbaxy Laboratories Limited | Process for the preparation of efavirenz |
US8604189B2 (en) * | 2008-05-30 | 2013-12-10 | Emcure Pharmaceuticals Limited | Process for the preparation of Efavirenz |
KR100878436B1 (ko) * | 2008-08-18 | 2009-01-13 | 주식회사 지씨에이치앤피 | 금은화 추출물을 포함하는 소화성 궤양 치료 또는 예방용 약학조성물 |
WO2010115641A1 (en) * | 2009-04-09 | 2010-10-14 | Lonza Ltd | Process for the synthesis of chiral cyclic carbamates |
WO2010115639A1 (en) * | 2009-04-09 | 2010-10-14 | Lonza Ltd | Process for the synthesis of a propargylic alcohol |
US20110172419A1 (en) * | 2009-04-09 | 2011-07-14 | Aleksander Warm | Process for the synthesis of cyclic carbamates |
WO2010115638A2 (en) * | 2009-04-09 | 2010-10-14 | Lonza Ltd. | Autocatalytic process for the synthesis of chiral propargylic alcohols |
WO2011000532A2 (de) | 2009-07-03 | 2011-01-06 | Archimica Gmbh | Verfahren zur enantioselektiven addition von organometallischen kohlenstoffnukleophilen an trifluormethylketone und verwendung des verfahrens in der synthese von hiv reverse transcriptase inhibitoren |
US8080655B2 (en) * | 2009-07-20 | 2011-12-20 | Apotex Pharmachem Inc. | Methods of making efavirenz and intermediates thereof |
EP2441759A1 (en) | 2010-10-14 | 2012-04-18 | Lonza Ltd. | Process for the synthesis of cyclic carbamates |
EP2447247A1 (en) * | 2010-10-14 | 2012-05-02 | Lonza Ltd. | Process for the synthesis of chiral propargylic alcohols |
EP2447255A1 (en) | 2010-10-14 | 2012-05-02 | Lonza Ltd. | Process for the synthesis of cyclic carbamates |
WO2012079235A1 (en) * | 2010-12-16 | 2012-06-21 | Lonza Ltd | Process for preparing efavirenz |
CN103254087B (zh) * | 2013-06-07 | 2015-03-18 | 郑州大学 | 依非韦伦中间体的制备方法 |
CN105330554B (zh) * | 2015-02-15 | 2017-07-11 | 上海迪赛诺药业股份有限公司 | 手性环丙基乙炔基叔醇类化合物的合成方法 |
DE202015104551U1 (de) | 2015-08-27 | 2015-12-03 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Reaktoren für die Herstellung von Efavirenz sowie Zwischenprodukte |
NL2018412B1 (en) * | 2017-02-23 | 2018-09-17 | Univ Nelson Mandela Metropolitan | Method for the manufacture of efavirenz |
CN106946718A (zh) * | 2017-04-27 | 2017-07-14 | 武汉工程大学 | 一种合成依非韦伦中间体的方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5665720A (en) * | 1992-08-07 | 1997-09-09 | Merck & Co., Inc. | Benzoxazinones as inhibitors of HIV reverse transcriptase |
AU1694295A (en) * | 1994-01-28 | 1995-08-15 | Merck & Co., Inc. | Benzoxazinones as inhibitors of hiv reverse transcriptase |
US5663467A (en) * | 1995-01-23 | 1997-09-02 | Merck & Co., Inc. | Synthesis of cyclopropylacetylene |
US5633405A (en) * | 1995-05-25 | 1997-05-27 | Merck & Co., Inc. | Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxanzin-2-one |
WO1998030540A1 (en) * | 1997-01-10 | 1998-07-16 | Merck & Co., Inc. | Efficient synthesis of a chiral mediator |
PL197740B1 (pl) * | 1997-02-05 | 2008-04-30 | Merck & Co Inc | Postać krystaliczna I (-)-6-chloro-4-cyklopropyloetynylo-4-trifluorometylo-1,4-dihydro-2H-3,1-benzoksazyn-2-onu i sposób krystalizacji postaci I (-)-6-chloro-4-cyklopropylo-etynylo-4-trifluorometylo-1,4-dihydro-2H-3,1-benzoksazyn-2-onu |
TW480253B (en) * | 1997-02-12 | 2002-03-21 | Merck & Co Inc | Efficient synthesis of a 1,4-dihydro-2H-3,1-benzoxazin-2-one |
-
1998
- 1998-05-11 AR ARP980102177A patent/AR011731A1/es active IP Right Grant
- 1998-05-11 US US09/075,476 patent/US6015926A/en not_active Expired - Lifetime
- 1998-05-12 ES ES98922084T patent/ES2224396T3/es not_active Expired - Lifetime
- 1998-05-12 EA EA199901040A patent/EA002192B1/ru not_active IP Right Cessation
- 1998-05-12 KR KR1019997010611A patent/KR100566683B1/ko not_active IP Right Cessation
- 1998-05-12 HU HU0003404A patent/HU226881B1/hu unknown
- 1998-05-12 CZ CZ0404699A patent/CZ297968B6/cs not_active IP Right Cessation
- 1998-05-12 SK SK1562-99A patent/SK285446B6/sk not_active IP Right Cessation
- 1998-05-12 CA CA002289206A patent/CA2289206C/en not_active Expired - Lifetime
- 1998-05-12 SI SI9830670T patent/SI0981520T1/xx unknown
- 1998-05-12 JP JP54926798A patent/JP3273615B2/ja not_active Expired - Lifetime
- 1998-05-12 WO PCT/US1998/008888 patent/WO1998051676A1/en active IP Right Grant
- 1998-05-12 AT AT98922084T patent/ATE270666T1/de active
- 1998-05-12 DK DK98922084T patent/DK0981520T3/da active
- 1998-05-12 PT PT98922084T patent/PT981520E/pt unknown
- 1998-05-12 PL PL98336717A patent/PL193448B1/pl unknown
- 1998-05-12 EP EP98922084A patent/EP0981520B1/en not_active Expired - Lifetime
- 1998-05-12 BR BR9809628-1A patent/BR9809628A/pt not_active Application Discontinuation
- 1998-05-12 AU AU74707/98A patent/AU739250B2/en not_active Expired
- 1998-05-12 DE DE69824958T patent/DE69824958T2/de not_active Expired - Lifetime
- 1998-05-12 NZ NZ500526A patent/NZ500526A/en not_active IP Right Cessation
- 1998-05-12 CN CN98805059A patent/CN1106389C/zh not_active Expired - Lifetime
- 1998-05-12 RS YUP-582/99A patent/RS49860B/sr unknown
- 1998-05-14 TW TW087107486A patent/TWI221833B/zh not_active IP Right Cessation
- 1998-05-15 HR HR980266A patent/HRP980266B1/xx not_active IP Right Cessation
- 1998-12-05 UA UA99126738A patent/UA59396C2/uk unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9809628A (pt) | Processos para preparação de um composto e para a preparação de um aminoálcool. | |
PA8464901A1 (es) | Procesos para la sintesis de 1,3-dioles | |
GT199900056A (es) | Nuevas dihidropirimidinas | |
BR9813544A (pt) | Adesivo com endurecimento em estágios múltiplos e uso do mesmo na produção de materiais compostos | |
BRPI9915679B8 (pt) | composições e métodos para aumentar a mineralização óssea | |
DK0892780T3 (da) | m-Amidinophenylanaloger som faktor Xa-inhibitorer | |
ES2190095T3 (es) | Sales nitricas de inhibidores del enzima de conversion. | |
BR0014157A (pt) | Escova | |
BR0010975A (pt) | Processos para modulação da produtividade e da eficiência do uso da água em uma planta | |
ATE203016T1 (de) | Cryptophycine | |
BR0013248A (pt) | Inibidores da adesão celular | |
BR0008239A (pt) | Processo de redução de crescimento de cabelos em mamìferos, uso de um inibidor de proteìna-tirosina quinase, processo de produção de uma composição para inibir o crescimento de cabelo de mamìferos, e, composição usada para inibir crescimento de cabelo em mamìferos | |
BR9812369A (pt) | Processos de redução do crescimento de pêlos de mamìferos e de produção de uma composição para inibir crescimento de pêlos de mamìferos, uso de um inibidor de aminoacil-trna sintetase, e, composição para inibir o crescimento de pêlos em mamìferos | |
BR0212966A (pt) | Fosfonita, uso da mesma, complexo de metal de transição, processo para a preparação e uso do mesmo, e, processos para a adição de ácido cianìdrico a uma ligação dupla olefìnica na presença de um catalisador, e para a isomerização de nitrilas orgânicas na presença de um catalisador | |
AR006058A1 (es) | Procedimientos para preparar compuestos de dicianoacetato y de 1,2-pirazol-5-amino-3-substituido | |
BR0007638A (pt) | Processo para determinação pós-genÈmica de estruturas atÈmicas macromoleculares | |
BR9807761A (pt) | oscópicos de l(-)carnitina | |
ES2172967T3 (es) | Metilciclotetradec-5-en-1-ona. | |
NZ508257A (en) | The semi-synthesis process for the conversion of 9-dihydro-13-acetylbaccatin III into baccatin III | |
BR0211425A (pt) | Método para a preparação de compostos, e, uso de uma composição | |
CO4970804A1 (es) | Nuevos derivados de la vitamina d3 | |
ES2162419T3 (es) | Procedimiento para la hidrogenacion de compuestos del grupo de las iminas o de las enaminas. | |
EA199900277A2 (ru) | Способ алкилирования затрудненных сульфонамидов | |
KR970064587A (ko) | 육모제(育毛劑) | |
ATE337288T1 (de) | Isomerisierung eines pentols |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PARECER ANTERIOR, DE ACORDO COM O ARTIGO 37 COM BASE NOS ARTIGOS 8O E 13 DA LPI |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |