ATE203016T1 - Cryptophycine - Google Patents
CryptophycineInfo
- Publication number
- ATE203016T1 ATE203016T1 AT95906059T AT95906059T ATE203016T1 AT E203016 T1 ATE203016 T1 AT E203016T1 AT 95906059 T AT95906059 T AT 95906059T AT 95906059 T AT95906059 T AT 95906059T AT E203016 T1 ATE203016 T1 AT E203016T1
- Authority
- AT
- Austria
- Prior art keywords
- cryptophycins
- methods
- pharmaceuticals
- proliferation
- inhibit
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17263293A | 1993-12-21 | 1993-12-21 | |
US24995594A | 1994-05-27 | 1994-05-27 | |
PCT/US1994/014740 WO1995017093A1 (en) | 1993-12-21 | 1994-12-21 | New cryptophycins |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE203016T1 true ATE203016T1 (de) | 2001-07-15 |
Family
ID=26868303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95906059T ATE203016T1 (de) | 1993-12-21 | 1994-12-21 | Cryptophycine |
Country Status (8)
Country | Link |
---|---|
US (2) | US6013626A (de) |
EP (1) | EP0735819B1 (de) |
JP (1) | JPH09510436A (de) |
AT (1) | ATE203016T1 (de) |
AU (1) | AU695873B2 (de) |
CA (1) | CA2179490A1 (de) |
DE (1) | DE69427706T2 (de) |
WO (1) | WO1995017093A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69427706T2 (de) * | 1993-12-21 | 2001-10-25 | University Of Hawaii, Honolulu | Cryptophycine |
DE69633667T2 (de) * | 1995-03-07 | 2006-03-02 | University Of Hawaii, Honolulu | Neue synthetische cryptophycine |
MA23823A1 (fr) | 1995-03-27 | 1996-10-01 | Aventis Pharma Sa | Nouveaux taxoides, leur preparation et les compositions qui les contiennent |
US6372780B2 (en) | 1995-03-27 | 2002-04-16 | Aventis Pharma S.A. | Methods of treating cell lines expressing multidrug resistance P-glycoprotein |
AU1469097A (en) * | 1995-12-22 | 1997-07-17 | Eli Lilly And Company | Pharmaceutical compounds |
WO1997031632A1 (en) * | 1996-02-27 | 1997-09-04 | Eli Lilly And Company | Pharmaceutical compounds |
US5977387A (en) * | 1996-08-30 | 1999-11-02 | Eli Lilly And Company | Process for preparing pharmaceutical compounds |
CA2264063C (en) * | 1996-08-30 | 2007-03-13 | Eli Lilly And Company | Cryptophycin compounds |
US6680311B1 (en) | 1996-08-30 | 2004-01-20 | Eli Lilly And Company | Cryptophycin compounds |
WO1998008506A1 (en) * | 1996-08-30 | 1998-03-05 | Eli Lilly And Company | Pharmaceutical compounds |
WO1998009955A1 (en) * | 1996-09-06 | 1998-03-12 | Eli Lilly And Company | Process and novel intermediates |
JP2001500128A (ja) * | 1996-09-06 | 2001-01-09 | イーライ・リリー・アンド・カンパニー | 薬用組成物を製造する方法 |
EP0956295A1 (de) * | 1996-09-06 | 1999-11-17 | Eli Lilly And Company | Herstellungsverfahren für arzneistoffe |
CA2281104A1 (en) * | 1997-02-26 | 1998-09-03 | University Of Hawaii | Selective epoxidation process for preparing pharmaceutical compounds |
US6180679B1 (en) * | 1998-04-07 | 2001-01-30 | Eli Lilly And Company | Method for treating fungal infections |
US6376230B1 (en) | 1998-10-16 | 2002-04-23 | Eli Lilly And Company | Stereoselective process for producing intermediates of cryptophycins |
US6103913A (en) * | 1998-10-16 | 2000-08-15 | Eli Lilly And Company | Process for preparing enollactone derivatives |
IT1307320B1 (it) * | 1999-06-29 | 2001-10-30 | Univ Firenze | Ceppo cianobatterico del genere nostoc, nonche' colture, biomasse,estratti, molocole bioattive derivate da tale ceppo e loro uso in |
CA2385528C (en) | 1999-10-01 | 2013-12-10 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
US6747021B2 (en) | 2000-10-02 | 2004-06-08 | Eli Lilly And Company | Cryptophycin compound |
AU2002246542A1 (en) * | 2000-10-31 | 2002-07-30 | Chemgenex Therapeutics, Inc. | Antiproliferative colchicine compositions and uses thereof |
US20050170015A1 (en) * | 2000-10-31 | 2005-08-04 | Brown Dennis M. | Antiproliferative colchicine compositions and uses thereof |
US6743598B2 (en) * | 2001-08-10 | 2004-06-01 | Mycologics, Inc. | Methods for the identification of fungal glucose utilization inhibitors and antifungal agents |
CA2556550A1 (en) * | 2004-02-17 | 2005-09-01 | University Of South Florida | Cytotoxin compound and method of isolation |
EP1751279A4 (de) | 2004-05-05 | 2008-03-19 | Univ Minnesota | An der herstellung von cryptophycin beteiligte nukleinsäuren und polypeptide |
US7566558B2 (en) | 2006-07-28 | 2009-07-28 | Regents Of The University Of Michigan | Nucleic acids and polypeptides involved in the production of cryptophycin |
EP2374868B1 (de) * | 2009-01-02 | 2013-11-06 | Chung-Aug University Industry-Academy Cooperation | Neues derivat von cyclischem pentadepsipeptid und fusariumstamm zu dessen herstellung |
TWI714661B (zh) * | 2015-11-05 | 2021-01-01 | 法商賽諾菲公司 | 新穎念珠藻素化合物及接合物、其製備與其治療用途 |
AU2017220830A1 (en) * | 2016-02-16 | 2018-09-06 | Yeda Research And Development Co. Ltd. | Non-protein phenylalanine analogues for inhibiting cyanobacteria and plant growth |
AR111781A1 (es) | 2017-05-10 | 2019-08-21 | Sanofi Sa | Ligadores peptídicos y conjugados de criptoficina, su preparación y su uso terapéutico |
JP2022549971A (ja) * | 2019-09-30 | 2022-11-29 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン | クリプトフィシン抗がん剤の生体触媒合成 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4868208A (en) * | 1988-07-15 | 1989-09-19 | Merck & Co., Inc. | Antifungal agent and method |
US4946835A (en) * | 1988-07-15 | 1990-08-07 | Merck & Co., Inc. | Antifungal fermentation product and method |
US4845086A (en) * | 1988-08-09 | 1989-07-04 | Merck & Co., Inc. | Antifungal agent |
US4845085A (en) * | 1988-08-09 | 1989-07-04 | Merck & Co., Inc. | Antifungal agent |
DE69427706T2 (de) * | 1993-12-21 | 2001-10-25 | University Of Hawaii, Honolulu | Cryptophycine |
-
1994
- 1994-12-21 DE DE69427706T patent/DE69427706T2/de not_active Expired - Fee Related
- 1994-12-21 JP JP7517579A patent/JPH09510436A/ja active Pending
- 1994-12-21 CA CA002179490A patent/CA2179490A1/en not_active Abandoned
- 1994-12-21 WO PCT/US1994/014740 patent/WO1995017093A1/en active IP Right Grant
- 1994-12-21 EP EP95906059A patent/EP0735819B1/de not_active Expired - Lifetime
- 1994-12-21 AU AU14423/95A patent/AU695873B2/en not_active Ceased
- 1994-12-21 AT AT95906059T patent/ATE203016T1/de not_active IP Right Cessation
-
1995
- 1995-03-07 US US08/400,057 patent/US6013626A/en not_active Expired - Lifetime
-
1996
- 1996-11-04 US US08/743,506 patent/US5945315A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6013626A (en) | 2000-01-11 |
WO1995017093A1 (en) | 1995-06-29 |
CA2179490A1 (en) | 1995-06-29 |
EP0735819A1 (de) | 1996-10-09 |
EP0735819B1 (de) | 2001-07-11 |
DE69427706D1 (en) | 2001-08-16 |
EP0735819A4 (de) | 1997-03-19 |
AU1442395A (en) | 1995-07-10 |
AU695873B2 (en) | 1998-08-27 |
JPH09510436A (ja) | 1997-10-21 |
DE69427706T2 (de) | 2001-10-25 |
US5945315A (en) | 1999-08-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |