ATE203016T1 - Cryptophycine - Google Patents

Cryptophycine

Info

Publication number
ATE203016T1
ATE203016T1 AT95906059T AT95906059T ATE203016T1 AT E203016 T1 ATE203016 T1 AT E203016T1 AT 95906059 T AT95906059 T AT 95906059T AT 95906059 T AT95906059 T AT 95906059T AT E203016 T1 ATE203016 T1 AT E203016T1
Authority
AT
Austria
Prior art keywords
cryptophycins
methods
pharmaceuticals
proliferation
inhibit
Prior art date
Application number
AT95906059T
Other languages
English (en)
Inventor
Richard E Moore
Charles D Smith
Gregory M L Patterson
Susan L Mooberry
Thomas H Corbett
Frederick A Valeriote
Trimurtulu Golakoti
Original Assignee
Univ Hawaii
Univ Wayne State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Hawaii, Univ Wayne State filed Critical Univ Hawaii
Application granted granted Critical
Publication of ATE203016T1 publication Critical patent/ATE203016T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95906059T 1993-12-21 1994-12-21 Cryptophycine ATE203016T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17263293A 1993-12-21 1993-12-21
US24995594A 1994-05-27 1994-05-27
PCT/US1994/014740 WO1995017093A1 (en) 1993-12-21 1994-12-21 New cryptophycins

Publications (1)

Publication Number Publication Date
ATE203016T1 true ATE203016T1 (de) 2001-07-15

Family

ID=26868303

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95906059T ATE203016T1 (de) 1993-12-21 1994-12-21 Cryptophycine

Country Status (8)

Country Link
US (2) US6013626A (de)
EP (1) EP0735819B1 (de)
JP (1) JPH09510436A (de)
AT (1) ATE203016T1 (de)
AU (1) AU695873B2 (de)
CA (1) CA2179490A1 (de)
DE (1) DE69427706T2 (de)
WO (1) WO1995017093A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69427706T2 (de) * 1993-12-21 2001-10-25 University Of Hawaii, Honolulu Cryptophycine
DE69633667T2 (de) * 1995-03-07 2006-03-02 University Of Hawaii, Honolulu Neue synthetische cryptophycine
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
AU1469097A (en) * 1995-12-22 1997-07-17 Eli Lilly And Company Pharmaceutical compounds
WO1997031632A1 (en) * 1996-02-27 1997-09-04 Eli Lilly And Company Pharmaceutical compounds
US5977387A (en) * 1996-08-30 1999-11-02 Eli Lilly And Company Process for preparing pharmaceutical compounds
CA2264063C (en) * 1996-08-30 2007-03-13 Eli Lilly And Company Cryptophycin compounds
US6680311B1 (en) 1996-08-30 2004-01-20 Eli Lilly And Company Cryptophycin compounds
WO1998008506A1 (en) * 1996-08-30 1998-03-05 Eli Lilly And Company Pharmaceutical compounds
WO1998009955A1 (en) * 1996-09-06 1998-03-12 Eli Lilly And Company Process and novel intermediates
JP2001500128A (ja) * 1996-09-06 2001-01-09 イーライ・リリー・アンド・カンパニー 薬用組成物を製造する方法
EP0956295A1 (de) * 1996-09-06 1999-11-17 Eli Lilly And Company Herstellungsverfahren für arzneistoffe
CA2281104A1 (en) * 1997-02-26 1998-09-03 University Of Hawaii Selective epoxidation process for preparing pharmaceutical compounds
US6180679B1 (en) * 1998-04-07 2001-01-30 Eli Lilly And Company Method for treating fungal infections
US6376230B1 (en) 1998-10-16 2002-04-23 Eli Lilly And Company Stereoselective process for producing intermediates of cryptophycins
US6103913A (en) * 1998-10-16 2000-08-15 Eli Lilly And Company Process for preparing enollactone derivatives
IT1307320B1 (it) * 1999-06-29 2001-10-30 Univ Firenze Ceppo cianobatterico del genere nostoc, nonche' colture, biomasse,estratti, molocole bioattive derivate da tale ceppo e loro uso in
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6747021B2 (en) 2000-10-02 2004-06-08 Eli Lilly And Company Cryptophycin compound
AU2002246542A1 (en) * 2000-10-31 2002-07-30 Chemgenex Therapeutics, Inc. Antiproliferative colchicine compositions and uses thereof
US20050170015A1 (en) * 2000-10-31 2005-08-04 Brown Dennis M. Antiproliferative colchicine compositions and uses thereof
US6743598B2 (en) * 2001-08-10 2004-06-01 Mycologics, Inc. Methods for the identification of fungal glucose utilization inhibitors and antifungal agents
CA2556550A1 (en) * 2004-02-17 2005-09-01 University Of South Florida Cytotoxin compound and method of isolation
EP1751279A4 (de) 2004-05-05 2008-03-19 Univ Minnesota An der herstellung von cryptophycin beteiligte nukleinsäuren und polypeptide
US7566558B2 (en) 2006-07-28 2009-07-28 Regents Of The University Of Michigan Nucleic acids and polypeptides involved in the production of cryptophycin
EP2374868B1 (de) * 2009-01-02 2013-11-06 Chung-Aug University Industry-Academy Cooperation Neues derivat von cyclischem pentadepsipeptid und fusariumstamm zu dessen herstellung
TWI714661B (zh) * 2015-11-05 2021-01-01 法商賽諾菲公司 新穎念珠藻素化合物及接合物、其製備與其治療用途
AU2017220830A1 (en) * 2016-02-16 2018-09-06 Yeda Research And Development Co. Ltd. Non-protein phenylalanine analogues for inhibiting cyanobacteria and plant growth
AR111781A1 (es) 2017-05-10 2019-08-21 Sanofi Sa Ligadores peptídicos y conjugados de criptoficina, su preparación y su uso terapéutico
JP2022549971A (ja) * 2019-09-30 2022-11-29 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン クリプトフィシン抗がん剤の生体触媒合成

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868208A (en) * 1988-07-15 1989-09-19 Merck & Co., Inc. Antifungal agent and method
US4946835A (en) * 1988-07-15 1990-08-07 Merck & Co., Inc. Antifungal fermentation product and method
US4845086A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
US4845085A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
DE69427706T2 (de) * 1993-12-21 2001-10-25 University Of Hawaii, Honolulu Cryptophycine

Also Published As

Publication number Publication date
US6013626A (en) 2000-01-11
WO1995017093A1 (en) 1995-06-29
CA2179490A1 (en) 1995-06-29
EP0735819A1 (de) 1996-10-09
EP0735819B1 (de) 2001-07-11
DE69427706D1 (en) 2001-08-16
EP0735819A4 (de) 1997-03-19
AU1442395A (en) 1995-07-10
AU695873B2 (en) 1998-08-27
JPH09510436A (ja) 1997-10-21
DE69427706T2 (de) 2001-10-25
US5945315A (en) 1999-08-31

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee