BR9803346A - Microorganismos e processo para a preparação fermentativa del-cisteìna, l-cistina, n-acetil-serina ou derivados de tiazoldina. - Google Patents
Microorganismos e processo para a preparação fermentativa del-cisteìna, l-cistina, n-acetil-serina ou derivados de tiazoldina.Info
- Publication number
- BR9803346A BR9803346A BR9803346-8A BR9803346A BR9803346A BR 9803346 A BR9803346 A BR 9803346A BR 9803346 A BR9803346 A BR 9803346A BR 9803346 A BR9803346 A BR 9803346A
- Authority
- BR
- Brazil
- Prior art keywords
- cystine
- cysteine
- microorganisms
- fermentative preparation
- derivatives
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title abstract 5
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 title abstract 4
- JJIHLJJYMXLCOY-BYPYZUCNSA-N N-acetyl-L-serine Chemical compound CC(=O)N[C@@H](CO)C(O)=O JJIHLJJYMXLCOY-BYPYZUCNSA-N 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 abstract 2
- 235000019393 L-cystine Nutrition 0.000 abstract 2
- 239000004158 L-cystine Substances 0.000 abstract 2
- 229960003067 cystine Drugs 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 150000003548 thiazolidines Chemical class 0.000 abstract 2
- XUJNEKJLAYXESH-XQSDEXCQSA-N (2r)-2-azanyl-3-sulfanyl-propanoic acid Chemical compound [35SH]C[C@H](N)C(O)=O XUJNEKJLAYXESH-XQSDEXCQSA-N 0.000 abstract 1
- OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical class C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19726083A DE19726083A1 (de) | 1997-06-19 | 1997-06-19 | Mikroorganismen und Verfahren zur fermentativen Herstellung von L-Cystein, L-Cystin, N-Acetyl-Serin oder Thiazolidinderivaten |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9803346A true BR9803346A (pt) | 2000-02-08 |
BR9803346B1 BR9803346B1 (pt) | 2013-11-12 |
Family
ID=7833043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9803346-8B1A BR9803346B1 (pt) | 1997-06-19 | 1998-06-17 | Cepa de microorganismos transformados, bem como processo para a preparação fermentativa de l-cisteína, l-cistina, n-acetil-serina ou derivados de tiazolidina |
Country Status (14)
Country | Link |
---|---|
US (1) | US5972663A (pt) |
EP (1) | EP0885962B1 (pt) |
JP (1) | JP2992010B2 (pt) |
KR (1) | KR19990007062A (pt) |
CN (1) | CN100347291C (pt) |
AT (1) | ATE293165T1 (pt) |
BR (1) | BR9803346B1 (pt) |
CA (1) | CA2235419C (pt) |
DE (2) | DE19726083A1 (pt) |
DK (1) | DK0885962T3 (pt) |
ES (1) | ES2236845T3 (pt) |
HU (1) | HU224343B1 (pt) |
ID (1) | ID20467A (pt) |
PL (1) | PL195784B1 (pt) |
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19857690A1 (de) * | 1998-12-14 | 2000-06-15 | Consortium Elektrochem Ind | Verfahren zur Isolierung oder Reinigung von 2-Methyl-thiazolidin-2,4-dicarbonsäure |
DE19949579C1 (de) * | 1999-10-14 | 2000-11-16 | Consortium Elektrochem Ind | Verfahren zur fermentativen Herstellung von L-Cystein oder L-Cystein-Derivaten |
DE10046934A1 (de) * | 2000-09-21 | 2002-04-18 | Consortium Elektrochem Ind | Verfahren zur fermentativen Herstellung von nicht-proteinogenen L-Aminosäuren |
EP1239041B1 (en) * | 2001-02-13 | 2006-04-19 | Ajinomoto Co., Inc. | Method for producing L-amino acid using bacteria belonging to the genus Escherichia |
DE10107002A1 (de) * | 2001-02-15 | 2002-08-29 | Consortium Elektrochem Ind | Verfahren zur fermentativen Herstellung von O-Acetyl-L-Serin |
DE60232120D1 (de) * | 2001-06-12 | 2009-06-10 | Ajinomoto Kk | Verfahren zur Herstellung von L-Lysin oder L-Arginin unter Verwendung methanolassimilierender Bakterien |
US7252978B2 (en) | 2001-07-25 | 2007-08-07 | Ajinomoto Co., Inc. | Method for producing L-arginine |
EP1298200B1 (en) * | 2001-09-28 | 2006-03-29 | Ajinomoto Co., Inc. | L-Cysteine producing bacterium and method for producing l-cysteine |
DE60236684D1 (de) * | 2001-11-23 | 2010-07-22 | Ajinomoto Kk | Verfahren zur l-aminosäureproduktion mit escherichia |
RU2229513C2 (ru) * | 2001-11-23 | 2004-05-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения l-аминокислот, штамм escherichia coli - продуцент l-аминокислоты (варианты) |
DE10219851B4 (de) * | 2002-05-03 | 2004-06-24 | Consortium für elektrochemische Industrie GmbH | Verfahren zur Herstellung von L-Serin |
DE10232930A1 (de) * | 2002-07-19 | 2004-02-05 | Consortium für elektrochemische Industrie GmbH | Verfahren zur fermentativen Herstellung von Aminosäuren und Aminosäure-Derivaten der Phosphoglycerat-Familie |
DE10237479A1 (de) * | 2002-08-16 | 2004-02-26 | Degussa Ag | Schwefel-haltiges Tierfuttermitteladditiv |
US7348037B2 (en) | 2002-08-16 | 2008-03-25 | Evonik Degussa Gmbh | Sulfur-containing animal-feed additives |
JP4120364B2 (ja) * | 2002-11-20 | 2008-07-16 | 味の素株式会社 | メタノール資化性菌を用いたl−リジンまたはl−アルギニンの製造法 |
JP2004166592A (ja) * | 2002-11-20 | 2004-06-17 | Ajinomoto Co Inc | メチロトローフを用いたl−アミノ酸の製造法 |
DE10305774A1 (de) * | 2003-02-06 | 2004-08-26 | Consortium für elektrochemische Industrie GmbH | Verfahren zur fermentativen Herstellung von L-Methionin |
US20060270013A1 (en) | 2003-02-18 | 2006-11-30 | Michel Chateau | Method for the production of evolved microorganisms which permit the generation or modification of metabolic pathways |
DE10331291A1 (de) | 2003-07-10 | 2005-02-17 | Consortium für elektrochemische Industrie GmbH | Varianten der 3-Phosphoglyceratdehydrogenase mit reduzierter Hemmung durch L-Serin und dafür codierende Gene |
RU2275425C2 (ru) * | 2003-11-03 | 2006-04-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Бактерия, принадлежащая к роду escherichia, - продуцент l-цистеина и способ получения l-цистеина |
KR100786987B1 (ko) * | 2004-01-30 | 2007-12-18 | 아지노모토 가부시키가이샤 | L-아미노산 생산 미생물 및 l-아미노산 생산 방법 |
US20050191684A1 (en) * | 2004-02-25 | 2005-09-01 | Zimenkov Danila V. | Method for producing L-amino acids |
JP4479283B2 (ja) | 2004-03-04 | 2010-06-09 | 味の素株式会社 | L−システイン生産菌及びl−システインの製造法 |
JP4604537B2 (ja) * | 2004-03-31 | 2011-01-05 | 味の素株式会社 | L−システイン生産菌及びl−システインの製造法 |
JP2007185184A (ja) * | 2005-12-16 | 2007-07-26 | Ajinomoto Co Inc | L−アミノ酸生産菌及びl−アミノ酸の製造法 |
JP2009089603A (ja) | 2006-02-02 | 2009-04-30 | Ajinomoto Co Inc | メタノール資化性細菌を用いたl−リジンの製造法 |
JP2009118740A (ja) | 2006-03-03 | 2009-06-04 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
WO2007119574A2 (en) | 2006-03-23 | 2007-10-25 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using bacterium of the enterobacteriaceae family with attenuated expression of a gene coding for small rna |
JP2009165355A (ja) | 2006-04-28 | 2009-07-30 | Ajinomoto Co Inc | L−アミノ酸を生産する微生物及びl−アミノ酸の製造法 |
RU2006143864A (ru) | 2006-12-12 | 2008-06-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНОВ cynT, cynS, cynX, ИЛИ cynR, ИЛИ ИХ КОМБИНАЦИИ |
JP2010041920A (ja) | 2006-12-19 | 2010-02-25 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
KR101730837B1 (ko) | 2007-01-22 | 2017-04-27 | 아지노모토 가부시키가이샤 | L-아미노산을 생산하는 미생물 및 l-아미노산의 제조법 |
DE102007007333A1 (de) | 2007-02-14 | 2008-08-21 | Wacker Chemie Ag | Verfahren zur Reinigung von L-Cystein |
JP2010110216A (ja) | 2007-02-20 | 2010-05-20 | Ajinomoto Co Inc | L−アミノ酸または核酸の製造方法 |
JP2010110217A (ja) | 2007-02-22 | 2010-05-20 | Ajinomoto Co Inc | L−アミノ酸生産菌及びl−アミノ酸の製造法 |
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JP5526785B2 (ja) | 2008-01-23 | 2014-06-18 | 味の素株式会社 | L−アミノ酸の製造法 |
RU2008105793A (ru) | 2008-02-19 | 2009-08-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Способ конструирования оперонов, содержащих трансляционно сопряженные гены, бактерия, содержащая такой оперон, способ продукции полезного метаболита и способ мониторинга экспрессии гена |
JP5476545B2 (ja) * | 2008-02-21 | 2014-04-23 | 味の素株式会社 | L−システイン生産菌及びl−システインの製造法 |
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DE602009000714D1 (de) * | 2008-03-06 | 2011-03-24 | Ajinomoto Kk | L-Zystein-produzierendes Bakterium und Verfahren zur Herstellung von L-Zystein |
US20120231537A1 (en) * | 2008-04-30 | 2012-09-13 | Gradalis, Inc. | Highly Pure Plasmid DNA Preparations |
CN103255130B (zh) * | 2008-04-30 | 2015-12-23 | 斯特莱科生物有限公司 | 高纯度质粒dna制备物及其制备方法 |
BRPI0918299B1 (pt) | 2008-09-08 | 2018-08-14 | Ajinomoto Co., Inc. | Método para produzir um l-aminoácido |
WO2010084995A2 (en) | 2009-01-23 | 2010-07-29 | Ajinomoto Co.,Inc. | A method for producing an l-amino acid |
EP2395096B1 (en) | 2009-02-09 | 2014-04-09 | Kyowa Hakko Bio Co., Ltd. | Process for producing L-amino acids |
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CN102471790B (zh) | 2009-07-29 | 2014-10-29 | 味之素株式会社 | 产生l-氨基酸的方法 |
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RU2460793C2 (ru) | 2010-01-15 | 2012-09-10 | Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) | Способ получения l-аминокислот с использованием бактерий семейства enterobacteriaceae |
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BR112013006031A2 (pt) | 2010-09-14 | 2016-06-07 | Ajinomoto Kk | bactéria,e, método para produzir um aminoácido contendo enxofre, uma substância relacionada ao mesmo, ou uma mnistura dos mesmos. |
KR101381048B1 (ko) | 2010-10-20 | 2014-04-14 | 씨제이제일제당 (주) | O-포스포세린 생산 균주 및 이로부터 생산된 o-포스포세린으로부터 l-시스테인 또는 이의 유도체의 생산방법 |
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JP2014036576A (ja) | 2010-12-10 | 2014-02-27 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
JP2014087259A (ja) | 2011-02-22 | 2014-05-15 | Ajinomoto Co Inc | L−システイン生産菌及びl−システインの製造法 |
CN104160024A (zh) | 2011-04-01 | 2014-11-19 | 味之素株式会社 | 用于生产l-半胱氨酸的方法 |
US9234223B2 (en) | 2011-04-01 | 2016-01-12 | Ajinomoto Co., Inc. | Method for producing L-cysteine |
JP2014131487A (ja) * | 2011-04-18 | 2014-07-17 | Ajinomoto Co Inc | L−システインの製造法 |
DE102011007790A1 (de) | 2011-04-20 | 2012-10-25 | Wacker Chemie Ag | Verfahren zur Reinigung von L-Cystein |
DE102011075656A1 (de) * | 2011-05-11 | 2012-03-29 | Wacker Chemie Ag | Verfahren zur fermentativen Produktion von L-Cystin |
DE102011078481A1 (de) | 2011-06-30 | 2013-01-03 | Wacker Chemie Ag | Verfahren zur fermentativen Produktion von natürlichem L-Cystein |
RU2011134436A (ru) | 2011-08-18 | 2013-10-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") | Способ получения l-аминокислоты с использованием бактерии семейства enterobacteriaceae, обладающей повышенной экспрессией генов каскада образования флагелл и клеточной подвижности |
DE102012208359A1 (de) | 2012-05-18 | 2013-11-21 | Wacker Chemie Ag | Verfahren zur fermentativen Produktion von L-Cystein und Derivaten dieser Aminosäure |
DE102012216527A1 (de) | 2012-09-17 | 2014-03-20 | Wacker Chemie Ag | Verfahren zur fermentativen Produktion von L-Cystein und Derivaten dieser Aminosäure |
JP6288649B2 (ja) | 2013-03-19 | 2018-03-07 | 国立大学法人 奈良先端科学技術大学院大学 | L−システイン生産能が高められた腸内細菌科に属する細菌 |
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Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3376341D1 (en) * | 1982-08-09 | 1988-05-26 | Ajinomoto Kk | Method for producing 2-substituted-thiazolidine-4-carboxylic acids |
DE19539952A1 (de) * | 1995-10-26 | 1997-04-30 | Consortium Elektrochem Ind | Verfahren zur Herstellung von O-Acetylserin, L-Cystein und L-Cystein-verwandten Produkten |
DE19548222A1 (de) * | 1995-12-22 | 1997-06-26 | Forschungszentrum Juelich Gmbh | Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern |
-
1997
- 1997-06-19 DE DE19726083A patent/DE19726083A1/de not_active Withdrawn
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1998
- 1998-05-22 DK DK98109269T patent/DK0885962T3/da active
- 1998-05-22 DE DE59812730T patent/DE59812730D1/de not_active Expired - Lifetime
- 1998-05-22 AT AT98109269T patent/ATE293165T1/de active
- 1998-05-22 EP EP98109269A patent/EP0885962B1/de not_active Expired - Lifetime
- 1998-05-22 ES ES98109269T patent/ES2236845T3/es not_active Expired - Lifetime
- 1998-06-15 ID IDP980878A patent/ID20467A/id unknown
- 1998-06-16 US US09/097,759 patent/US5972663A/en not_active Expired - Lifetime
- 1998-06-16 CA CA002235419A patent/CA2235419C/en not_active Expired - Fee Related
- 1998-06-17 BR BRPI9803346-8B1A patent/BR9803346B1/pt not_active IP Right Cessation
- 1998-06-17 KR KR1019980022734A patent/KR19990007062A/ko not_active Application Discontinuation
- 1998-06-18 HU HU9801369A patent/HU224343B1/hu not_active IP Right Cessation
- 1998-06-18 CN CNB981026176A patent/CN100347291C/zh not_active Expired - Fee Related
- 1998-06-19 JP JP10173278A patent/JP2992010B2/ja not_active Expired - Fee Related
- 1998-06-19 PL PL326915A patent/PL195784B1/pl not_active IP Right Cessation
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HUP9801369A2 (hu) | 1999-05-28 |
ES2236845T3 (es) | 2005-07-16 |
EP0885962A1 (de) | 1998-12-23 |
DE19726083A1 (de) | 1998-12-24 |
PL195784B1 (pl) | 2007-10-31 |
JPH1156381A (ja) | 1999-03-02 |
ID20467A (id) | 1998-12-24 |
EP0885962B1 (de) | 2005-04-13 |
CA2235419A1 (en) | 1998-12-19 |
PL326915A1 (en) | 1998-12-21 |
CA2235419C (en) | 2009-06-02 |
JP2992010B2 (ja) | 1999-12-20 |
US5972663A (en) | 1999-10-26 |
CN1203274A (zh) | 1998-12-30 |
HUP9801369A3 (en) | 2000-08-28 |
HU224343B1 (hu) | 2005-08-29 |
DK0885962T3 (da) | 2005-05-09 |
HU9801369D0 (en) | 1998-08-28 |
BR9803346B1 (pt) | 2013-11-12 |
KR19990007062A (ko) | 1999-01-25 |
ATE293165T1 (de) | 2005-04-15 |
DE59812730D1 (de) | 2005-05-19 |
CN100347291C (zh) | 2007-11-07 |
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