BR9713492A - ésteres de ácido graxo de ácido glicólico e seus sais como realçadores de permeação - Google Patents
ésteres de ácido graxo de ácido glicólico e seus sais como realçadores de permeaçãoInfo
- Publication number
- BR9713492A BR9713492A BR9713492-9A BR9713492A BR9713492A BR 9713492 A BR9713492 A BR 9713492A BR 9713492 A BR9713492 A BR 9713492A BR 9713492 A BR9713492 A BR 9713492A
- Authority
- BR
- Brazil
- Prior art keywords
- fatty acid
- glycolic acid
- salts
- glycolic
- incorporated
- Prior art date
Links
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Natural products OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 title abstract 6
- 235000014113 dietary fatty acids Nutrition 0.000 title abstract 6
- 229930195729 fatty acid Natural products 0.000 title abstract 6
- 239000000194 fatty acid Substances 0.000 title abstract 6
- -1 glycolic acid fatty acid esters Chemical class 0.000 title abstract 6
- 239000003623 enhancer Substances 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000011159 matrix material Substances 0.000 abstract 2
- 239000002674 ointment Substances 0.000 abstract 2
- 239000011505 plaster Substances 0.000 abstract 2
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 239000006071 cream Substances 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000006210 lotion Substances 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
- 238000013271 transdermal drug delivery Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fats And Perfumes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Patente de Invenção: <B>"ESTERES DE áCIDO GRAXO DE áCIDO GLICóLICO E SEUS SAIS COMO REALçADORES DE PERMEAçãO"<D>. Um sistema de liberação transdérmica de medicamento, que acentua a liberação do medicamento, compreende uma composição contendo, como um reforçador, um ou mais C~ 5~ a C~ 21~ ésteres de ácido graxo de ácido glicórico e seus sais. Estas composições são compostas de uma quantidade segura de um permeante farmacêutico ativo contido em num veículo de intensificação da penetração, compreendendo de 0,25 a 50% em peso do acentuador de éster de ácido graxos em um veículo portador adequado. Estes reforçadores de éster de ácido glicórico de ácidos graxos podem ser usados em vários veículos portadores para acentuar a liberação transdérmica dos permeantes ativos, ou na forma livre ou usado em um dispositivo oclusivo, particularmente em um emplastro transdérmico na forma de matriz ou de reservatório. Quando usado na forma de emplastro de matriz, os reforçadores de éster de ácido glicórico de ácidos graxos e os permeantes são incorporados em um adesivo biocompatível. quando usado em um emplastro tipo reservatório, o permeante e os reforçadores de éster de ácido glicórico de ácidos graxos são incorporados em um fluido portador de viscosidade controlada, tal como um gel ou um unguento, preferivelmente contendo um alcanol inferior e água. Na forma livre o reforçador e o permeante podem ser incorporados em um unguento, loção, creme ou formulação similar.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74107196A | 1996-10-30 | 1996-10-30 | |
PCT/US1997/019600 WO1998018416A1 (en) | 1996-10-30 | 1997-10-29 | Fatty acid esters of glycolic acid and its salts as permeation enhancers |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9713492A true BR9713492A (pt) | 2000-02-29 |
Family
ID=24979259
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9713492-9A BR9713492A (pt) | 1996-10-30 | 1997-10-29 | ésteres de ácido graxo de ácido glicólico e seus sais como realçadores de permeação |
BR9712474-5A BR9712474A (pt) | 1996-10-30 | 1997-10-29 | steres de ácido graxo de sais de ácido láctico como melhoradores de permeação |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9712474-5A BR9712474A (pt) | 1996-10-30 | 1997-10-29 | steres de ácido graxo de sais de ácido láctico como melhoradores de permeação |
Country Status (10)
Country | Link |
---|---|
US (2) | US5952000A (pt) |
EP (2) | EP0942697A1 (pt) |
JP (2) | JP2001503749A (pt) |
KR (2) | KR20000035800A (pt) |
CN (2) | CN1231592A (pt) |
AU (2) | AU718811B2 (pt) |
BR (2) | BR9713492A (pt) |
CA (2) | CA2263300A1 (pt) |
WO (2) | WO1998018416A1 (pt) |
ZA (2) | ZA979765B (pt) |
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-
1997
- 1997-10-29 EP EP97946387A patent/EP0942697A1/en not_active Withdrawn
- 1997-10-29 BR BR9713492-9A patent/BR9713492A/pt not_active Application Discontinuation
- 1997-10-29 KR KR1019997001408A patent/KR20000035800A/ko not_active Application Discontinuation
- 1997-10-29 KR KR1019997001409A patent/KR20000035801A/ko not_active Application Discontinuation
- 1997-10-29 WO PCT/US1997/019600 patent/WO1998018416A1/en not_active Application Discontinuation
- 1997-10-29 WO PCT/US1997/019731 patent/WO1998018417A1/en not_active Application Discontinuation
- 1997-10-29 EP EP97947295A patent/EP0971662A1/en not_active Withdrawn
- 1997-10-29 BR BR9712474-5A patent/BR9712474A/pt not_active IP Right Cessation
- 1997-10-29 AU AU52409/98A patent/AU718811B2/en not_active Ceased
- 1997-10-29 JP JP52072198A patent/JP2001503749A/ja active Pending
- 1997-10-29 US US08/959,946 patent/US5952000A/en not_active Expired - Lifetime
- 1997-10-29 US US08/959,944 patent/US5912009A/en not_active Expired - Lifetime
- 1997-10-29 AU AU51570/98A patent/AU717183B2/en not_active Ceased
- 1997-10-29 CA CA002263300A patent/CA2263300A1/en not_active Abandoned
- 1997-10-29 CN CN97198273A patent/CN1231592A/zh active Pending
- 1997-10-29 JP JP10520767A patent/JP2001503062A/ja active Pending
- 1997-10-29 CN CN97198274A patent/CN1231593A/zh active Pending
- 1997-10-29 CA CA002263334A patent/CA2263334A1/en not_active Abandoned
- 1997-10-30 ZA ZA9709765A patent/ZA979765B/xx unknown
- 1997-10-30 ZA ZA9709771A patent/ZA979771B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
WO1998018417A1 (en) | 1998-05-07 |
EP0971662A1 (en) | 2000-01-19 |
AU5157098A (en) | 1998-05-22 |
US5912009A (en) | 1999-06-15 |
JP2001503749A (ja) | 2001-03-21 |
CN1231592A (zh) | 1999-10-13 |
KR20000035800A (ko) | 2000-06-26 |
JP2001503062A (ja) | 2001-03-06 |
AU5240998A (en) | 1998-05-22 |
ZA979765B (en) | 1998-05-22 |
AU717183B2 (en) | 2000-03-16 |
BR9712474A (pt) | 1999-10-26 |
KR20000035801A (ko) | 2000-06-26 |
EP0942697A1 (en) | 1999-09-22 |
AU718811B2 (en) | 2000-04-20 |
CA2263300A1 (en) | 1998-05-07 |
ZA979771B (en) | 1998-05-22 |
CA2263334A1 (en) | 1998-05-07 |
WO1998018416A1 (en) | 1998-05-07 |
CN1231593A (zh) | 1999-10-13 |
US5952000A (en) | 1999-09-14 |
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Legal Events
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FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |