BR9710648A - S¡ntese de indolilmaleimidas - Google Patents
S¡ntese de indolilmaleimidasInfo
- Publication number
- BR9710648A BR9710648A BR9710648A BR9710648A BR9710648A BR 9710648 A BR9710648 A BR 9710648A BR 9710648 A BR9710648 A BR 9710648A BR 9710648 A BR9710648 A BR 9710648A BR 9710648 A BR9710648 A BR 9710648A
- Authority
- BR
- Brazil
- Prior art keywords
- indolylmaleimides
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1373196P | 1996-03-20 | 1996-03-20 | |
| PCT/US1997/004416 WO1997034890A1 (en) | 1996-03-20 | 1997-03-20 | Synthesis of indolylmaleimides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9710648A true BR9710648A (pt) | 1999-08-17 |
Family
ID=21761453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9710648A BR9710648A (pt) | 1996-03-20 | 1997-03-20 | S¡ntese de indolilmaleimidas |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5919946A (pt) |
| EP (1) | EP0888339A4 (pt) |
| JP (1) | JP3258334B2 (pt) |
| KR (1) | KR20000064764A (pt) |
| CN (1) | CN1225634A (pt) |
| AU (1) | AU2217797A (pt) |
| BR (1) | BR9710648A (pt) |
| CA (1) | CA2249205A1 (pt) |
| IL (1) | IL126272A0 (pt) |
| WO (1) | WO1997034890A1 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
| US7129250B2 (en) | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| RU2004135382A (ru) | 2002-06-05 | 2005-06-27 | Янссен Фармацевтика Н.В. (Be) | Замещенные пирролины в качестве ингибиторов киназы |
| EP1513520B1 (en) * | 2002-06-05 | 2008-09-24 | Janssen Pharmaceutica N.V. | Substituted pyrrolines as kinase inhibitors |
| EP1819697B1 (en) | 2004-12-08 | 2012-08-01 | Johannes Gutenberg-Universität Mainz | 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors |
| ATE486872T1 (de) | 2005-02-09 | 2010-11-15 | Arqule Inc | Maleimid-derivate, pharmazeutische zusammensetzungen und verfahren zur behandlung von krebs |
| CA2912546A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Compositions and methods for treatment of cancer |
| US8304425B2 (en) | 2007-06-22 | 2012-11-06 | Arqule, Inc. | Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer |
| MX2009013815A (es) | 2007-06-22 | 2010-03-01 | Arqule Inc | Compuestos de quinazolinona y metodos de uso para los mismos. |
| EP2343291A1 (en) | 2009-12-18 | 2011-07-13 | Johannes Gutenberg-Universität Mainz | 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| EP2474541A1 (en) | 2010-12-23 | 2012-07-11 | Johannes- Gutenberg-Universität Mainz | Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| CN105153126B (zh) * | 2015-09-10 | 2017-10-24 | 东华大学 | 一种双吲哚马来酰亚胺类化合物的制备方法 |
| EP3187495A1 (en) | 2015-12-30 | 2017-07-05 | Johannes Gutenberg-Universität Mainz | 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| US11319320B2 (en) | 2017-11-06 | 2022-05-03 | Snap Bio, Inc. | PIM kinase inhibitor compositions, methods, and uses thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4537902A (en) * | 1979-06-11 | 1985-08-27 | Merck & Co., Inc. | 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase |
| US4785085A (en) * | 1986-11-21 | 1988-11-15 | Bristol-Myers Company | Rebeccamycin analogs |
| CZ280738B6 (cs) * | 1988-02-10 | 1996-04-17 | F. Hoffmann - La Roche And Co., Aktiengesellschaft | Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi |
| US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| DE4005969A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
| GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
| AU678435B2 (en) * | 1993-05-10 | 1997-05-29 | F. Hoffmann-La Roche Ag | Substituted pyrroles |
| US5405864A (en) * | 1993-10-15 | 1995-04-11 | Syntex (U.S.A.) Inc. | Chemotherapeutic maleimides |
| EP0657411B1 (en) * | 1993-12-07 | 1999-06-09 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
| PL182124B1 (pl) * | 1993-12-07 | 2001-11-30 | Lilly Co Eli | Nowe zwiazki oraz srodek farmaceutyczny przeznaczony do leczenia powiklan cukrzycowych lub do leczenia nowotworów PL PL PL PL PL PL PL PL |
| US5541347A (en) * | 1993-12-07 | 1996-07-30 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
| PT817627E (pt) * | 1993-12-23 | 2005-07-29 | Lilly Co Eli | Inibidores da proteina cinase c |
| US5545636A (en) * | 1993-12-23 | 1996-08-13 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5491242A (en) * | 1994-06-22 | 1996-02-13 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5475110A (en) * | 1994-10-14 | 1995-12-12 | Cephalon, Inc. | Fused Pyrrolocarbazoles |
-
1997
- 1997-03-20 CN CN97194663A patent/CN1225634A/zh active Pending
- 1997-03-20 CA CA002249205A patent/CA2249205A1/en not_active Abandoned
- 1997-03-20 US US08/821,356 patent/US5919946A/en not_active Expired - Fee Related
- 1997-03-20 IL IL12627297A patent/IL126272A0/xx unknown
- 1997-03-20 JP JP53366997A patent/JP3258334B2/ja not_active Expired - Fee Related
- 1997-03-20 EP EP97915167A patent/EP0888339A4/en not_active Withdrawn
- 1997-03-20 KR KR1019980707527A patent/KR20000064764A/ko not_active Application Discontinuation
- 1997-03-20 WO PCT/US1997/004416 patent/WO1997034890A1/en not_active Application Discontinuation
- 1997-03-20 BR BR9710648A patent/BR9710648A/pt not_active Application Discontinuation
- 1997-03-20 AU AU22177/97A patent/AU2217797A/en not_active Abandoned
-
1999
- 1999-02-11 US US09/248,263 patent/US6037475A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0888339A1 (en) | 1999-01-07 |
| JP3258334B2 (ja) | 2002-02-18 |
| KR20000064764A (ko) | 2000-11-06 |
| EP0888339A4 (en) | 2001-02-28 |
| US6037475A (en) | 2000-03-14 |
| IL126272A0 (en) | 1999-05-09 |
| CA2249205A1 (en) | 1997-09-25 |
| WO1997034890A1 (en) | 1997-09-25 |
| AU2217797A (en) | 1997-10-10 |
| JPH11511487A (ja) | 1999-10-05 |
| US5919946A (en) | 1999-07-06 |
| CN1225634A (zh) | 1999-08-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |