BR9612115A - Inibidor de proliferação de célula endotelial e processo de uso - Google Patents

Inibidor de proliferação de célula endotelial e processo de uso

Info

Publication number
BR9612115A
BR9612115A BR9612115A BR9612115A BR9612115A BR 9612115 A BR9612115 A BR 9612115A BR 9612115 A BR9612115 A BR 9612115A BR 9612115 A BR9612115 A BR 9612115A BR 9612115 A BR9612115 A BR 9612115A
Authority
BR
Brazil
Prior art keywords
cell proliferation
endothelial cell
proliferation inhibitor
inhibitor
endothelial
Prior art date
Application number
BR9612115A
Other languages
English (en)
Inventor
Judah Folkamm
Yihai Cao
Michael S O'reilly
Original Assignee
Childrens Medical Center
Moses
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/763,528 external-priority patent/US5854221A/en
Application filed by Childrens Medical Center, Moses filed Critical Childrens Medical Center
Publication of BR9612115A publication Critical patent/BR9612115A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Medicines Containing Plant Substances (AREA)
BR9612115A 1995-12-13 1996-12-13 Inibidor de proliferação de célula endotelial e processo de uso BR9612115A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US851995P 1995-12-13 1995-12-13
US08/763,528 US5854221A (en) 1996-12-12 1996-12-12 Endothelial cell proliferation inhibitor and method of use
PCT/US1996/020447 WO1997023500A1 (en) 1995-12-13 1996-12-13 Endothelial cell proliferation inhibitor and method of use

Publications (1)

Publication Number Publication Date
BR9612115A true BR9612115A (pt) 1999-02-17

Family

ID=26678280

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9612115A BR9612115A (pt) 1995-12-13 1996-12-13 Inibidor de proliferação de célula endotelial e processo de uso

Country Status (20)

Country Link
US (1) US20010016644A1 (pt)
EP (1) EP0869970B1 (pt)
JP (1) JP3684371B2 (pt)
KR (1) KR100477280B1 (pt)
CN (1) CN1554444A (pt)
AT (1) ATE262537T1 (pt)
AU (1) AU710612B2 (pt)
BR (1) BR9612115A (pt)
CA (1) CA2240296C (pt)
CZ (1) CZ298612B6 (pt)
DE (1) DE69631972T2 (pt)
DK (1) DK0869970T3 (pt)
ES (1) ES2217340T3 (pt)
HK (1) HK1017692A1 (pt)
HU (1) HUP9900979A3 (pt)
NO (1) NO321775B1 (pt)
NZ (1) NZ330537A (pt)
PL (1) PL188719B1 (pt)
PT (1) PT869970E (pt)
WO (1) WO1997023500A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9900979A3 (en) * 1995-12-13 2001-10-29 Children S Medical Ct Corp Bos Endothelial cell proliferation inhibitor and method of use
JP4426650B2 (ja) * 1996-05-03 2010-03-03 アボット・ラボラトリーズ 新規な抗血管形成ペプチド、それをコードするポリヌクレオチド、および血管形成を阻害する方法
US5801146A (en) * 1996-05-03 1998-09-01 Abbott Laboratories Compound and method for inhibiting angiogenesis
US6699838B1 (en) 1996-05-03 2004-03-02 Abbott Laboratories Antiangiogenic peptides
US5801012A (en) 1996-09-17 1998-09-01 Northwestern University Methods and compositions for generating angiostatin
JP2002510209A (ja) * 1997-06-26 2002-04-02 カロリンスカ イノベイションズ アクチボラゲット インビボで血管形成を調節することができるプラスミノーゲンのクリングルドメイン１−５
AU1598599A (en) * 1997-11-20 1999-06-15 Genetix Pharmaceuticals, Inc. Anti-angiogenic gene therapy vectors and their use in treating angiogenesis-related diseases
US6632961B1 (en) 1998-05-22 2003-10-14 Abbott Laboratories Antiangiogenic drug to treat cancer, arthritis and retinopathy
US7144854B1 (en) 1999-09-10 2006-12-05 Conjuchem, Inc. Long lasting anti-angiogenic peptides
EA003922B1 (ru) 1999-05-17 2003-10-30 Конджачем, Инк. Продолжительно действующие инсулинотропные пептиды
AU764103B2 (en) * 1999-05-17 2003-08-07 Conjuchem Biotechnologies Inc. Long lasting anti-angiogenic peptides
AU784359B2 (en) * 1999-12-15 2006-03-16 Entremed, Inc Compositions and methods for inhibiting endothelial cell proliferation
AU8591901A (en) 2000-09-05 2002-03-22 Karolinska Innovations Ab Materials and methods relating to endothelial cell growth inhibitors
AU2002239414A1 (en) * 2000-11-02 2002-05-27 Bristol-Myers Squibb Company Modified plasminogen related peptide fragments and their use as angiogenesis inhibitors
EP2444805A3 (en) * 2004-01-21 2012-06-20 Fujirebio America, Inc. Detection of mesothelin-/megakaryocyte potentiating factor-related peptides in peritoneal fluid for assessment of the peritoneum and the peritoneal cavity
CN100355458C (zh) * 2005-03-16 2007-12-19 北京大学 人增殖抑制基因－腺病毒表达载体的应用
WO2010138631A1 (en) 2009-05-26 2010-12-02 Biolex Therapeutics, Inc. Compositions and methods for production of aglycosylated plasminogen
CN103060265B (zh) * 2013-01-23 2014-12-03 山东大学 老年大鼠脑血管内皮细胞原代培养方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
US5302390A (en) * 1987-07-01 1994-04-12 Beecham Group Plc Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
CA2101614A1 (en) * 1992-07-30 1994-01-31 Shmuel Shaltiel Synthetic peptides derived from vitronectin and pharmaceutical compositions comprising them
NZ285501A (en) * 1994-04-26 1998-02-26 Childrens Medical Center Plasminogen analogs (angiostatin), endothelial inhibitors, assays and kits
EP0758393A1 (en) * 1994-04-26 1997-02-19 PHARMACIA & UPJOHN COMPANY Mac-1 i-domain protein useful in blocking adhesion and migration of neutrophils
NZ307044A (en) * 1995-04-26 2002-03-01 Childrens Medical Center Angiostatin fragments with antiangiogenic activity
HUP9900979A3 (en) * 1995-12-13 2001-10-29 Children S Medical Ct Corp Bos Endothelial cell proliferation inhibitor and method of use

Also Published As

Publication number Publication date
NZ330537A (en) 2001-06-29
JP2002502359A (ja) 2002-01-22
HUP9900979A3 (en) 2001-10-29
JP3684371B2 (ja) 2005-08-17
ES2217340T3 (es) 2004-11-01
DE69631972D1 (de) 2004-04-29
EP0869970A1 (en) 1998-10-14
ATE262537T1 (de) 2004-04-15
CZ298612B6 (cs) 2007-11-21
CA2240296C (en) 2004-05-04
NO982715D0 (no) 1998-06-12
CZ182898A3 (cs) 1998-10-14
PL327200A1 (en) 1998-11-23
AU710612B2 (en) 1999-09-23
WO1997023500A1 (en) 1997-07-03
HUP9900979A2 (hu) 1999-07-28
US20010016644A1 (en) 2001-08-23
CA2240296A1 (en) 1997-07-03
KR100477280B1 (ko) 2005-07-18
KR19990072126A (ko) 1999-09-27
EP0869970B1 (en) 2004-03-24
NO982715L (no) 1998-08-12
HK1017692A1 (en) 1999-11-26
EP0869970A4 (en) 2002-01-30
DE69631972T2 (de) 2005-01-05
AU1687097A (en) 1997-07-17
PT869970E (pt) 2004-08-31
PL188719B1 (pl) 2005-04-29
NO321775B1 (no) 2006-07-03
DK0869970T3 (da) 2004-07-05
CN1554444A (zh) 2004-12-15

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Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO, COM BASE NOS ARTS. 8, 10 (IX), 11 E 37O.

B12B Appeal against refusal [chapter 12.2 patent gazette]