BR112023023065A2 - Compostos para direcionar a degradação da tirosina quinase de bruton - Google Patents

Compostos para direcionar a degradação da tirosina quinase de bruton

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Publication number
BR112023023065A2
BR112023023065A2 BR112023023065A BR112023023065A BR112023023065A2 BR 112023023065 A2 BR112023023065 A2 BR 112023023065A2 BR 112023023065 A BR112023023065 A BR 112023023065A BR 112023023065 A BR112023023065 A BR 112023023065A BR 112023023065 A2 BR112023023065 A2 BR 112023023065A2
Authority
BR
Brazil
Prior art keywords
btk
degradation
compounds
dsm
ligand
Prior art date
Application number
BR112023023065A
Other languages
English (en)
Inventor
T Hopkins Brian
Don Anderson Corey
Eric Stefan
Isaac Marx
Young Ahn Jae
L Yap Jeremy
M Guckian Kevin
Marta Nevalainen
Welzel O'shea Morgan
Xinpeng Cheng
Original Assignee
Biogen Ma Inc
C4 Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Ma Inc, C4 Therapeutics Inc filed Critical Biogen Ma Inc
Publication of BR112023023065A2 publication Critical patent/BR112023023065A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

compostos para direcionar a degradação da tirosina quinase de bruton. a presente invenção refere-se a compostos de fórmula (a): btk - l - dsm (a) ou um sal farmaceuticamente aceitável da mesma, em que dsm é uma porção química de sinalização de degradação que está covalentemente ligada ao ligante l, l é um ligante que liga covalentemente btk a dsm, e btk é uma ligação de conexão química para btk representado pela fórmula (i) ou fórmula (ii) que está covalentemente ligado ao ligante l: em que todas as variáveis são como definidas no pedido. os compostos ou sais farmaceuticamente aceitáveis dos mesmos, como aqui descritos, são capazes de ativar a ubiquitinação seletiva de proteínas btk através das vias ubiquitina-proteassoma (upp) e causar degradação de proteínas btk. a presente invenção também fornece métodos de tratamento de distúrbios responsivos à modulação da atividade de btk e/ou degradação de btk com pelo menos um composto aqui descrito.
BR112023023065A 2021-05-05 2022-05-05 Compostos para direcionar a degradação da tirosina quinase de bruton BR112023023065A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163184439P 2021-05-05 2021-05-05
PCT/US2022/027888 WO2022235945A1 (en) 2021-05-05 2022-05-05 Compounds for targeting degradation of bruton's tyrosine kinase

Publications (1)

Publication Number Publication Date
BR112023023065A2 true BR112023023065A2 (pt) 2024-01-30

Family

ID=82115630

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023023065A BR112023023065A2 (pt) 2021-05-05 2022-05-05 Compostos para direcionar a degradação da tirosina quinase de bruton

Country Status (12)

Country Link
EP (1) EP4333899A1 (pt)
KR (1) KR20240017814A (pt)
CN (1) CN117580592A (pt)
AR (1) AR125768A1 (pt)
AU (1) AU2022268977A1 (pt)
BR (1) BR112023023065A2 (pt)
CA (1) CA3217417A1 (pt)
CO (1) CO2023016743A2 (pt)
IL (1) IL308219A (pt)
TW (1) TW202309039A (pt)
UY (1) UY39756A (pt)
WO (1) WO2022235945A1 (pt)

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Also Published As

Publication number Publication date
CN117580592A (zh) 2024-02-20
WO2022235945A1 (en) 2022-11-10
AU2022268977A1 (en) 2023-11-30
CO2023016743A2 (es) 2023-12-29
CA3217417A1 (en) 2022-11-10
TW202309039A (zh) 2023-03-01
AR125768A1 (es) 2023-08-09
KR20240017814A (ko) 2024-02-08
UY39756A (es) 2022-11-30
IL308219A (en) 2024-01-01
EP4333899A1 (en) 2024-03-13

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