BR112023022844A2 - Anticorpos - Google Patents

Anticorpos

Info

Publication number
BR112023022844A2
BR112023022844A2 BR112023022844A BR112023022844A BR112023022844A2 BR 112023022844 A2 BR112023022844 A2 BR 112023022844A2 BR 112023022844 A BR112023022844 A BR 112023022844A BR 112023022844 A BR112023022844 A BR 112023022844A BR 112023022844 A2 BR112023022844 A2 BR 112023022844A2
Authority
BR
Brazil
Prior art keywords
antibodies
trem1
bind
inhibit
interaction
Prior art date
Application number
BR112023022844A
Other languages
English (en)
Inventor
Anastasios Spiliotopoulos
John Lightwood Daniel
Irena Kadiu
Martin Keaney James
Jan Abendroth
Pallavi Bhatta
Charles Elliott Peter
L Delker Silvia
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of BR112023022844A2 publication Critical patent/BR112023022844A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

anticorpos. a presente invenção se refere a anticorpos que se ligam a trem1 e inibem sua interação com um ou mais de seus ligantes naturais. os exemplos específicos de tais anticorpos são providos. os usos terapêuticos dos anticorpos e métodos de gerar tais também são providos.
BR112023022844A 2021-05-03 2022-05-02 Anticorpos BR112023022844A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163183280P 2021-05-03 2021-05-03
PCT/EP2022/061661 WO2022233764A1 (en) 2021-05-03 2022-05-02 Antibodies

Publications (1)

Publication Number Publication Date
BR112023022844A2 true BR112023022844A2 (pt) 2024-01-23

Family

ID=81878071

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023022844A BR112023022844A2 (pt) 2021-05-03 2022-05-02 Anticorpos

Country Status (11)

Country Link
EP (1) EP4334355A1 (pt)
JP (1) JP2024516305A (pt)
KR (1) KR20240004694A (pt)
CN (1) CN117642428A (pt)
AR (1) AR125732A1 (pt)
AU (1) AU2022268545A1 (pt)
BR (1) BR112023022844A2 (pt)
CA (1) CA3218933A1 (pt)
IL (1) IL308100A (pt)
TW (1) TW202309089A (pt)
WO (1) WO2022233764A1 (pt)

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Also Published As

Publication number Publication date
AR125732A1 (es) 2023-08-09
JP2024516305A (ja) 2024-04-12
KR20240004694A (ko) 2024-01-11
AU2022268545A1 (en) 2023-11-02
CN117642428A (zh) 2024-03-01
EP4334355A1 (en) 2024-03-13
TW202309089A (zh) 2023-03-01
CA3218933A1 (en) 2022-11-10
WO2022233764A1 (en) 2022-11-10
IL308100A (en) 2023-12-01
AU2022268545A9 (en) 2023-11-16

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