BR112023002395A2 - Sistema de baculovírus modificado para produção aprimorada de dna com extremidades fechadas (cedna) - Google Patents

Sistema de baculovírus modificado para produção aprimorada de dna com extremidades fechadas (cedna)

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Publication number
BR112023002395A2
BR112023002395A2 BR112023002395A BR112023002395A BR112023002395A2 BR 112023002395 A2 BR112023002395 A2 BR 112023002395A2 BR 112023002395 A BR112023002395 A BR 112023002395A BR 112023002395 A BR112023002395 A BR 112023002395A BR 112023002395 A2 BR112023002395 A2 BR 112023002395A2
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BR
Brazil
Prior art keywords
cedna
ended dna
baculovirus system
dna production
closed
Prior art date
Application number
BR112023002395A
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English (en)
Inventor
Maghodia Ajay
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Bioverativ Therapeutics Inc
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Publication date
Application filed by Bioverativ Therapeutics Inc filed Critical Bioverativ Therapeutics Inc
Publication of BR112023002395A2 publication Critical patent/BR112023002395A2/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
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    • C12N2710/14011—Baculoviridae
    • C12N2710/14041—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/14011—Baculoviridae
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    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
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    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
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    • C12N2820/00—Vectors comprising a special origin of replication system
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
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  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
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  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SISTEMA DE BACULOVÍRUS MODIFICADO PARA PRODUÇÃO APRIMORADA DE DNA COM EXTREMIDADES FECHADAS (ceDNA). A presente invenção refere-se a um vetor de expressão de baculovírus recombinante (rBEV) para a produção de DNA com extremidades fechadas (ceDNA) em células de inseto.
BR112023002395A 2020-08-23 2021-08-23 Sistema de baculovírus modificado para produção aprimorada de dna com extremidades fechadas (cedna) BR112023002395A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063069115P 2020-08-23 2020-08-23
PCT/US2021/047202 WO2022046665A1 (en) 2020-08-23 2021-08-23 MODIFIED BACULOVIRUS SYSTEM FOR IMPROVED PRODUCTION OF CLOSED-ENDED DNA (ceDNA)

Publications (1)

Publication Number Publication Date
BR112023002395A2 true BR112023002395A2 (pt) 2023-03-21

Family

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BR112023002395A BR112023002395A2 (pt) 2020-08-23 2021-08-23 Sistema de baculovírus modificado para produção aprimorada de dna com extremidades fechadas (cedna)

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Country Link
US (1) US20220090130A1 (pt)
EP (1) EP4199971A1 (pt)
JP (1) JP2023538666A (pt)
KR (1) KR20230046323A (pt)
CN (1) CN116194152A (pt)
AU (1) AU2021330936A1 (pt)
BR (1) BR112023002395A2 (pt)
CA (1) CA3189673A1 (pt)
IL (1) IL300445A (pt)
MX (1) MX2023002221A (pt)
TW (1) TW202227466A (pt)
WO (1) WO2022046665A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3889173T (pt) 2013-02-15 2023-10-10 Bioverativ Therapeutics Inc Gene do fator viii otimizado
RS63548B1 (sr) 2016-02-01 2022-09-30 Bioverativ Therapeutics Inc Optimizovani geni faktora viii
KR20240049332A (ko) * 2021-08-23 2024-04-16 바이오버라티브 테라퓨틱스 인크. 최적화된 인자 viii 유전자

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1395293B1 (en) 2001-05-14 2009-07-22 Gbp Ip, Llc Lentiviral vectors encoding clotting factors for gene therapy
US8501464B2 (en) 2003-04-24 2013-08-06 Ospedale San Raffaele S.R.L. Lentiviral vectors carrying synthetic bi-directional promoters and uses thereof
KR20130114758A (ko) 2005-05-27 2013-10-17 오스페달레 산 라파엘 에스.알.엘. Ｍｉ-ｒｎａ를 포함하는 유전자 벡터
WO2010055413A1 (en) 2008-11-12 2010-05-20 Fondazione Centro San Raffaele Del Monte Tabor Gene vector for inducing transgene-specific immune tolerance
KR101793615B1 (ko) 2009-04-30 2017-11-03 오스페달레 산 라파엘 에스.알.엘. 유전자 벡터
EP2292781A1 (en) * 2009-08-17 2011-03-09 Genethon Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
JP2016537028A (ja) 2013-11-18 2016-12-01 クリスパー セラピューティクス アーゲー Ｃｒｉｓｐｒ−ｃａｓシステムの材料及び方法
TWI707951B (zh) 2015-04-08 2020-10-21 美商健臻公司 過大腺相關載體之製造
MX2018003337A (es) * 2015-09-17 2018-08-16 Alternative Gene Expression Sl Expresion de proteinas recombinantes en pupas de trichoplusia ni.
DK3423110T3 (da) 2016-03-03 2021-11-15 Univ Massachusetts Lineært duplex-dna med lukket ende til ikke-viral genoverførsel
FR3054841B1 (fr) * 2016-08-05 2021-01-29 Centre Nat Rech Scient Systeme d'expression baculovirus
SG11202000764RA (en) 2017-08-09 2020-02-27 Bioverativ Therapeutics Inc Nucleic acid molecules and uses thereof
MA50100A (fr) 2017-09-08 2020-07-15 Generation Bio Co Adn à extrémité fermée (cedna) modifié
WO2019165050A1 (en) * 2018-02-22 2019-08-29 Generation Bio Co. Controlled expression of transgenes using close-ended dna (cedna) vectors
CN113227385A (zh) 2018-08-09 2021-08-06 比奥维拉迪维治疗股份有限公司 核酸分子及其用于非病毒基因疗法的用途
US20220042040A1 (en) * 2018-09-17 2022-02-10 Universität Für Bodenkultur Wien Dual vector system for improved production of proteins in animal cells

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Publication number Publication date
MX2023002221A (es) 2023-03-15
KR20230046323A (ko) 2023-04-05
US20220090130A1 (en) 2022-03-24
WO2022046665A1 (en) 2022-03-03
CA3189673A1 (en) 2022-03-03
EP4199971A1 (en) 2023-06-28
AU2021330936A1 (en) 2023-05-04
TW202227466A (zh) 2022-07-16
IL300445A (en) 2023-04-01
CN116194152A (zh) 2023-05-30
JP2023538666A (ja) 2023-09-08

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