BR112022010839A2 - Compostos heterocíclicos funcionalizados como moduladores de estimulador de genes de interferon (sting) - Google Patents

Compostos heterocíclicos funcionalizados como moduladores de estimulador de genes de interferon (sting)

Info

Publication number
BR112022010839A2
BR112022010839A2 BR112022010839A BR112022010839A BR112022010839A2 BR 112022010839 A2 BR112022010839 A2 BR 112022010839A2 BR 112022010839 A BR112022010839 A BR 112022010839A BR 112022010839 A BR112022010839 A BR 112022010839A BR 112022010839 A2 BR112022010839 A2 BR 112022010839A2
Authority
BR
Brazil
Prior art keywords
sting
modulators
heterocyclic compounds
interferon gene
gene stimulator
Prior art date
Application number
BR112022010839A
Other languages
English (en)
Inventor
Izabela Zawadzka Magdalena
Piero Stasi Luigi
Krzysztof Rogacki Maciej
Wojciech Cwiertnia Grzegorz
Piotr Dudek Lukasz
Justyna Gibas Agnieszka
Rajda Anna
Fabritius Charles-Henry
Radzimierski Adam
Ravindra Mahajan Tushar
Wojciech Les Marcin
Zuchowicz Karol
Wronowski Marek
Jörg Synak David
Raghuram Tangirala Sundara
Original Assignee
Ryvu Therapeutics S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ryvu Therapeutics S A filed Critical Ryvu Therapeutics S A
Publication of BR112022010839A2 publication Critical patent/BR112022010839A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

COMPOSTOS HETEROCÍCLICOS FUNCIONALIZADOS COMO MODULADORES DE ESTIMULADOR DE GENES DE INTERFERON (STING). A presente invenção refere-se a construtos composto-ligante e conjugados anticorpo-fármaco de compostos de fórmula (I) que são úteis como moduladores de STING (Estimulador de Genes de Interferon).
BR112022010839A 2019-12-11 2020-12-11 Compostos heterocíclicos funcionalizados como moduladores de estimulador de genes de interferon (sting) BR112022010839A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19460066 2019-12-11
PCT/EP2020/085833 WO2021116446A1 (en) 2019-12-11 2020-12-11 Functionalized heterocyclic compounds as modulators of stimulator of interferon genes (sting)

Publications (1)

Publication Number Publication Date
BR112022010839A2 true BR112022010839A2 (pt) 2022-09-13

Family

ID=69137703

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022010839A BR112022010839A2 (pt) 2019-12-11 2020-12-11 Compostos heterocíclicos funcionalizados como moduladores de estimulador de genes de interferon (sting)

Country Status (11)

Country Link
US (1) US20230055741A1 (pt)
EP (1) EP4073062A1 (pt)
JP (1) JP2023505877A (pt)
KR (1) KR20220112824A (pt)
CN (1) CN114787148A (pt)
AU (2) AU2020401358B2 (pt)
BR (1) BR112022010839A2 (pt)
CA (1) CA3159943A1 (pt)
IL (1) IL293558A (pt)
MX (1) MX2022007179A (pt)
WO (1) WO2021116446A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113754574B (zh) * 2021-09-18 2024-03-19 苏州大学 一种绿色的可见光催化的乙酸酯化合物的制备方法
WO2023109942A1 (en) * 2021-12-17 2023-06-22 Jacobio Pharmaceuticals Co., Ltd. Compound-linker constructs comprising novel compounds useful as sting agonists and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9388199B2 (en) * 2012-06-28 2016-07-12 Novartis Ag Pyrrolidine derivatives and their use as complement pathway modulators
GB2563642A (en) * 2017-06-22 2018-12-26 Curadev Pharma Ltd Small molecule modulators of human STING
EP3807264A1 (en) * 2018-06-12 2021-04-21 Ryvu Therapeutics S.A. Modulators of stimulator of interferon genes (sting)
KR20220024467A (ko) * 2019-06-12 2022-03-03 리부 세라퓨틱스 에스.에이. 인터페론 유전자 자극인자(sting)의 차세대 조절제

Also Published As

Publication number Publication date
US20230055741A1 (en) 2023-02-23
AU2024203206A1 (en) 2024-05-30
AU2020401358A1 (en) 2022-05-26
AU2020401358B2 (en) 2024-02-15
MX2022007179A (es) 2022-07-19
EP4073062A1 (en) 2022-10-19
WO2021116446A1 (en) 2021-06-17
JP2023505877A (ja) 2023-02-13
IL293558A (en) 2022-08-01
KR20220112824A (ko) 2022-08-11
CA3159943A1 (en) 2021-06-17
CN114787148A (zh) 2022-07-22

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