BR112022019047A2 - Peptídeos de domínio knob autônomos - Google Patents
Peptídeos de domínio knob autônomosInfo
- Publication number
- BR112022019047A2 BR112022019047A2 BR112022019047A BR112022019047A BR112022019047A2 BR 112022019047 A2 BR112022019047 A2 BR 112022019047A2 BR 112022019047 A BR112022019047 A BR 112022019047A BR 112022019047 A BR112022019047 A BR 112022019047A BR 112022019047 A2 BR112022019047 A2 BR 112022019047A2
- Authority
- BR
- Brazil
- Prior art keywords
- autonomous
- domain peptides
- knob domain
- isolated
- formulations
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PEPTÍDEOS DE DOMÍNIO KNOB AUTÔNOMOS. A presente descrição se refere a fragmentos isolados de anticorpos, em particular aos domínios knob isolados de CDR-H3 bovina ultralonga ou porções da mesma que se liga a um antígeno de interesse e formulações que compreendem os mesmos. A descrição se refere adicionalmente ao uso dos fragmentos de anticorpo isolados e formulações em terapia. A presente descrição também se estende aos métodos de preparar os ditos fragmentos de anticorpo isolados.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB2004462.4A GB202004462D0 (en) | 2020-03-27 | 2020-03-27 | Antibody fragments |
GBGB2008095.8A GB202008095D0 (en) | 2020-05-29 | 2020-05-29 | Antibody fragments |
PCT/EP2021/057946 WO2021191424A1 (en) | 2020-03-27 | 2021-03-26 | Autonomous knob domain peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022019047A2 true BR112022019047A2 (pt) | 2022-11-01 |
Family
ID=75339748
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022019047A BR112022019047A2 (pt) | 2020-03-27 | 2021-03-26 | Peptídeos de domínio knob autônomos |
Country Status (14)
Country | Link |
---|---|
US (1) | US20240024520A1 (pt) |
EP (1) | EP4126936A1 (pt) |
JP (1) | JP2023519576A (pt) |
KR (1) | KR20220160069A (pt) |
CN (1) | CN115667298A (pt) |
AU (1) | AU2021245031A1 (pt) |
BR (1) | BR112022019047A2 (pt) |
CA (1) | CA3175034A1 (pt) |
CL (1) | CL2022002635A1 (pt) |
CO (1) | CO2022015049A2 (pt) |
IL (1) | IL296732A (pt) |
MX (1) | MX2022012021A (pt) |
TW (1) | TW202202520A (pt) |
WO (1) | WO2021191424A1 (pt) |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060228364A1 (en) | 1999-12-24 | 2006-10-12 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
EP2338900B1 (en) | 2001-11-13 | 2014-01-01 | The Trustees of The University of Pennsylvania | Adeno-associated virus (AAV) Cy.5 sequences, vectors containing the same and uses thereof |
CA2469785C (en) | 2001-12-17 | 2014-04-22 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (aav) serotype 8 sequences, vectors containing same, and uses therefor |
GB0315457D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
US7989594B2 (en) | 2003-07-01 | 2011-08-02 | Celltech R & D Limited | Modified antibody fab fragments |
GB0315450D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
CN102199626B (zh) | 2003-09-30 | 2015-06-24 | 宾夕法尼亚大学托管会 | 腺伴随病毒(aav)进化支、序列、含有这些序列的载体及它们的应用 |
GB0412181D0 (en) | 2004-06-01 | 2004-06-30 | Celltech R&D Ltd | Biological products |
CN101203613B (zh) | 2005-04-07 | 2012-12-12 | 宾夕法尼亚大学托管会 | 增强腺相关病毒载体功能的方法 |
WO2007120542A2 (en) | 2006-03-30 | 2007-10-25 | The Board Of Trustees Of The Leland Stanford Junior University | Aav capsid library and aav capsid proteins |
GB0614780D0 (en) | 2006-07-25 | 2006-09-06 | Ucb Sa | Biological products |
EP2195341B1 (en) | 2007-09-26 | 2017-03-22 | UCB Biopharma SPRL | Dual specificity antibody fusions |
SI2334705T1 (sl) | 2008-09-26 | 2017-05-31 | Ucb Biopharma Sprl | Biološki produkti |
ES2667258T3 (es) | 2009-09-10 | 2018-05-10 | Ucb Biopharma Sprl | Anticuerpos multivalentes |
GB0920127D0 (en) | 2009-11-17 | 2009-12-30 | Ucb Pharma Sa | Antibodies |
GB0920324D0 (en) | 2009-11-19 | 2010-01-06 | Ucb Pharma Sa | Antibodies |
GB201000467D0 (en) | 2010-01-12 | 2010-02-24 | Ucb Pharma Sa | Antibodies |
GB201005064D0 (en) | 2010-03-25 | 2010-05-12 | Ucb Pharma Sa | Biological products |
CN103946237B (zh) | 2011-11-11 | 2017-04-12 | Ucb医药有限公司 | 白蛋白结合抗体及其结合片段 |
JP2015509091A (ja) * | 2012-01-09 | 2015-03-26 | ザ スクリプス リサーチ インスティテュート | ヒト化抗体 |
CA2863224A1 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
US10048253B2 (en) | 2012-06-28 | 2018-08-14 | Ucb Biopharma Sprl | Method for identifying compounds of therapeutic interest |
GB201223276D0 (en) | 2012-12-21 | 2013-02-06 | Ucb Pharma Sa | Antibodies and methods of producing same |
GB201310544D0 (en) | 2013-06-13 | 2013-07-31 | Ucb Pharma Sa | Obtaining an improved therapeutic ligand |
CN111518199A (zh) * | 2013-07-18 | 2020-08-11 | 图鲁斯生物科学有限责任公司 | 具有超长互补决定区的人源化抗体 |
GB201411320D0 (en) | 2014-06-25 | 2014-08-06 | Ucb Biopharma Sprl | Antibody construct |
GB201411420D0 (en) | 2014-06-26 | 2014-08-13 | Ucb Biopharma Sprl | Antibody constructs |
GB201811368D0 (en) | 2018-07-11 | 2018-08-29 | Ucb Biopharma Sprl | Antibody |
-
2021
- 2021-03-26 KR KR1020227037447A patent/KR20220160069A/ko active Search and Examination
- 2021-03-26 BR BR112022019047A patent/BR112022019047A2/pt unknown
- 2021-03-26 CN CN202180037575.9A patent/CN115667298A/zh active Pending
- 2021-03-26 CA CA3175034A patent/CA3175034A1/en active Pending
- 2021-03-26 EP EP21715868.2A patent/EP4126936A1/en active Pending
- 2021-03-26 MX MX2022012021A patent/MX2022012021A/es unknown
- 2021-03-26 AU AU2021245031A patent/AU2021245031A1/en active Pending
- 2021-03-26 WO PCT/EP2021/057946 patent/WO2021191424A1/en active Application Filing
- 2021-03-26 TW TW110111008A patent/TW202202520A/zh unknown
- 2021-03-26 US US17/907,116 patent/US20240024520A1/en active Pending
- 2021-03-26 IL IL296732A patent/IL296732A/en unknown
- 2021-03-26 JP JP2022558096A patent/JP2023519576A/ja active Pending
-
2022
- 2022-09-27 CL CL2022002635A patent/CL2022002635A1/es unknown
- 2022-10-21 CO CONC2022/0015049A patent/CO2022015049A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20220160069A (ko) | 2022-12-05 |
WO2021191424A1 (en) | 2021-09-30 |
AU2021245031A1 (en) | 2022-11-03 |
TW202202520A (zh) | 2022-01-16 |
EP4126936A1 (en) | 2023-02-08 |
CN115667298A (zh) | 2023-01-31 |
IL296732A (en) | 2022-11-01 |
CA3175034A1 (en) | 2021-09-30 |
MX2022012021A (es) | 2022-10-27 |
CO2022015049A2 (es) | 2022-11-08 |
JP2023519576A (ja) | 2023-05-11 |
US20240024520A1 (en) | 2024-01-25 |
CL2022002635A1 (es) | 2023-03-31 |
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