BR112022011570A2 - Anticorpos anti-mertk e métodos de uso dos mesmos - Google Patents

Anticorpos anti-mertk e métodos de uso dos mesmos

Info

Publication number
BR112022011570A2
BR112022011570A2 BR112022011570A BR112022011570A BR112022011570A2 BR 112022011570 A2 BR112022011570 A2 BR 112022011570A2 BR 112022011570 A BR112022011570 A BR 112022011570A BR 112022011570 A BR112022011570 A BR 112022011570A BR 112022011570 A2 BR112022011570 A2 BR 112022011570A2
Authority
BR
Brazil
Prior art keywords
mertk
methods
antibodies
compositions
mertk antibodies
Prior art date
Application number
BR112022011570A
Other languages
English (en)
Inventor
Lee Seung-Joo
Liang Spencer
Yee Angie
Roell Marina
Rosenthal Arnon
Original Assignee
Alector Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alector Llc filed Critical Alector Llc
Publication of BR112022011570A2 publication Critical patent/BR112022011570A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Abstract

ANTICORPOS ANTI-MERTK E MÉTODOS DE USO DOS MESMOS. A presente divulgação é, de modo geral, direcionada a composições que incluem anticorpos, por exemplo, anticorpos monoclonais, fragmentos de anticorpos, etc., que se ligam especificamente a um polipeptídeo MerTK, por exemplo, uma MerTK de mamífero ou MerTK humana, e uso de tais composições no tratamento de um indivíduo em necessidade.
BR112022011570A 2019-12-13 2020-12-11 Anticorpos anti-mertk e métodos de uso dos mesmos BR112022011570A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962947855P 2019-12-13 2019-12-13
US202063016821P 2020-04-28 2020-04-28
US202063121773P 2020-12-04 2020-12-04
PCT/US2020/064640 WO2021119508A1 (en) 2019-12-13 2020-12-11 Anti-mertk antibodies and methods of use thereof

Publications (1)

Publication Number Publication Date
BR112022011570A2 true BR112022011570A2 (pt) 2022-12-13

Family

ID=74186824

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022011570A BR112022011570A2 (pt) 2019-12-13 2020-12-11 Anticorpos anti-mertk e métodos de uso dos mesmos

Country Status (17)

Country Link
US (1) US11897968B2 (pt)
EP (1) EP4072680A1 (pt)
JP (1) JP2023506465A (pt)
KR (1) KR20220127252A (pt)
CN (1) CN115151307A (pt)
AU (1) AU2020401319A1 (pt)
BR (1) BR112022011570A2 (pt)
CA (1) CA3160210A1 (pt)
CL (1) CL2022001554A1 (pt)
CO (1) CO2022008314A2 (pt)
CR (1) CR20220329A (pt)
EC (1) ECSP22055004A (pt)
IL (1) IL293827A (pt)
MX (1) MX2022007231A (pt)
PE (1) PE20221326A1 (pt)
TW (1) TW202136303A (pt)
WO (1) WO2021119508A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022011570A2 (pt) 2019-12-13 2022-12-13 Alector Llc Anticorpos anti-mertk e métodos de uso dos mesmos
CA3217372A1 (en) * 2021-05-14 2022-11-17 Masoud TAVAZOIE Mertk peptides and uses thereof
CN117642426A (zh) 2021-06-16 2024-03-01 艾莱克特有限责任公司 双特异性抗MerTK和抗PDL1抗体及其使用方法
WO2022266221A1 (en) 2021-06-16 2022-12-22 Alector Llc Monovalent anti-mertk antibodies and methods of use thereof
WO2023063026A1 (ja) * 2021-10-15 2023-04-20 株式会社カイオム・バイオサイエンス ＭｅｒＴＫに特異的に結合する抗体又はその断片、及び抗腫瘍剤
WO2024022495A1 (en) * 2022-07-28 2024-02-01 Concept To Medicine Biotech Co., Ltd. Anti-MerTK ANTIBODIES AND USES THEREOF

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Publication number Publication date
ECSP22055004A (es) 2022-08-31
CL2022001554A1 (es) 2023-03-24
CO2022008314A2 (es) 2022-07-08
EP4072680A1 (en) 2022-10-19
JP2023506465A (ja) 2023-02-16
PE20221326A1 (es) 2022-09-09
IL293827A (en) 2022-08-01
CN115151307A (zh) 2022-10-04
CR20220329A (es) 2022-11-23
KR20220127252A (ko) 2022-09-19
US20210261685A1 (en) 2021-08-26
CA3160210A1 (en) 2021-06-17
US11897968B2 (en) 2024-02-13
MX2022007231A (es) 2022-07-12
WO2021119508A1 (en) 2021-06-17
TW202136303A (zh) 2021-10-01
AU2020401319A1 (en) 2022-06-30

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