BR112022005460A2 - Métodos e compostos para a restauração da função de p53 mutante - Google Patents

Métodos e compostos para a restauração da função de p53 mutante

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Publication number
BR112022005460A2
BR112022005460A2 BR112022005460A BR112022005460A BR112022005460A2 BR 112022005460 A2 BR112022005460 A2 BR 112022005460A2 BR 112022005460 A BR112022005460 A BR 112022005460A BR 112022005460 A BR112022005460 A BR 112022005460A BR 112022005460 A2 BR112022005460 A2 BR 112022005460A2
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compounds
mutant
methods
function
restoration
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BR112022005460A
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English (en)
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Vu Binh
Dominique Romyr
Li Hongju
Fahr Bruce
Good Andrew
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Pmv Pharmaceuticals Inc
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Abstract

Mutações em oncogenes e supressores de tumor contribuem para o desenvolvimento e progressão do câncer. A presente divulgação descreve compostos e métodos para recuperar a função de tipo selvagem para mutantes de p53. Os compostos da presente invenção podem se ligar ao mutante p53 e restaurar a capacidade do mutante p53 de se ligar ao DNA e ativar efetores a jusante envolvidos na supressão tumoral. Os compostos divulgados podem ser usados para reduzir a progressão de cânceres que contêm uma mutação p53.
BR112022005460A 2019-09-23 2020-09-22 Métodos e compostos para a restauração da função de p53 mutante BR112022005460A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962904369P 2019-09-23 2019-09-23
US202063038388P 2020-06-12 2020-06-12
PCT/US2020/051998 WO2021061643A1 (en) 2019-09-23 2020-09-22 METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

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BR112022005460A2 true BR112022005460A2 (pt) 2022-08-16

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US (2) US11814373B2 (pt)
EP (1) EP4034104A4 (pt)
JP (2) JP7374309B2 (pt)
KR (1) KR20220070255A (pt)
CN (1) CN115003299A (pt)
AU (1) AU2020352516A1 (pt)
BR (1) BR112022005460A2 (pt)
CA (1) CA3152160A1 (pt)
IL (1) IL291593A (pt)
MX (1) MX2022003456A (pt)
WO (1) WO2021061643A1 (pt)

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KR102577241B1 (ko) 2017-12-28 2023-09-11 주식회사 대웅제약 카이네이즈 저해제로서의 아미노-플루오로피페리딘 유도체

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